Pyrrolidinones as herbicides

ABSTRACT

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof: 
     
       
         
         
             
             
         
       
     
     wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q 1 , Q 2 , Y 1 , and Y 2  are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

FIELD OF THE INVENTION

This invention relates to certain pyrrolidinones, their N-oxides and salts, and compositions and methods of their use for controlling undesirable vegetation.

BACKGROUND OF THE INVENTION

The control of undesired vegetation is extremely important in achieving high crop efficiency. Achievement of selective control of the growth of weeds especially in such useful crops as rice, soybean, sugar beet, maize, potato, wheat, barley, tomato and plantation crops, among others, is very desirable. Unchecked weed growth in such useful crops can cause significant reduction in productivity and thereby result in increased costs to the consumer. The control of undesired vegetation in noncrop areas is also important. Many products are commercially available for these purposes, but the need continues for new compounds that are more effective, less costly, less toxic, environmentally safer or have different sites of action.

SUMMARY OF THE INVENTION

This invention is directed to compounds of Formula 1 (including all stereoisomers), including N-oxides and salts thereof, agricultural compositions containing them and their use as herbicides:

wherein

-   -   Q¹ is a phenyl ring or a naphthalenyl ring system, each ring or         ring system optionally substituted with up to 5 substituents         independently selected from R⁷; or a 5- to 6-membered fully         unsaturated heterocyclic ring or an 8- to 10-membered         heteroaromatic bicyclic ring system, each ring or ring system         containing ring members selected from carbon atoms and 1 to 4         heteroatoms independently selected from up to 2 O, up to 2 S and         up to 4 N atoms, wherein up to 3 carbon ring members are         independently selected from C(═O) and C(═S), and the sulfur atom         ring members are independently selected from         S(═O)_(u)(═NR⁸)_(v), each ring or ring system optionally         substituted with up to 5 substituents independently selected         from R⁷ on carbon atom ring members and selected from R⁹ on         nitrogen atom ring members;     -   Q² is a phenyl ring or a naphthalenyl ring system, each ring or         ring system optionally substituted with up to 5 substituents         independently selected from R¹⁰; or a 5- to 6-membered fully         unsaturated heterocyclic ring or an 8- to 10-membered         heteroaromatic bicyclic ring system, each ring or ring system         containing ring members selected from carbon atoms and 1 to 4         heteroatoms independently selected from up to 2 0, up to 2 S and         up to 4 N atoms, wherein up to 3 carbon ring members are         independently selected from C(═0) and C(═S), and the sulfur atom         ring members are independently selected from         S(═O)_(u)(═NR⁸)_(v), each ring or ring system optionally         substituted with up to 5 substituents independently selected         from R¹⁰ on carbon atom ring members and selected from R¹¹ on         nitrogen atom ring members;     -   Y¹ and Y² are each independently O, S or NR¹²;     -   R¹ is H, hydroxy, amino, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆         alkenyl, C₃-C₆ alkynyl, C₄-C₈ cycloalkylalkyl, C₂-C₈         alkoxyalkyl, C₂-C₈ haloalkoxyalkyl, C₂-C₈ alkylthioalkyl, C₂-C₈         alkylsulfinylalkyl, C₂-C₈ alkylsulfonylalkyl, C₂-C₈         alkylcarbonyl, C₂-C₈ haloalkylcarbonyl, C₄-C₁₀         cycloalkylcarbonyl, C₂-C₈ alkoxycarbonyl, C₂-C₈         haloalkoxycarbonyl, C₄-C₁₀ cycloalkoxycarbonyl, C₂-C₈         alkylaminocarbonyl, C₃-C₁₀ dialkylaminocarbonyl, C₄-C₁₀         cycloalkylaminocarbonyl, C₁-C₆ alkoxy, C₁-C₆ alkylthio, C₁-C₆         haloalkylthio, C₃-C₈ cycloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆         haloalkylsulfinyl, C₃-C₈ cycloalkylsulfinyl, C₁-C₆         alkylsulfonyl, C₁-C₆ haloalkylsulfonyl, C₃-C₈         cycloalkylsulfonyl, C₁-C₆ alkylaminosulfonyl, C₂-C₈         dialkylaminosulfonyl, C₃-C₁₀ trialkylsilyl or G¹;     -   R² and R³ are each independently H, halogen or C₁-C₄ alkyl; or     -   R² and R³ are taken together with the carbon atom to which they         are bonded to form a C₃-C₇ cycloalkyl ring;     -   R⁴ and R⁵ are each independently H, halogen or C₁-C₄ alkyl;     -   R⁶ is H, hydroxy, amino, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₂-C₆         alkenyl, C₃-C₆ alkynyl, C₂-C₈ alkoxyalkyl, C₂-C₈         haloalkoxyalkyl, C₂-C₈ alkylthioalkyl, C₂-C₈ alkylsulfinylalkyl,         C₂-C₈ alkylsulfonylalkyl, C₂-C₈ alkylcarbonyl, C₂-C₈         haloalkylcarbonyl, C₄-C₁₀ cycloalkylcarbonyl, C₂-C₈         alkoxycarbonyl, C₂-C₈ haloalkoxycarbonyl, C₄-C₁₀         cycloalkoxycarbonyl, C₂-C₈ alkylaminocarbonyl, C₃-C₁₀         dialkylaminocarbonyl, C₄-C₁₀ cycloalkylaminocarbonyl, C₁-C₆         alkoxy, C₁-C₆ alkylthio, C₁-C₆ haloalkylthio, C₃-C₈         cycloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆ haloalkylsulfinyl,         C₃-C₈ cycloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆         haloalkylsulfonyl, C₃-C₈ cycloalkylsulfonyl, C₁-C₆         alkylaminosulfonyl, C₂-C₈ dialkylaminosulfonyl, C₃-C₁₀         trialkylsilyl or G¹;     -   each R⁷ and R¹⁰ is independently halogen, cyano, nitro, C₁-C₈         alkyl, C₁-C₈ haloalkyl, C₁-C₈ nitroalkyl, C₂-C₈ alkenyl, C₂-C₈         haloalkenyl, C₂-C₈ nitroalkenyl, C₂-C₈ alkynyl, C₂-C₈         haloalkynyl, C₄-C₁₀ cycloalkylalkyl, C₄-C₁₀ halocycloalkylalkyl,         C₅-C₁₂ alkylcycloalkylalkyl, C₅-C₁₂ cycloalkylalkenyl, C₅-C₁₂         cycloalkylalkynyl, C₃-C₈ cycloalkyl, C₃-C₈ halocycloalkyl,         C₄-C₁₀ alkylcycloalkyl, C₆-C₁₂ cycloalkylcycloalkyl, C₃-C₈         cycloalkenyl, C₃-C₈ halocycloalkenyl, C₂-C₈ alkoxyalkyl, C₂-C₈         haloalkoxyalkyl, C₃-C₈ haloalkoxyalkoxy, C₃-C₈ alkoxyalkoxy,         C₄-C₁₀ cycloalkoxyalkyl, C₃-C₁₀ alkoxyalkoxyalkyl, C₂-C₈         alkylthioalkyl, C₂-C₈ alkylsulfinylalkyl, C₂-C₈         alkylsulfonylalkyl, C₂-C₈ alkylaminoalkyl, C₂-C₈         haloalkylaminoalkyl, C₄-C₁₀ cycloalkylaminoalkyl, C₃-C₁₀         dialkylaminoalkyl, —CHO, C₂-C₈ alkylcarbonyl, C₂-C₈         haloalkylcarbonyl, C₄-C₁₀ cycloalkylcarbonyl, —C(═O)OH, C₂-C₈         alkoxycarbonyl, C₂-C₈ haloalkoxycarbonyl, C₄-C₁₀         cycloalkoxycarbonyl, C₅-C₁₂ cycloalkylalkoxycarbonyl, —C(═O)NH₂,         C₂-C₈ alkylaminocarbonyl, C₄-C₁₀ cycloalkylaminocarbonyl, C₃-C₁₀         dialkylaminocarbonyl, C₁-C₈ alkoxy, C₁-C₈ haloalkoxy, C₂-C₈         alkoxyalkoxy, C₂-C₈ alkenyloxy, C₂-C₈ haloalkenyloxy, C₃-C₈         alkynyloxy, C₃-C₈ haloalkynyloxy, C₃-C₈ cycloalkoxy, C₃-C₈         halocycloalkoxy, C₄-C₁₀ cycloalkylalkoxy, C₃-C₁₀         alkylcarbonylalkoxy, C₂-C₈ alkylcarbonyloxy, C₂-C₈         haloalkylcarbonyloxy, C₄-C₁₀ cycloalkylcarbonyloxy, C₁-C₈         alkylsulfonyloxy, C₁-C₈ haloalkylsulfonyloxy, C₁-C₈ alkylthio,         C₁-C₈ haloalkylthio, C₃-C₈ cycloalkylthio, C₁-C₈ alkylsulfinyl,         C₁-C₈ haloalkylsulfinyl, C₁-C₈ alkylsulfonyl, C₁-C₈         haloalkylsulfonyl, C₃-C₈ cycloalkylsulfonyl, formylamino, C₂-C₈         alkylcarbonylamino, C₂-C₈ haloalkylcarbonylamino, C₂-C₈         alkoxycarbonylamino, C₁-C₆ alkylsulfonylamino, C₁-C₆         haloalkylsulfonylamino, —SF₅, —SCN, SO₂NH₂, C₃-C₁₂         trialkylsilyl, C₄-C₁₂ trialkylsilylalkyl, C₄-C₁₂         trialkylsilylalkoxy or G²;     -   each R⁸ is independently H, cyano, C₂-C₃ alkylcarbonyl or C₂-C₃         haloalkylcarbonyl;     -   each R⁹ and R¹¹ is independently cyano, C₁-C₃ alkyl, C₂-C₃         alkenyl, C₂-C₃ alkynyl, C₃-C₆ cycloalkyl, C₂-C₃ alkoxyalkyl,         C₁-C₃ alkoxy, C₂-C₃ alkylcarbonyl, C₂-C₃ alkoxycarbonyl, C₂-C₃         alkylaminoalkyl or C₃-C₄ dialkylaminoalkyl;     -   each R¹² is independently H, cyano, C₁-C₄ alkyl, C₁-C₄         haloalkyl, —(C═O)CH₃ or —(C═O)CF₃;     -   each G¹ is independently phenyl, phenylmethyl (i.e. benzyl),         pyridinylmethyl, phenylcarbonyl (i.e. benzoyl), phenoxy,         phenylethynyl, phenylsulfonyl or a 5- or 6-membered         heteroaromatic ring, each optionally substituted on ring members         with up to 5 substituents independently selected from R¹³;     -   each G² is independently phenyl, phenylmethyl (i.e. benzyl),         pyridinylmethyl, phenylcarbonyl (i.e. benzoyl), phenoxy,         phenylethynyl, phenylsulfonyl or a 5- or 6-membered         heteroaromatic ring, each optionally substituted on ring members         with up to 5 substituents independently selected from R¹⁴;     -   each R¹³ and R¹⁴ is independently halogen, cyano, hydroxy,         amino, nitro, —CHO, —C(═O)OH, —C(═O)NH₂, —SO₂NH₂, C₁-C₆ alkyl,         C₁-C₆ haloalkyl, C₂-C₆ alkenyl, C₂-C₆ alkynyl, C₂-C₈         alkylcarbonyl, C₂-C₈ haloalkylcarbonyl, C₂-C₈ alkoxycarbonyl,         C₄-C₁₀ cycloalkoxycarbonyl, C₅-C₁₂ cycloalkylalkoxycarbonyl,         C₂-C₈ alkylaminocarbonyl, C₃-C₁₀ dialkylaminocarbonyl, C₁-C₆         alkoxy, C₁-C₆ haloalkoxy, C₂-C₈ alkylcarbonyloxy, C₁-C₆         alkylthio, C₁-C₆ haloalkylthio, C₁-C₆ alkylsulfinyl, C₁-C₆         haloalkylsulfinyl, C₁-C₆ alkylsulfonyl, C₁-C₆ haloalkylsulfonyl,         C₁-C₆ alkylaminosulfonyl, C₂-C₈ dialkylaminosulfonyl, C₃-C₁₀         trialkylsilyl, C₁-C₆ alkylamino, C₂-C₈ dialkylamino, C₂-C₈         alkylcarbonylamino, C₁-C₆ alkylsulfonylamino, phenyl, pyridinyl         or thienyl; and     -   each u and v are independently 0, 1 or 2 in each instance of         S(═O)_(u)(═NR⁸)_(v), provided that the sum of u and v is 0, 1 or         2;     -   provided that     -   (a) the compound of Formula 1 is other than         N-1H-benzotriazol-1-yl-2-oxo-4-phenyl-3-pyrrolidinecarboxamide;

(b) when Q¹ comprises a 3-furanyl or 3-pyridinyl ring directly bonded to the remainder of Formula 1, then said ring is substituted with at least one substituent selected from R⁷;

-   -   (c) when Q¹ is an unsubstituted phenyl ring, and Q² comprises a         phenyl ring directly bonded to the remainder of Formula 1, then         said Q² ring is substituted with R¹⁰ other than optionally         substituted phenoxy or F at a 2-position, cyano or —CF₃ at the         4-position and R⁵ is H or halogen;     -   (d) when Q¹ is unsubstituted phenyl, and Q² comprises a         pyridinyl ring directly bonded to the remainder of Formula 1,         then said pyridinyl ring is substituted with at least one         substituent selected from R¹⁰;     -   (e) when Q¹ is a phenyl ring substituted with 4-phenyl or         4-phenoxy, said Q¹ ring is further substituted with and R⁷         substituent;     -   (f) when Q¹ comprises a phenyl ring directly bonded to the         remainder of Formula 1 and said ring is substituted with R⁷ at         both ortho positions (relative to the bond to the remainder of         Formula 1), then said ring is also independently substituted         with R⁷ on at least one additional position;     -   (g) when Q¹ is other than unsubstituted 1-naphthalenyl, then Q²         is other than 2,3-di-fluorophenyl or 2-CF₃-phenyl;

(h) Q² is other than optionally substituted 1H-pyrazol-5-yl; and

-   -   (i) when Q² comprises a 1H-pyrazol-3-yl ring directly bonded to         the remainder of Formula 1, said ring is substituted at the         1-position with R⁹.

More particularly, this invention pertains to a compound of Formula 1 (including all stereoisomers), an N-oxide or a salt thereof. This invention also relates to a herbicidal composition comprising a compound of the invention (i.e. in a herbicidally effective amount) and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents, the composition optionally further comprising at least one additional active ingredient selected from the group consisting of other herbicides and herbicide safeners. This invention further relates to a method for controlling the growth of undesired vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of the invention (e.g., as a composition described herein).

DETAILS OF THE INVENTION

As used herein, the terms “comprises,” “comprising,” “includes,” “including,” “has,” “having,” “contains”, “containing,” “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process, or method.

The transitional phrase “consisting of” excludes any element, step, or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase “consisting of” appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.

The transitional phrase “consisting essentially of” is used to define a composition, method that includes materials, steps, features, components, or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components, or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term “consisting essentially of” occupies a middle ground between “comprising” and “consisting of”.

Where applicants have defined an invention or a portion thereof with an open-ended term such as “comprising,” it should be readily understood that (unless otherwise stated) the description should be interpreted to also describe such an invention using the terms “consisting essentially of” or “consisting of.”

Further, unless expressly stated to the contrary, “or” refers to an inclusive or and not to an exclusive or. For example, a condition A or B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present).

Also, the indefinite articles “a” and “an” preceding an element or component of the invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore “a” or “an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular.

As referred to herein, the term “seedling”, used either alone or in a combination of words means a young plant developing from the embryo of a seed.

As referred to herein, the term “broadleaf” used either alone or in words such as “broadleaf weed” means dicot or dicotyledon, a term used to describe a group of angiosperms characterized by embryos having two cotyledons.

As used herein, the term “alkylating agent” refers to a chemical compound in which a carbon-containing radical is bound through a carbon atom to a leaving group such as halide or sulfonate, which is displaceable by bonding of a nucleophile to said carbon atom. Unless otherwise indicated, the term “alkylating” does not limit the carbon-containing radical to alkyl; the carbon-containing radicals in alkylating agents include the variety of carbon-bound substituent radicals specified for R¹.

In the above recitations, the term “alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” includes straight-chain or branched alkyl, such as, methyl, ethyl, n-propyl, i-propyl, or the different butyl, pentyl or hexyl isomers. “Alkenyl” includes straight-chain or branched alkenes such as ethenyl, 1-propenyl, 2-propenyl, and the different butenyl, pentenyl and hexenyl isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. “Alkynyl” includes straight-chain or branched alkynes such as ethynyl, 1-propynyl, 2-propynyl and the different butynyl, pentynyl and hexynyl isomers. “Alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl.

“Alkoxy” includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy, pentoxy and hexyloxy isomers. “Alkoxyalkyl” denotes alkoxy substitution on alkyl. Examples of “alkoxyalkyl” include CH₃OCH₂, CH₃OCH₂CH₂, CH₃CH₂OCH₂, CH₃CH₂CH₂CH₂OCH₂ and CH₃CH₂OCH₂CH₂. “Alkoxyalkoxyalkyl” denotes at least alkoxy substitution on the alkoxy moiety of alkoxyalkyl moiety. Examples of “alkoxyalkoxyalkyl” include CH₃OCH₂OCH₂—, CH₃CH₂O(CH₃)CHOCH₂— and (CH₃O)₂CHOCH₂—. “Alkoxyalkoxy” denotes alkoxy substitution on alkoxy. “Alkenyloxy” includes straight-chain or branched alkenyloxy moieties. Examples of “alkenyloxy” include H₂C═CHCH₂O, (CH₃)₂C═CHCH₂O, (CH₃)CH═CHCH₂O, (CH₃)CH═C(CH₃)CH₂O and CH₂═CHCH₂CH₂O. “Alkynyloxy” includes straight-chain or branched alkynyloxy moieties. Examples of “alkynyloxy” include HC≡CCH₂O, CH₃C≡CCH₂O and CH₃C≡CCH₂CH₂O. “Alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, and the different propylthio, butylthio, pentylthio and hexylthio isomers. “Alkylsulfinyl” includes both enantiomers of an alkylsulfinyl group. Examples of “alkylsulfinyl” include CH₃S(O)—, CH₃CH₂S(O)—, CH₃CH₂CH₂S(O)—, (CH₃)₂CHS(O)— and the different butylsulfinyl, pentylsulfinyl and hexylsulfinyl isomers. Examples of “alkylsulfonyl” include CH₃S(O)₂—, CH₃CH₂S(O)₂—, CH₃CH₂CH₂S(O)₂—, (CH₃)₂CHS(O)₂—, and the different butylsulfonyl, pentylsulfonyl and hexylsulfonyl isomers. “Alkylthioalkyl” denotes alkylthio substitution on alkyl. Examples of “alkylthioalkyl” include CH₃SCH₂, CH₃SCH₂CH₂, CH₃CH₂SCH₂, CH₃CH₂CH₂CH₂SCH₂ and CH₃CH₂SCH₂CH₂. “Alkylsulfinylalkyl” denotes alkylsulfinyl substitution on alkyl. Examples of “alkylsulfinylalkyl” include CH₃S(═O)CH₂, CH₃S(═O)CH₂CH₂, CH₃CH₂S(═O)CH₂ and CH₃CH₂S(═O)CH₂CH₂. “Alkylsulfonylalkyl” denotes alkylsulfinyl substitution on alkyl. Examples of “alkylsulfinylalkyl” include CH₃S(═O)₂CH₂, CH₃S(═O)₂CH₂CH₂, CH₃CH₂S(═O)₂CH₂ and CH₃CH₂S(═O)₂CH₂CH₂. “Alkylamino”, “dialkylamino”, and the like, are defined analogously to the above examples. Examples of “alkylaminoalkyl” include CH₃NHCH₂—, (CH₃)₂CHNHCH₂— and CH₃NHCH(CH₃)—. Examples of “dialkylaminoalkyl” include (CH₃)₂NCH₂—, (CH₃)₂NC(CH₃)H— and (CH₃)(CH₃)NCH₂—. Examples of “dialkylaminocarbonyl” include (CH₃)₂NC(O)—. Examples of “dialkylaminosulfonyl” include (CH₃)₂NS(O)₂—. The term “alkoxycarbonylamino” denotes a straight-chain or branched alkoxy moieties bonded to a C(═O) moiety of carbonylamino group. Examples of “alkoxycarbonylamino” include CH₃OC(═O)NH— and CH₃CH₂OC(═O)NH—.

“Cycloalkyl” includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. The term “alkylcycloalkyl” denotes alkyl substitution on a cycloalkyl moiety and includes, for example, ethylcyclopropyl, i-propylcyclobutyl, 3-methylcyclopentyl and 4-methylcyclohexyl. The term “cycloalkylalkyl” denotes cycloalkyl substitution on an alkyl moiety. Examples of “cycloalkylalkyl” include cyclopropylmethyl, cyclopentylethyl, and other cycloalkyl moieties bonded to straight-chain or branched alkyl groups. The term “cycloalkoxy” denotes cycloalkyl linked through an oxygen atom such as cyclopentyloxy and cyclohexyloxy. “Cycloalkylalkoxy” denotes cycloalkylalkyl linked through an oxygen atom attached to the alkyl chain. Examples of “cycloalkylalkoxy” include cyclopropylmethoxy, cyclopentylethoxy, and other cycloalkyl moieties bonded to straight-chain or branched alkoxy groups. “Cycloalkenyl” includes groups such as cyclopentenyl and cyclohexenyl as well as groups with more than one double bond such as 1,3- and 1,4-cyclohexadienyl.

The term “halogen”, either alone or in compound words such as “haloalkyl”, or when used in descriptions such as “alkyl substituted with halogen” includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, or when used in descriptions such as “alkyl substituted with halogen” said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” or “alkyl substituted with halogen” include F₃C, ClCH₂, CF₃CH₂ and CF₃CCl₂. The terms “halocycloalkyl”, “haloalkoxy”, “haloalkylthio”, “haloalkenyl”, “haloalkynyl”, “haloalkenyloxy”, “haloalkylcarbonylamino”, “haloalkylsulfonylamino”, “haloalkylsulfonyl-oxy”, “haloalkoxyalkyl”, “haloalkylcarbonyloxy”, “haloalkylaminoalkyl” and the like, are defined analogously to the term “haloalkyl”. Examples of “haloalkoxy” include CF₃O—, CCl₃CH₂O—, HCF₂CH₂CH₂O— and CF₃CH₂O—. Examples of “haloalkylthio” include CCl₃S—, CF₃S—, CCl₃CH₂S— and ClCH₂CH₂CH₂S—. Examples of “haloalkylsulfinyl” include CF₃S(O)—, CCl₃S(O)—, CF₃CH₂S(O)— and CF₃CF₂S(O)—. Examples of “haloalkylsulfonyl” include CF₃S(O)₂—, CCl₃S(O)₂—, CF₃CH₂S(O)₂— and CF₃CF₂S(O)₂—. Examples of “haloalkenyl” include (Cl)₂C═CHCH₂— and CF₃CH₂CH═CHCH₂—. Examples of “haloalkenyloxy” include (Cl)₂C═CHCH₂O— and CF₃CH₂CH═CHCH₂O—. Examples of “haloalkynyl” include HC≡CCHCl—, CF₃C≡C—, CCl₃C≡C— and FCH₂C≡CCH₂—. Examples of “haloalkoxyalkyl” include CF₃OCH₂—, ClCH₂CH₂OCH₂CH₂—, Cl₃CCH₂OCH₂— as well as branched alkyl derivatives. Examples of “haloalkoxycarbonyl” include CF₃OC(O)—, ClCH₂CH₂OCH₂CH₂—, Cl₃CCH₂OCH₂OC(O)— as well as branched alkyl derivatives.

“Alkylcarbonyl” denotes a straight-chain or branched alkyl moieties bonded to a C(═O) moiety. Examples of “alkylcarbonyl” include CH₃C(═O)—, CH₃CH₂CH₂C(═O)— and (CH₃)₂CHC(═O)—. Examples of “alkoxycarbonyl” include CH₃OC(═O)—, CH₃CH₂OC(═O)—, CH₃CH₂CH₂OC(═O)—, (CH₃)₂CHOC(═O)— and the different butoxy- or pentoxycarbonyl isomers. “Cycloalkylalkoxycarbonyl” denotes a cycloalkylalkyl moieties bonded to an oxygen atom of alkoxycarbonyl moiety. Examples of “cycloalkylalkoxycarbonyl” include cyclopropyl-CH₂OC(═O)—, cyclopropyl-CH(CH₃)OC(═O)— and cyclopentyl-CH₂OC(═O)—.

The total number of carbon atoms in a substituent group is indicated by the “C_(i)-C_(j)” prefix where i and j are numbers from 1 to 12. For example, C₁-C₄ alkylsulfonyl designates methylsulfonyl through butylsulfonyl; C₂ alkoxyalkyl designates CH₃OCH₂—; C₃ alkoxyalkyl designates, for example, CH₃CH(OCH₃)—, CH₃OCH₂CH₂— or CH₃CH₂OCH₂—; and C₄ alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH₃CH₂CH₂OCH₂— and CH₃CH₂OCH₂CH₂—.

When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents, e.g., [R⁷)_(n)], n is 1, 2, 3, 4 or 5). Further, when the subscript indicates a range, e.g. (R)_(i-j), then the number of substituents may be selected from the integers between i and j inclusive. When a group contains a substituent which can be hydrogen, for example R¹ or R², then when this substituent is taken as hydrogen, it is recognized that this is equivalent to said group being unsubstituted. When a variable group is shown to be optionally attached to a position, for example [R(⁷)_(n)] wherein n may be 0, then hydrogen may be at the position even if not recited in the variable group definition. When one or more positions on a group are said to be “not substituted” or “unsubstituted”, then hydrogen atoms are attached to take up any free valency.

The expression “fully saturated” in relation to a ring of atoms means that the bonds between the atoms of the ring are all single. The expression “fully unsaturated” in relation to a ring means that the bonds between the atoms in the ring are single or double bonds according to valence bond theory and furthermore the bonds between the atoms in the ring include as many double bonds as possible without double bonds being cumulative (i.e. no C═C═C, N═C═C, etc.). The term “partially unsaturated” in relation to a ring denotes a ring comprising at least one ring member bonded to an adjacent ring member though a double bond and which conceptually potentially accommodates a number of non-cumulated double bonds through adjacent ring members (i.e. in its fully unsaturated counterpart form) greater than the number of double bonds present (i.e. in its partially unsaturated form). When a fully unsaturated ring satisfies Hückel's rule then it can also be described as aromatic.

Unless otherwise indicated, a “ring” or “ring system” as a component of Formula 1 (e.g., substituent Q¹) is carbocyclic or heterocyclic. The term “ring system” denotes two or more fused rings. The terms “bicyclic ring system” and “fused bicyclic ring system” denote a ring system consisting of two fused rings, in which either ring can be saturated, partially unsaturated, or fully unsaturated unless otherwise indicated. The term “fused heterobicyclic ring system” denotes a fused bicyclic ring system in which at least one ring atom is not carbon. A “bridged bicyclic ring system” is formed by bonding a segment of one or more atoms to nonadjacent ring members of a ring. The term “ring member” refers to an atom or other moiety (e.g., C(═O), C(═S), S(O) or S(O)₂) forming the backbone of a ring or ring system.

The terms “carbocyclic ring”, “carbocycle” or “carbocyclic ring system” denote a ring or ring system wherein the atoms forming the ring backbone are selected only from carbon. Unless otherwise indicated, a carbocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated carbocyclic ring satisfies Hückel's rule, then said ring is also called an “aromatic ring”. “Saturated carbocyclic” refers to a ring having a backbone consisting of carbon atoms linked to one another by single bonds; unless otherwise specified, the remaining carbon valences are occupied by hydrogen atoms.

The terms “heterocyclic ring”, “heterocycle” or “heterocyclic ring system” denote a ring or ring system in which at least one atom forming the ring backbone is not carbon, e.g., nitrogen, oxygen or sulfur. Typically a heterocyclic ring contains no more than 4 nitrogens, no more than 2 oxygens and no more than 2 sulfurs. Unless otherwise indicated, a heterocyclic ring can be a saturated, partially unsaturated, or fully unsaturated ring. When a fully unsaturated heterocyclic ring satisfies Hückel's rule, then said ring is also called a “heteroaromatic ring” or “aromatic heterocyclic ring”. Unless otherwise indicated, heterocyclic rings and ring systems can be attached through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen.

“Aromatic” indicates that each of the ring atoms is essentially in the same plane and has a p-orbital perpendicular to the ring plane, and that (4n+2)π electrons, where n is a positive integer, are associated with the ring to comply with Hückel's rule. The term “aromatic ring system” denotes a carbocyclic or heterocyclic ring system in which at least one ring of the ring system is aromatic. The term “aromatic carbocyclic ring system” denotes a carbocyclic ring system in which at least one ring of the ring system is aromatic. The term “aromatic heterocyclic ring system” denotes a heterocyclic ring system in which at least one ring of the ring system is aromatic. The term “nonaromatic ring system” denotes a carbocyclic or heterocyclic ring system that may be fully saturated, as well as partially or fully unsaturated, provided that none of the rings in the ring system are aromatic. The term “nonaromatic carbocyclic ring system” in which no ring in the ring system is aromatic. The term “nonaromatic heterocyclic ring system” denotes a heterocyclic ring system in which no ring in the ring system is aromatic.

The term “optionally substituted” in connection with the heterocyclic rings refers to groups which are unsubstituted or have at least one non-hydrogen substituent that does not extinguish the biological activity possessed by the unsubstituted analog. As used herein, the following definitions shall apply unless otherwise indicated. The term “optionally substituted” is used interchangeably with the phrase “substituted or unsubstituted” or with the term “(un)substituted.” Unless otherwise indicated, an optionally substituted group may have a substituent at each substitutable position of the group, and each substitution is independent of the other.

When Q¹ or Q² is 5- or 6-membered nitrogen-containing heterocyclic ring, it may be attached to the remainder of Formula 1 though any available carbon or nitrogen ring atom, unless otherwise described. As noted above, Q¹ and Q² can be (among others) phenyl optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. An example of phenyl optionally substituted with one to five substituents is the ring illustrated as U-1 in Exhibit 1, wherein, for example, R^(v) is R⁷ as defined in the Summary of the Invention for Q¹, or R^(v) is R¹⁰ as defined in the Summary of the Invention for Q², and r is an integer (from 0 to 5).

As noted above, Q¹ and Q² can be (among others) a 5- or 6-membered fully unsaturated heterocyclic ring, optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention. Examples of a 5- or 6-membered unsaturated aromatic heterocyclic ring optionally substituted with from one or more substituents include the rings U-2 through U-61 illustrated in Exhibit 1 wherein R^(v) is any substituent as defined in the Summary of the Invention for Q¹ and Q², and r is an integer from 0 to 4, limited by the number of available positions on each U group. As U-29, U-30, U-36, U-37, U-38, U-39, U-40, U-41, U-42 and U-43 have only one available position, for these U groups r is limited to the integers 0 or 1, and r being 0 means that the U group is unsubstituted and a hydrogen is present at the position indicated by (R^(v))_(r).

As noted above, Q¹ and Q² can be (among others) an 8-, 9- or 10-membered heteroaromatic bicyclic ring system optionally substituted with one or more substituents selected from a group of substituents as defined in the Summary of the Invention for Q¹ and Q². Examples of 8-, 9- or 10-membered heteroaromatic bicyclic ring system optionally substituted with from one or more substituents include the rings U-62 through U-100 illustrated in Exhibit 2 wherein R^(v) is any substituent as defined in the Summary of the Invention for Q¹ or Q², and r is typically an integer from 0 to 4.

Although R^(v) groups are shown in the structures U-1 through U-100, it is noted that they do not need to be present since they are optional substituents. Note that when R^(v) is H when attached to an atom, this is the same as if said atom is unsubstituted. The nitrogen atoms that require substitution to fill their valence are substituted with H or R^(v). Note that when the attachment point between (R^(v))_(r) and the U group is illustrated as floating, (R^(v))_(r) can be attached to any available carbon atom or nitrogen atom of the U group. Note that when the attachment point on the U group is illustrated as floating, the U group can be attached to the remainder of Formula 1 through any available carbon or nitrogen of the U group by replacement of a hydrogen atom. Preferably for greatest herbicidal activity, the U group is attached to the remainder of Formula 1 through an available carbon or nitrogen on a fully unsaturated ring of the U group. Note that some U groups can only be substituted with less than 4 R^(v) groups (e.g., U-2 through U-5, U-7 through U-48, and U-52 through U-61).

In the present disclosure and claims, the term “pyrrolidinone” and related terms such as “pyrrolidinone ring” refer to 2-oxo-pyrrolidine derivatives according to the Chemical Abstracts system of nomenclature, including derivatives in which the oxygen atom of the 2-oxo moiety is replaced by S or NR¹² as Y¹, unless limited to oxygen by particular context.

A wide variety of synthetic methods are known in the art to enable preparation of aromatic and nonaromatic heterocyclic rings and ring systems; for extensive reviews see the eight volume set of Comprehensive Heterocyclic Chemistry, A. R. Katritzky and C. W. Rees editors-in-chief, Pergamon Press, Oxford, 1984 and the twelve volume set of Comprehensive Heterocyclic Chemistry II, A. R. Katritzky, C. W. Rees and E. F. V. Scriven editors-in-chief, Pergamon Press, Oxford, 1996.

Compounds of this invention can exist as one or more stereoisomers. The various stereoisomers include enantiomers, diastereomers, atropisomers and geometric isomers. Stereoisomers are isomers of identical constitution but differing in the arrangement of their atoms in space and include enantiomers, diastereomers, cis-trans isomers (also known as geometric isomers) and atropisomers. Atropisomers result from restricted rotation about single bonds where the rotational barrier is high enough to permit isolation of the isomeric species. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers. The compounds of the invention may be present as a mixture of stereoisomers, individual stereoisomers or as an optically active form. Particularly when R⁴ and R⁵ are each H, the C(O)N(Q²)(R⁶) and Q¹ substituents are typically mostly in the thermodynamically preferred trans configuration on the pyrrolidinone ring.

For example the C(O)N(Q²)(R⁶) moiety (bonded to the carbon at the 3-position of the pyrrolidinone ring) and Q¹ (bonded to the carbon at the 4-position of the pyrrolidinone ring) are generally found in the trans configuration. These two carbon atoms (i.e. at the 3- and 4-positions each possess the pyrroldinone ring of Formula 1) both possess a chiral center. The two most prevalent pairs of enantiomers are depicted as Formula 1′ and Formula 1″ where the chiral centers are identified (i.e. as 3R,4S or as 3S,4R) wherein R¹ is hydrogen. While this invention pertains to all stereoisomers, the preferred enantiomeric pair for biological operability is identified as Formula 1′ (i.e. the 3R,4S configuration) wherein R¹ is hydrogen. For a comprehensive discussion of all aspects of stereoisomerism, see Ernest L. Eliel and Samuel H. Wilen, Stereochemistry of Organic Compounds, John Wiley & Sons, 1994.

The skilled artisan will also recognize that the carbon atom at the 5-position of the pyrrolidinone ring (i.e. the carbon atom to which both R² and R³ are bonded) also contains a stereocenter indicated by a (*) as shown in Formula 1′″. This invention pertains to all stereoisomers, and therefore, when either R² or R³ are other than the same substituent, then a mixture of diastereomers is possible.

Molecular depictions drawn herein follow standard conventions for depicting stereochemistry. To indicate stereoconfiguration, bonds rising from the plane of the drawing and towards the viewer are denoted by solid wedges wherein the broad end of the wedge is attached to the atom rising from the plane of the drawing towards the viewer. Bonds going below the plane of the drawing and away from the viewer are denoted by dashed wedges wherein the narrow end of the wedge is attached to the atom further away from the viewer. Constant width lines indicate bonds with a direction opposite or neutral relative to bonds shown with solid or dashed wedges; constant width lines also depict bonds in molecules or parts of molecules in which no particular stereoconfiguration is intended to be specified.

This invention also comprises racemic mixtures, for example, equal amounts of the enantiomers of Formulae 1′ and 1″ (and optionally 1′″). In addition, this invention includes compounds that are enriched compared to the racemic mixture in an enantiomer of Formula 1. Also included are the essentially pure enantiomers of compounds of Formula 1, for example, Formula 1′ and Formula 1″.

When enantiomerically enriched, one enantiomer is present in greater amounts than the other, and the extent of enrichment can be defined by an expression of enantiomeric ratio (ER) expressed as the relative area % of the two entantiomers determined by chiral high-performance liquid chromatography.

Preferably the compositions of this invention have at least a 50% ER; more preferably at least a 75% ER; still more preferably at least a 90% ER; and the most preferably at least a 94% ER of the more active isomer. Of particular note are enantiomerically pure embodiments of the more active isomer.

Compounds of Formula 1 can comprise additional chiral centers. For example, substituents and other molecular constituents such as R², R³ and R⁶ may themselves contain chiral centers. This invention comprises racemic mixtures as well as enriched and essentially pure stereoconfigurations at these additional chiral centers.

Compounds of this invention can exist as one or more conformational isomers due to restricted rotation about the amide bond C(O)N(Q²)(R⁶) in Formula 1. This invention comprises mixtures of conformational isomers. In addition, this invention includes compounds that are enriched in one conformer relative to others. Compounds of Formula 1 typically exist in more than one form, and Formula 1 thus include all crystalline and non-crystalline forms of the compounds they represent. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The term “polymorph” refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due the presence or absence of co-crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound of Formula 1 can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound of Formula 1. Preparation and isolation of a particular polymorph of a compound of Formula 1 can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. For a comprehensive discussion of polymorphism see R. Hilfiker, Ed., Polymorphism in the Pharmaceutical Industry, Wiley-VCH, Weinheim, 2006.

One skilled in the art will appreciate that not all nitrogen-containing heterocycles can form N-oxides since the nitrogen requires an available lone pair for oxidation to the oxide; one skilled in the art will recognize those nitrogen-containing heterocycles which can form N-oxides. One skilled in the art will also recognize that tertiary amines can form N-oxides. Synthetic methods for the preparation of N-oxides of heterocycles and tertiary amines are very well known by one skilled in the art including the oxidation of heterocycles and tertiary amines with peroxy acids such as peracetic and m-chloroperbenzoic acid (MCPBA), hydrogen peroxide, alkyl hydroperoxides such as t-butyl hydroperoxide, sodium perborate, and dioxiranes such as dimethyldioxirane. These methods for the preparation of N-oxides have been extensively described and reviewed in the literature, see for example: T. L. Gilchrist in Comprehensive Organic Synthesis, vol. 7, pp 748-750, S. V. Ley, Ed., Pergamon Press; M. Tisler and B. Stanovnik in Comprehensive Heterocyclic Chemistry, vol. 3, pp 18-20, A. J. Boulton and A. McKillop, Eds., Pergamon Press; M. R. Grimmett and B. R. T. Keene in Advances in Heterocyclic Chemistry, vol. 43, pp 149-161, A. R. Katritzky, Ed., Academic Press; M. Tisler and B. Stanovnik in Advances in Heterocyclic Chemistry, vol. 9, pp 285-291, A. R. Katritzky and A. J. Boulton, Eds., Academic Press; and G. W. H. Cheeseman and E. S. G. Werstiuk in Advances in Heterocyclic Chemistry, vol. 22, pp 390-392, A. R. Katritzky and A. J. Boulton, Eds., Academic Press.

One skilled in the art recognizes that because in the environment and under physiological conditions salts of chemical compounds are in equilibrium with their corresponding nonsalt forms, salts share the biological utility of the nonsalt forms. Thus a wide variety of salts of a compound of Formula 1 are useful for control of undesired vegetation (i.e. are agriculturally suitable). The salts of a compound of Formula 1 include acid-addition salts with inorganic or organic acids such as hydrobromic, hydrochloric, nitric, phosphoric, sulfuric, acetic, butyric, fumaric, lactic, maleic, malonic, oxalic, propionic, salicylic, tartaric, 4-toluenesulfonic or valeric acids. When a compound of Formula 1 contains an acidic moiety such as a carboxylic acid or phenol, salts also include those formed with organic or inorganic bases such as pyridine, triethylamine or ammonia, or amides, hydrides, hydroxides or carbonates of sodium, potassium, lithium, calcium, magnesium or barium. Accordingly, the present invention comprises compounds selected from Formula 1, N-oxides and agriculturally suitable salts thereof.

Embodiments of the present invention as described in the Summary of the Invention include (where Formula 1 as used in the following Embodiments includes N-oxides and salts thereof):

-   -   Embodiment 1. A compound of Formula 1 wherein when Q¹ is an 8-         to 10-membered heteroaromatic bicyclic ring system optionally         substituted with R⁷ and R⁹, the remainder of Formula 1 is bonded         to a fully unsaturated ring of said bicyclic ring system.     -   Embodiment 2. A compound of Formula 1 or Embodiment 1 wherein Q¹         is a phenyl ring optionally substituted with up to 5         substituents independently selected from R⁷.     -   Embodiment 3. A compound of Embodiment 2 wherein Q¹ is a phenyl         ring substituted with 1 to 3 substituents independently selected         from R⁷.     -   Embodiment 4. A compound of Embodiment 3 wherein Q¹ is a phenyl         ring substituted with 1 to 2 substituents independently selected         from R⁷.     -   Embodiment 5. A compound of Formula 1 or any one of Embodiments         1 through 4 wherein Q¹ is a phenyl ring having a substituent         selected from R⁷ at the para (4-) position (and optionally other         substituents).     -   Embodiment 6. A compound of Formula 1 or any one of Embodiments         1 through 5 wherein when Q¹ is a phenyl ring substituted with at         least two substituents selected from R⁷, then one substituent is         at the para (4-) position and at least one other substituent is         at a meta position (of the phenyl ring).     -   Embodiment 7. A compound of Formula 1 or any one of Embodiments         1 through 6 wherein when Q² is an 8- to 10-membered         heteroaromatic bicyclic ring system optionally substituted with         R¹⁰ and R¹¹, the remainder of Formula 1 is bonded to a fully         unsaturated ring of said bicyclic ring system.     -   Embodiment 8. A compound of Formula 1 or any one of Embodiments         1 through 7 wherein Q² is a phenyl ring substituted with up to 5         substituents independently selected from R¹⁰.     -   Embodiment 9. A compound of Embodiment 8 wherein Q² is a phenyl         ring substituted with 1 to 3 substituents independently selected         from R¹⁰.     -   Embodiment 10. A compound of Embodiment 9 wherein Q² is a phenyl         ring substituted with 1 to 2 substituents independently selected         from R¹⁰.     -   Embodiment 11. A compound of Formula 1 or any one of Embodiments         1 through 10 wherein Q² is a phenyl ring having at least one         substituent selected from R¹⁰ at an ortho (e.g., 2-) position         (and optionally other substituents).     -   Embodiment 12. A compound of Formula 1 or any one of Embodiments         1 through 11 wherein when Q² is a phenyl ring substituted with         at least two substituents selected from R¹⁰, then at least one         substituent is at an ortho (e.g., 2-) position and at least one         substituent is at an adjacent meta (e.g., 3-) position (of the         phenyl ring).     -   Embodiment 13. A compound of Formula 1 or any one of Embodiments         1 through 12 wherein, independently, each R⁷ and R¹⁰ is         independently halogen, cyano, nitro, C₁-C₄ alkyl, C₁-C₄         haloalkyl, C₂-C₄ alkenyl, C₂-C₄ haloalkenyl C₂-C₄ alkynyl, C₂-C₄         haloalkynyl, C₁-C₄ nitroalkyl, C₂-C₄ nitroalkenyl, C₂-C₄         alkoxyalkyl, C₂-C₄ haloalkoxyalkyl, C₃-C₄ cycloalkyl, C₃-C₄         halocycloalkyl, cyclopropylmethyl, methylcyclopropyl, C₁-C₄         alkoxy, C₁-C₄ haloalkoxy, C₂-C₄ alkenyloxy, C₂-C₄         haloalkenyloxy, C₃-C₄ alkynyloxy, C₃-C₄ haloalkynyloxy, C₃-C₄         cycloalkoxy, C₁-C₄ alkylthio, C₁-C₄ haloalkylthio, C₁-C₄         alkylsulfinyl, C₁-C₄ haloalkylsulfinyl, C₁-C₄ alkylsulfonyl,         C₁-C₄ haloalkylsulfonyl, hydroxy, formyl, C₂-C₄ alkylcarbonyl,         C₂-C₄ alkylcarbonyloxy, C₁-C₄ alkylsulfonyloxy, C₁-C₄         haloalkylsulfonyloxy, amino, C₁-C₄ alkylamino, C₂-C₄         dialkylamino, formylamino, C₂-C₄ alkylcarbonylamino, —SF₅, —SCN,         C₃-C₄ trialkylsilyl, trimethylsilylmethyl or         trimethylsilylmethoxy.     -   Embodiment 14. A compound of Embodiment 13 wherein each R⁷ is         independently halogen, cyano, C₁-C₂ alkyl, C₁-C₃ haloalkyl or         C₁-C₃ alkylsulfonyl.     -   Embodiment 15. A compound of Embodiment 14 wherein each R⁷ is         independently halogen or C₁-C₂ haloalkyl.     -   Embodiment 16. A compound of Embodiment 15 wherein each R⁷ is         independently halogen or C₁ haloalkyl.     -   Embodiment 17. A compound of Embodiment 16 wherein each R⁷ is         independently halogen or C₁ fluoroalkyl.     -   Embodiment 18. A compound of Embodiment 17 wherein each R⁷ is         independently halogen or CF₃.     -   Embodiment 19. A compound of Embodiment 18 wherein each R⁷ is         independently F, Cl, Br or CF₃.     -   Embodiment 20. A compound of Embodiment 19 wherein each R⁷ is         independently F or CF₃.     -   Embodiment 21. A compound of Embodiment 19 or 20 wherein at most         only one CF₃ substituent is present and is at the para position         of the Q¹ phenyl ring.     -   Embodiment 22. A compound of any one of Embodiments 13 through         21 wherein each R¹⁰ is independently halogen, cyano, nitro,         C₁-C₂ alkyl, C₁-C₃ haloalkyl or C₁-C₃ alkylsulfonyl.     -   Embodiment 23. A compound of Embodiment 22 wherein each R¹⁰ is         independently halogen or C₁-C₂ haloalkyl.     -   Embodiment 24. A compound of Embodiment 23 wherein each R¹⁰ is         independently halogen or C₁ haloalkyl.     -   Embodiment 25. A compound of Embodiment 24 wherein each R¹⁰ is         independently halogen or C₁ fluoroalkyl.     -   Embodiment 26. A compound of Embodiment 25 wherein each R¹⁰ is         independently halogen or CF₃.     -   Embodiment 27. A compound of Embodiment 26 wherein each R¹⁰ is         independently F, Cl, Br or CF₃.     -   Embodiment 28. A compound of Embodiment 27 wherein each R¹⁰ is         independently F or CF₃.     -   Embodiment 29. A compound of Embodiment 28 wherein each R¹⁰ is         F.     -   Embodiment 30. A compound of Formula 1 or any one of Embodiments         1 through 29 wherein, independently, each R⁹ and R¹¹ is         independently H or C₁-C₂ alkyl.     -   Embodiment 31. A compound of Embodiment 28 wherein,         independently, each R⁹ and R¹¹ is CH₃.     -   Embodiment 32. A compound of Formula 1 or any one of Embodiments         1 through 31 wherein Y¹ is O.     -   Embodiment 33. A compound of Formula 1 or any one of Embodiments         1 through 32 wherein Y² is O.     -   Embodiment 33a. A compound of Formula 1 or any one of         Embodiments 1 through 33 wherein R¹ is H, C₁-C₆ alkyl, C₁-C₆         haloalkyl or C₄-C₈ cycloalkylalkyl.     -   Embodiment 33b. A compound of Formula 1 or any one of         Embodiments 1 through 33a wherein R¹ is H, C₁-C₆ alkyl or C₁-C₆         haloalkyl.     -   Embodiment 33c. A compound of Formula 1 or any one of         Embodiments 1 through 33b wherein R¹ is H, Me, Et or CHF₂.     -   Embodiment 33d. A compound of Formula 1 or any one of         Embodiments 1 through 33c wherein R¹ is H, Me or Et.     -   Embodiment 34. A compound of Formula 1 or any one of Embodiments         1 through 33 wherein R¹ is H or CH₃.     -   Embodiment 34a. A compound of Formula 1 or any one of         Embodiments 1 through 34 wherein R¹ is CH₃.     -   Embodiment 35. A compound of Embodiment 34 wherein R¹ is H.     -   Embodiment 36. A compound of Formula 1 or any one of Embodiments         1 through 35 wherein R² is H or CH₃.     -   Embodiment 37. A compound of Embodiment 36 wherein R² is H.     -   Embodiment 38. A compound of Formula 1 or any one of Embodiments         1 through 37 wherein R³ is H or CH₃.     -   Embodiment 39. A compound of Embodiment 38 wherein R³ is H.     -   Embodiment 40. A compound of Formula 1 or any one of Embodiments         1 through 39 wherein R⁴ is H or CH₃.     -   Embodiment 41. A compound of Embodiment 40 wherein R⁴ is H.     -   Embodiment 42. A compound of Formula 1 or any one of Embodiments         1 through 41 wherein R⁵ is H or CH₃.     -   Embodiment 43. A compound of Embodiment 42 wherein R⁵ is H.     -   Embodiment 44. A compound of Formula 1 or any one of Embodiments         1 through 43 wherein R⁶ is H or CH₃.     -   Embodiment 45. A compound of Embodiment 44 wherein R⁶ is H.     -   Embodiment 46. A compound of Formula 1 or any one of Embodiments         1 through 45 wherein Q² is other than 1H-indazol-5-yl optionally         substituted at the 3-position.     -   Embodiment 47. A compound of Embodiment 46 wherein Q² is other         than 1H-indazol-5-yl optionally substituted at the 1- and         3-positions.     -   Embodiment 48. A compound of Embodiment 47 wherein Q² is other         than optionally substituted 1H-indazol-5-yl.     -   Embodiment 49. A compound of any one of Embodiments 1 through 48         wherein Q¹ is other than unsubstituted phenyl.     -   Embodiment 50. A compound of any one of Embodiments 1 through 49         wherein Q² is other than unsubstituted pyridinyl.     -   Embodiment 51. A compound of any one of Embodiments 1 through 50         wherein Q¹ is other than optionally substituted naphthalenyl.     -   Embodiment 52. A compound of any one of Embodiments 1 through 51         wherein G² is other than optionally substituted phenyl.     -   Embodiment 53. A compound of any one of Embodiments 1 through 51         wherein G2 is other then optionally substituted phenyl at the 4         position (of Q¹).     -   Embodiment 54. A compound of any one of Embodiments 1 through 52         wherein G² is other than optionally substituted phenoxy     -   Embodiment 55. A compound of any one of Embodiments 1 through 54         wherein G² is other than optionally substituted phenoxy at the         4-position (of Q¹).     -   Embodiment 56. A compound of Formula 1 or any one of Embodiments         1 through 55 wherein the stereochemistry is (3R,4S) or (3S,4R).     -   Embodiment 57. A compound of Embodiment 54 wherein the         stereochemistry is (3R,4S)     -   Embodiment 58. A compound of Embodiment 54 wherein the         stereochemistry is (3S,4R).

Embodiments of this invention, including Embodiments 1-58 above as well as any other embodiments described herein, can be combined in any manner, and the descriptions of variables in the embodiments pertain not only to the compounds of Formula 1 but also to the starting compounds and intermediate compounds useful for preparing the compounds of Formula 1. In addition, embodiments of this invention, including Embodiments 1-58 above as well as any other embodiments described herein, and any combination thereof, pertain to the compositions and methods of the present invention.

Combinations of Embodiments 1-58 are illustrated by:

-   -   Embodiment A. A compound of Formula 1 wherein         -   each R⁷ and R¹⁰ is independently halogen, cyano, nitro,             C₁-C₄ alkyl, C₁-C₄ haloalkyl, C₂-C₄ alkenyl, C₂-C₄             haloalkenyl C₂-C₄ alkynyl, C₂-C₄ haloalkynyl, C₁-C₄             nitroalkyl, C₂-C₄ nitroalkenyl, C₂-C₄ alkoxyalkyl, C₂-C₄             haloalkoxyalkyl, C₃-C₄ cycloalkyl, C₃-C₄ halocycloalkyl,             cyclopropylmethyl, methylcyclopropyl, C₁-C₄ alkoxy, C₁-C₄             haloalkoxy, C₂-C₄ alkenyloxy, C₂-C₄ haloalkenyloxy, C₃-C₄             alkynyloxy, C₃-C₄ haloalkynyloxy, C₃-C₄ cycloalkoxy, C₁-C₄             alkylthio, C₁-C₄ haloalkylthio, C₁-C₄ alkylsulfinyl,             C₁-C₄haloalkylsulfinyl, C₁-C₄ alkylsulfonyl, C₁-C₄             haloalkylsulfonyl, hydroxy, formyl, C₂-C₄ alkylcarbonyl,             C₂-C₄ alkylcarbonyloxy, C₁-C₄ alkylsulfonyloxy, C₁-C₄             haloalkylsulfonyloxy, amino, C₁-C₄ alkylamino, C₂-C₄             dialkylamino, formylamino, C₂-C₄ alkylcarbonylamino, —SF₅,             —SCN, C₃-C₄ trialkylsilyl, trimethylsilylmethyl or             trimethylsilylmethoxy; and         -   each R⁹ and RH is independently H or C₁-C₂ alkyl.     -   Embodiment B. A compound of Embodiment A wherein         -   Y¹ and Y² are each O; and         -   R¹, R², R³, R⁴, R⁵ and R⁶ are each H.     -   Embodiment C. A compound of Embodiment B wherein         -   Q¹ is a phenyl ring substituted with 1 to 3 substituents             independently selected from R⁷; and         -   Q² is a phenyl ring substituted with 1 to 3 substituents             independently selected from R¹⁰.     -   Embodiment D. A compound of Embodiment C wherein         -   each R⁷ is independently halogen, cyano, C₁-C₂ alkyl, C₁-C₃             haloalkyl or C₁-C₃ alkylsulfonyl; and         -   each R¹⁰ is independently halogen, cyano, nitro, C₁-C₂             alkyl, C₁-C₃ haloalkyl or C₁-C₃ alkylsulfonyl.     -   Embodiment E. A compound of Embodiment D wherein         -   Q¹ is a phenyl ring substituted with 1 substituent selected             from R⁷ at the para position or substituted with 2             substituents independently selected from R⁷ wherein one             substituent is at the para position and the other             substituent is at a meta position; and         -   Q² is a phenyl ring substituted with 1 substituent selected             from R¹⁰ at an ortho position or substituted with 2             substituents independently selected from R¹⁰ wherein one             substituent is at an ortho position and the other             substituent is at the adjacent meta position.     -   Embodiment F. A compound of Embodiment E wherein         -   each R⁷ is independently F or CF₃; and         -   each R¹⁰ is F.

Specific embodiments include compounds of Formula 1 selected from the group consisting of:

N-(2,3-difluorophenyl)-4-(3,4-difluorophenyl)-2-oxo-3-pyrrolidinecarboxamide (Compound 17);

N-(2-fluorophenyl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 79);

N-(2,3-difluorophenyl)-2-oxo-4-[4-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 80);

N-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide (Compound 5); and

(3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 204).

Specific Embodiments include a compound of Formula 1 selected from the group consisting of Compound Numbers (where the Compound Number refers to the compound in Index Tables A, B or C): 80, 202, 204, 206, 232, 263, 304, 306, 315 and 319; or 202, 206, 232, 304 and 306; or 202, 232 and 306.

Specific Embodiments include a compound of Formula 1 selected from the group consisting of Compound Numbers (where the Compound Number refers to the compound in Index Tables A, B or C): 3, 5, 17, 101, 103, 156, 204, 271, 323 and 351; or 3, 17, 103, 156, and 204; or 103, 204 and 351.

This invention also relates to a method for controlling undesired vegetation comprising applying to the locus of the vegetation herbicidally effective amounts of the compounds of the invention (e.g., as a composition described herein). Of note as embodiments relating to methods of use are those involving the compounds of embodiments described above. Compounds of the invention are particularly useful for selective control of weeds in crops such as wheat, barley, maize, soybean, sunflower, cotton, oilseed rape and rice, and specialty crops such as sugarcane, citrus, fruit and nut crops.

Also noteworthy as embodiments are herbicidal compositions of the present invention comprising the compounds of embodiments described above.

This invention also includes a herbicidal mixture comprising (a) a compound selected from Formula 1, N-oxides, and salts thereof, and (b) at least one additional active ingredient selected from (b1) photosystem II inhibitors, (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b3) acetyl-CoA carboxylase (ACCase) inhibitors, (b4) auxin mimics, (b5) 5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, (b6) photosystem I electron diverters, (b7) protoporphyrinogen oxidase (PPO) inhibitors, (b8) glutamine synthetase (GS) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors, (b10) auxin transport inhibitors, (b11) phytoene desaturase (PDS) inhibitors, (b12) 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors, (b13) homogentisate solenesyltransererase (HST) inhibitors, (b14) cellulose biosynthesis inhibitors, (b15) other herbicides including mitotic disruptors, organic arsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet, difenzoquat, dymron, etobenzanid, flurenol, fosamine, fosamine-ammonium, metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid and pyributicarb, and (b16) herbicide safeners; and salts of compounds of (b1) through (b16). “Photosystem II inhibitors” (b1) are chemical compounds that bind to the D-1 protein at the Q_(B)-binding niche and thus block electron transport from Q_(A) to Q_(B) in the chloroplast thylakoid membranes. The electrons blocked from passing through photosystem II are transferred through a series of reactions to form toxic compounds that disrupt cell membranes and cause chloroplast swelling, membrane leakage, and ultimately cellular destruction. The Q_(B)-binding niche has three different binding sites: binding site A binds the triazines such as atrazine, triazinones such as hexazinone, and uracils such as bromacil, binding site B binds the phenylureas such as diuron, and binding site C binds benzothiadiazoles such as bentazone, nitriles such as bromoxynil and phenyl-pyridazines such as pyridate. Examples of photosystem II inhibitors include ametryn, amicarbazone, atrazine, bentazon, bromacil, bromofenoxim, bromoxynil, chlorbromuron, chloridazon, chlorotoluron, chloroxuron, cumyluron, cyanazine, daimuron, desmedipham, desmetryn, dimefuron, dimethametryn, diuron, ethidimuron, fenuron, fluometuron, hexazinone, ioxynil, isoproturon, isouron, lenacil, linuron, metamitron, methabenzthiazuron, metobromuron, metoxuron, metribuzin, monolinuron, neburon, pentanochlor, phenmedipham, prometon, prometryn, propanil, propazine, pyridafol, pyridate, siduron, simazine, simetryn, tebuthiuron, terbacil, terbumeton, terbuthylazine, terbutryn and trietazine.

“AHAS inhibitors” (b2) are chemical compounds that inhibit acetohydroxy acid synthase (AHAS), also known as acetolactate synthase (ALS), and thus kill plants by inhibiting the production of the branched-chain aliphatic amino acids such as valine, leucine and isoleucine, which are required for protein synthesis and cell growth. Examples of AHAS inhibitors include amidosulfuron, azimsulfuron, bensulfuron-methyl, bispyribac-sodium, cloransulam-methyl, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, diclosulam, ethametsulfuron-methyl, ethoxysulfuron, flazasulfuron, florasulam, flucarbazone-sodium, flumetsulam, flupyrsulfuron-methyl, flupyrsulfuron-sodium, foramsulfuron, halosulfuron-methyl, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, iodosulfuron-methyl (including sodium salt), iofensulfuron (2-iodo-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]-benzenesulfonamide), mesosulfuron-methyl, metazosulfuron (3-chloro-4-(5,6-dihydro-5-methyl-1,4,2-dioxazin-3-yl)-N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-1-methyl-1H-pyrazole-5-sulfonamide), metosulam, metsulfuron-methyl, nicosulfuron, oxasulfuron, penoxsulam, primisulfuron-methyl, propoxycarbazone-sodium, propyrisulfuron (2-chloro-N-[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]-6-propylimidazo[1,2-b]pyridazine-3-sulfonamide), prosulfuron, pyrazosulfuron-ethyl, pyribenzoxim, pyriftalid, pyriminobac-methyl, pyrithiobac-sodium, rimsulfuron, sulfometuron-methyl, sulfosulfuron, thiencarbazone, thifensulfuron-methyl, triafamone (N-[2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)carbonyl]-6-fluorophenyl]-1,1-difluoro-N-methylmethanesulfonamide), triasulfuron, tribenuron-methyl, trifloxysulfuron (including sodium salt), triflusulfuron-methyl and tritosulfuron.

“ACCase inhibitors” (b3) are chemical compounds that inhibit the acetyl-CoA carboxylase enzyme, which is responsible for catalyzing an early step in lipid and fatty acid synthesis in plants. Lipids are essential components of cell membranes, and without them, new cells cannot be produced. The inhibition of acetyl CoA carboxylase and the subsequent lack of lipid production leads to losses in cell membrane integrity, especially in regions of active growth such as meristems. Eventually shoot and rhizome growth ceases, and shoot meristems and rhizome buds begin to die back. Examples of ACCase inhibitors include alloxydim, butroxydim, clethodim, clodinafop, cycloxydim, cyhalofop, diclofop, fenoxaprop, fluazifop, haloxyfop, pinoxaden, profoxydim, propaquizafop, quizalofop, sethoxydim, tepraloxydim and tralkoxydim, including resolved forms such as fenoxaprop-P, fluazifop-P, haloxyfop-P and quizalofop-P and ester forms such as clodinafop-propargyl, cyhalofop-butyl, diclofop-methyl and fenoxaprop-P-ethyl.

Auxin is a plant hormone that regulates growth in many plant tissues. “Auxin mimics” (b4) are chemical compounds mimicking the plant growth hormone auxin, thus causing uncontrolled and disorganized growth leading to plant death in susceptible species. Examples of auxin mimics include aminocyclopyrachlor (6-amino-5-chloro-2-cyclopropyl-4-pyrimidinecarboxylic acid) and its methyl and ethyl esters and its sodium and potassium salts, aminopyralid, benazolin-ethyl, chloramben, clacyfos, clomeprop, clopyralid, dicamba, 2,4-D, 2,4-DB, dichlorprop, fluroxypyr, halauxifen (4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylic acid), halauxifen-methyl (methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylate), MCPA, MCPB, mecoprop, picloram, quinclorac, quinmerac, 2,3,6-TBA, triclopyr, and methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate.

“EPSP (5-enol-pyruvylshikimate-3-phosphate) synthase inhibitors” (b5) are chemical compounds that inhibit the enzyme, 5-enol-pyruvylshikimate-3-phosphate synthase, which is involved in the synthesis of aromatic amino acids such as tyrosine, tryptophan and phenylalanine. EPSP inhibitor herbicides are readily absorbed through plant foliage and translocated in the phloem to the growing points. Glyphosate is a relatively nonselective postemergence herbicide that belongs to this group. Glyphosate includes esters and salts such as ammonium, isopropylammonium, potassium, sodium (including sesquisodium) and trimesium (alternatively named sulfosate).

“Photosystem I electron diverters” (b6) are chemical compounds that accept electrons from Photosystem I, and after several cycles, generate hydroxyl radicals. These radicals are extremely reactive and readily destroy unsaturated lipids, including membrane fatty acids and chlorophyll. This destroys cell membrane integrity, so that cells and organelles “leak”, leading to rapid leaf wilting and desiccation, and eventually to plant death. Examples of this second type of photosynthesis inhibitor include diquat and paraquat.

“PPO inhibitors” (b7) are chemical compounds that inhibit the enzyme protoporphyrinogen oxidase, quickly resulting in formation of highly reactive compounds in plants that rupture cell membranes, causing cell fluids to leak out. Examples of PPO inhibitors include acifluorfen-sodium, azafenidin, benzfendizone, bifenox, butafenacil, carfentrazone, carfentrazone-ethyl, chlomethoxyfen, cinidon-ethyl, fluazolate, flufenpyr-ethyl, flumiclorac-pentyl, flumioxazin, fluoroglycofen-ethyl, fluthiacet-methyl, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil, pyraflufen-ethyl, saflufenacil, sulfentrazone, thidiazimin, tiafenacil (methyl N-[2-[[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenyl]thio]-1-oxopropyl]-β-alaninate) and 3-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione.

“GS (glutamine synthase) inhibitors” (b8) are chemical compounds that inhibit the activity of the glutamine synthetase enzyme, which plants use to convert ammonia into glutamine. Consequently, ammonia accumulates and glutamine levels decrease. Plant damage probably occurs due to the combined effects of ammonia toxicity and deficiency of amino acids required for other metabolic processes. The GS inhibitors include glufosinate and its esters and salts, such as glufosinate-ammonium and other phosphinothricin derivatives, glufosinate-P ((2S)-2-amino-4-(hydroxymethylphosphinyl)butanoic acid) and bilanaphos.

“VLCFA (very long chain fatty acid) elongase inhibitors” (b9) are herbicides having a wide variety of chemical structures, which inhibit the elongase. Elongase is one of the enzymes located in or near chloroplasts which are involved in biosynthesis of VLCFAs. In plants, very-long-chain fatty acids are the main constituents of hydrophobic polymers that prevent desiccation at the leaf surface and provide stability to pollen grains. Such herbicides include acetochlor, alachlor, anilofos, butachlor, cafenstrole, dimethachlor, dimethenamid, diphenamid, fenoxasulfone (3-[[(2,5-dichloro-4-ethoxyphenyl)methyl]sulfonyl]-4,5-dihydro-5,5-dimethylisoxazole), fentrazamide, flufenacet, indanofan, mefenacet, metazachlor, metolachlor, naproanilide, napropamide, napropamide-M ((2R)—N,N-diethyl-2-(1-naphthalenyloxy)propanamide), pethoxamid, piperophos, pretilachlor, propachlor, propisochlor, pyroxasulfone, and thenylchlor, including resolved forms such as S-metolachlor and chloroacetamides and oxyacetamides.

“Auxin transport inhibitors” (b10) are chemical substances that inhibit auxin transport in plants, such as by binding with an auxin-carrier protein. Examples of auxin transport inhibitors include diflufenzopyr, naptalam (also known as N-(1-naphthyl)phthalamic acid and 2-[(1-naphthalenylamino)carbonyl]benzoic acid).

“PDS (phytoene desaturase inhibitors) (b11) are chemical compounds that inhibit carotenoid biosynthesis pathway at the phytoene desaturase step. Examples of PDS inhibitors include beflubutamid, diflufenican, fluridone, flurochloridone, flurtamone norflurzon and picolinafen.

“HPPD (4-hydroxyphenyl-pyruvate dioxygenase) inhibitors” (b12) are chemical substances that inhibit the biosynthesis of synthesis of 4-hydroxyphenyl-pyruvate dioxygenase. Examples of HPPD inhibitors include benzobicyclon, benzofenap, bicyclopyrone (4-hydroxy-3-[[2-[(2-methoxyethoxy)methyl]-6-(trifluoromethyl)-3-pyridinyl]carbonyl]bicyclo[3.2.1]oct-3-en-2-one), fenquinotrione (2-[[8-chloro-3,4-dihydro-4-(4-methoxyphenyl)-3-oxo-2-quinoxalinyl]carbonyl]-1,3-cyclohexanedione), isoxachlortole, isoxaflutole, mesotrione, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, topramezone, 5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone, 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone, 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione, 5-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-(3-methoxyphenyl)-3-(3-methoxy-propyl)-4(3H)-pyrimidinone, 2-methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(methyl-sulfinyl)-4-(trifluoromethyl)benzamide and 2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide.

HST (homogentisate solenesyltransererase) inhibitors (b13) disrupt a plant's ability to convert homogentisate to 2-methyl-6-solanyl-1,4-benzoquinone, thereby disrupting carotenoid biosynthesis. Examples of HST inhibitors include haloxydine, pyriclor, 3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one, dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido[2,3-b]pyrazin-6(5H)-one and 4-(2,6-diethyl-4-methylphenyl)-5-hydroxy-2,6-dimethyl-3(2H)-pyridazinone.

HST inhibitors also include compounds of Formulae A and B.

-   wherein R^(d1) is H, Cl or CF₃; R^(d2) is H, Cl or Br; R^(d3) is H     or Cl; R^(d4) is H, Cl or CF₃; R^(d5) is CH₃, CH₂CH₃ or CH₂CHF₂; and     R^(d6) is OH, or —OC(═O)-i-Pr; and R^(e1) is H, F, Cl, CH₃ or     CH₂CH₃; R^(e2) is H or CF₃; R^(e3) is H, CH₃ or CH₂CH₃; R^(e4) is H,     F or Br; R^(e5) is Cl, CH₃, CF₃, OCF₃ or CH₂CH₃; R^(e6) is H, CH₃,     CH₂CHF₂ or C≡CH; R^(e7) is OH, —OC(═O)Et, —OC(═O)-i-Pr or     —OC(═O)-t-Bu; and A^(e8) is N or CH.

Cellulose biosynthesis inhibitors (b14) inhibit the biosynthesis of cellulose in certain plants. They are most effective when using a pre-application or early post-application on young or rapidly growing plants. Examples of cellulose biosynthesis inhibitors include chlorthiamid, dichlobenil, flupoxam, indaziflam (N²-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine), isoxaben and triaziflam.

Other herbicides (b15) include herbicides that act through a variety of different modes of action such as mitotic disruptors (e.g., flamprop-M-methyl and flamprop-M-isopropyl) organic arsenicals (e.g., DSMA, and MSMA), 7,8-dihydropteroate synthase inhibitors, chloroplast isoprenoid synthesis inhibitors and cell-wall biosynthesis inhibitors. Other herbicides include those herbicides having unknown modes of action or do not fall into a specific category listed in (b1) through (b14) or act through a combination of modes of action listed above. Examples of other herbicides include aclonifen, asulam, amitrole, bromobutide, cinmethylin, clomazone, cumyluron, cyclopyrimorate (6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinyl 4-morpholinecarboxylate), daimuron, difenzoquat, etobenzanid, fluometuron, flurenol, fosamine, fosamine-ammonium, dazomet, dymron, ipfencarbazone (1-(2,4-dichlorophenyl)-N-(2,4-difluorophenyl)-1,5-dihydro-N-(1-methylethyl)-5-oxo-4H-1,2,4-triazole-4-carboxamide), metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid, pyributicarb and 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole.

“Herbicide safeners” (b16) are substances added to a herbicide formulation to eliminate or reduce phytotoxic effects of the herbicide to certain crops. These compounds protect crops from injury by herbicides but typically do not prevent the herbicide from controlling undesired vegetation. Examples of herbicide safeners include but are not limited to benoxacor, cloquintocet-mexyl, cumyluron, cyometrinil, cyprosulfamide, daimuron, dichlormid, dicyclonon, dimepiperate, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl, mephenate, methoxyphenone, naphthalic anhydride, oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide and N-(aminocarbonyl)-2-fluorobenzenesulfonamide, 1-bromo-4-[(chloromethyl)sulfonyl]benzene, 2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191), 4-(dichloroacetyl)-1-oxa-4-azospiro-[4.5]decane (MON 4660).

The compounds of Formula 1 can be prepared by general methods known in the art of synthetic organic chemistry. Of note are the following methods described in Schemes 1-15 and variations thereof. The definitions of R¹, R², R³, R⁴, R⁵, R⁶, Q¹, Q², Y¹, and Y² in the compounds of Formulae 1 through 19 below are as defined above in the Summary of the Invention unless otherwise noted. Formulae 1a-1h and 5a and 10a are various subsets of a compound of Formulae 1, 5 and 10 respectively. Substituents for each subset formula are as defined for its parent formula unless otherwise noted.

As shown in Scheme 1 compounds of Formula 1a (i.e. Formula 1 wherein R¹, R⁴ and R⁵ are H, and Y¹ and Y² are O) can be prepared by reaction of acids of Formula 2 with amines of Formula 3 in the presence of a dehydrative coupling reagent such as propylphosphonic anhydride, dicyclohexylcarbodiimide, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide, N,N-carbonyldiimidazole, 2-chloro-1,3-dimethylimidazolium chloride or 2-chloro-1-methylpyridinium iodide. Polymer-supported reagents, such as polymer-supported cyclohexylcarbodiimide, are also suitable. These reactions are typically run at temperatures ranging from 0-60° C. in a solvent such as dichloromethane, acetonitrile, N,N-dimethylformamide or ethyl acetate in the presence of a base such as triethylamine, N,N-diisopropylamine, or 1,8-diazabicyclo[5.4.0]undec-7-ene. See Organic Process Research & Development 2009, 13, 900-906 for coupling conditions employing propylphosphonic anhydride. The method of Scheme 1 utilizing propylphosphonic anhydride is illustrated by Step E of Synthesis Example 1. Substituents in the 3- and 4-positions of the pyrrolidinone ring of compounds of Formula 1a, i.e. C(O)N(Q²)(R⁶) and Q¹, respectively, are predominantly in the trans configuration. In some instances, the presence of minor amounts of the cis isomer can be detected by NMR.

As shown in Scheme 2 compounds of Formula 2 can be prepared by hydrolysis of esters of Formula 4 by methods well known to those skilled in the art. Hydrolysis is carried out with aqueous base or aqueous acid, typically in the presence of a co-solvent. Suitable bases for the reaction include, but are not limited to, hydroxides such as sodium and potassium hydroxide and carbonates such as sodium and potassium carbonate. Suitable acids for the reaction include, but are not limited to, inorganic acids such as hydrochloric acid, hydrobromic acid and sulfuric acid, and organic acids such as acetic acid and trifluoroacetic acid. A wide variety of co-solvents are suitable for the reaction including, but not limited to, methanol, ethanol and tetrahydrofuran. The reaction is conducted at temperatures ranging from −20° C. to the boiling point of the solvent, and typically from 0 to 100° C. The method of Scheme 2 is illustrated by Step D of Synthesis Example 1.

As shown in Scheme 3, compounds of Formula 4 can be obtained by reduction of compounds of Formula 5 and subsequent in situ cyclization of the resulting intermediate amine. A wide variety of methods for reduction of the aliphatic nitro group in compounds of Formula 5 are known in the literature. Methods well known to those skilled in the art include catalytic hydrogenation in the presence of palladium on carbon or Raney nickel, iron or zinc metal in acidic medium (see, for example, Berichte der Deutschen Chemischen Gesellschaft 1904, 37, 3520-3525), and lithium aluminum hydride. Reduction can also be achieved with samarium(II) iodide in the presence of a proton source such as methanol (see for example, Tetrahedron Letters 1991, 32 (14), 1699-1702). Alternatively sodium borohydride in the presence of a nickel catalyst such as nickel(II) acetate or nickel(II) chloride can be used (see for example, Tetrahedron Letters 1985, 26 (52), 6413-6416). The method of Scheme 3 utilizing sodium borohydride in the presence of nickel(II) acetate is illustrated by Step C of Synthesis Example 1. Specific examples of a compound of Formula 4 that is useful in the preparation of a compound of Formula 1 can be found in Tables I through IV.

As shown in Scheme 4, compounds of Formula 5 can be prepared by reacting diesters of Formula 6 with nitroalkanes of Formula 7, typically in the presence of a base. Suitable bases for the reaction include alkali metal lower alkoxides such as sodium methoxide in methanol or sodium ethoxide in ethanol. The method of Scheme 4 is illustrated by Step B of Synthesis Example 1. Compounds of Formula 6 can readily be prepared by methods known to those skilled in the art, e.g., by Knoevenagel condensation of aldehydes and malonates (see for example G. Jones, Organic Reactions Volume 15, John Wiley and Sons, 1967).

Compounds of Formula 5a (i.e. Formula 5 wherein R² and R³ are H) can be prepared by reacting nitroalkenes of Formula 8 with malonates of Formula 9 in the presence of a base as shown in Scheme 5. Suitable bases for this reaction include, but are not limited to, alkali metal lower alkoxides such as sodium methoxide in methanol or sodium ethoxide in ethanol, or bases such as lithium bis(trimethylsilyl)amide, sodium bis(trimethylsilyl)amide and lithium diisopropylamide in solvents such as tetrahydrofuran. Typically, the reaction is carried out in the range of from −78° C. to 23° C. See Synthesis 2005, 2239-2245 for conditions for effecting this transformation. Conditions for effecting this transformation in refluxing water in the absence of a catalyst have been reported in Synthetic Communications 2013, 43, 744-748. Nitroalkenes of Formula 8 can readily be prepared from aldehydes and nitromethane by methods known to those skilled in the art.

Compounds of Formula 5a′ and 5a″ can be prepared stereoselectively by reacting nitroalkenes of Formula 8 with malonates of Formula 9 in the presence of a chiral catalyst and optionally in the presence of a suitable base as shown in Scheme 5A. Suitable catalysts include, but are not limited to Ni(II) with vicinal diamine ligands such as Ni(II) Bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-di amine]dibromide, Ni(II) Bis[(S,S)—N,N-dibenzylcyclohexane-1,2-diamine]dibromide or nickel(II) bromide with chiral 1,1′-bi(tetrahydroisoquinoline) type diamines. Suitable organic bases for this reaction include, but are not limited to, piperidine, morpholine, triethylamine, 4-methylmorpholine or N,N-diisopropylethylamine. This transformation can be accomplished neat or in solvents such as tetrahydrofuran, toluene or dichloromethane. Typically, the reaction is carried out in the range of from −78° C. to 80° C. using 0 to 1 equivalent of catalyst and optionally 0 to 1 equivalent of a base. Conditions for effecting this transformation have been reported in J. Am. Chem. Soc. 2005, 9958-9959 or Eur. J. Org. Chem. 2011, 5441-5446 for conditions. Nitroalkenes of Formula 8 can readily be prepared from aldehydes and nitromethane by methods known to those skilled in the art.

As shown in Scheme 6, compounds of Formula 1a can also be prepared by reductive cyclization of compounds of Formula 10 analogous to the method of Scheme 3. As also shown in Scheme 6, compounds of Formula 1b (i.e. Formula 1 wherein R¹ is OH, R⁴ and R⁵ are H, and Y¹ and Y² are O) can be prepared from compounds of Formula 10 by catalytic transfer hydrogenation with ammonium formate in the presence of palladium on carbon, and subsequent in situ cyclization of the intermediate hydroxylamine. See J. Med. Chem. 1993, 36, 1041-1047 for catalytic transfer hydrogenation/cyclization conditions to produce N-hydroxypyrrolidinones. The method of Scheme 6 for preparing N-hydroxypyrrolidinones is illustrated by Step D of Synthesis Example 3.

As shown in Scheme 7, compounds of Formula 10 can be prepared by reacting compounds of Formula 11 with nitroalkanes of Formula 7 in a solvent, in the presence of a base analogous to the method described in Scheme 4. The method of Scheme 7 is illustrated by Step C of Synthesis Example 3.

As shown in Scheme 8, compounds of Formula 10a (i.e. Formula 10 wherein R² and R³ are H) can be prepared, analogous to the method of Scheme 5, by reacting nitroalkenes of Formula 8 with malonates of Formula 12.

As shown in Scheme 9, compounds of Formula 11 can be prepared by reaction of malonic amide Formula 12 with aldehydes of Formula 14 by methods known to those skilled in the art. As also shown in Scheme 9, malonates of Formula 12 can readily be prepared from lower alkyl malonyl chlorides of Formula 13 such as methyl malonyl chloride and amines of Formula 3 by methods known to those skilled in the art. The method of Scheme 9 is illustrated by Steps A and B of Synthesis Example 3.

As shown in Scheme 10, mixtures of compounds of Formula 1c (i.e. Formula 1 wherein R¹ and R⁵ are H, R⁴ is halogen and Y¹ and Y² are O) and Formula 1d (i.e. Formula 1 wherein R¹ and R⁴ are H, R⁵ is halogen and Y¹ and Y² are O) can be prepared by reacting compounds of Formula 1a with a halogen source in a solvent, in the presence or absence of an initiator. Separation of the regioisomers produced in this reaction can be achieved by standard methods such as chromatography or fractional crystallization. Suitable halogen sources for this reaction include bromine, chlorine, N-chlorosuccinimide, N-bromosuccinimide and N-iodosuccinimide. Suitable initiators for this reaction include 2,2′-azobisisobutyronitrile (AIBN) and benzoyl peroxide. Typically, the reaction is carried out in solvents such as dichloromethane in the range of from 0° C. to the boiling point of the solvent. The method of Scheme 10 is illustrated by Synthesis Example 2.

As shown in Scheme 11, compounds of Formula 1e (i.e. Formula 1 wherein R¹ is NH₂, R⁴ and R⁵ are H and Y¹ and Y² are O) can be prepared by reacting compounds of Formula 1a with an aminating reagent such as O-(diphenylphosphinyl)hydroxylamine and hydroxylamino-O-sulphonic acid. For procedures, conditions and reagents see Bioorganic & Medicinal Chemistry Letters 2009, 19, 5924-5926 and Journal of Organic Chemistry 2002, 67, 6236-6239.

As shown in Scheme 12, compounds of Formula if (i.e. Formula 1 wherein R⁴, R⁵ and R⁶ are H and Y¹ is O) can be produced by reaction of compounds of Formula 15 with isocyanates (i.e. Formula 16 wherein Y² is O) or isothiocyanates (i.e. Formula 16 wherein Y² is S) in the presence of base. Examples of the base which can be used for the present process include those listed for the method of Scheme 4. The reaction temperature can be selected from the range of from −78° C. to the boiling point of an inert solvent used. Typically, the reaction is carried out at temperatures ranging from −78° C. to 100° C. in solvents such as toluene.

As shown in Scheme 13, compounds of Formula 15 can be prepared by reaction of compounds of Formula 17 with corresponding electrophiles of Formula 18 in the presence of base. In Formula 18, G denotes a leaving group, i.e. a nucleofuge. Depending upon selection of R¹, suitable electrophiles for the reaction can include alkyl halides such as chlorides, bromides and iodides, alkylsulfonates, acid anhydrides such as tert-butoxycarbonyl anhydride and acetic anhydride, and haloalkylsilanes such as chlorotrimethylsilane. Suitable bases for the reaction include inorganic bases such as alkali or alkaline earth metal (e.g., lithium, sodium, potassium and cesium) hydroxides, alkoxides, carbonates, and phosphates, and organic bases such as triethylamine, N,N-diisopropylethylamine and 1,8-diazabicyclo[5.4.0]undec-7-ene. A wide variety of solvents are suitable for the reaction including, for example but not limited to, tetrahydrofuran, dichloromethane, N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidinone, acetonitrile, C₂-C₆ alcohols and acetone as well as mixtures of these solvents. This reaction is conducted at temperatures ranging from −20 to 200° C., and typically between 0 and 50° C.

As shown in Scheme 14, compounds of Formula 17 can be prepared by decarboxylation of acids of Formula 2 by methods well known to those skilled in the art. Decarboxylation is carried by heating compounds of Formula 2 in a solvent, typically in the presence of an acid. Suitable acids for the reaction include, but are not limited to, p-toluenesulfonic acid. A wide variety of co-solvents are suitable for the reaction including, but not limited to, toluene, isopropanol acetate and isobutyl methylketone. The reaction is conducted at temperatures ranging from −20° C. and to the boiling point of the solvent, and typically from 0 to 150° C. The method of Scheme 14 is illustrated by Step A of Synthesis Example 6.

As shown in Scheme 15, compounds of Formula 1g (i.e. Formula 1 wherein R¹ is H, R⁴ and R⁵ are H, and Y¹ and Y² are S) can be prepared by reacting compounds of Formula 1a with at least two equivalents of a thionation reagent such as Lawesson's reagent, tetraphosphorus decasulfide or diphosphorus pentasulfide in a solvent such as tetrahydrofuran or toluene. Typically, the reaction is carried out at temperatures ranging from 0 to 115° C. One skilled in the art recognizes that using less than two equivalents of the thionating reagent can provide mixtures comprising Formula 1 products wherein Y¹ is O and Y² is S, or Y¹ is S and Y² is O, which can be separated by conventional methods such as chromatography and crystallization.

As shown in Scheme 16, compounds of Formula 1h (i.e. Formula 1 wherein R¹, R⁴, R⁵ are H, Y² is O and Y¹ is NH) can be prepared by alkylation of compounds of Formula 1a triethyloxonium tetrafluoroborate (Meerwein's reagent) followed by treatment of the resulting imino ether of Formula 19 with aqueous ammonia. The method of Scheme 16 is illustrated by Steps A and B of Synthesis Example 4.

It is recognized by one skilled in the art that various functional groups can be converted into others to provide different compounds of Formula 1. For a valuable resource that illustrates the interconversion of functional groups in a simple and straightforward fashion, see Larock, R. C., Comprehensive Organic Transformations: A Guide to Functional Group Preparations, 2nd Ed., Wiley-VCH, New York, 1999. For example, intermediates for the preparation of compounds of Formula 1 may contain aromatic nitro groups, which can be reduced to amino groups, and then be converted via reactions well known in the art such as the Sandmeyer reaction, to various halides, providing compounds of Formula 1. The above reactions can also in many cases be performed in alternate order

It is recognized that some reagents and reaction conditions described above for preparing compounds of Formula 1 may not be compatible with certain functionalities present in the intermediates. In these instances, the incorporation of protection/deprotection sequences or functional group interconversions into the synthesis will aid in obtaining the desired products. The use and choice of the protecting groups will be apparent to one skilled in chemical synthesis (see, for example, Greene, T. W.; Wuts, P. G. M. Protective Groups in Organic Synthesis, 2nd ed.; Wiley: New York, 1991). One skilled in the art will recognize that, in some cases, after the introduction of a given reagent as it is depicted in any individual scheme, it may be necessary to perform additional routine synthetic steps not described in detail to complete the synthesis of compounds of Formula 1. One skilled in the art will also recognize that it may be necessary to perform a combination of the steps illustrated in the above schemes in an order other than that implied by the particular presented to prepare the compounds of Formula 1.

One skilled in the art will also recognize that compounds of Formula 1 and the intermediates described herein can be subjected to various electrophilic, nucleophilic, radical, organometallic, oxidation, and reduction reactions to add substituents or modify existing substituents.

Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Steps in the following Examples illustrate a procedure for each step in an overall synthetic transformation, and the starting material for each step may not have necessarily been prepared by a particular preparative run whose procedure is described in other Examples or Steps. Percentages are by weight except for chromatographic solvent mixtures or where otherwise indicated. Parts and percentages for chromatographic solvent mixtures are by volume unless otherwise indicated. ¹H NMR spectra are reported in ppm downfield from tetramethylsilane in CDCl₃ solution unless indicated otherwise; “s” means singlet, “d” means doublet, “t” means triplet, “q” means quartet, “m” means multiplet and “br s” means broad singlet. ¹⁹F NMR spectra are reported in ppm downfield from CFCl₃ in CDCl₃ unless indicated otherwise. The enantiomeric ratio (ER) was determined by chiral high performance liquid chromatography analysis using a Chiralpak AD-RH column and eluting with a 50:50 isopropanol/water mixture at 40° C. at 0.3 mL/min.

SYNTHESIS EXAMPLE 1 Preparation of 4-(3-chloro-4-fluorophenyl)-2-oxo-N-[2-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 74) Step A: Preparation of 1,3-diethyl 2-(3-chloro-4-fluorophenyl)methylene-propanedioate

A mixture of 3-chloro-4-fluorobenzaldehyde (3 g, 18.9 mmol), diethyl malonate (3.16 mL, 20.8 mmol), piperidine (0.37 mL, 3.8 mmol) and toluene (40 mL) was refluxed for 18 h with continuous removal of water (Dean-Stark trap). The cooled reaction mixture was concentrated under reduced pressure, and the residue was chromatographed on silica gel, eluted with 0% to 10% ethyl acetate in hexanes, to afford the title compound as a yellow oil (5 g).

¹H NMR δ 7.61 (m, 1H), 7.61 (m, 1H), 7.53 (m, 1H), 7.35 (m, 1H), 7.15 (m, 1H), 4.33 (m, 4H), 1.33 (m, 6H).

Step B: Preparation 1,3-diethyl 2-[1-(3-chloro-4-fluorophenyl)-2-nitroethyl]-propanedioate

A mixture of 1,3-diethyl 2-(3-chloro-4-fluorophenyl)methylenepropanedioate (i.e. the product of Step A, 5 g, 16.7 mmol), nitromethane (8.9 mL, 166 mmol) and a methanol solution of sodium methoxide (25 wt %, 0.36 g, 1.67 mmol) in ethanol (60 mL) was stirred at 23° C. for 18 h. The reaction mixture was then concentrated under reduced pressure to afford a thick oil, which was diluted with 25% ethyl acetate in hexanes and filtered through a pad of Celite® diatomaceous filter aid to remove insoluble particulates. The filtrate was concentrated under reduced pressure to afford the title compound as a yellow oil (5.3 g).

¹H NMR δ 7.32 (m, 1H), 7.15 (m, 1H), 7.10 (m, 1H), 4.87 (m, 2H), 4.22 (m, 3H), 4.07 (m, 2H), 3.76 (d, 1H), 1.27 (m, 3H), 1.12 (m, 3H).

Step C: Preparation of ethyl 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidine-carboxylate

A stirred mixture of 1,3-diethyl 2-[1-(3-chloro-4-fluorophenyl)-2-nitroethyl]-propanedioate (i.e. the product of Step B, 5.3 g, 14.7 mmol), nickel(II) acetate tetrahydrate (18.3 g, 73.4 mmol) and ethanol (120 mL) was cooled in an ice bath and treated with sodium borohydride (2.8 g, 73.4 mmol) in 0.5 g portions added over 5 minutes. The resulting mixture was stirred at 26° C. for 18 h. Saturated ammonium chloride solution (120 mL) and ethyl acetate (120 mL) were then added, the mixture was stirred for 1 h and then filtered through a pad of Celite® diatomaceous filter aid to remove insoluble particulates. The layers of the filtrate were separated, and the aqueous layer was extracted with ethyl acetate (2×100 mL). The combined organic extracts were washed with saturated ammonium chloride solution (100 mL), brine (100 mL), dried (MgSO₄) and concentrated under reduced pressure to afford the title compound as a yellow-orange solid (4.73 g) which was used without purification.

¹H NMR δ 7.31 (m, 1H), 7.12 (m, 2H), 6.93 (br s, 1H), 4.24 (m, 2H), 4.06 (m, 1H), 3.82 (m, 1H), 3.49 (d, 1H), 3.39 (m, 1H), 1.29 (m, 3H).

Step D: Preparation of 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

A mixture of ethyl 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylate (i.e. the product of Step C, 4.73 g, 16.5 mmol) and aqueous sodium hydroxide (50 wt %, 1.98 g, 49.5 mmol) in ethanol (50 mL) was stirred at 26° C. for 18 h. The reaction mixture was then diluted with water (50 mL) and extracted with diethyl ether (2×50 mL). The aqueous phase was acidified with concentrated hydrochloric acid to pH 2 and extracted with dichloromethane (3×50 mL). The combined dichloromethane extracts were washed with brine, dried (MgSO₄), and concentrated under reduced pressure to afford the title compound as a white solid (2.37 g).

¹H NMR (acetone-d₆) δ 7.63 (m, 1H), 7.46 (m, 1H), 7.31 (m, 1H), 4.05 (m, 1H), 3.82 (m, 1H), 3.70 (d, 1H), 3.45 (m, 1H).

Step E: Preparation of 4-(3-chloro-4-fluorophenyl)-2-oxo-N-[2-(trifluoromethyl)-phenyl]-3-pyrrolidinecarboxamide

A mixture of 4-(3-chloro-4-fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid (i.e. the product of Step D, 0.3 g, 1.17 mmol), triethylamine (0.49 mL, 3.5 mmol) and 2-(trifluoromethyl)aniline (0.16 mL, 1.28 mmol) in dichloromethane (8 mL) was stirred at ambient temperature for 30 minutes, and then treated with propylphosphonic anhydride in ethyl acetate (50%, 1.26 g, 1.98 mmol). The resulting mixture was stirred at ambient temperature for 18 h. The reaction mixture was then concentrated under reduced pressure, and the residue was chromatographed on silica gel, eluted with 0-30% ethyl acetate in hexanes, to afford a solid residue which on trituration with 1-chlorobutane afforded the title product, a compound of the present invention, as a light pink solid (0.2 g).

¹H NMR δ 9.85 (s, 1H), 8.15 (m, 1H), 7.62 (m, 1H), 7.52 (m, 1H), 7.43 (m, 1H), 7.27 (m, 1H), 7.22 (m, 1H), 7.14 (m, 1H), 6.93 (s, 1H), 4.15 (m, 1H), 3.82 (m, 1H), 3.55 (d, 1H), 3.44 (m, 1H).

SYNTHESIS EXAMPLE 2 Preparation of 4-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide and 3-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide (Compounds 92 and 93)

A mixture of 4-phenyl-2-oxo-N-(2-fluorophenyl)-3-pyrrolidinecarboxamide (prepared by the method of Example 1, 0.75 g, 2.5 mmol) in dichloromethane (25 mL) at room temperature was treated with bromine (0.16 mL, 3.0 mmol), and the resulting mixture was stirred for 18 h. The reaction mixture was then concentrated under reduced pressure, and the residue was chromatographed on silica gel, eluted with 0-2% methanol in dichloromethane, to give as the faster eluting product, 4-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxamide, a compound of the present invention, as a white solid (90 mg):

¹H NMR δ 10.2 (br s, 1H), 8.00 (m, 1H), 7.28 (m, 5H), 7.02 (m, 3H), 6.45 (br s, 1H), 4.15 (d, 1H), 4.05 (m, 1H), 3.55 (d, 1H);

and the slower eluting product, 3-bromo-N-(2-fluorophenyl)-2-oxo-4-phenyl-3-pyrrolidine-carboxamide, a compound of the present invention, as a clear yellow oil (0.31 g):

¹H NMR δ 9.55 (br s, 1H), 8.25 (t, 1H), 7.48 (d, 2H), 7.38 (m, 3H), 7.11 (m, 3H), 6.85 (br s, 1H), 4.45 (m, 1H), 3.77 (m, 1H), 3.65 (m, 1H).

SYNTHESIS EXAMPLE 3 Preparation of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-1-hydroxy-2-oxo-3-pyrrolidinecarboxamide (Compound 44) Step A: Preparation of ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanote

To a stirred solution of 2-fluoroaniline (10 g, 90.0 mmol) and triethylamine (9.1 g, 90.0 mmol) in dichloromethane (50 mL) at 0° C. was added dropwise over 10 minutes a solution of ethyl malonyl chloride (15.5 g, 90.0 mmol) in dichloromethane (30 mL). The resulting mixture was stirred at room temperature for 24 h. The reaction mixture was then poured into water (100 mL), and the organic layer was separated, washed with water (50 mL) and brine (50 mL), dried (MgSO₄) and concentrated under reduced pressure to provide the title compound as an amber oil (19.0 g).

¹H NMR δ 9.46 (br s, 1H), 8.28 (m,1H), 7.1 (m, 2H), 4.26 (m, 2H), 3.51 (s, 2H), 1.32 (t, 3H).

Step B: Preparation of ethyl 3-(3,4-difluorophenyl)-2-[[(2-fluorophenyl)amino]-carbonyl]-2-propenoate

A solution of ethyl 3-[(2-fluorophenyl)amino]-3-oxopropanote (i.e. the product of Step A, 20.27 g, 90.0 mmol), 3,4-difluorobenzaldehyde (16.62 g, 117 mmol), acetic acid (2.6 mL, 45 mmol) and piperidine (0.89 mL, 9.0 mmol) in toluene (150 mL) was refluxed for 10 h with continuous removal of water (Dean-Stark trap). The reaction mixture was then cooled to room temperature and poured into water (100 mL). The organic layer was separated, and the water layer was extracted with ethyl acetate (3×50 mL). The combined organic extracts were washed with aqueous hydrochloric acid (1 N, 100 mL), dried (MgSO₄) and concentrated under reduced pressure to give a solid residue. Recrystallization of the solid from diethyl ether (100 mL) afforded the title compound as a white solid (10.5 g).

¹H NMR δ 8.26-8.48 (m, 1H), 8.15 (m, 1H), 7.74 (s, 1H), 7.51 (m, 1H), 7.35 (m, 1H), 7.11 (m, 4H), 4.35 (m, 2H), 1.36 (t, 3H).

Step C: Preparation of ethyl 3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)benzenepropanoate

To a stirred suspension of ethyl 3-(3,4-difluorophenyl)-2-[[(2-fluorophenyl)amino]-carbonyl]-2-propenoate (i.e. the product of Step B, 4.42 g, 12.7 mmol) and nitromethane (17 mL, 317.5 mmol) at −20° C. was added 1,1,3,3-tetramethylguanidine (0.288 mL, 2.3 mmol). The mixture was stirred at −20° C. for 30 minutes, and then allowed to come to room temperature and stirred for an additional 2 h. The reaction mixture was diluted with dichloromethane (50 mL) and extracted with water (3×25 mL). The organic layer was dried (MgSO₄) and concentrated under reduced pressure to provide a solid residue. The solid was chromatographed on silica gel, eluted with 0-100% ethyl acetate in hexane, to provide the title compound as a white solid (4.42 g).

¹H NMR δ 8.6 (br s, 1H), 8.00-8.30 (m, 3H), 7.23 (m, 4H), 5.41 (m, 1H), 4.6 (m, 1H), 4.35 (m, 2H), 3.77-4.00 (m, 2H), 1.45 (m, 3H).

Step D: Preparation of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-1-hydroxy-2-oxo-3-pyrrolidinecarboxamide

A mixture of ethyl 3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)-benzenepropanoate (i.e. the product of Step C, 0.50 g, 1.22 mmol), 5% palladium on carbon (0.25 g) and methanol-ethyl acetate (1:1 by volume, 10 mL) was stirred at room temperature for 30 minutes, then cooled to at 0° C. and treated with ammonium formate (0.5 g). The resulting mixture was stirred for 1 h at room temperature. Additional 5% palladium on carbon (0.25 g) and ammonium formate (0.5 g) were added, and stirring at room temperature was continued for an additional 4 h. The reaction mixture was then filtered, and the filtrate was concentrated under reduced pressure to provide a residue, which was suspended in water (10 mL) and extracted with ethyl acetate (3×20 mL). The combined organic extracts were dried (MgSO₄) and concentrated under reduced pressure to provide an oil, which on recrystallization from dichloromethane afforded the title product, a compound of the present invention, as a white solid (0.1 g).

¹H NMR (DMSO-d₆) δ 10.11 (br s, 2H), 8.00 (m, 1H), 7.71 (m, 1H), 7.42 (m, 1H), 7.33 (m, 3H), 7.1 (m, 1H), 4.25-3.61 (m, 4H).

SYNTHESIS EXAMPLE 4 Preparation of 2-amino-4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-3H-pyrrole-3-carboxamide (Compound 95) Step A: Preparation of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidinecarboxamide

To a stirred mixture of ethyl 3,4-difluoro-α-[[(2-fluorophenyl)amino]carbonyl]-β-(nitromethyl)benzenepropanoate (i.e. the product of Example 3 Step C, 3.346 g, 8.16 mmol) and nickel(II) acetate tetrahydrate (10.15 g, 40.8 mmol) in ethanol (50 mL) at 0° C., was added portionwise sodium borohydride (1.54 g, 40.8 mmol), and the resulting mixture was stirred at room temperature for 24 h. The reaction mixture was concentrated under reduced pressure, dissolved in ethyl acetate (100 mL) and washed successively with saturated ammonium chloride solution (50 mL), water (2×25 mL) and saturated sodium chloride (20 mL). The organic layer was dried (MgSO₄) and concentrated under reduced pressure to provide a solid residue. The residue was chromatographed on silica gel, eluted with 0-100% ethyl acetate in hexane, to provide the title compound as a white solid (0.746 g).

¹H NMR δ 9.67 (br s, 1H), 8.21 (m, 1H), 7.09 (m, 6H), 4.75 (br s, 1H), 4.21 (m,1H), 3.82 (m, 1H), 3.52 (m, 1H), 3.43 (m, 1H).

Step B: Preparation of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-2-methoxy-3H-pyrrole-3-carboxamide

A mixture of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)-2-oxo-3-pyrrolidine-carboxamide (i.e. the product of Step A, 0.187 g, 0.56 mmol) and trimethyloxonium tetrafluoroborate (0.083 g, 0.56 mmol) in dichloromethane (5 mL) was stirred under an atmosphere of nitrogen for 2 days. The reaction mixture was then treated with 1 N aqueous sodium hydroxide until basic (pH 10) and extracted with dichloromethane (3×5 mL). The organic layer was dried (MgSO₄) and concentrated under reduced pressure to provide title compound as light yellow oil (0.138 g).

¹H NMR δ 9.7 (br s, 1H), 8.62 (m, 1H), 8.25 (s, 1H), 7.26 (m, 4H),7.00 (m, 1H), 4.26 (m, 2H), 4.00 (s, 3H), 3.42 (m, 2H).

Step C: Preparation of 2-amino-4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-3H-pyrrole-3-carboxamide

A mixture of 4-(3,4-difluorophenyl)-N-(2-fluorophenyl)dihydro-2-methoxy-3H-pyrrole-3-carboxamide (i.e. the product Step B, 0.10 g, 0.287 mmol) and aqueous ammonium hydroxide (50%, 0.5 mL) in ethanol (2 mL) was heated in microwave apparatus for 10 minutes. The reaction mixture was concentrated under reduced pressure and the residue chromatographed on silica gel, eluted with 0-100% ethyl acetate/hexane, to afford the title product, a compound of the present invention, as a solid (0.016 g).

¹H NMR δ 9.67 (br s, 1H), 8.21 (m, 1H), 7.27-7.01 (m, 6H), 6.50 (br s, 1H), 5.00 (br s, 1H), 4.26 (m, 1H), 3.82 (m, 1H), 3.55 (m, 1H), 3.43 (m, 1H).

SYNTHESIS EXAMPLE 5 Preparation of (3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 204) Step A: Preparation of 1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene

To a stirred solution of 3-(trifluoromethyl)benzaldehyde (12.2 g, 70.1 mmol) in methanol (50 mL) was added nitromethane (4.34 g, 71.1 mmol). The mixture was cooled to 2° C. and sodium hydroxide (5.65 g, 70.6 mmol) was added as a 50% solution in 24.3 mL of water dropwise over 15 min. An exotherm was noted and additional ice was added to maintain the temperature below 10° C. while stirring for an additional 1 h. The reaction mixture was poured into 75 mL (75 mmol) of 1 N hydrochloric acid, rinsing the flask with 10 mL of methanol/water. The quenched reaction mixture was transferred to a separatory funnel and extracted with 150 mL of toluene. The aqueous layer was separated and concentrated under vacuum to yield 15.84 g of a yellow oil.

The intermediate thus obtained (15.84 g, 67.3 mmol) was taken up in 160 mL dichloromethane. The solution was cooled to 3° C. and methanesulfonyl chloride (8.03 g, 71.1 mmol) was added via pipette as a solution in 50 mL of dichloromethane. A solution of triethylamine (14.2 g, 140 mmol) in 50 mL of dichloromethane was then added dropwise over 50 min, and the resulting solution was stirred for 2 h. The reaction mixture was poured into 150 mL (150 mmol) of 1 N hydrochloric acid and transferred to a separatory funnel. The layers were separated and the organic layer was washed with 150 mL water and then filtered. The organic layer was concentrated under reduced pressure and the crude solid was tritrated with hexanes to yield 12.09 g of product as a yellow solid.

¹H NMR (500 MHz) δ 7.54-7.66 (m, 2H) 7.69-7.84 (m, 3H) 7.96-8.08 (m, 1H).

Step B: Preparation of 1,3-diethyl 2-[(1S)-2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl]propanedioate

To a stirred mixture of 1-[(E)-2-nitroethenyl]-3-(trifluoromethyl)benzene (i.e. the product of Step A, 3 g, 13.8 mmol) and diethyl malonate (3.319 g, 20.7 mmol) in toluene (1.5 mL) was added Ni(II) bis[(R,R)—N,N′-dibenzylcyclohexane-1,2-diamine]bromide (prepared as described in J. Am. Chem. Soc. 2005, 127, 9958-9959; 0.111 g, 0.1 mmol). The resulting solution was stirred at 55° C. for 16 h. The solution was diluted with dichloromethane (20 mL) and concentrated under reduced pressure onto silica gel and purified by chromatography eluting with a gradient of ethyl acetate in hexanes (0 to 50%) to give 3.6 g of a light yellow oil. ER 94:6 (major eluting at 26.5 min, minor eluting at 20.3 min).

¹H NMR (500 MHz) δ 7.54-7.60 (m, 1H), 7.43-7.48 (m, 2H), 7.51 (s, 1H), 4.83-5.00 (m, 2H), 4.17-4.35 (m, 3H), 3.98-4.06 (m, 2H), 3.77-3.85 (m, 1H), 1.20-1.29 (m, 3H), 0.99-1.10 (m, 3H). ¹⁹F NMR (471 MHz) δ −62.78 (s, 3F). ESI [M−1] 376.3.

Step C: Preparation of ethyl (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylate

A stirred mixture of 1,3-diethyl 2-[(1S)-2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl]propanedioate (i.e. the product of Step B, 3.24 g, 8.48 mmol), nickel(II) chloride hexahydrate (2.01 g, 8.48 mmol) and ethanol (60 mL) was cooled in an ice bath and treated with sodium borohydride (0.97 g, 25.8 mmol) in 0.5 g portions added over 5 min. The resulting mixture was stirred at 26° C. for 18 h. Saturated ammonium chloride solution (120 mL) and ethyl acetate (120 mL) were then added, the mixture was stirred for 1 h and then filtered through a pad of Celite® diatomaceous filter aid to remove insoluble particulates. The layers of the filtrate were separated, and the aqueous layer was extracted with ethyl acetate (2×100 mL). The combined organic extracts were washed with saturated ammonium chloride solution (100 mL), brine (100 mL), dried (MgSO₄) and concentrated under reduced pressure to afford the title compound as a thick yellow oil (2.66 g) which was used without purification.

¹H NMR (500 MHz) δ 7.38-7.62 (m, 4H), 6.50 (br s, 1H), 4.21-4.31 (m, 2H), 4.15-4.21 (m, 1H), 3.82-3.92 (m, 1H), 3.51-3.58 (m, 1H), 3.37-3.50 (m, 1H), 1.27-1.34 (m, 3H). ¹⁹F NMR (471 MHz) δ −62.70 (s, 3F). ESI; [M+1]=302.0.

Step D: Preparation of (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid

A mixture of ethyl (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylate (i.e. the product of Step C, 2.66 g, 8.8 mmol) and aqueous sodium hydroxide (50 wt %, 2.12 g, 26.5 mmol) in ethanol (30 mL) was stirred at 26° C. for 18 h. The reaction mixture was then diluted with water (50 mL) and extracted with diethyl ether (2×50 mL). The aqueous phase was acidified with concentrated hydrochloric acid to pH 2 and extracted with dichloromethane (3×50 mL). The combined dichloromethane extracts were washed with brine, dried (MgSO₄), and concentrated under reduced pressure to afford the title compound as a white solid (2.05 g).

¹H NMR (500 MHz, acetone-d₆) δ 11.50 (br s, 1H), 7.70-7.89 (m, 2H), 7.56-7.68 (m, 2H), 7.45 (br s, 1H), 4.09-4.21 (m, 1H), 3.83-3.92 (m, 1H), 3.73-3.81 (m, 1H), 3.42-3.55 (m, 1H). ¹⁹F NMR (471 MHz, acetone-d₆) δ −63.03 (s, 3F). ESI [M+1] 274.0.

Step E: Preparation of (3R,4S)—N-(2-fluorophenyl)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

A mixture of (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid (i.e. the product of Step D, 2.0 g, 7.32 mmol), triethylamine (3.06 mL, 21.96 mmol) and 2-fluoroaniline (0.85 mL, 8.78 mmol) in dichloromethane (50 mL) was stirred at ambient temperature for 30 min, and then treated with propylphosphonic anhydride in ethyl acetate (50%, 7.92 g, 12.44 mmol). The resulting mixture was stirred at ambient temperature for 18 h. The reaction mixture was then concentrated under reduced pressure, and the residue was chromatographed on silica gel, eluted with 0-100% ethyl acetate in hexanes, to afford a solid residue which on trituration with 1-chlorobutane afforded the title product, a compound of the present invention, as a white solid (1.9 g). ER 88:12 (major eluting at 25.86 min, minor eluting at 17.66 min). Specific Rotation +74.71 at 23.4° C. at 589 nm, as a 1% solution (1 g/100 mL) in CHCl₃.

¹H NMR (500 MHz, acetone-d₆) δ 10.05 (br s, 1H), 8.21-8.35 (m, 1H), 7.77-7.91 (m, 2H), 7.58-7.66 (m, 2H), 7.51 (br s, 1H), 7.02-7.22 (m, 3H), 4.18-4.30 (m, 1H), 3.94-4.04 (m, 1H), 3.84-3.93 (m, 1H), 3.42-3.53 (m, 1H). ¹⁹F NMR (471 MHz, acetone-d₆) δ −62.93 (s, 3F), −131.13−-−131.02 (m, 1F).

SYNTHESIS EXAMPLE 6 Preparation of (3S,4S)—N-(2-fluorophenyl)-1-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide (Compound 351)

Step A Preparation of (4S)-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

A mixture of (3R,4S)-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxylic acid acid (i.e. the product of Example 5, Step D, 1.5 g, 5.5 mmol) and toluene-4-sulfonic acid (0.010 g, 0.055 mmol) in toluene (12 mL) was stirred at 90° C. overnight. The reaction mixture was then concentrated under reduced pressure to afford a clear oil (1.29 g). The crude product was used without further purification.

¹H NMR (500 MHz) δ 7.36-7.59 (m, 4H), 6.84 (br s, 1H), 3.70-3.88 (m, 2H), 3.35-3.50 (m, 1H), 2.72-2.87 (m, 1H), 2.44-2.58 (m, 1H). ¹⁹F NMR (471 MHz) δ −62.66 (s, 3F).

Step B: Preparation of (4S)-1-methyl-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone

To a solution of (4S)-4[3-(trifluoromethyl)phenyl]-2-pyrrolidinone (i.e. the product of Step A, 1.29 g, 5.6 mmol) in N,N-dimethylformamide (7 mL) was added sodium hydride (60% dispersion in mineral oil, 0.25 g, 6.2 mmol) in portions. The mixture was stirred for 10 min and then iodomethane (0.88 mL, 14.1 mmol) was added. The solution was stirred overnight at ambient temperature. The reaction mixture was diluted with water and extracted with diethyl ether (2×50 mL). The organic layer was washed with water, brine and then dried (MgSO₄), filtered and concentrated under reduced pressure. The crude residue was chromatographed on silica gel, eluted with 0-20% ethyl acetate in dichloromethane, to afford a light brown oil (0.775 g).

¹H NMR (500 MHz) δ 7.38-7.57 (m, 4H), 3.75-3.83 (m, 1H), 3.59-3.70 (m, 1H), 3.38-3.45 (m, 1H), 2.90-2.94 (m, 3H), 2.80-2.89 (m, 1H), 2.48-2.58 (m, 1H). ¹⁹F NMR (471 MHz) δ −62.67 (s, 3F).

Step C Preparation of (3S,4S)—N-(2-fluorophenyl-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide

A solution of (4S)-1-methyl-4-[3-(trifluoromethyl)phenyl]-2-pyrrolidinone (i.e. the product of Step B, 0.350 g, 1.44 mmol) in tetrahydrofuran (5 mL) was cooled to −78° C. To this mixture lithium bis(trimethylsilyl)amide (1.6 mL, 1.6 mmol as a 1 M solution in tetrahydrofuran) was added dropwise and the resulting solution was stirred for 30 min. Then 1-fluoro-2-isocyanatobenzene (0.17 mL, 1.44 mmol) was added dropwise and the solution was stirred for 2 h at −78° C. The reaction mixture was quenched with saturated aqueous ammonium chloride (10 mL), warmed to ambient temperature and the aqueous layer was extracted with ethyl acetate (3×25 mL). The organic layers were combined, washed with brine and then dried (MgSO₄), filtered and concentrated under reduced pressure onto silica gel. The crude residue was chromatographed on silica gel, eluting with 0 to 40% ethyl acetate in hexanes, to afford a light pink solid (0.223 g).

¹H NMR (500 MHz) δ 9.93 (br s, 1H), 8.15-8.27 (m, 1H), 7.38-7.65 (m, 4H), 6.93-7.15 (m, 3H), 4.10-4.23 (m, 1H), 3.72-3.88 (m, 1H), 3.56-3.68 (m, 1H), 3.39-3.53 (m, 1H), 2.90-3.06 (m, 3H). ¹⁹F NMR (471 MHz) δ −62.55 (s, 3F), 129.83-−129.50 (m, 1F). ESI [M+1] 381.0.

SYNTHESIS EXAMPLE 7 Preparation of 1,3-diethyl 2-[(1S)-1-(3,4-difluorophenyl)-2-nitro-ethyl]propanedioate (Intermediate to Prepare Compound 103) Step A: Preparation of 1,3-diethyl 2-[(1S)-1-(3,4-difluorophenyl)-2-nitro-ethyl]propanedioate

To a stirred mixture of 1-[(E)-2-nitroethenyl]-3,4-difluorobenzene (prepared as described generally in WO2008/39882 A1, 1.67 g, 9.0 mmol) and diethyl malonate (1.73 g, 10.8 mmol) in toluene (10 mL) was added Ni(II) bis[(R,R)—N,N-dibenzylcyclohexane-1,2-diamine]bromide (prepared as described in J. Am. Chem. Soc. 2005, 127, 9958-9959; 0.072 g, 0.1 mmol). The resulting solution was stirred at ambient temperature for 72 h. The solution was diluted with dichloromethane (20 mL) and concentrated under reduced pressure onto silica gel and purified by silica gel chromatography eluting with a gradient of ethyl acetate in hexanes (0 to 50%) to provide 2.18 g of a light yellow waxy solid. ER 96:4 (major eluting at 37.05 min, minor eluting at 27.09 min).

¹H NMR (500 MHz) δ 7.06-7.16 (m, 2H), 6.95-7.03 (m, 1H), 4.73-4.94 (m, 2H), 4.16-4.29 (m, 3H), 4.01-4.10 (m, 2H), 3.71-3.79 (m, 1H), 1.22-1.30 (m, 3H), 1.07-1.15 (m, 3H). ¹⁹F NMR (471 MHz) δ −137.66-−137.47 (m, 1F) −136.10-−135.87 (m, 1F). ESI [M+1]; 346.4

By the procedures described herein together with methods known in the art, the following compounds of Tables 1 to 6800 can be prepared. The following abbreviations are used in the Tables which follow: t means tertiary, s means secondary, n means normal, i means iso, c means cyclo, Me means methyl, Et means ethyl, Pr means propyl, Bu means butyl, i-Pr means isopropyl, c-Pr cyclopropyl, t-Bu means tertiary butyl, c-Bu means cyclobutyl, Ph means phenyl, OMe means methoxy, OEt means ethoxy, SMe means methylthio, NHMe means methylamino, CN means cyano, NO₂ means nitro, TMS means trimethylsilyl, SOMe means methylsulfinyl, C₂F₅ means CF₂CF₃ and SO₂Me means methylsulfonyl.

TABLE 1

Q1 Ph(3-Cl) Ph(3-F) Ph(3-Br) Ph(3-Me) Ph(3-Et) Ph(3-t-Bu) Ph(3-i-Pr) Ph(3-c-Pr) Ph(3-cyclohexyl) Ph(3-CH═CH₂) Ph(3-CF₃) Ph(3-CH₂CF₃) Ph(3-CHF₂) Ph(3-CH₂F) Ph(3-OCF₃) Ph(3-OCH₂F) Ph(3-SCF₃) Ph(3-SMe) Ph(3-SOMe) 3-SO₂Me Ph(3-OSO₂Me) Ph(3-C≡CH) Ph(3-OMe) Ph(3-OEt) Ph(3-NHCO₂-t-Bu) Ph(3-NHCOMe) Ph(3-NHCOCF₃) Ph(3-CN) Ph(3-NO₂) Ph(3-Ph) Ph(3-COMe) Ph(3-OCOMe) Ph(3-CO₂Me) Ph(3-OCO₂Me) Ph(3-TMS) Ph(3-SF₅) Ph[3-(1H-pyrazol-1-yl)] Ph[3-(2H-1,2,3-triazol-2-yl)] Ph[3-(1H-imidazol-1-yl)] Ph[3-(3-pyridinyl)] Ph[3-(4-pyridinyl)] Ph[3-(2-pyridinyl)] 4-Pyridinyl(2-CF₃) 4-Pyridinyl(2-Cl) 4-Pyridinyl(2-F) 4-Pyridinyl(2-OCF₃) 4-Pyridinyl(2-Me) 4-Pyridinyl(2-Br) 4-Pyridinyl 1H-Pyrazol-4-yl(1-Me) 1H-Pyrazol-4-yl(1-CH₂CF₃) 1H-Imidazol-2-yl(1-Me) 1H-Imidazol-2-yl(1-CH₂CF₃) 1H-Imidazol-2-yl(1-Me,5-Cl) 1H-Imidazol-2-yl(1-Me,5-F) 2-Thienyl 2-Thienyl(4-F) 2-Thienyl(4-Cl) 2-Thienyl(4-CF₃) 2-Thienyl(5-F) 2-Thienyl(5-Cl) 2-Thienyl(5-CF₃) Ph(4-Cl) Ph(4-F) Ph(4-Br) Ph(4-Me) Ph(4-Et) Ph(4-t-Bu) Ph(4-i-Pr) Ph(4-c-Pr) Ph(4-cyclohexyl) Ph(4-CH═CH₂) Ph(4-CF₃) Ph(4-CH₂CF₃) Ph(4-CHF₂) Ph(4-CH₂F) Ph(4-OCF₃) Ph(4-OCH₂F) Ph(4-SCF₃) Ph(4-SMe) Ph(4-SOMe) Ph(4-SO₂Me) Ph(4-OSO₂Me) Ph(4-C≡CH) Ph(4-OMe) Ph(4-OEt) Ph(4-NHCO₂-t-Bu) Ph(4-NHCOMe) Ph(4-NHCOCF₃) Ph(4-CN) Ph(4-NO₂) Ph(4-Ph) Ph(4-COMe) Ph(4-OCOMe) Ph(4-CO₂Me) Ph(4-OCO₂Me) Ph(4-TMS) Ph(4-SF₅) Ph(1H-pyrazol-1-yl) Ph(2H-1,2,3-triazol-2-yl) Ph(1H-imidazol-1-yl) Ph[4-(3-pyridinyl)] Ph[4-(4-pyridinyl)] Ph[4-(2-pyridinyl)] 3-Pyridinyl(5-CF₃) 3-Pyridinyl(5-Cl) 3-Pyridinyl(5-F) 3-Pyridinyl(5-OCF₃) 3-Pyridinyl(5-Me) 3-Pyridinyl(5-Br) 3-Pyridinyl 1H-Pyrazol-3-yl(1-Me) 1H-Pyrazol-3-yl(1-CH₂CF₃) 1H-Pyrazol-3-yl(1-Me,4-F) 1H-Pyrazol-3-yl(1-Me,4-Cl) 1H-Imidazol-5-yl(1-Me) 1H-Imidazol-5-yl(1-CH₂CF₃) 1H-Imidazol-4-yl(1-Me) 1H-Imidazol-4-yl(1-CH₂CF₃) 3-Thienyl 3-Thienyl(5-F) 3-Thienyl(5-Cl) 3-Thienyl(5-CF₃) Ph(3,4-di-Cl) Ph(3-Cl,4-F) Ph(3-Cl,4-Br) Ph(3-Cl,4-Me) Ph(3-Cl,4-t-Bu) Ph(3-Cl,4-c-Pr) Ph(3-Cl,4-CF₃) Ph(3-Cl,4-CHF₂) Ph(3-Cl,4-OCF₃) Ph(3-Cl,4-OCHF₂) Ph(3-Cl,4-SO₂Me) Ph(3-Cl,4-TMS) Ph(3-Cl,4-CN) Ph(3-F,4-Cl) Ph(3,4-di-F)* Ph(3-F,4-Br) Ph(3-F,4-Me) Ph(3-F,4-t-Bu) Ph(3-F,4-c-Pr) Ph(3-F,4-CF₃) Ph(3-F,4-CHF₂) Ph(3-F,4-OCF₃) Ph(3-F,4-OCHF₂) Ph(3-F,4-SO₂Me) Ph(3-F,4-TMS) Ph(3-F,4-CN) Ph(3-F,4-SF₅) Ph(3-Br,4-Cl) Ph(3-Br,4-F) Ph(3,4-di-Br) Ph(3-Br,4-Me) Ph(3-Br,4-c-Pr) Ph(3-Br,4-CF₃) Ph(3-Br,4-CHF₂) Ph(3-Br,4-OCF₃) Ph(3-Br,4-OCHF₂) Ph(3-Br,4-SO₂Me) Ph(3-Br,4-TMS) Ph(3-Br,4-CN) Ph(3-Me,4-Cl) Ph(3-Me,4-F) Ph(3-Me,4-Br) Ph(3,4-di-Me) Ph(3-Me,4-t-Bu) Ph(3-Me,4-c-Pr) Ph(3-Me,4-CF₃) Ph(3-Me,4-OCF₃) Ph(3-Me,4-OCHF₂) Ph(3-Me,4-SO₂Me) Ph(3-Me,4-TMS) Ph(3-Me,4-CN) Ph(3-t-Bu,4-Cl) Ph(3-t-Bu,4-F) Ph(3-t-Bu,4-Br) Ph(3-t-Bu,4-Me) Ph(3,4-di-t-Bu) Ph(3-t-Bu,4-c-Pr) Ph(3-t-Bu,4-CF₃) Ph(3-t-Bu,4-CHF₂) Ph(3-t-Bu,4-OCF₃) Ph(3-t-Bu,4-OCHF₂) Ph(3-t-Bu,4-SO₂Me) Ph(3-t-Bu,4-TMS) Ph(3-t-Bu,4-CN) Ph(3-c-Pr,4-Cl) Ph(3-c-Pr,4-F) Ph(3-c-Pr,4-Br) Ph(3-c-Pr,4-Me) Ph(3-c-Pr,4-t-Bu) Ph(3,4-di-c-Pr) Ph(3-c-Pr,4-CF₃) Ph(3-c-Pr,4-CHF₂) Ph(3-c-Pr,4-OCF₃) Ph(3-c-Pr,4-OCHF₂) Ph(3-c-Pr,4-SO₂Me) Ph(3-c-Pr,4-TMS) Ph(3-c-Pr,4-CN) Ph(3-CF3,4-Cl) Ph(3-CF3,4-F) Ph(3-CF3,4-Br) Ph(3-CF3,4-Me) Ph(3-CF3,4-t-Bu) Ph(3-CF3,4-c-Pr) Ph(3,4-di-CF₃) Ph(3-CF₃,4-CHF₂) Ph(3-CF₃,4-OCF₃) Ph(3-CF₃,4-OCHF₂) Ph(3-CF₃,4-SO₂Me) Ph(3-CF₃,4-TMS) Ph(3-CF₃,4-CN) Ph(3-OCF₃,4-Cl) Ph(3-OCF₃,4-F) Ph(3-OCF₃,4-Br) Ph(3-OCF₃,4-Me) Ph(3-OCF₃,4-t-Bu) Ph(3-OCF₃,4-c-Pr) Ph(3-OCF₃-4-CF₃) Ph(3-OCF₃,4-CHF₂) Ph(3,4-di-OCF₃) Ph(3-OCF₃,4-OCHF₂) Ph(3-OCF₃,4-SO₂Me) Ph(3-OCF₃,4-TMS) Ph(3-OCF₃,4-CN) Ph(3-SO₂Me,4-Cl) Ph(3-SO₂Me,4-F) Ph(3-SO₂Me,4-Br) Ph(3-SO₂Me,4-Me) Ph(3-SO₂Me,4-t-Bu) Ph(3-SO₂Me,4-c-Pr) Ph(3-SO₂Me,4-CF₃) Ph(3-SO₂Me,4-CHF₂) Ph(3-SO₂Me,4-OCF₃) Ph(3-SO₂Me,4-OCHF₂) Ph(3,4-di-SO₂Me) Ph(3-SO₂Me,4-TMS) Ph(3-SO₂Me,4-CN) Ph(3-CHF₂,4-Cl) Ph(3-CHF₂,4-F) Ph(3-CHF₂,4-Br) Ph(3-CHF₂,4-Me) Ph(3-CHF₂,4-t-Bu) Ph(3-CHF₂,4-c-Pr) Ph(3-CHF₂,4-CF₃) Ph(3-CHF₂,4-CHF₂) Ph(3-CHF₂,4-OCF₃) Ph(3-CHF₂,4-OCHF₂) Ph(3-CHF₂,4-SO₂Me) Ph(3-CHF₂,4-TMS) Ph(3-CHF₂,4-CN) Ph(3-CN,4-Cl) Ph(3-CN,4-F) Ph(3-CN,4-Br) Ph(3-CN,4-Me) Ph(3-CN,4-t-Bu) Ph(3-CN,4-c-Pr) Ph(3-CN,4-CF₃) Ph(3-CN,4-CHF₂) Ph(3-CN,4-OCF₃) Ph(3-CN,4-OCHF₂) Ph(3-CN,4-SO₂Me) Ph(3-CN,4-TMS) Ph(3,4-di-CN) Ph(3-SF₅,4-F) Ph(2-F,3-Cl,4-Cl) Ph(2-F,3-Cl,4-F) Ph(2-F,3-Cl,4-Br) Ph(2-F,3-Cl,4-Me) Ph(2-F,3-Cl,4-t-Bu) Ph(2-F,3-Cl,4-c-Pr) Ph(2-F,3-Cl,4-CF3) Ph(2-F,3-Cl,4-CHF2) Ph(2-F,3-Cl,4-OCF3) Ph(2-F,3-Cl,4-OCHF2) Ph(2-F,3-Cl,4-SO2Me) Ph(2-F,3-Cl,4-TMS) Ph(2-F,3-Cl,4-CN) Ph(2-F,3-F,4-Cl) Ph(2-F,3-F,4-F) Ph(2-F,3-F,4-Br) Ph(2-F,3-F,4-Me) Ph(2-F,3-F,4-t-Bu) Ph(2-F,3-F,4-c-Pr) Ph(2-F,3-F,4-CF₃) Ph(2-F,3-F,4-CHF₂) Ph(2-F,3-F,4-OCF₃) Ph(2-F,3-F,4-OCHF₂) Ph(2-F,3-F,4-SO₂Me) Ph(2-F,3-F,4-TMS) Ph(2-F,3-F,4-CN) Ph(2-F,3-Br,4-Cl) Ph(2-F,3-Br,4-F) Ph(2-F,3-Br,4-Br) Ph(2-F,3-Br,4-Me) Ph(2-F,3-Br,4-t-Bu) Ph(2-F,3-Br,4-c-Pr) Ph(2-F,3-Br,4-CF₃) Ph(2-F,3-Br,4-CHF₂) Ph(2-F,3-Br,4-OCF₃) Ph(2-F,3-Br,4-OCHF₂) Ph(2-F,3-Br,4-SO₂Me) Ph(2-F,3-Br,4-TMS) Ph(2-F,3-Br,4-CN) Ph(2-F,3-Me,4-Cl) Ph(2-F,3-Me,4-F) Ph(2-F,3-Me,4-Br) Ph(2-F,3-Me,4-Me) Ph(2-F,3-Me,4-t-Bu) Ph(2-F,3-Me,4-CF₃) Ph(2-F,3-Me,4-CHF₂) Ph(2-F,3-Me,4-OCF₃) Ph(2-F,3-Me,4-OCHF₂) Ph(2-F,3-Me,4-SO₂Me) Ph(2-F,3-Me,4-TMS) Ph(2-F,3-Me,4-CN) Ph(2-F,3-t-Bu,4-Cl) Ph(2-F,3-t-Bu,4-F) Ph(2-F,3-t-Bu,4-Br) Ph(2-F,3-t-Bu,4-Me) Ph(2-F,3-t-Bu,4-t-Bu) Ph(2-F,3-t-Bu,4-c-Pr) Ph(2-F,3-t-Bu,4-CF₃) Ph(2-F,3-t-Bu,4-CHF₂) Ph(2-F,3-t-Bu,4-OCF₃) Ph(2-F,3-t-Bu,4-OCHF₂) Ph(2-F,3-t-Bu,4-SO₂Me) Ph(2-F,3-t-Bu,4-TMS) Ph(2-F,3-t-Bu,4-CN) Ph(2-F,3-c-Pr,4-Cl) Ph(2-F,3-c-Pr,4-F) Ph(2-F,3-c-Pr,4-Br) Ph(2-F,3-c-Pr,4-Me) Ph(2-F,3-c-Pr,4-t-Bu) Ph(2-F,3,4-di-c-Pr) Ph(2-F,3-c-Pr,4-CF₃) Ph(2-F,3-c-Pr,4-CHF₂ Ph(2-F,3-c-Pr,4-OCF₃) Ph(2-F,3-c-Pr,4-OCHF₂) Ph(2-F,3-c-Pr,4-SO₂Me) Ph(2-F,3-c-Pr,4-TMS) Ph(2-F,3-c-Pr,4-CN) Ph(2-F,3-CF₃,4-Cl) Ph(2-F,3-CF₃,4-F) Ph(2-F,3-CF₃,4-Br) Ph(2-F,3-CF₃,4-Me) Ph(2-F,3-CF₃,4-t-Bu) Ph(2-F,3-CF₃,4-c-Pr) Ph(2-F,3-CF₃,4-CF₃) Ph(2-F,3-CF₃,4-CHF₂) Ph(2-F,3-CF₃,4-OCF₃) Ph(2-F,3-CF₃,4-OCHF₂) Ph(2-F,3-CF₃,4-SO₂Me) Ph(2-F,3-CF₃,4-TMS) Ph(2-F,3-CF₃,4-CN) Ph(2-F,3-OCF₃,4-Cl) Ph(2-F,3-OCF₃,4-F) Ph(2-F,3-OCF₃,4-Br) Ph(2-F,3-OCF₃,4-Me) Ph(2-F,3-OCF₃,4-t-Bu) Ph(2-F,3-OCF₃,4-c-Pr) Ph(2-F,3-OCF₃,4-CF₃) Ph(2-F,3-OCF₃,4-CHF₂) Ph(2-F,3-OCF₃,4-OCF₃) Ph(2-F,3-OCF₃,4-OCHF₂) Ph(2-F,3-OCF₃,4-SO₂Me) Ph(2-F,3-OCF₃,4-TMS) Ph(2-F,3-OCF₃,4-CN) Ph(2-F,3-SO₂Me,4-Cl) Ph(2-F,3-SO₂Me,4-F) Ph(2-F,3-SO₂Me,4-Br) Ph(2-F,3-SO₂Me,4-Me) Ph(2-F,3-SO₂Me,4-t-Bu) Ph(2-F,3-SO₂Me,4-c-Pr) Ph(2-F,3-SO₂Me,4-CF₃) Ph(2-F,3-SO₂Me,4-CHF₂) Ph(2-F,3-SO₂Me,4-OCF₃) Ph(2-F,3-SO₂Me,4-OCHF₂) Ph(2-F,3,4-di-SO₂Me) Ph(2-F,3-SO₂Me,4-TMS) Ph(2-F,3-SO₂Me,4-CN) Ph(2-F,3-CHF2,4-Cl) Ph(2-F,3-CHF₂,4-F) Ph(2-F,3-CHF₂,4-Br) Ph(2-F,3-CHF₂,4-Me) Ph(2-F,3-CHF₂,4-t-Bu) Ph(2-F,3-CHF₂,4-c-Pr) Ph(2-F,3-CHF₂,4-CF₃) Ph(2-F,3-CHF₂,4-CHF₂) Ph(2-F,3-CHF₂,4-OCF₃) Ph(2-F,3-CHF₂,4-OCHF₂) Ph(2-F,3-CHF₂,4-SO₂Me) Ph(2-F,3-CHF₂,4-TMS) Ph(2-F,3-CHF₂,4-CN) Ph(2-F,3-CN,4-Cl) Ph(2-F,3-CN,4-F) Ph(2-F,3-CN,4-Br) Ph(2-F,3-CN,4-Me) Ph(2-F,3-CN,4-t-Bu) Ph(2-F,3-CN,4-c-Pr) Ph(2-F,3-CN,4-CF₃) Ph(2-F,3-CN,4-CHF₂) Ph(2-F,3-CN,4-OCF₃) Ph(2-F,3-CN,4-OCHF₂) Ph(2-F,3-CN,4-SO₂Me) Ph(2-F,3-CN,4-TMS) Ph(2-F,3-CN,4-CN) Ph(2-F,4-Cl) Ph(2-F,4-F) Ph(2-F,4-Br) Ph(2-F,4-Me) Ph(2-F,4-t-Bu) Ph(2-F,4-c-Pr) Ph(2-F,4-CF₃) Ph(2-F,4-CHF₂) Ph(2-F,4-OCF₃) Ph(2-F,4-OCHF₂) Ph(2-F,4-SO₂Me) Ph(2-F,4-TMS) Ph(2-F,4-CN) Ph(2-F,3-Cl) Ph(2-F,3-F) Ph(2-F,3-Br) Ph(2-F,3-Me) Ph(2-F,3-t-Bu) Ph(2-F,3-c-Pr) Ph(2-F,3-CF₃) Ph(2-F,3-CHF₂) Ph(2-F,3-OCF₃) Ph(2-F,3-OCHF₂) Ph(2-F,3-SO₂Me) Ph(2-F,3-TMS) Ph(2-F,3-CN) Ph(2-Cl) Ph(2-F) Ph(2-Br) Ph(2-I) Ph(2-Me) Ph(2-Et) Ph(2-n-Pr) Ph(2-t-Bu) Ph(2-i-Pr) Ph(2-c-Pr) Ph(2-cyclohexyl) Ph(2-CH═CH₂) Ph(2-CF₃) Ph(2-CH₂CF₃) Ph(2-CF₂H) Ph(2-CH₂F) Ph(2-OCF₃) Ph(2-OCH₂F) Ph(2-OCF₂H) Ph(2-SCF₃) Ph(2-SMe) Ph(2-SOMe) Ph(2-SO₂Me) Ph(2-OSO₂Me) Ph(2-C≡CH) Ph(2-OMe) Ph(2-OEt) Ph(2-NHCO₂-t-Bu) Ph(2-NHCOMe) Ph(2-NHCOCF₃) Ph(2-CN) Ph(2-NO₂) Ph(2-Ph) Ph(2-COMe) Ph(2-OCOMe) Ph(2-CO₂Me) Ph(2-OCO₂Me) Ph(2-TMS) Ph[2-(1H-pyrazol-1-yl)] Ph[2-(2H-1,2,3-triazol-2-yl)] Ph[2-(1H-imidazol-1-yl)] Ph[2-(3-pyridinyl)] Ph[2-(4-pyridinyl)] Ph[2-(2-pyridinyl)] Ph(2-C₂F₅) Ph(2-CF₂CF₂H) Ph(2-OCF₂CF₂H) Ph(2-OC₂F₅) Ph(2-OCH₂CF₃) Ph(2-OCH₂C≡CH) Ph(2-OCH₂C≡CCF₃) Ph(2-OCH₂C≡CCF₂H) Ph(2-OCH₂C≡CCH₃) Ph(2-OCH₂C≡C-c-Pr) Ph(2-C≡CCF₂H) Ph(2-C≡CCH₃) Ph(2-C≡C-c-Pr) Ph(2-OPh) Ph(2-C≡CCF₃) Ph(2-CH═CF₂) Ph(2-CH═CCl₂) Ph(2-CH═CBr₂) Ph(2-OCH═CH₂) Ph(2-OCH═CF₂) Ph(2-OCH═CCl₂) Ph(2-OCH═CBr₂) Ph(2-CH₂CH═CH₂) Ph(2-CH₂CH═CF₂) Ph(2-CH₂CH═CCl₂) Ph(2-CH₂CH═CBr₂) Ph(2-OCH₂CH═CH₂) Ph(2-OCH₂CH═CF₂) Ph(2-OCH₂CH═CCl₂) Ph(2-OCH₂CH═CBr₂) Ph(2-SCF₂H) Ph(2-SCF₂CF₂H) Ph(3-I) Ph(3-n-Pr) Ph(3-CF₂H) Ph(3-OCF₂H) Ph(3-SO₂Me) Ph(3-C₂F₅) Ph(3-CF₂CF₂H) Ph(3-OCF₂CF₂H) Ph(3-OC₂F₅) Ph(3-OCH₂CF₃) Ph(3-OCH₂C≡CH) Ph(3-OCH₂C≡CCF₃) Ph(3-OCH₂C≡CCF₂H) Ph(3-OCH₂C≡CCH₃) Ph(3-OCH₂C≡C-c-Pr) Ph(3-C≡CCF₂H) Ph(3-C≡CCH₃) Ph(3-C≡C-c-Pr) Ph(3-OPh) Ph(3-C≡CCF₃) Ph(3-CH═CF₂) Ph(3-CH═CCl₂) Ph(3-CH═CBr₂) Ph(3-OCH═CH₂) Ph(3-OCH═CF₂) Ph(3-OCH═CCl₂) Ph(3-OCH═CBr₂) Ph(3-CH₂CH═CH₂) Ph(3-CH₂CH═CF₂) Ph(3-CH₂CH═CCl₂) Ph(3-CH₂CH═CBr₂) Ph(3-OCH₂CH═CH₂) Ph(3-OCH₂CH═CF₂) Ph(3-OCH₂CH═CCl₂) Ph(3-OCH₂CH═CBr₂) Ph(3-SCF₂H) Ph(3-SCF₂CF₂H) Ph(2-Cl,3-Cl) Ph(2-Cl,3-F) Ph(2-Cl,3-Br) Ph(2-Cl,3-I) Ph(2-Cl,3-Me) Ph(2-Cl,3-Et) Ph(2-Cl,3-n-Pr) Ph(2-Cl,3-t-Bu) Ph(2-Cl,3-i-Pr) Ph(2-Cl,3-c-Pr) Ph(2-Cl,3-cyclohexyl) Ph(2-Cl,3-CH═CH₂) Ph(2-Cl,3-CF3) Ph(2-Cl,3-CH₂CF₃) Ph(2-Cl,3-CF₂H) Ph(2-Cl,3-CH₂F) Ph(2-Cl,3-OCF₃) Ph(2-Cl,3-OCH₂F) Ph(2-Cl,3-OCF₂H) Ph(2-Cl,3-SCF₃) Ph(2-Cl,3-SMe) Ph(2-Cl,3-SOMe) Ph(2-Cl,3-SO₂Me) Ph(2-Cl,3-OSO₂Me) Ph(2-Cl,3-CCH) Ph(2-Cl,3-OMe) Ph(2-Cl,3-OEt) Ph(2-Cl,3-NHCO₂-t-Bu) Ph(2-Cl,3-NHCOMe) Ph(2-Cl,3-NHCOCF₃) Ph(2-Cl,3-CN) Ph(2-Cl,3-NO₂) Ph(2-Cl,3-Ph) Ph(2-Cl,3-COMe) Ph(2-Cl,3-OCOMe) Ph(2-Cl,3-CO₂Me) Ph(2-Cl,3-OCO₂Me) Ph(2-Cl,3-TMS) Ph[3-(2-Cl,1H-pyrazol-1-yl)] Ph[3-(2-Cl,2H-1,2,3-triazol-2-yl)] Ph[3-(2-Cl,1H-imidazol-1-yl)] Ph[3-(2-Cl,3-pyridinyl) Ph[3-(2-Cl,4-pyridinyl) Ph[3-(2-Cl,2-pyridinyl) Ph(2-Cl,3-C₂F₅) Ph(2-Cl,3-CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H) Ph(2-Cl,3-OC₂F₅) Ph(2-Cl,3-OCH₂CF₃) Ph(2-Cl,3-OCH₂C≡CH) Ph(2-Cl,3-OCH₂C≡CCF₃) Ph(2-Cl,3-OCH₂C≡CCF₂H) Ph(2-Cl,3-OCH₂C≡CCH₃) Ph(2-Cl,3-OCH₂C≡C-c-Pr) Ph(2-Cl,3-C≡CCF₂H) Ph(2-Cl,3-CCCH₃) Ph(2-Cl,3-CC-c-Pr) Ph(2-Cl,3-OPh) Ph(2-Cl,3-C≡CCF₃) Ph(2-Cl,3-CH═CF₂) Ph(2-Cl,3-CH═CCl₂) Ph(2-Cl,3-CH═CBr₂) Ph(2-Cl,3-OCH═CH₂) Ph(2-Cl,3-OCH═CF₂) Ph(2-Cl,3-OCH═CCl₂) Ph(2-Cl,3-OCH═CBr₂) Ph(2-Cl,3-CH₂CH═CH₂) Ph(2-Cl,3-CH₂CH═CF₂) Ph(2-Cl,3-CH₂CH═CCl₂) Ph(2-Cl,3-CH₂CH═CBr₂) Ph(2-Cl,3-OCH₂CH═CH₂) Ph(2-Cl,3-OCH₂CH═CF₂) Ph(2-Cl,3-OCH₂CH═CCl₂) Ph(2-Cl,3-OCH₂CH═CBr₂) Ph(2-Cl,3-SCF₂H) Ph(2-Cl,3-SCF₂CF₂H) Ph(2-F,3-F) Ph(2-F,3-Br) Ph(2-F,3-I) Ph(2-F,3-Me) Ph(2-F,3-Et) Ph(2-F,3-n-Pr) Ph(2-F,3-t-Bu) Ph(2-F,3-i-Pr) Ph(2-F,3-cyclohexyl) Ph(2-F,3-CH═CH₂) Ph(2-F,3-CF₃) Ph(2-F,3-CH₂CF₃) Ph(2-F,3-CF₂H) Ph(2-F,3-CH₂F) Ph(2-F,3-OCH₂F) Ph(2-F,3-OCF₂H) Ph(2-F,3-SCF₃) Ph(2-F,3-SMe) Ph(2-F,3-SOMe) Ph(2-F,3-SO₂Me) Ph(2-F,3-OSO₂Me) Ph(2-F,3-CCH) Ph(2-F,3-OMe) Ph(2-F,3-OEt) Ph(2-F,3-NHCO₂-t-Bu) Ph(2-F,3-NHCOMe) Ph(2-F,3-NHCOCF₃) Ph(2-F,3-NO₂) Ph(2-F,3-Ph) Ph(2-F,3-COMe) Ph(2-F,3-OCOMe) Ph(2-F,3-CO₂Me) Ph(2-F,3-OCO₂Me) Ph[3-(2-F,1H-imidazol-1-yl)] Ph[3-(2-F,3-pyridinyl)] Ph[3-(2-F,4-pyridinyl)] Ph[3-(2-F,2-pyridinyl)] Ph(2-F,3-C₂F₅) Ph(2-F,3-CF₂CF₂H) Ph(2-F,3-OCF₂CF₂H) Ph(2-F,3-OC₂F₅) Ph(2-F,3-OCH₂CF₃) Ph(2-F,3-OCH₂C≡CH) Ph(2-F,3-OCH₂C≡CCF₃) Ph(2-F,3-OCH₂C≡CCF₂H) Ph(2-F,3-OCH₂C≡CCH₃) Ph(2-F,3-OCH₂C≡C-c-Pr) Ph(2-F,3-C≡CCF₂H) Ph(2-F,3-C≡CCH₃) Ph(2-F,3-C≡C-c-Pr) Ph(2-F,3-OPh) Ph(2-F,3-C≡CCF₃) Ph(2-F,3-CH═CF₂) Ph(2-F,3-CH═CCl₂) Ph(2-F,3-CH═CBr₂) Ph(2-F,3-OCH═CH₂) Ph(2-F,3-OCH═CF₂) Ph(2-F,3-OCH═CCl₂) Ph(2-F,3-OCH═CBr₂) Ph(2-F,3-CH₂CH═CH₂) Ph(2-F,3-CH₂CH═CF₂) Ph(2-F,3-CH₂CH═CCl₂) Ph(2-F,3-CH₂CH═CBr₂) Ph(2-F,3-OCH₂CH═CH₂) Ph(2-F,3-OCH₂CH═CF₂) Ph(2-F,3-OCH₂CH═CCl2) Ph(2-F,3-OCH₂CH═CBr₂) Ph(2-F,3-SCF₂H) Ph(2-F,3-SCF₂CF₂H) Ph(2-F,3-SF5) 4-Pyridinyl(5-OCF₂H) 4-Pyridinyl(5-CF₂H) 4-Pyridinyl(5-OCF₂CF₂H) 2-Thienyl(4-Me) 2-Thienyl(4-Et) 2-Thienyl(4-i-Pr) 2-Thienyl(4-c-Pr) 2-Thienyl(4-CF₂H) 2-Thienyl(4-OCF₂H) 2-Thienyl(4-OCF₂CF₂H) 2-Thienyl(5-Me) 2-Thienyl(5-Et) 2-Thienyl(5-i-Pr) 2-Thienyl(5-c-Pr) 2-Thienyl(5-CF₂H) 2-Thienyl(5-OCF₂H) 2-Thienyl(5-OCF₂CF₂H) 2-Thienyl(5-OC₂F₅) 2-Furanyl(4-F) 2-Furanyl(4-Cl) 2-Furanyl(4-CF₃) 2-Furanyl(5-F) 2-Furanyl(5-Cl) 2-Furanyl(5-CF₃) 2-Furanyl(4-Me) 2-Furanyl(4-Et) 2-Furanyl(4-i-Pr) 2-Furanyl(4-c-Pr) 2-Furanyl(4-CF₂H) 2-Furanyl(4-OCF₂H) 2-Furanyl(4-OCF₂CF₂H) 2-Furanyl(5-Me) 2-Furanyl(5-Et) 2-Furanyl(5-i-Pr) 2-Furanyl(5-c-Pr) 2-Furanyl(5-CF₂H) 2-Furanyl(5-OCF₂H) 2-Furanyl(5-OCF₂CF₂H) 2-Furanyl(5-OC₂F₅) Ph(4-I) Ph(4-n-Pr) Ph(4-OCHF₂) Ph(4-C2F₅) Ph(4-CF₂CF₂H) Ph(4-OCF₂CF₂H) Ph(4-OC₂F₅) Ph(4-OCH₂CF₃) Ph(4-OCH₂C≡CH) Ph(4-OCH₂C≡CCF₃) Ph(4-OCH₂C≡CCF₂H) Ph(4-OCH₂C≡CCH₃) Ph(4-OCH₂C≡C-c-Pr) Ph(4-C≡CCF₂H) Ph(4-C≡CCH₃) Ph(4-C≡C-c-Pr) Ph(4-OPh) Ph(4-C≡CCF₃) Ph(4-CH═CF₂) Ph(4-CH═CCl₂) Ph(4-CH═CBr₂) Ph(4-OCH═CH₂) Ph(4-OCH═CF₂) Ph(4-OCH═CCl₂) Ph(4-OCH═CBr₂) Ph(4-CH₂CH═CH₂) Ph(4-CH₂CH═CF₂) Ph(4-CH₂CH═CCl₂) Ph(4-CH₂CH═CBr₂) Ph(4-OCH₂CH═CH₂) Ph(4-OCH₂CH═CF₂) Ph(4-OCH₂CH═CCl₂) Ph(4-OCH₂CH═CBr₂) Ph(4-SCF₂H) Ph(4-SCF₂CF₂H) Ph(2,4-di-Cl) Ph(2-Cl,4-F) Ph(2-Cl,4-Br) Ph(2-Cl,4-I) Ph(2-Cl,4-Me) Ph(2-Cl,4-Et) Ph(2-Cl,4-n-Pr) Ph(2-Cl,4-t-Bu) Ph(2-Cl,4-i-Pr) Ph(2-Cl,4-c-Pr) Ph(2-Cl,4-cyclohexyl) Ph(2-Cl,4-CH═CH₂) Ph(2-Cl,4-CF₃) Ph(2-Cl,4-CH₂CF₃) Ph(2-Cl,4-CHF₂) Ph(2-Cl,4-CH₂F) Ph(2-Cl,4-OCF₃) Ph(2-Cl,4-OCH₂F) Ph(2-Cl,4-OCHF₂) Ph(2-Cl,4-SCF₃) Ph(2-Cl,4-SMe) Ph(2-Cl,4-SOMe) Ph(2-Cl,4-SO₂Me) Ph(2-Cl,4-OSO₂Me) Ph(2-Cl,4-CCH) Ph(2-Cl,4-OMe) Ph(2-Cl,4-OEt) Ph(2-Cl,4-NHCO₂-t-Bu) Ph(2-Cl,4-NHCOMe) Ph(2-Cl,4-NHCOCF₃) Ph(2-Cl,4-CN) Ph(2-Cl,4-NO₂) Ph(2-Cl,4-Ph) Ph(2-Cl,4-COMe) Ph(2-Cl,4-OCOMe) Ph(2-Cl,4-CO₂Me) Ph(2-Cl,4-OCO₂Me) Ph(2-Cl,4-TMS) Ph(2-Cl,4-C₂F₅) Ph(2-Cl,4-CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H) Ph(2-Cl,4-OC₂F₅) Ph(2-Cl,4-OCH₂CF₃) Ph(2-Cl,4-OCH₂C≡CH) Ph(2-Cl,4-OCH₂C≡CCF₃) Ph(2-Cl,4-OCH₂C≡CCF₂H) Ph(2-Cl,4-OCH₂C≡CCH₃) Ph(2-Cl,4-OCH₂C≡C-c-Pr) Ph(2-Cl,4-C≡CCF₂H) Ph(2-Cl,4-C≡CCH₃) Ph(2-Cl,4-C≡C-c-Pr) Ph(2-Cl,4-OPh) Ph(2-Cl,4-C≡CCF₃) Ph(2-Cl,4-CH═CF₂) Ph(2-Cl,4-CH═CCl₂) Ph(2-Cl,4-CH═CBr₂) Ph(2-Cl,4-OCH═CH₂) Ph(2-Cl,4-OCH═CF₂) Ph(2-Cl,4-OCH═CCl₂) Ph(2-Cl,4-OCH═CBr₂) Ph(2-Cl,4-CH₂CH═CH₂) Ph(2-Cl,4-CH₂CH═CF₂) Ph(2-Cl,4-CH₂CH═CCl₂) Ph(2-Cl,4-CH₂CH═CBr₂) Ph(2-Cl,4-OCH₂CH═CH₂) Ph(2-Cl,4-OCH₂CH═CF₂) Ph(2-Cl,4-OCH₂CH═CCl₂) Ph(2-Cl,4-OCH₂CH═CBr₂) Ph(2-Cl,4-SCF₂H) Ph(2-Cl,4-SCF₂CF₂H) Ph(2-F,4-Cl) Ph(2,4-di-F) Ph(2-F,4-Br) Ph(2-F,4-I) Ph(2-F,4-Me) Ph(2-F,4-Et) Ph(2-F,4-n-Pr) Ph(2-F,4-t-Bu) Ph(2-F,4-i-Pr) Ph(2-F,4-cyclohexyl) Ph(2-F,4-CH═CH₂) Ph(2-F,4-CF₃) Ph(2-F,4-CH₂CF₃) Ph(2-F,4-CHF₂) Ph(2-F,4-CH₂F) Ph(2-F,4-OCF₃) Ph(2-F,4-OCH₂F) Ph(2-F,4-OCHF₂) Ph(2-F,4-SCF₃) Ph(2-F,4-SMe) Ph(2-F,4-SOMe) Ph(2-F,4-SO₂Me) Ph(2-F,4-OSO₂Me) Ph(2-F,4-C≡CH) Ph(2-F,4-OMe) Ph(2-F,4-OEt) Ph(2-F,4-NHCO₂-t-Bu) Ph(2-F,4-NHCOMe) Ph(2-F,4-NHCOCF₃) Ph(2-F,4-CN) Ph(2-F,4-NO₂) Ph(2-F,4-Ph) Ph(2-F,4-COMe) Ph(2-F,4-OCOMe) Ph(2-F,4-CO₂Me) Ph(2-F,4-OCO₂Me) Ph(2-F,4-C₂F₅) Ph(2-F,4-CF₂CF₂H) Ph(2-F,4-OCF₂CF₂H) Ph(2-F,4-OC₂F₅) Ph(2-F,4-OCH₂CF₃) Ph(2-F,4-OCH₂C≡CH) Ph(2-F,4-OCH₂C≡CCF₃) Ph(2-F,4-OCH₂C≡CCF₂H) Ph(2-F,4-OCH₂C≡CCH₃) Ph(2-F,4-OCH₂C≡C-c-Pr) Ph(2-F,4-C≡CCF₂H) Ph(2-F,4-C≡CCH₃) Ph(2-F,4-C≡C-c-Pr) Ph(2-F,4-OPh) Ph(2-F,4-C≡CCF₃) Ph(2-F,4-CH═CF₂) Ph(2-F,4-CH═CCl₂) Ph(2-F,4-CH═CBr₂) Ph(2-F,4-OCH═CH₂) Ph(2-F,4-OCH═CF₂) Ph(2-F,4-OCH═CCl₂) Ph(2-F,4-OCH═CBr₂) Ph(2-F,4-CH₂CH═CH₂) Ph(2-F,4-CH₂CH═CF₂) Ph(2-F,4-CH₂CH═CCl₂) Ph(2-F,4-CH₂CH═CBr₂) Ph(2-F,4-OCH₂CH═CH₂) Ph(2-F,4-OCH₂CH═CF₂) Ph(2-F,4-OCH₂CH═CCl₂) Ph(2-F,4-OCH₂CH═CBr₂) Ph(2-F,4-SCF₂H) Ph(2-F,4-SCF₂CF₂H) Ph(2-F,4-SF₅) 3-Pyridinyl(5-OCF₂H) 3-Pyridinyl(5-CF₂H) 3-Pyridinyl(5-OCF₂CF₂H) 3-Thienyl(4-Me) 3-Thienyl(4-Et) 3-Thienyl(4-i-Pr) 3-Thienyl(4-c-Pr) 3-Thienyl(4-CFH) 3-Thienyl(4-OCF₂H) 3-Thienyl(4-OCF₂CF₂H) 3-Thienyl(4-OC₂F₅) 3-Furanyl(5-F) 3-Furanyl(5-Cl) 3-Furanyl(5-CF₃) 3-Furanyl(4-Me) 3-Furanyl(4-Et) 3-Furanyl(4-i-Pr) 3-Furanyl(4-c-Pr) 3-Furanyl(4-CFH) 3-Furanyl(4-OCF2H) 3-Furanyl(4-OCF₂CF₂H) 3-Furanyl(4-OC₂F₅) Ph(3-Cl,4-I) Ph(3-Cl,4-Et) Ph(3-Cl,4-n-Pr) Ph(3-Cl,4-i-Pr) Ph(3-Cl,4-C₂F₅) Ph(3-Cl,4-CF₂CF₂H) Ph(3-Cl,4-CF₂H) Ph(3-Cl,4-OMe) Ph(3-Cl,4-OCF₂CF₂H) Ph(3-Cl,4-OC₂F₅) Ph(3,4-di-F) Ph(3-F,4-I) Ph(3-F,4-Et) Ph(3-F,4-n-Pr) Ph(3-F,4-i-Pr) Ph(3-F,4-C₂F₅) Ph(3-F,4-CF₂CF₂H) Ph(3-F,4-CF₂H) Ph(3-F,4-OMe) Ph(3-F,4-OCF₂CF₂H) Ph(3-F,4-OC₂F₅) Ph(3-Br,4-I) Ph(3-Br,4-Et) Ph(3-Br,4-n-Pr) Ph(3-Br,4-t-Bu) Ph(3-Br,4-i-Pr) Ph(3-Br,4-C₂F₅) Ph(3-Br,4-CF₂CF₂H) Ph(3-Br,4-CF₂H) Ph(3-Br,4-OMe) Ph(3-Br,4-OCF₂CF₂H) Ph(3-Br,4-OC₂F₅) Ph(3-I,4-Cl) Ph(3-I,4-F) Ph(3-I,4-Br) Ph(3,4-di-I) Ph(3-I,4-Me) Ph(3-I,4-Et) Ph(3-I,4-n-Pr) Ph(3-I,4-t-Bu) Ph(3-I,4-i-Pr) Ph(3-I,4-c-Pr) Ph(3-I,4-CF₃) Ph(3-I,4-C₂F₅) Ph(3-I,4-CF₂CF₂H) Ph(3-I,4-CF₂H) Ph(3-I,4-OMe) Ph(3-I,4-OCF₃) Ph(3-I,4-OCHF₂) Ph(3-I,4-OCF₂CF₂H) Ph(3-I,4-OC₂F₅) Ph(3-I,4-SO₂Me) Ph(3-I,4-TMS) Ph(3-I,4-CN) Ph(3-Me,4-I) Ph(3-Me,4-Et) Ph(3-Me,4-n-Pr) Ph(3-Me,4-i-Pr) Ph(3-Me,4-C₂F₅) Ph(3-Me,4-CF₂CF₂H) Ph(3-Me,4-CF₂H) Ph(3-Me,4-OMe) Ph(3-Me,4-OCF₂CF₂H) Ph(3-Me,4-OC₂F₅) Ph(3-Et,4-Cl) Ph(3-Et,4-F) Ph(3-Et,4-Br) Ph(3-Et,4-I) Ph(3-Et,4-Me) Ph(3,4-di-Et) Ph(3-Et,4-n-Pr) Ph(3-Et,4-t-Bu) Ph(3-Et,4-i-Pr) Ph(3-Et,4-c-Pr) Ph(3-Et,4-CF₃) Ph(3-Et,4-C₂F₅) Ph(3-Et,4-CF₂CF₂H) Ph(3-Et,4-CF₂H) Ph(3-Et,4-OMe) Ph(3-Et,4-OCF₃) Ph(3-Et,4-OCHF₂) Ph(3-Et,4-OCF₂CF₂H) Ph(3-Et,4-OC₂F₅) Ph(3-Et,4-SO₂Me) Ph(3-Et,4-TMS) Ph(3-Et,4-CN) Ph(3-n-Pr,4-Cl) Ph(3-n-Pr,4-F) Ph(3-n-Pr,4-Br) Ph(3-n-Pr,4-I) Ph(3-n-Pr,4-Me) Ph(3-n-Pr,4-Et) Ph(3,4-di-n-Pr) Ph(3-n-Pr,4-t-Bu) Ph(3-n-Pr,4-i-Pr) Ph(3-n-Pr,4-c-Pr) Ph(3-n-Pr,4-CF₃) Ph(3-n-Pr,4-C₂F₅) Ph(3-n-Pr,4-CF₂CF₂H) Ph(3-n-Pr,4-CF₂H) Ph(3-n-Pr,4-OMe) Ph(3-n-Pr,4-OCF₃) Ph(3-n-Pr,4-OCHF₂) Ph(3-n-Pr,4-OCF₂CF₂H) Ph(3-n-Pr,4-OC₂F₅) Ph(3-n-Pr,4-SO₂Me) Ph(3-n-Pr,4-TMS) Ph(3-n-Pr,4-CN) Ph(3-t-Bu,4-I) Ph(3-t-Bu,4-Et) Ph(3-t-Bu,4-n-Pr) Ph(3-t-Bu,4-i-Pr) Ph(3-t-Bu,4-C₂F₅) Ph(3-t-Bu,4-CF₂CF₂H) Ph(3-t-Bu,4-CF₂H) Ph(3-t-Bu,4-OMe) Ph(3-t-Bu,4-OCF₂CF₂H) Ph(3-i-Pr,4-Cl) Ph(3-i-Pr,4-F) Ph(3-i-Pr,4-Br) Ph(3-i-Pr,4-I) Ph(3-i-Pr,4-Me) Ph(3-i-Pr,4-Et) Ph(3-i-Pr,4-n-Pr) Ph(3-i-Pr,4-t-Bu) Ph(3,4-di-i-Pr) Ph(3-i-Pr,4-c-Pr) Ph(3-i-Pr,4-CF₃) Ph(3-i-Pr,4-C₂F₅) Ph(3-i-Pr,4-CF₂CF₂H) Ph(3-i-Pr,4-CF₂H) Ph(3-i-Pr,4-OMe) Ph(3-i-Pr,4-OCF₃) Ph(3-i-Pr,4-OCHF₂) Ph(3-i-Pr,4-OCF₂CF₂H) Ph(3-i-Pr,4-OC₂F₅) Ph(3-i-Pr,4-SO₂Me) Ph(3-i-Pr,4-TMS) Ph(3-i-Pr,4-CN) Ph(3-c-Pr,4-I) Ph(3-c-Pr,4-Et) Ph(3-c-Pr,4-n-Pr) Ph(3-c-Pr,4-i-Pr) Ph(3-c-Pr,4-C₂F₅) Ph(3-c-Pr,4-CF₂CF₂H) Ph(3-c-Pr,4-CF₂H) Ph(3-c-Pr,4-OMe) Ph(3-c-Pr,4-OCF₂CF₂H) Ph(3-c-Pr,4-OC₂F₅) Ph(3-CF₃,4-I) Ph(3-CF₃,4-Et) Ph(3-CF₃,4-n-Pr) Ph(3-CF₃,4-i-Pr) Ph(3-CF₃,4-C₂F₅) Ph(3-CF₃,4-CF₂CF₂H) Ph(3-CF₃,4-CF₂H) Ph(3-CF₃,4-OMe) Ph(3-CF₃,4-OCF₂CF₂H) Ph(3-CF₃,4-OC₂F₅) Ph(3-CF₃,4-TMS) Ph(3-C₂F₅,4-Cl) Ph(3-C₂F₅,4-F) Ph(3-C₂F₅,4-Br) Ph(3-C₂F₅,4-I) Ph(3-C₂F₅,4-Me) Ph(3-C₂F₅,4-Et) Ph(3-C₂F₅,4-n-Pr) Ph(3-C₂F₅,4-t-Bu) Ph(3-C₂F₅,4-i-Pr) Ph(3-C₂F₅,4-c-Pr) Ph(3-C₂F₅CF₃,4-CF₃) Ph(3,4-di-C₂F₅) Ph(3-C₂F₅,4-CF₂CF₂H) Ph(3-C₂F₅,4-CF₂H) Ph(3-C₂F₅,4-OMe) Ph(3-C₂F₅,4-OCF₃) Ph(3-C₂F₅,4-OCHF₂) Ph(3-C₂F₅,4-OCF₂CF₂H) Ph(3-C₂F₅,4-OC₂F₅) Ph(3-C₂F₅,4-SO₂Me) Ph(3-C₂F₅,4-TMS) Ph(3-C₂F₅,4-CN) Ph(3-CF₂CF₂H,4-Cl) Ph(3-CF₂CF₂H,4-F) Ph(3-CF₂CF₂H,4-Br) Ph(3-CF₂CF₂H,4-I) Ph(3-CF₂CF₂H,4-Me) Ph(3-CF₂CF₂H,4-Et) Ph(3-CF₂CF₂H,4-n-Pr) Ph(3-CF₂CF₂H,4-t-Bu) Ph(3-CF₂CF₂H,4-i-Pr) Ph(3-CF₂CF₂H,4-c-Pr) Ph(3-CF₂CF₂H,4-CF₃) Ph(3-CF₂CF₂H,4-C₂F₅) Ph(3,4-di-CF₂CF₂H) Ph(3-CF₂CF₂H,4-CF₂H) Ph(3-CF₂CF₂H,4-OMe) Ph(3-CF₂CF₂H,4-OCF₃) Ph(3-CF₂CF₂H,4-OCHF₂) Ph(3-CF₂CF₂H,4-OCF₂CF₂H) Ph(3-CF₂CF₂H,4-OC₂F₅) Ph(3-CF₂CF₂H,4-SO₂Me) Ph(3-CF₂CF₂H,4-TMS) Ph(3-CF₂CF₂H,4-CN) Ph(3-CF₂H,4-Cl) Ph(3-CF₂H,4-F) Ph(3-CF₂H,4-Br) Ph(3-CF₂H,4-I) Ph(3-CF₂H,4-Me) Ph(3-CF₂H,4-Et) Ph(3-CF₂H,4-n-Pr) Ph(3-CF₂H,4-t-Bu) Ph(3-CF₂H,4-i-Pr) Ph(3-CF₂H,4-c-Pr) Ph(3-CF₂H,4-CF₃) Ph(3-CF₂H,4-C₂F₅) Ph(3-CF₂H,4-CF₂CF₂H) Ph(3,4-di-CF₂H) Ph(3-CF₂H,4-OMe) Ph(3-CF₂H,4-OCF₃) Ph(3-CF₂H,4-OCHF₂) Ph(3-CF₂H,4-OCF₂CF₂H) Ph(3-CF₂H,4-OC₂F₅) Ph(3-CF₂H,4-SO₂Me) Ph(3-CF₂H,4-TMS) Ph(3-CF₂H,4-CN) Ph(3-OMe,4-Cl) Ph(3-OMe,4-F) Ph(3-OMe,4-Br) Ph(3-OMe,4-I) Ph(3-OMe,4-Me) Ph(3-OMe,4-Et) Ph(3-OMe,4-n-Pr) Ph(3-OMe,4-t-Bu) Ph(3-OMe,4-i-Pr) Ph(3-OMe,4-c-Pr) Ph(3-OMe,4-CF₃) Ph(3-OMe,4-C₂F₅) Ph(3-OMe,4-CF₂CF₂H) Ph(3-OMe,4-CF₂H) Ph(3,4-di-OMe) Ph(3-OMe,4-OCF₃) Ph(3-OMe,4-OCHF₂) Ph(3-OMe,4-OCF₂CF₂H) Ph(3-OMe,4-OC₂F₅) Ph(3-OMe,4-SO₂Me) Ph(3-OMe,4-TMS) Ph(3-OMe,4-CN) Ph(3-OCF₃,4-I) Ph(3-OCF₃,4-Et) Ph(3-OCF₃,4-n-Pr) Ph(3-OCF₃,4-i-Pr) Ph(3-OCF₃,4-CF₃) Ph(3-OCF₃,4-C₂F₅) Ph(3-OCF₃,4-CF₂CF₂H) Ph(3-OCF₃,4-CF₂H) Ph(3-OCF₃,4-OMe) Ph(3-OCF₃,4-OCF₂CF₂H) Ph(3-OCF₃,4-OC₂F₅) Ph(3-OCHF₂,4-Cl) Ph(3-OCHF₂,4-F) Ph(3-OCHF₂,4-Br) Ph(3-OCHF₂,4-I) Ph(3-OCHF₂,4-Me) Ph(3-OCHF₂,4-Et) Ph(3-OCHF₂,4-n-Pr) Ph(3-OCHF₂,4-t-Bu) Ph(3-OCHF₂,4-i-Pr) Ph(3-OCHF₂,4-c-Pr) Ph(3-OCHF₂CF₃,4-CF₃) Ph(3-OC₂F₅,4-C₂F₅) Ph(3-OCHF₂,4-CF₂CF₂H) Ph(3-OCHF₂,4-CF₂H) Ph(3-OCHF₂,4-OMe) Ph(3-OCHF₂,4-OCF₃) Ph(3,4-di-OCHF₂) Ph(3-OCHF₂,4-OCF₂CF₂H) Ph(3-OCHF₂,4-OC₂F₅) Ph(3-OCHF₂,4-SO₂Me) Ph(3-OCHF₂,4-TMS) Ph(3-OCHF₂,4-CN) Ph(3-OCF₂CF₂H,4-Cl) Ph(3-OCF₂CF₂H,4-F) Ph(3-OCF₂CF₂H,4-Br) Ph(3-OCF₂CF₂H,4-I) Ph(3-OCF₂CF₂H,4-Me) Ph(3-OCF₂CF₂H,4-Et) Ph(3-OCF₂CF₂H,4-n-Pr) Ph(3-OCF₂CF₂H,4-t-Bu) Ph(3-OCF₂CF₂H,4-i-Pr) Ph(3-OCF₂CF₂H,4-c-Pr) Ph(3-OCF₂CF₂H,4-CF₃) Ph(3-OCF₂CF₂H,4-C₂F₅) Ph(3-OCF₂CF₂H,4-CF₂CF₂H) Ph(3-OCF₂CF₂H,4-CF₂H) Ph(3-OCF₂CF₂H,4-OMe) Ph(3-OCF₂CF₂H,4-OCF₃) Ph(3-OCF₂CF₂H,4-OCHF₂) Ph(3,4-di-OCF₂CF₂H) Ph(3-OCF₂CF₂H,4-OC₂F₅) Ph(3-OCF₂CF₂H,4-SO₂Me) Ph(3-OCF₂CF₂H,4-TMS) Ph(3-OCF₂CF₂H,4-CN) Ph(3-OC₂F₅,4-Cl) Ph(3-OC₂F₅,4-F) Ph(3-OC₂F₅,4-Br) Ph(3-OC₂F₅,4-I) Ph(3-OC₂F₅,4-Me) Ph(3-OC₂F₅,4-Et) Ph(3-OC₂F₅,4-n-Pr) Ph(3-OC₂F₅,4-t-Bu) Ph(3-OC₂F₅,4-i-Pr) Ph(3-OC₂F₅,4-c-Pr) Ph(3-OC₂F₅CF₃,4-CF₃) Ph(3-OC₂F₅,4-CF₂CF₂H) Ph(3-OC₂F₅,4-CF₂H) Ph(3-OC₂F₅,4-OMe) Ph(3-OC₂F₅,4-OCF₃) Ph(3-OC₂F₅,4-OCHF₂) Ph(3-OC₂F₅,4-OCF₂CF₂H) Ph(3,4-di-OC₂F₅) Ph(3-OC₂F₅,4-SO₂Me) Ph(3-OC₂F₅,4-TMS) Ph(3-OC₂F₅,4-CN) Ph(3-SO₂Me,4-I) Ph(3-SO₂Me,4-Et) Ph(3-SO₂Me,4-n-Pr) Ph(3-SO₂Me,4-i-Pr) Ph(3-SO₂MeCF₃,4-CF₃) Ph(3-SO₂Me,4-C₂F₅) Ph(3-SO₂Me,4-CF₂CF₂H) Ph(3-SO₂Me,4-CF₂H) Ph(3-SO₂Me,4-OMe) Ph(3-SO₂Me,4-OCF₂CF₂H) Ph(3-SO₂Me,4-OC₂F₅) Ph(3-TMS,4-Cl) Ph(3-TMS,4-F) Ph(3-TMS,4-Br) Ph(3-TMS,4-I) Ph(3-TMS,4-Me) Ph(3-TMS,4-Et) Ph(3-TMS,4-n-Pr) Ph(3-TMS,4-t-Bu) Ph(3-TMS,4-i-Pr) Ph(3-TMS,4-c-Pr) Ph(3-TMS,4-CF₃) Ph(3-TMS,4-C₂F₅) Ph(3-TMS,4-CF₂CF₂H) Ph(3-TMS,4-CF₂H) Ph(3-TMS,4-OMe) Ph(3-TMS,4-OCF₃) Ph(3-TMS,4-OCHF₂) Ph(3-TMS,4-OCF₂CF₂H) Ph(3-TMS,4-OC₂F₅) Ph(3-TMS,4-SO₂Me) Ph(3,4-di-TMS) Ph(3-TMS,4-CN) Ph(3-CN,4-I) Ph(3-CN,4-Et) Ph(3-CN,4-n-Pr) Ph(3-CN,4-i-Pr) Ph(3-CN,4-C₂F₅) Ph(3-CN,4-CF₂CF₂H) Ph(3-CN,4-CF₂H) Ph(3-CN,4-OMe) Ph(3-CN,4-OCF₂CF₂H) Ph(3-CN,4-OC₂F₅) Ph(3,5-di-Cl) Ph(3-Cl,5-F) Ph(3-Cl,5-Br) Ph(3-Cl,5-I) Ph(3-Cl,5-Me) Ph(3-Cl,5-Et) Ph(3-Cl,5-n-Pr) Ph(3-Cl,5-t-Bu) Ph(3-Cl,5-i-Pr) Ph(3-Cl,5-c-Pr) Ph(3-Cl,5-CF₃) Ph(3-Cl,5-C₂F₅) Ph(3-Cl,5-CF₂CF₂H) Ph(3-Cl,5-CF₂H) Ph(3-Cl,5-OMe) Ph(3-Cl,5-OCF₃) Ph(3-Cl,5-OCHF₂) Ph(3-Cl,5-OCF₂CF₂H) Ph(3-Cl,5-OC₂F₅) Ph(3-Cl,5-SO₂Me) Ph(3-Cl,5-TMS) Ph(3-Cl,5-CN) Ph(3-F,5-Cl) Ph(3,5-di-F) Ph(3-F,5-Br) Ph(3-F,5-I) Ph(3-F,5-Me) Ph(3-F,5-Et) Ph(3-F,5-n-Pr) Ph(3-F,5-t-Bu) Ph(3-F,5-i-Pr) Ph(3-F,5-c-Pr) Ph(3-F,5-CF₃) Ph(3-F,5-C₂F₅) Ph(3-F,5-CF₂CF₂H) Ph(3-F,5-CF₂H) Ph(3-F,5-OMe) Ph(3-F,5-OCF₃) Ph(3-F,5-OCHF₂) Ph(3-F,5-OCF₂CF₂H) Ph(3-F,5-OC₂F₅) Ph(3-F,5-SO₂Me) Ph(3-F,5-TMS) Ph(3-F,5-CN) Ph(3-Br,5-Cl) Ph(3-Br,5-F) Ph(3,5-di-Br) Ph(3-Br,5-I) Ph(3-Br,5-Me) Ph(3-Br,5-Et) Ph(3-Br,5-n-Pr) Ph(3-Br,5-t-Bu) Ph(3-Br,5-i-Pr) Ph(3-Br,5-c-Pr) Ph(3-Br,5-CF₃) Ph(3-Br,5-C₂F₅) Ph(3-Br,5-CF₂CF₂H) Ph(3-Br,5-CF₂H) Ph(3-Br,5-OMe) Ph(3-Br,5-OCF₃) Ph(3-Br,5-OCHF₂) Ph(3-Br,5-OCF₂CF₂H) Ph(3-Br,5-OC₂F₅) Ph(3-Br,5-SO₂Me) Ph(3-Br,5-TMS) Ph(3-Br,5-CN) Ph(3-I,5-Cl) Ph(3-I,5-F) Ph(3-I,5-Br) Ph(3,5-di-I) Ph(3-I,5-Me) Ph(3-I,5-Et) Ph(3-I,5-n-Pr) Ph(3-I,5-t-Bu) Ph(3-I,5-i-Pr) Ph(3-I,5-c-Pr) Ph(3-I,5-CF₃) Ph(3-I,5-C₂F₅) Ph(3-I,5-CF₂CF₂H) Ph(3-I,5-CF₂H) Ph(3-I,5-OMe) Ph(3-I,5-OCF₃) Ph(3-I,5-OCHF₂) Ph(3-I,5-OCF₂CF₂H) Ph(3-I,5-OC₂F₅) Ph(3-I,5-SO₂Me) Ph(3-I,5-TMS) Ph(3-I,5-CN) Ph(3-Me,5-Cl) Ph(3-Me,5-F) Ph(3-Me,5-Br) Ph(3-Me,5-I) Ph(3,5-di-Me) Ph(3-Me,5-Et) Ph(3-Me,5-n-Pr) Ph(3-Me,5-t-Bu) Ph(3-Me,5-i-Pr) Ph(3-Me,5-c-Pr) Ph(3-Me,5-CF₃) Ph(3-Me,5-C₂F₅) Ph(3-Me,5-CF₂CF₂H) Ph(3-Me,5-CF₂H) Ph(3-Me,5-OMe) Ph(3-Me,5-OCF₃) Ph(3-Me,5-OCHF₂) Ph(3-Me,5-OCF₂CF₂H) Ph(3-Me,5-OC₂F₅) Ph(3-Me,5-SO₂Me) Ph(3-Me,5-TMS) Ph(3-Me,5-CN) Ph(3-Et,5-Cl) Ph(3-Et,5-F) Ph(3-Et,5-Br) Ph(3-Et,5-I) Ph(3-Et,5-Me) Ph(3,5-di-Et) Ph(3-Et,5-n-Pr) Ph(3-Et,5-t-Bu) Ph(3-Et,5-i-Pr) Ph(3-Et,5-c-Pr) Ph(3-Et,5-CF₃) Ph(3-Et,5-C₂F₅) Ph(3-Et,5-CF₂CF₂H) Ph(3-Et,5-CF₂H) Ph(3-Et,5-OMe) Ph(3-Et,5-OCF₃) Ph(3-Et,5-OCHF₂) Ph(3-Et,5-OCF₂CF₂H) Ph(3-Et,5-OC₂F₅) Ph(3-Et,5-SO₂Me) Ph(3-Et,5-TMS) Ph(3-Et,5-CN) Ph(3-n-Pr,5-Cl) Ph(3-n-Pr,5-F) Ph(3-n-Pr,5-Br) Ph(3-n-Pr,5-I) Ph(3-n-Pr,5-Me) Ph(3-n-Pr,5-Et) Ph(3,5-di-n-Pr) Ph(3-n-Pr,5-t-Bu) Ph(3-n-Pr,5-i-Pr) Ph(3-n-Pr,5-c-Pr) Ph(3-n-Pr,5-CF₃) Ph(3-n-Pr,5-C₂F₅) Ph(3-n-Pr,5-CF₂CF₂H) Ph(3-n-Pr,5-CF₂H) Ph(3-n-Pr,5-OMe) Ph(3-n-Pr,5-OCF₃) Ph(3-n-Pr,5-OCHF₂) Ph(3-n-Pr,5-OCF₂CF₂H) Ph(3-n-Pr,5-OC₂F₅) Ph(3-n-Pr,5-SO₂Me) Ph(3-n-Pr,5-TMS) Ph(3-n-Pr,5-CN) Ph(3-t-Bu,5-Cl) Ph(3-t-Bu,5-F) Ph(3-t-Bu,5-Br) Ph(3-t-Bu,5-I) Ph(3-t-Bu,5-Me) Ph(3-t-Bu,5-Et) Ph(3-t-Bu,5-n-Pr) Ph(3,5-di-t-Bu) Ph(3-t-Bu,5-i-Pr) Ph(3-t-Bu,5-c-Pr) Ph(3-t-Bu,5-CF₃) Ph(3-t-Bu,5-C₂F₅) Ph(3-t-Bu,5-CF₂CF₂H) Ph(3-t-Bu,5-CF₂H) Ph(3-t-Bu,5-OMe) Ph(3-t-Bu,5-OCF₃) Ph(3-t-Bu,5-OCHF₂) Ph(3-t-Bu,5-OCF₂CF₂H) Ph(3-t-Bu,5-OC₂F₅) Ph(3-t-Bu,5-SO₂Me) Ph(3-t-Bu,5-TMS) Ph(3-t-Bu,5-CN) Ph(3-i-Pr,5-Cl) Ph(3-i-Pr,5-F) Ph(3-i-Pr,5-Br) Ph(3-i-Pr,5-I) Ph(3-i-Pr,5-Me) Ph(3-i-Pr,5-Et) Ph(3-i-Pr,5-n-Pr) Ph(3-i-Pr,5-t-Bu) Ph(3,5-di-i-Pr) Ph(3-i-Pr,5-c-Pr) Ph(3-i-Pr,5-CF₃) Ph(3-i-Pr,5-C₂F₅) Ph(3-i-Pr,5-CF₂CF₂H) Ph(3-i-Pr,5-CF₂H) Ph(3-i-Pr,5-OMe) Ph(3-i-Pr,5-OCF₃) Ph(3-i-Pr,5-OCHF₂) Ph(3-i-Pr,5-OCF₂CF₂H) Ph(3-i-Pr,5-OC₂F₅) Ph(3-i-Pr,5-SO₂Me) Ph(3-i-Pr,5-TMS) Ph(3-i-Pr,5-CN) Ph(3-c-Pr,5-Cl) Ph(3-c-Pr,5-F) Ph(3-c-Pr,5-Br) Ph(3-c-Pr,5-I) Ph(3-c-Pr,5-Me) Ph(3-c-Pr,5-Et) Ph(3-c-Pr,5-n-Pr) Ph(3-c-Pr,5-t-Bu) Ph(3-c-Pr,5-i-Pr) Ph(3,5-di-c-Pr) Ph(3-c-Pr,5-CF₃) Ph(3-c-Pr,5-C₂F₅) Ph(3-c-Pr,5-CF₂CF₂H) Ph(3-c-Pr,5-CF₂H) Ph(3-c-Pr,5-OMe) Ph(3-c-Pr,5-OCF₃) Ph(3-c-Pr,5-OCHF₂) Ph(3-c-Pr,5-OCF₂CF₂H) Ph(3-c-Pr,5-OC₂F₅) Ph(3-c-Pr,5-SO₂Me) Ph(3-c-Pr,5-TMS) Ph(3-c-Pr,5-CN) Ph(3-CF₃,5-Cl) Ph(3-CF₃,5-F) Ph(3-CF₃,5-Br) Ph(3-CF₃,5-I) Ph(3-CF₃,5-Me) Ph(3-CF₃,5-Et) Ph(3-CF₃,5-n-Pr) Ph(3-CF₃,5-t-Bu) Ph(3-CF₃,5-i-Pr) Ph(3-CF₃,5-c-Pr) Ph(3,5-di-CF₃) Ph(3-CF₃,5-C₂F₅) Ph(3-CF₃,5-CF₂CF₂H) Ph(3-CF₃,5-CF₂H) Ph(3-CF₃,5-OMe) Ph(3-CF₃,5-OCF₃) Ph(3-CF₃,5-OCHF₂) Ph(3-CF₃,5-OCF₂CF₂H) Ph(3-CF₃,5-OC₂F₅) Ph(3-CF₃,5-SO₂Me) Ph(3-CF₃,5-TMS) Ph(3-CF₃,5-CN) Ph(3-C₂F₅,5-Cl) Ph(3-C₂F₅,5-F) Ph(3-C₂F₅,5-Br) Ph(3-C₂F₅,5-I) Ph(3-C₂F₅,5-Me) Ph(3-C₂F₅,5-Et) Ph(3-C₂F₅,5-n-Pr) Ph(3-C₂F₅,5-t-Bu) Ph(3-C₂F₅,5-i-Pr) Ph(3-C₂F₅,5-c-Pr) Ph(3-C₂F₅CF₃,5-CF₃) Ph(3,5-di-C₂F₅) Ph(3-C₂F₅,5-CF₂CF₂H) Ph(3-C₂F₅,5-CF₂H) Ph(3-C₂F₅,5-OMe) Ph(3-C₂F₅,5-OCF₃) Ph(3-C₂F₅,5-OCHF₂) Ph(3-C₂F₅,5-OCF₂CF₂H) Ph(3-C₂F₅,5-OC₂F₅) Ph(3-C₂F₅,5-SO₂Me) Ph(3-C₂F₅,5-TMS) Ph(3-C₂F₅,5-CN) Ph(3-CF₂CF₂H,5-Cl) Ph(3-CF₂CF₂H,5-F) Ph(3-CF₂CF₂H,5-Br) Ph(3-CF₂CF₂H,5-I) Ph(3-CF₂CF₂H,5-Me) Ph(3-CF₂CF₂H,5-Et) Ph(3-CF₂CF₂H,5-n-Pr) Ph(3-CF₂CF₂H,5-t-Bu) Ph(3-CF₂CF₂H,5-i-Pr) Ph(3-CF₂CF₂H,5-c-Pr) Ph(3-CF₂CF₂H,5-CF₃) Ph(3-CF₂CF₂H,5-C₂F₅) Ph(3,5-di-CF₂CF₂H) Ph(3-CF₂CF₂H,5-CF₂H) Ph(3-CF₂CF₂H,5-OMe) Ph(3-CF₂CF₂H,5-OCF₃) Ph(3-CF₂CF₂H,5-OCHF₂) Ph(3-CF₂CF₂H,5-OCF₂CF₂H) Ph(3-CF₂CF₂H,5-OC₂F₅) Ph(3-CF₂CF₂H,5-SO₂Me) Ph(3-CF₂CF₂H,5-TMS) Ph(3-CF₂CF₂H,5-CN) Ph(3-CF₂H,5-Cl) Ph(3-CF₂H,5-F) Ph(3-CF₂H,5-Br) Ph(3-CF₂H,5-I) Ph(3-CF₂H,5-Me) Ph(3-CF₂H,5-Et) Ph(3-CF₂H,5-n-Pr) Ph(3-CF₂H,5-t-Bu) Ph(3-CF₂H,5-i-Pr) Ph(3-CF₂H,5-c-Pr) Ph(3-CF₂H,5-CF₃) Ph(3-CF₂H,5-C₂F₅) Ph(3-CF₂H,5-CF₂CF₂H) Ph(3,5-di-CF₂H) Ph(3-CF₂H,5-OMe) Ph(3-CF₂H,5-OCF₃) Ph(3-CF₂H,5-OCHF₂) Ph(3-CF₂H,5-OCF₂CF₂H) Ph(3-CF₂H,5-OC₂F5) Ph(3-CF₂H,5-SO₂Me) Ph(3-CF₂H,5-TMS) Ph(3-CF₂H,5-CN) Ph(3-OMe,5-Cl) Ph(3-OMe,5-F) Ph(3-OMe,5-Br) Ph(3-OMe,5-I) Ph(3-OMe,5-Me) Ph(3-OMe,5-Et) Ph(3-OMe,5-n-Pr) Ph(3-OMe,5-t-Bu) Ph(3-OMe,5-i-Pr) Ph(3-OMe,5-c-Pr) Ph(3-OMeCF₃,5-CF₃) Ph(3-OMe,5-C₂F₅) Ph(3-OMe,5-CF₂CF₂H) Ph(3-OMe,5-CF₂H) Ph(3,5-di-OMe) Ph(3-OMe,5-OCF₃) Ph(3-OMe,5-OCHF₂) Ph(3-OMe,5-OCF₂CF₂H) Ph(3-OMe,5-OC₂F₅) Ph(3-OMe,5-SO₂Me) Ph(3-OMe,5-TMS) Ph(3-OMe,5-CN) Ph(3-OCF₃,5-Cl) Ph(3-OCF₃,5-F) Ph(3-OCF₃,5-Br) Ph(3-OCF₃,5-I) Ph(3-OCF₃,5-Me) Ph(3-OCF₃,5-Et) Ph(3-OCF₃,5-n-Pr) Ph(3-OCF₃,5-t-Bu) Ph(3-OCF₃,5-i-Pr) Ph(3-OCF₃,5-c-Pr) Ph(3-OCF₃,5-CF₃) Ph(3-OCF₃,5-C₂F₅) Ph(3-OCF₃,5-CF₂CF₂H) Ph(3-OCF₃,5-CF₂H) Ph(3-OCF₃,5-OMe) Ph(3,5-di-OCF₃) Ph(3-OCF₃,5-OCHF₂) Ph(3-OCF₃,5-OCF₂CF₂H) Ph(3-OCF₃,5-OC₂F₅) Ph(3-OCF₃,5-SO₂Me) Ph(3-OCF₃,5-TMS) Ph(3-OCF₃,5-CN) Ph(3-OCHF₂,5-Cl) Ph(3-OCHF₂,5-F) Ph(3-OCHF₂,5-Br) Ph(3-OCHF₂,5-I) Ph(3-OCHF₂,5-Me) Ph(3-OCHF₂,5-Et) Ph(3-OCHF₂,5-n-Pr) Ph(3-OCHF₂,5-t-Bu) Ph(3-OCHF₂,5-i-Pr) Ph(3-OCHF₂,5-c-Pr) Ph(3-OCHF₂CF₃,5-CF₃) Ph(3-OC₂F₅,5-C₂F₅) Ph(3-OCHF₂,5-CF₂CF₂H) Ph(3-OCHF₂,5-CF₂H) Ph(3-OCHF₂,5-OMe) Ph(3-OCHF₂,5-OCF₃) Ph(3,5-di-OCHF₂) Ph(3-OCHF₂,5-OCF₂CF₂H) Ph(3-OCHF₂,5-OC₂F₅) Ph(3-OCHF₂,5-SO₂Me) Ph(3-OCHF₂,5-TMS) Ph(3-OCHF₂,5-CN) Ph(3-OCF₂CF₂H,5-Cl) Ph(3-OCF₂CF₂H,5-F) Ph(3-OCF₂CF₂H,5-Br) Ph(3-OCF₂CF₂H,5-I) Ph(3-OCF₂CF₂H,5-Me) Ph(3-OCF₂CF₂H,5-Et) Ph(3-OCF₂CF₂H,5-n-Pr) Ph(3-OCF₂CF₂H,5-t-Bu) Ph(3-OCF₂CF₂H,5-i-Pr) Ph(3-OCF₂CF₂H,5-c-Pr) Ph(3-OCF₂CF₂H,5-CF₃) Ph(3-OCF₂CF₂H,5-C₂F₅) Ph(3-OCF₂CF₂H,5-CF₂CF₂H) Ph(3-OCF₂CF₂H,5-CF₂H) Ph(3-OCF₂CF₂H,5-OMe) Ph(3-OCF₂CF₂H,5-OCF₃) Ph(3-OCF₂CF₂H,5-OCHF₂) Ph(3,5-di-OCF₂CF₂H) Ph(3-OCF₂CF₂H,5-OC₂F₅) Ph(3-OCF₂CF₂H,5-SO₂Me) Ph(3-OCF₂CF₂H,5-TMS) Ph(3-OCF₂CF₂H,5-CN) Ph(3-OC₂F₅,5-Cl) Ph(3-OC₂F₅,5-F) Ph(3-OC₂F₅,5-Br) Ph(3-OC₂F₅,5-I) Ph(3-OC₂F₅,5-Me) Ph(3-OC₂F₅,5-Et) Ph(3-OC₂F₅,5-n-Pr) Ph(3-OC₂F₅,5-t-Bu) Ph(3-OC₂F₅,5-i-Pr) Ph(3-OC₂F₅,5-c-Pr) Ph(3-OC₂F₅CF₃,5-CF₃) Ph(3-OC₂F₅,5-CF₂CF₂H) Ph(3-OC₂F₅,5-CF₂H) Ph(3-OC₂F₅,5-OMe) Ph(3-OC₂F₅,5-OCF₃) Ph(3-OC₂F₅,5-OCHF₂) Ph(3,5-di-OC₂F₅) Ph(3,5-di-OC₂F₅) Ph(3-OC₂F₅,5-SO₂Me) Ph(3-OC₂F₅,5-TMS) Ph(3-OC₂F₅,5-CN) Ph(3-SO₂Me,5-Cl) Ph(3-SO₂Me,5-F) Ph(3-SO₂Me,5-Br) Ph(3-SO₂Me,5-I) Ph(3-SO₂Me,5-Me) Ph(3-SO₂Me,5-Et) Ph(3-SO₂Me,5-n-Pr) Ph(3-SO₂Me,5-t-Bu) Ph(3-SO₂Me,5-i-Pr) Ph(3-SO₂Me,5-c-Pr) Ph(3-SO₂MeCF₃,5-CF₃) Ph(3-SO₂Me,5-C₂F₅) Ph(3-SO₂Me,5-CF₂CF₂H) Ph(3-SO₂Me,5-CF₂H) Ph(3-SO₂Me,5-OMe) Ph(3-SO₂Me,5-OCF₃) Ph(3-SO₂Me,5-OCHF₂) Ph(3-SO₂Me,5-OCF₂CF₂H) Ph(3-SO₂Me,5-OC₂F₅) Ph(3,5-di-SO₂Me) Ph(3-SO₂Me,5-TMS) Ph(3-SO₂Me,5-CN) Ph(3-TMS,5-Cl) Ph(3-TMS,5-F) Ph(3-TMS,5-Br) Ph(3-TMS,5-I) Ph(3-TMS,5-Me) Ph(3-TMS,5-Et) Ph(3-TMS,5-n-Pr) Ph(3-TMS,5-t-Bu) Ph(3-TMS,5-i-Pr) Ph(3-TMS,5-c-Pr) Ph(3-TMS,5-CF₃) Ph(3-TMS,5-C₂F₅) Ph(3-TMS,5-CF₂CF₂H) Ph(3-TMS,5-CF₂H) Ph(3-TMS,5-OMe) Ph(3-TMS,5-OCF₃) Ph(3-TMS,5-OCHF₂) Ph(3-TMS,5-OCF₂CF₂H) Ph(3-TMS,5-OC₂F₅) Ph(3-TMS,5-SO₂Me) Ph(3,5-di-TMS) Ph(3-TMS,5-CN) Ph(3-CN,5-Cl) Ph(3-CN,5-F) Ph(3-CN,5-Br) Ph(3-CN,5-I) Ph(3-CN,5-Me) Ph(3-CN,5-Et) Ph(3-CN,5-n-Pr) Ph(3-CN,5-t-Bu) Ph(3-CN,5-i-Pr) Ph(3-CN,5-c-Pr) Ph(3-CN,5-CF₃) Ph(3-CN,5-C₂F₅) Ph(3-CN,5-CF₂CF₂H) Ph(3-CN,5-CF₂H) Ph(3-CN,5-OMe) Ph(3-CN,5-OCF₃) Ph(3-CN,5-OCHF₂) Ph(3-CN,5-OCF₂CF₂H) Ph(3-CN,5-OC₂F₅) Ph(3-CN,5-SO₂Me) Ph(3-CN,5-TMS) Ph(3,5-di-CN) Ph(2,3,4-tri-Cl) Ph(2-Cl,3-Cl,4-F) Ph(2-Cl,3-Cl,4-Br) Ph(2-Cl,3-Cl,4-I) Ph(2-Cl,3-Cl,4-Me) Ph(2-Cl,3-Cl,4-Et) Ph(2-Cl,3-Cl,4-n-Pr) Ph(2-Cl,3-Cl,4-t-Bu) Ph(2-Cl,3-Cl,4-i-Pr) Ph(2-Cl,3-Cl,4-c-Pr) Ph(2-Cl,3-Cl,4-CF₃) Ph(2-Cl,3-Cl,4-C₂F₅) Ph(2-Cl,3-Cl,4-CF₂CF₂H) Ph(2-Cl,3-Cl,4-CF₂H) Ph(2-Cl,3-Cl,4-OMe) Ph(2-Cl,3-Cl,4-OCF₃) Ph(2-Cl,3-Cl,4-OCHF₂) Ph(2-Cl,3-Cl,4-OCF₂CF₂H) Ph(2-Cl,3-Cl,4-OC₂F₅) Ph(2-Cl,3-Cl,4-SO₂Me) Ph(2-Cl,3-Cl,4-TMS) Ph(2-Cl,3-Cl,4-CN) Ph(2-Cl,3-F,4-Cl) Ph(2-Cl,3,4-di-F) Ph(2-Cl,3-F,4-Br) Ph(2-Cl,3-F,4-I) Ph(2-Cl,3-F,4-Me) Ph(2-Cl,3-F,4-Et) Ph(2-Cl,3-F,4-n-Pr) Ph(2-Cl,3-F,4-t-Bu) Ph(2-Cl,3-F,4-i-Pr) Ph(2-Cl,3-F,4-c-Pr) Ph(2-Cl,3-F,4-CF₃) Ph(2-Cl,3-F,4-C₂F₅) Ph(2-Cl,3-F,4-CF₂CF₂H) Ph(2-Cl,3-F,4-CF₂H) Ph(2-Cl,3-F,4-OMe) Ph(2-Cl,3-F,4-OCF₃) Ph(2-Cl,3-F,4-OCHF₂) Ph(2-Cl,3-F,4-OCF₂CF₂H) Ph(2-Cl,3-F,4-OC₂F₅) Ph(2-Cl,3-F,4-SO₂Me) Ph(2-Cl,3-F,4-TMS) Ph(2-Cl,3-F,4-CN) Ph(2-Cl,3-Br,4-Cl) Ph(2-Cl,3-Br,4-F) Ph(2-Cl,3,4-di-Br) Ph(2-Cl,3-Br,4-I) Ph(2-Cl,3-Br,4-Me) Ph(2-Cl,3-Br,4-Et) Ph(2-Cl,3-Br,4-n-Pr) Ph(2-Cl,3-Br,4-t-Bu) Ph(2-Cl,3-Br,4-i-Pr) Ph(2-Cl,3-Br,4-c-Pr) Ph(2-Cl,3-Br,4-CF₃) Ph(2-Cl,3-Br,4-C₂F₅) Ph(2-Cl,3-Br,4-CF₂CF₂H) Ph(2-Cl,3-Br,4-CF₂H) Ph(2-Cl,3-Br,4-OMe) Ph(2-Cl,3-Br,4-OCF₃) Ph(2-Cl,3-Br,4-OCHF₂) Ph(2-Cl,3-Br,4-OCF₂CF₂H) Ph(2-Cl,3-Br,4-OC₂F₅) Ph(2-Cl,3-Br,4-SO₂Me) Ph(2-Cl,3-Br,4-TMS) Ph(2-Cl,3-Br,4-CN) Ph(2-Cl,3-I,4-Cl) Ph(2-Cl,3-I,4-F) Ph(2-Cl,3-I,4-Br) Ph(2-Cl,3,4-di-I) Ph(2-Cl,3-I,4-Me) Ph(2-Cl,3-I,4-Et) Ph(2-Cl,3-I,4-n-Pr) Ph(2-Cl,3-I,4-t-Bu) Ph(2-Cl,3-I,4-i-Pr) Ph(2-Cl,3-I,4-c-Pr) Ph(2-Cl,3-I,4-CF₃) Ph(2-Cl,3-I,4-C₂F₅) Ph(2-Cl,3-I,4-CF₂CF₂H) Ph(2-Cl,3-I,4-CF₂H) Ph(2-Cl,3-I,4-OMe) Ph(2-Cl,3-I,4-OCF₃) Ph(2-Cl,3-I,4-OCHF₂) Ph(2-Cl,3-I,4-OCF₂CF₂H) Ph(2-Cl,3-I,4-OC₂F₅) Ph(2-Cl,3-I,4-SO₂Me) Ph(2-Cl,3-I,4-TMS) Ph(2-Cl,3-I,4-CN) Ph(2-Cl,3-Me,4-Cl) Ph(2-Cl,3-Me,4-F) Ph(2-Cl,3-Me,4-Br) Ph(2-Cl,3-Me,4-I) Ph(2-Cl,3,4-di-Me) Ph(2-Cl,3-Me,4-Et) Ph(2-Cl,3-Me,4-n-Pr) Ph(2-Cl,3-Me,4-t-Bu) Ph(2-Cl,3-Me,4-i-Pr) Ph(2-Cl,3-Me,4-c-Pr) Ph(2-Cl,3-Me,4-CF₃) Ph(2-Cl,3-Me,4-C₂F₅) Ph(2-Cl,3-Me,4-CF₂CF₂H) Ph(2-Cl,3-Me,4-CF₂H) Ph(2-Cl,3-Me,4-OMe) Ph(2-Cl,3-Me,4-OCF₃) Ph(2-Cl,3-Me,4-OCHF₂) Ph(2-Cl,3-Me,4-OCF₂CF₂H) Ph(2-Cl,3-Me,4-OC₂F₅) Ph(2-Cl,3-Me,4-SO₂Me) Ph(2-Cl,3-Me,4-TMS) Ph(2-Cl,3-Me,4-CN) Ph(2-Cl,3-Et,4-Cl) Ph(2-Cl,3-Et,4-F) Ph(2-Cl,3-Et,4-Br) Ph(2-Cl,3-Et,4-I) Ph(2-Cl,3-Et,4-Me) Ph(2-Cl,3,4-di-Et) Ph(2-Cl,3-Et,4-n-Pr) Ph(2-Cl,3-Et,4-t-Bu) Ph(2-Cl,3-Et,4-i-Pr) Ph(2-Cl,3-Et,4-c-Pr) Ph(2-Cl,3-Et,4-CF₃) Ph(2-Cl,3-Et,4-C₂F₅) Ph(2-Cl,3-Et,4-CF₂CF₂H) Ph(2-Cl,3-Et,4-CF₂H) Ph(2-Cl,3-Et,4-OMe) Ph(2-Cl,3-Et,4-OCF₃) Ph(2-Cl,3-Et,4-OCHF₂) Ph(2-Cl,3-Et,4-OCF₂CF₂H) Ph(2-Cl,3-Et,4-OC₂F₅) Ph(2-Cl,3-Et,4-SO₂Me) Ph(2-Cl,3-Et,4-TMS) Ph(2-Cl,3-Et,4-CN) Ph(2-Cl,3-n-Pr,4-Cl) Ph(2-Cl,3-n-Pr,4-F) Ph(2-Cl,3-n-Pr,4-Br) Ph(2-Cl,3-n-Pr,4-I) Ph(2-Cl,3-n-Pr,4-Me) Ph(2-Cl,3-n-Pr,4-Et) Ph(2-Cl,3,4-di-n-Pr) Ph(2-Cl,3-n-Pr,4-t-Bu) Ph(2-Cl,3-n-Pr,4-i-Pr) Ph(2-Cl,3-n-Pr,4-c-Pr) Ph(2-Cl,3-n-Pr,4-CF₃) Ph(2-Cl,3-n-Pr,4-C₂F₅) Ph(2-Cl,3-n-Pr,4-CF₂CF₂H) Ph(2-Cl,3-n-Pr,4-CF₂H) Ph(2-Cl,3-n-Pr,4-OMe) Ph(2-Cl,3-n-Pr,4-OCF₃) Ph(2-Cl,3-n-Pr,4-OCHF₂) Ph(2-Cl,3-n-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-n-Pr,4-OC₂F₅) Ph(2-Cl,3-n-Pr,4-SO₂Me) Ph(2-Cl,3-n-Pr,4-TMS) Ph(2-Cl,3-n-Pr,4-CN) Ph(2-Cl,3-t-Bu,4-Cl) Ph(2-Cl,3-t-Bu,4-F) Ph(2-Cl,3-t-Bu,4-Br) Ph(2-Cl,3-t-Bu,4-I) Ph(2-Cl,3-t-Bu,4-Me) Ph(2-Cl,3-t-Bu,4-Et) Ph(2-Cl,3-t-Bu,4-n-Pr) Ph(2-Cl,3,4-di-t-Bu) Ph(2-Cl,3-t-Bu,4-i-Pr) Ph(2-Cl,3-t-Bu,4-c-Pr) Ph(2-Cl,3-t-Bu,4-CF₃) Ph(2-Cl,3-t-Bu,4-C₂F₅) Ph(2-Cl,3-t-Bu,4-CF₂CF₂H) Ph(2-Cl,3-t-Bu,4-CF₂H) Ph(2-Cl,3-t-Bu,4-OMe) Ph(2-Cl,3-t-Bu,4-OCF₃) Ph(2-Cl,3-t-Bu,4-OCHF₂) Ph(2-Cl,3-t-Bu,4-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,4-OC₂F₅) Ph(2-Cl,3-t-Bu,4-SO₂Me) Ph(2-Cl,3-t-Bu,4-TMS) Ph(2-Cl,3-t-Bu,4-CN) Ph(2-Cl,3-i-Pr,4-Cl) Ph(2-Cl,3-i-Pr,4-F) Ph(2-Cl,3-i-Pr,4-Br) Ph(2-Cl,3-i-Pr,4-I) Ph(2-Cl,3-i-Pr,4-Me) Ph(2-Cl,3-i-Pr,4-Et) Ph(2-Cl,3-i-Pr,4-n-Pr) Ph(2-Cl,3-i-Pr,4-t-Bu) Ph(2-Cl,3,4-di-i-Pr) Ph(2-Cl,3-i-Pr,4-c-Pr) Ph(2-Cl,3-i-Pr,4-CF₃) Ph(2-Cl,3-i-Pr,4-C₂F₅) Ph(2-Cl,3-i-Pr,4-CF₂CF₂H) Ph(2-Cl,3-i-Pr,4-CF₂H) Ph(2-Cl,3-i-Pr,4-OMe) Ph(2-Cl,3-i-Pr,4-OCF₃) Ph(2-Cl,3-i-Pr,4-OCHF₂) Ph(2-Cl,3-i-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-i-Pr,4-OC₂F5) Ph(2-Cl,3-i-Pr,4-SO₂Me) Ph(2-Cl,3-i-Pr,4-TMS) Ph(2-Cl,3-i-Pr,4-CN) Ph(2-Cl,3-c-Pr,4-Cl) Ph(2-Cl,3-c-Pr,4-F) Ph(2-Cl,3-c-Pr,4-Br) Ph(2-Cl,3-c-Pr,4-I) Ph(2-Cl,3-c-Pr,4-Me) Ph(2-Cl,3-c-Pr,4-Et) Ph(2-Cl,3-c-Pr,4-n-Pr) Ph(2-Cl,3-c-Pr,4-t-Bu) Ph(2-Cl,3-c-Pr,4-i-Pr) Ph(2-Cl,3,4-di-c-Pr) Ph(2-Cl,3-c-Pr,4-CF₃) Ph(2-Cl,3-c-Pr,4-C₂F₅) Ph(2-Cl,3-c-Pr,4-CF₂CF₂H) Ph(2-Cl,3-c-Pr,4-CF₂H) Ph(2-Cl,3-c-Pr,4-OMe) Ph(2-Cl,3-c-Pr,4-OCF₃) Ph(2-Cl,3-c-Pr,4-OCHF₂) Ph(2-Cl,3-c-Pr,4-OCF₂CF₂H) Ph(2-Cl,3-c-Pr,4-OC₂F₅) Ph(2-Cl,3-c-Pr,4-SO₂Me) Ph(2-Cl,3-c-Pr,4-TMS) Ph(2-Cl,3-c-Pr,4-CN) Ph(2-Cl,3-CF₃,4-Cl) Ph(2-Cl,3-CF₃,4-F) Ph(2-Cl,3-CF₃,4-Br) Ph(2-Cl,3-CF₃,4-I) Ph(2-Cl,3-CF₃,4-Me) Ph(2-Cl,3-CF₃,4-Et) Ph(2-Cl,3-CF₃,4-n-Pr) Ph(2-Cl,3-CF₃,4-t-Bu) Ph(2-Cl,3-CF₃,4-i-Pr) Ph(2-Cl,3-CF3,4-c-Pr) Ph(2-Cl,3,4-di-CF₃) Ph(2-Cl,3-CF₃,4-C₂F₅) Ph(2-Cl,3-CF₃,4-CF₂CF₂H) Ph(2-Cl,3-CF₃,4-CF₂H) Ph(2-Cl,3-CF₃,4-OMe) Ph(2-Cl,3-CF₃,4-OCF₃) Ph(2-Cl,3-CF₃,4-OCHF₂) Ph(2-Cl,3-CF₃,4-OCF₂CF₂H) Ph(2-Cl,3-CF₃,4-OC₂F₅) Ph(2-Cl,3-CF₃,4-SO₂Me) Ph(2-Cl,3-CF₃,4-TMS) Ph(2-Cl,3-CF₃,4-CN) Ph(2-Cl,3-C₂F₅,4-Cl) Ph(2-Cl,3-C₂F₅,4-F) Ph(2-Cl,3-C₂F₅,4-Br) Ph(2-Cl,3-C₂F₅,4-I) Ph(2-Cl,3-C₂F₅,4-Me) Ph(2-Cl,3-C₂F₅,4-Et) Ph(2-Cl,3-C₂F₅,4-n-Pr) Ph(2-Cl,3-C₂F₅,4-t-Bu) Ph(2-Cl,3-C₂F₅,4-i-Pr) Ph(2-Cl,3-C₂F₅,4-c-Pr) Ph(2-Cl,3-C₂F₅CF₃,4-CF₃) Ph(2-Cl,3,4-di-C₂F₅) Ph(2-Cl,3-C₂F₅,4-CF₂CF₂H) Ph(2-Cl,3-C₂F₅,4-CF₂H) Ph(2-Cl,3-C₂F₅,4-OMe) Ph(2-Cl,3-C₂F₅,4-OCF₃) Ph(2-Cl,3-C₂F₅,4-OCHF₂) Ph(2-Cl,3-C₂F₅,4-OCF₂CF₂H) Ph(2-Cl,3-C₂F₅,4-OC₂F₅) Ph(2-Cl,3-C₂F₅,4-SO₂Me) Ph(2-Cl,3-C₂F₅,4-TMS) Ph(2-Cl,3-C₂F₅,4-CN) Ph(2-Cl,3-CF₂CF₂H,4-Cl) Ph(2-Cl,3-CF₂CF₂H,4-F) Ph(2-Cl,3-CF₂CF₂H,4-Br) Ph(2-Cl,3-CF₂CF₂H,4-I) Ph(2-Cl,3-CF₂CF₂H,4-Me) Ph(2-Cl,3-CF₂CF₂H,4-Et) Ph(2-Cl,3-CF₂CF₂H,4-n-Pr) Ph(2-Cl,3-CF₂CF₂H,4-t-Bu) Ph(2-Cl,3-CF₂CF₂H,4-i-Pr) Ph(2-Cl,3-CF₂CF₂H,4-c-Pr) Ph(2-Cl,3-CF₂CF₂H,4-CF₃) Ph(2-Cl,3-CF₂CF₂H,4-C₂F₅) Ph(2-Cl,3,4-di-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,4-CF₂H) Ph(2-Cl,3-CF₂CF₂H,4-OMe) Ph(2-Cl,3-CF₂CF₂H,4-OCF₃) Ph(2-Cl,3-CF₂CF₂H,4-OCHF₂) Ph(2-Cl,3-CF₂CF₂H,4- OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,4-OC₂F₅) Ph(2-Cl,3-CF₂CF₂H,4-SO₂Me) Ph(2-Cl,3-CF₂CF₂H,4-TMS) Ph(2-Cl,3-CF₂CF₂H,4-CN) Ph(2-Cl,3-CF₂H,4-Cl) Ph(2-Cl,3-CF₂H,4-F) Ph(2-Cl,3-CF₂H,4-Br) Ph(2-Cl,3-CF₂H,4-I) Ph(2-Cl,3-CF₂H,4-Me) Ph(2-Cl,3-CF₂H,4-Et) Ph(2-Cl,3-CF₂H,4-n-Pr) Ph(2-Cl,3-CF₂H,4-t-Bu) Ph(2-Cl,3-CF₂H,4-i-Pr) Ph(2-Cl,3-CF₂H,4-c-Pr) Ph(2-Cl,3-CF₂H,4-CF₃) Ph(2-Cl,3-CF₂H,4-C₂F₅) Ph(2-Cl,3-CF₂H,4-CF₂CF₂H) Ph(2-Cl,3,4-di-CF₂H) Ph(2-Cl,3-CF₂H,4-OMe) Ph(2-Cl,3-CF₂H,4-OCF₃) Ph(2-Cl,3-CF₂H,4-OCHF₂) Ph(2-Cl,3-CF₂H,4-OCF₂CF₂H) Ph(2-Cl,3-CF₂H,4-OC₂F₅) Ph(2-Cl,3-CF₂H,4-SO₂Me) Ph(2-Cl,3-CF₂H,4-TMS) Ph(2-Cl,3-CF₂H,4-CN) Ph(2-Cl,3-OMe,4-Cl) Ph(2-Cl,3-OMe,4-F) Ph(2-Cl,3-OMe,4-Br) Ph(2-Cl,3-OMe,4-I) Ph(2-Cl,3-OMe,4-Me) Ph(2-Cl,3-OMe,4-Et) Ph(2-Cl,3-OMe,4-n-Pr) Ph(2-Cl,3-OMe,4-t-Bu) Ph(2-Cl,3-OMe,4-i-Pr) Ph(2-Cl,3-OMe,4-c-Pr) Ph(2-Cl,3-OMe,4-CF₃) Ph(2-Cl,3-OMe,4-C2F5) Ph(2-Cl,3-OMe,4-CF₂CF₂H) Ph(2-Cl,3-OMe,4-CF₂H) Ph(2-Cl,3,4-di-OMe) Ph(2-Cl,3-OMe,4-OCF₃) Ph(2-Cl,3-OMe,4-OCHF₂) Ph(2-Cl,3-OMe,4-OCF₂CF₂H) Ph(2-Cl,3-OMe,4-OC₂F₅) Ph(2-Cl,3-OMe,4-SO₂Me) Ph(2-Cl,3-OMe,4-TMS) Ph(2-Cl,3-OMe,4-CN) Ph(2-Cl,3-OCF₃,4-Cl) Ph(2-Cl,3-OCF₃,4-F) Ph(2-Cl,3-OCF₃,4-Br) Ph(2-Cl,3-OCF₃,4-I) Ph(2-Cl,3-OCF₃,4-Me) Ph(2-Cl,3-OCF₃,4-Et) Ph(2-Cl,3-OCF₃,4-n-Pr) Ph(2-Cl,3-OCF₃,4-t-Bu) Ph(2-Cl,3-OCF₃,4-i-Pr) Ph(2-Cl,3-OCF₃,4-c-Pr) Ph(2-Cl,3-OCF₃,4-CF₃) Ph(2-Cl,3-OCF₃,4-C₂F₅) Ph(2-Cl,3-OCF₃,4-CF₂CF₂H) Ph(2-Cl,3-OCF₃,4-CF₂H) Ph(2-Cl,3-OCF₃,4-OMe) Ph(2-Cl,3,4-di-OCF₃) Ph(2-Cl,3-OCF₃,4-OCHF₂) Ph(2-Cl,3-OCF₃,4-OCF₂CF₂H) Ph(2-Cl,3-OCF₃,4-OC₂F₅) Ph(2-Cl,3-OCF₃,4-SO₂Me) Ph(2-Cl,3-OCF₃,4-TMS) Ph(2-Cl,3-OCF₃,4-CN) Ph(2-Cl,3-OCHF₂,4-Cl) Ph(2-Cl,3-OCHF₂,4-F) Ph(2-Cl,3-OCHF₂,4-Br) Ph(2-Cl,3-OCHF₂,4-I) Ph(2-Cl,3-OCHF₂,4-Me) Ph(2-Cl,3-OCHF₂,4-Et) Ph(2-Cl,3-OCHF₂,4-n-Pr) Ph(2-Cl,3-OCHF₂,4-t-Bu) Ph(2-Cl,3-OCHF₂,4-i-Pr) Ph(2-Cl,3-OCHF₂,4-c-Pr) Ph(2-Cl,3-OCHF₂CF₃,4-CF₃) Ph(2-Cl,3-OC₂F₅,4-C₂F₅) Ph(2-Cl,3-OCHF₂,4-CF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-CF₂H) Ph(2-Cl,3-OCHF₂,4-OMe) Ph(2-Cl,3-OCHF₂,4-OCF₃) Ph(2-Cl,3,4-di-OCHF₂) Ph(2-Cl,3-OCHF₂,4-OCF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-OC₂F₅) Ph(2-Cl,3-OCHF₂,4-SO₂Me) Ph(2-Cl,3-OCHF₂,4-TMS) Ph(2-Cl,3-OCHF₂,4-CN) Ph(2-Cl,3-OCF₂CF₂H,4-Cl) Ph(2-Cl,3-OCF₂CF₂H,4-F) Ph(2-Cl,3-OCF₂CF₂H,4-Br) Ph(2-Cl,3-OCF₂CF₂H,4-I) Ph(2-Cl,3-OCF₂CF₂H,4-Me) Ph(2-Cl,3-OCF₂CF₂H,4-Et) Ph(2-Cl,3-OCF₂CF₂H,4-n-Pr) Ph(2-Cl,3-OCF₂CF₂H,4-t-Bu) Ph(2-Cl,3-OCF₂CF₂H,4-i-Pr) Ph(2-Cl,3-OCF₂CF₂H,4-c-Pr) Ph(2-Cl,3-OCF₂CF₂H,4-CF₃) Ph(2-Cl,3-OCF₂CF₂H,4-C₂F₅) Ph(2-Cl,3-OCF₂CF₂H,4- CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-OMe) Ph(2-Cl,3-OCF₂CF₂H,4-OCF₃) Ph(2-Cl,3-OCF₂CF₂H,4-OCHF₂) Ph(2-Cl,3,4-di-OCF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,4-OC₂F₅) Ph(2-Cl,3-OCF₂CF₂H,4-SO₂Me) Ph(2-Cl,3-OCF₂CF₂H,4-TMS) Ph(2-Cl,3-OCF₂CF₂H,4-CN) Ph(2-Cl,3-OC₂F₅,4-Cl) Ph(2-Cl,3-OC₂F₅,4-F) Ph(2-Cl,3-OC₂F₅,4-Br) Ph(2-Cl,3-OC₂F₅,4-I) Ph(2-Cl,3-OC₂F₅,4-Me) Ph(2-Cl,3-OC₂F₅,4-Et) Ph(2-Cl,3-OC₂F₅,4-n-Pr) Ph(2-Cl,3-OC₂F₅,4-t-Bu) Ph(2-Cl,3-OC₂F₅,4-i-Pr) Ph(2-Cl,3-OC₂F₅,4-c-Pr) Ph(2-Cl,3-OC₂F₅CF₃,4-CF₃) Ph(2-Cl,3-OC₂F₅,4-CF₂CF₂H) Ph(2-Cl,3-OC₂F₅,4-CF₂H) Ph(2-Cl,3-OC₂F₅,4-OMe) Ph(2-Cl,3-OC₂F₅,4-OCF₃) Ph(2-Cl,3-OC₂F₅,4-OCHF₂) Ph(2-Cl,3-OC₂F₅,4-OCF₂CF₂H) Ph(2-Cl,3,4-di-OC₂F₅) Ph(2-Cl,3-OC₂F₅,4-SO₂Me) Ph(2-Cl,3-OC₂F₅,4-TMS) Ph(2-Cl,3-OC₂F₅,4-CN) Ph(2-Cl,3-SO₂Me,4-Cl) Ph(2-Cl,3-SO₂Me,4-F) Ph(2-Cl,3-SO₂Me,4-Br) Ph(2-Cl,3-SO₂Me,4-I) Ph(2-Cl,3-SO₂Me,4-Me) Ph(2-Cl,3-SO₂Me,4-Et) Ph(2-Cl,3-SO₂Me,4-n-Pr) Ph(2-Cl,3-SO₂Me,4-t-Bu) Ph(2-Cl,3-SO₂Me,4-i-Pr) Ph(2-Cl,3-SO₂Me,4-c-Pr) Ph(2-Cl,3-SO₂MeCF₃,4-CF₃) Ph(2-Cl,3-SO₂Me,4-C₂F₅) Ph(2-Cl,3-SO₂Me,4-CF₂CF₂H) Ph(2-Cl,3-SO₂Me,4-CF₂H) Ph(2-Cl,3-SO₂Me,4-OMe) Ph(2-Cl,3-SO₂Me,4-OCF₃) Ph(2-Cl,3-SO₂Me,4-OCHF₂) Ph(2-Cl,3-SO₂Me,4-OCF₂CF₂H) Ph(2-Cl,3-SO₂Me,4-OC₂F₅) Ph(2-Cl,3,4-di-SO₂Me) Ph(2-Cl,3-SO₂Me,4-TMS) Ph(2-Cl,3-SO₂Me,4-CN) Ph(2-Cl,3-TMS,4-Cl) Ph(2-Cl,3-TMS,4-F) Ph(2-Cl,3-TMS,4-Br) Ph(2-Cl,3-TMS,4-I) Ph(2-Cl,3-TMS,4-Me) Ph(2-Cl,3-TMS,4-Et) Ph(2-Cl,3-TMS,4-n-Pr) Ph(2-Cl,3-TMS,4-t-Bu) Ph(2-Cl,3-TMS,4-i-Pr) Ph(2-Cl,3-TMS,4-c-Pr) Ph(2-Cl,3-TMS,4-CF₃) Ph(2-Cl,3-TMS,4-C₂F₅) Ph(2-Cl,3-TMS,4-CF₂CF₂H) Ph(2-Cl,3-TMS,4-CF₂H) Ph(2-Cl,3-TMS,4-OMe) Ph(2-Cl,3-TMS,4-OCF₃) Ph(2-Cl,3-TMS,4-OCHF₂) Ph(2-Cl,3-TMS,4-OCF₂CF₂H) Ph(2-Cl,3-TMS,4-OC₂F₅) Ph(2-Cl,3-TMS,4-SO₂Me) Ph(2-Cl,3,4-di-TMS) Ph(2-Cl,3-TMS,4-CN) Ph(2-Cl,3-CN,4-Cl) Ph(2-Cl,3-CN,4-F) Ph(2-Cl,3-CN,4-Br) Ph(2-Cl,3-CN,4-I) Ph(2-Cl,3-CN,4-Me) Ph(2-Cl,3-CN,4-Et) Ph(2-Cl,3-CN,4-n-Pr) Ph(2-Cl,3-CN,4-t-Bu) Ph(2-Cl,3-CN,4-i-Pr) Ph(2-Cl,3-CN,4-c-Pr) Ph(2-Cl,3-CN,4-CF₃) Ph(2-Cl,3-CN,4-C₂F₅) Ph(2-Cl,3-CN,4-CF₂CF₂H) Ph(2-Cl,3-CN,4-CF₂H) Ph(2-Cl,3-CN,4-OMe) Ph(2-Cl,3-CN,4-OCF₃) Ph(2-Cl,3-CN,4-OCHF₂) Ph(2-Cl,3-CN,4-OCF₂CF₂H) Ph(2-Cl,3-CN,4-OC₂F₅) Ph(2-Cl,3-CN,4-SO₂Me) Ph(2 -Cl,3-CN,4-TMS) Ph(2-Cl,3,4-di-CN) Ph(2,3,5-tri-Cl) Ph(2-Cl,3-Cl,5-F) Ph(2-Cl,3-Cl,5-Br) Ph(2-Cl,3-Cl,5-I) Ph(2-Cl,3-Cl,5-Me) Ph(2-Cl,3-Cl,5-Et) Ph(2-Cl,3-Cl,5-n-Pr) Ph(2-Cl,3-Cl,5-t-Bu) Ph(2-Cl,3-Cl,5-i-Pr) Ph(2-Cl,3-Cl,5-c-Pr) Ph(2-Cl,3-Cl,5-CF₃) Ph(2-Cl,3-Cl,5-C₂F₅) Ph(2-Cl,3-Cl,5-CF₂CF₂H) Ph(2-Cl,3-Cl,5-CF₂H) Ph(2-Cl,3-Cl,5-OMe) Ph(2-Cl,3-Cl,5-OCF₃) Ph(2-Cl,3-Cl,5-OCHF₂) Ph(2-Cl,3-Cl,5-OCF₂CF₂H) Ph(2-Cl,3-Cl,5-OC₂F₅) Ph(2-Cl,3-Cl,5-SO₂Me) Ph(2-Cl,3-Cl,5-TMS) Ph(2-Cl,3-Cl,5-CN) Ph(2-Cl,3-F,5-Cl) Ph(2-Cl,3,5-di-F) Ph(2-Cl,3-F,5-Br) Ph(2-Cl,3-F,5-I) Ph(2-Cl,3-F,5-Me) Ph(2-Cl,3-F,5-Et) Ph(2-Cl,3-F,5-n-Pr) Ph(2-Cl,3-F,5-t-Bu) Ph(2-Cl,3-F,5-i-Pr) Ph(2-Cl,3-F,5-c-Pr) Ph(2-Cl,3-F,5-CF₃) Ph(2-Cl,3-F,5-C₂F₅) Ph(2-Cl,3-F,5-CF₂CF₂H) Ph(2-Cl,3-F,5-CF₂H) Ph(2-Cl,3-F,5-OMe) Ph(2-Cl,3-F,5-OCF₃) Ph(2-Cl,3-F,5-OCHF₂) Ph(2-Cl,3-F,5-OCF₂CF₂H) Ph(2-Cl,3-F,5-OC₂F₅) Ph(2-Cl,3-F,5-SO₂Me) Ph(2-Cl,3-F,5-TMS) Ph(2-Cl,3-F,5-CN) Ph(2-Cl,3-Br,5-Cl) Ph(2-Cl,3-Br,5-F) Ph(2-Cl,3,5-di-Br) Ph(2-Cl,3-Br,5-I) Ph(2-Cl,3-Br,5-Me) Ph(2-Cl,3-Br,5-Et) Ph(2-Cl,3-Br,5-n-Pr) Ph(2-Cl,3-Br,5-t-Bu) Ph(2-Cl,3-Br,5-i-Pr) Ph(2-Cl,3-Br,5-c-Pr) Ph(2-Cl,3-Br,5-CF₃) Ph(2-Cl,3-Br,5-C₂F₅) Ph(2-Cl,3-Br,5-CF₂CF₂H) Ph(2-Cl,3-Br,5-CF₂H) Ph(2-Cl,3-Br,5-OMe) Ph(2-Cl,3-Br,5-OCF₃) Ph(2-Cl,3-Br,5-OCHF₂) Ph(2-Cl,3-Br,5-OCF₂CF₂H) Ph(2-Cl,3-Br,5-OC₂F₅) Ph(2-Cl,3-Br,5-SO₂Me) Ph(2-Cl,3-Br,5-TMS) Ph(2-Cl,3-Br,5-CN) Ph(2-Cl,3-I,5-Cl) Ph(2-Cl,3-I,5-F) Ph(2-Cl,3-I,5-Br) Ph(2-Cl,3,5-di-I) Ph(2-Cl,3-I,5-Me) Ph(2-Cl,3-I,5-Et) Ph(2-Cl,3-I,5-n-Pr) Ph(2-Cl,3-I,5-t-Bu) Ph(2-Cl,3-I,5-i-Pr) Ph(2-Cl,3-I,5-c-Pr) Ph(2-Cl,3-I,5-CF₃) Ph(2-Cl,3-I,5-C₂F₅) Ph(2-Cl,3-I,5-CF₂CF₂H) Ph(2-Cl,3-I,5-CF₂H) Ph(2-Cl,3-I,5-OMe) Ph(2-Cl,3-I,5-OCF₃) Ph(2-Cl,3-I,5-OCHF₂) Ph(2-Cl,3-I,5-OCF₂CF₂H) Ph(2-Cl,3-I,5-OC₂F₅) Ph(2-Cl,3-I,5-SO₂Me) Ph(2-Cl,3-I,5-TMS) Ph(2-Cl,3-I,5-CN) Ph(2-Cl,3-Me,5-Cl) Ph(2-Cl,3-Me,5-F) Ph(2-Cl,3-Me,5-Br) Ph(2-Cl,3-Me,5-I) Ph(2-Cl,3,5-di-Me) Ph(2-Cl,3-Me,5-Et) Ph(2-Cl,3-Me,5-n-Pr) Ph(2-Cl,3-Me,5-t-Bu) Ph(2-Cl,3-Me,5-i-Pr) Ph(2-Cl,3-Me,5-c-Pr) Ph(2-Cl,3-Me,5-CF₃) Ph(2-Cl,3-Me,5-C₂F₅) Ph(2-Cl,3-Me,5-CF₂CF₂H) Ph(2-Cl,3-Me,5-CF₂H) Ph(2-Cl,3-Me,5-OMe) Ph(2-Cl,3-Me,5-OCF₃) Ph(2-Cl,3-Me,5-OCHF₂) Ph(2-Cl,3-Me,5-OCF₂CF₂H) Ph(2-Cl,3-Me,5-OC₂F₅) Ph(2-Cl,3-Me,5-SO₂Me) Ph(2-Cl,3-Me,5-TMS) Ph(2-Cl,3-Me,5-CN) Ph(2-Cl,3-Et,5-Cl) Ph(2-Cl,3-Et,5-F) Ph(2-Cl,3-Et,5-Br) Ph(2-Cl,3-Et,5-I) Ph(2-Cl,3-Et,5-Me) Ph(2-Cl,3,5-di-Et) Ph(2-Cl,3-Et,5-n-Pr) Ph(2-Cl,3-Et,5-t-Bu) Ph(2-Cl,3-Et,5-i-Pr) Ph(2-Cl,3-Et,5-c-Pr) Ph(2-Cl,3-Et,5-CF₃) Ph(2-Cl,3-Et,5-C₂F₅) Ph(2-Cl,3-Et,5-CF₂CF₂H) Ph(2-Cl,3-Et,5-CF₂H) Ph(2-Cl,3-Et,5-OMe) Ph(2-Cl,3-Et,5-OCF₃) Ph(2-Cl,3-Et,5-OCHF₂) Ph(2-Cl,3-Et,5-OCF₂CF₂H) Ph(2-Cl,3-Et,5-OC₂F₅) Ph(2-Cl,3-Et,5-SO₂Me) Ph(2-Cl,3-Et,5-TMS) Ph(2-Cl,3-Et,5-CN) Ph(2-Cl,3-n-Pr,5-Cl) Ph(2-Cl,3-n-Pr,5-F) Ph(2-Cl,3-n-Pr,5-Br) Ph(2-Cl,3-n-Pr,5-I) Ph(2-Cl,3-n-Pr,5-Me) Ph(2-Cl,3-n-Pr,5-Et) Ph(2-Cl,3,5-di-n-Pr) Ph(2-Cl,3-n-Pr,5-t-Bu) Ph(2-Cl,3-n-Pr,5-i-Pr) Ph(2-Cl,3-n-Pr,5-c-Pr) Ph(2-Cl,3-n-Pr,5-CF₃) Ph(2-Cl,3-n-Pr,5-C₂F₅) Ph(2-Cl,3-n-Pr,5-CF₂CF₂H) Ph(2-Cl,3-n-Pr,5-CF₂H) Ph(2-Cl,3-n-Pr,5-OMe) Ph(2-Cl,3-n-Pr,5-OCF₃) Ph(2-Cl,3-n-Pr,5-OCHF₂) Ph(2-Cl,3-n-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-n-Pr,5-OC₂F₅) Ph(2-Cl,3-n-Pr,5-SO₂Me) Ph(2-Cl,3-n-Pr,5-TMS) Ph(2-Cl,3-n-Pr,5-CN) Ph(2-Cl,3-t-Bu,5-Cl) Ph(2-Cl,3-t-Bu,5-F) Ph(2-Cl,3-t-Bu,5-Br) Ph(2-Cl,3-t-Bu,54) Ph(2-Cl,3-t-Bu,5-Me) Ph(2-Cl,3-t-Bu,5-Et) Ph(2-Cl,3-t-Bu,5-n-Pr) Ph(2-Cl,3,5-di-t-Bu) Ph(2-Cl,3-t-Bu,5-i-Pr) Ph(2-Cl,3-t-Bu,5-c-Pr) Ph(2-Cl,3-t-Bu,5-CF₃) Ph(2-Cl,3-t-Bu,5-C₂F₅) Ph(2-Cl,3-t-Bu,5-CF₂CF₂H) Ph(2-Cl,3-t-Bu,5-CF₂H) Ph(2-Cl,3-t-Bu,5-OMe) Ph(2-Cl,3-t-Bu,5-OCF₃) Ph(2-Cl,3-t-Bu,5-OCHF₂) Ph(2-Cl,3-t-Bu,5-OCF₂CF₂H) Ph(2-Cl,3-t-Bu,5-OC₂F₅) Ph(2-Cl,3-t-Bu,5-SO₂Me) Ph(2-Cl,3-t-Bu,5-TMS) Ph(2-Cl,3-t-Bu,5-CN) Ph(2-Cl,3-i-Pr,5-Cl) Ph(2-Cl,3-i-Pr,5-F) Ph(2-Cl,3-i-Pr,5-Br) Ph(2-Cl,3-i-Pr,5-I) Ph(2-Cl,3-i-Pr,5-Me) Ph(2-Cl,3-i-Pr,5-Et) Ph(2-Cl,3-i-Pr,5-n-Pr) Ph(2-Cl,3-i-Pr,5-t-Bu) Ph(2-Cl,3,5-di-i-Pr) Ph(2-Cl,3-i-Pr,5-c-Pr) Ph(2-Cl,3-i-Pr,5-CF₃) Ph(2-Cl,3-i-Pr,5-C₂F₅) Ph(2-Cl,3-i-Pr,5-CF₂CF₂H) Ph(2-Cl,3-i-Pr,5-CF₂H) Ph(2-Cl,3-i-Pr,5-OMe) Ph(2-Cl,3-i-Pr,5-OCF₃) Ph(2-Cl,3-i-Pr,5-OCHF₂) Ph(2-Cl,3-i-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-i-Pr,5-OC₂F₅) Ph(2-Cl,3-i-Pr,5-SO₂Me) Ph(2-Cl,3-i-Pr,5-TMS) Ph(2-Cl,3-i-Pr,5-CN) Ph(2-Cl,3-c-Pr,5-Cl) Ph(2-Cl,3-c-Pr,5-F) Ph(2-Cl,3-c-Pr,5-Br) Ph(2-Cl,3-c-Pr,5-I) Ph(2-Cl,3-c-Pr,5-Me) Ph(2-Cl,3-c-Pr,5-Et) Ph(2-Cl,3-c-Pr,5-n-Pr) Ph(2-Cl,3-c-Pr,5-t-Bu) Ph(2-Cl,3-c-Pr,5-i-Pr) Ph(2-Cl,3,5-di-c-Pr) Ph(2-Cl,3-c-Pr,5-CF₃) Ph(2-Cl,3-c-Pr,5-C₂F₅) Ph(2-Cl,3-c-Pr,5-CF₂CF₂H) Ph(2-Cl,3-c-Pr,5-CF₂H) Ph(2-Cl,3-c-Pr,5-OMe) Ph(2-Cl,3-c-Pr,5-OCF₃) Ph(2-Cl,3-c-Pr,5-OCHF₂) Ph(2-Cl,3-c-Pr,5-OCF₂CF₂H) Ph(2-Cl,3-c-Pr,5-OC₂F₅) Ph(2-Cl,3-c-Pr,5-SO₂Me) Ph(2-Cl,3-c-Pr,5-TMS) Ph(2-Cl,3-c-Pr,5-CN) Ph(2-Cl,3-CF3,5-Cl) Ph(2-Cl,3-CF3,5-F) Ph(2-Cl,3-CF3,5-Br) Ph(2-Cl,3-CF3,5-I) Ph(2-Cl,3-CF3,5-Me) Ph(2-Cl,3-CF₃,5-Et) Ph(2-Cl,3-CF₃,5-n-Pr) Ph(2-Cl,3-CF₃,5-t-Bu) Ph(2-Cl,3-CF₃,5-i-Pr) Ph(2-Cl,3-CF₃,5-c-Pr) Ph(2-Cl,3,5-di-CF₃) Ph(2-Cl,3-CF₃,5-C₂F₅) Ph(2-Cl,3-CF₃,5-CF₂CF₂H) Ph(2-Cl,3-CF₃,5-CF₂H) Ph(2-Cl,3-CF₃,5-OMe) Ph(2-Cl,3-CF₃,5-OCF₃) Ph(2-Cl,3-CF₃,5-OCHF₂) Ph(2-Cl,3-CF₃,5-OCF₂CF₂H) Ph(2-Cl,3-CF₃,5-OC₂F₅) Ph(2-Cl,3-CF₃,5-SO₂Me) Ph(2-Cl,3-CF₃,5-TMS) Ph(2-Cl,3-CF₃,5-CN) Ph(2-Cl,3-C₂F₅,5-Cl) Ph(2-Cl,3-C₂F₅,5-F) Ph(2-Cl,3-C₂F₅,5-Br) Ph(2-Cl,3-C₂F₅,5-I) Ph(2-Cl,3-C₂F₅,5-Me) Ph(2-Cl,3-C₂F₅,5-Et) Ph(2-Cl,3-C₂F₅,5-n-Pr) Ph(2-Cl,3-C₂F₅,5-t-Bu) Ph(2-Cl,3-C₂F₅,5-i-Pr) Ph(2-Cl,3-C₂F₅,5-c-Pr) Ph(2-Cl,3-C₂F₅CF₃,5-CF₃) Ph(2-Cl,3,5-di-C₂F₅) Ph(2-Cl,3-C₂F₅,5-CF₂CF₂H) Ph(2-Cl,3-C₂F₅,5-CF₂H) Ph(2-Cl,3-C₂F₅,5-OMe) Ph(2-Cl,3-C₂F₅,5-OCF₃) Ph(2-Cl,3-C₂F₅,5-OCHF₂) Ph(2-Cl,3-C₂F₅,5-OCF₂CF₂H) Ph(2-Cl,3-C₂F₅,5-OC₂F₅) Ph(2-Cl,3-C₂F₅,5-SO₂Me) Ph(2-Cl,3-C₂F₅,5-TMS) Ph(2-Cl,3-C₂F₅,5-CN) Ph(2-Cl,3-CF₂CF₂H,5-Cl) Ph(2-Cl,3-CF₂CF₂H,5-F) Ph(2-Cl,3-CF₂CF₂H,5-Br) Ph(2-Cl,3-CF₂CF₂H,5-I) Ph(2-Cl,3-CF₂CF₂H,5-Me) Ph(2-Cl,3-CF₂CF₂H,5-Et) Ph(2-Cl,3-CF₂CF₂H,5-n-Pr) Ph(2-Cl,3-CF₂CF₂H,5-t-Bu) Ph(2-Cl,3-CF₂CF₂H,5-i-Pr) Ph(2-Cl,3-CF₂CF₂H,5-c-Pr) Ph(2-Cl,3-CF₂CF₂H,5-CF₃) Ph(2-Cl,3-CF₂CF₂H,5-C₂F₅) Ph(2-Cl,3,5-di-CF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-OMe) Ph(2-Cl,3-CF₂CF₂H,5-OCF₃) Ph(2-Cl,3-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-CF₂CF₂H,5- OCF₂CF₂H) Ph(2-Cl,3-CF₂CF₂H,5-OC₂F₅) Ph(2-Cl,3-CF₂CF₂H,5-SO₂Me) Ph(2-Cl,3-CF₂CF₂H,5-TMS) Ph(2-Cl,3-CF₂CF₂H,5-CN) Ph(2-Cl,3-CF₂H,5-Cl) Ph(2-Cl,3-CF₂H,5-F) Ph(2-Cl,3-CF₂H,5-Br) Ph(2-Cl,3-CF₂H,5-I) Ph(2-Cl,3-CF₂H,5-Me) Ph(2-Cl,3-CF₂H,5-Et) Ph(2-Cl,3-CF₂H,5-n-Pr) Ph(2-Cl,3-CF₂H,5-t-Bu) Ph(2-Cl,3-CF₂H,5-i-Pr) Ph(2-Cl,3-CF₂H,5-c-Pr) Ph(2-Cl,3-CF₂H,5-CF₃) Ph(2-Cl,3-CF₂H,5-C₂F₅) Ph(2-Cl,3-CF₂H,5-CF₂CF₂H) Ph(2-Cl,3,5-di-CF₂H) Ph(2-Cl,3-CF₂H,5-OMe) Ph(2-Cl,3-CF₂H,5-OCF₃) Ph(2-Cl,3-CF₂H,5-OCHF₂) Ph(2-Cl,3-CF₂H,5-OCF₂CF₂H) Ph(2-Cl,3-CF₂H,5-OC₂F5) Ph(2-Cl,3-CF₂H,5-SO₂Me) Ph(2-Cl,3-CF₂H,5-TMS) Ph(2-Cl,3-CF₂H,5-CN) Ph(2-Cl,3-OMe,5-Cl) Ph(2-Cl,3-OMe,5-F) Ph(2-Cl,3-OMe,5-Br) Ph(2-Cl,3-OMe,54) Ph(2-Cl,3-OMe,5-Me) Ph(2-Cl,3-OMe,5-Et) Ph(2-Cl,3-OMe,5-n-Pr) Ph(2-Cl,3-OMe,5-t-Bu) Ph(2-Cl,3-OMe,5-i-Pr) Ph(2-Cl,3-OMe,5-c-Pr) Ph(2-Cl,3-OMe,5-CF₃) Ph(2-Cl,3-OMe,5-C₂F₅) Ph(2-Cl,3-OMe,5-CF₂CF₂H) Ph(2-Cl,3-OMe,5-CF₂H) Ph(2-Cl,3,5-di-OMe) Ph(2-Cl,3-OMe,5-OCF₃) Ph(2-Cl,3-OMe,5-OCHF₂) Ph(2-Cl,3-OMe,5-OCF₂CF₂H) Ph(2-Cl,3-OMe,5-OC₂F₅) Ph(2-Cl,3-OMe,5-SO₂Me) Ph(2-Cl,3-OMe,5-TMS) Ph(2-Cl,3-OMe,5-CN) Ph(2-Cl,3-OCF₃,5-Cl) Ph(2-Cl,3-OCF₃,5-F) Ph(2-Cl,3-OCF₃,5-Br) Ph(2-Cl,3-OCF₃,5-I) Ph(2-Cl,3-OCF₃,5-Me) Ph(2-Cl,3-OCF₃,5-Et) Ph(2-Cl,3-OCF₃,5-n-Pr) Ph(2-Cl,3-OCF₃,5-t-Bu) Ph(2-Cl,3-OCF₃,5-i-Pr) Ph(2-Cl,3-OCF₃,5-c-Pr) Ph(2-Cl,3-OCF₃,5-CF₃) Ph(2-Cl,3-OCF₃,5-C₂F₅) Ph(2-Cl,3-OCF₃,5-CF₂CF₂H) Ph(2-Cl,3-OCF₃,5-CF₂H) Ph(2-Cl,3-OCF₃,5-OMe) Ph(2-Cl,3,5-di-OCF₃) Ph(2-Cl,3-OCF₃,5-OCHF₂) Ph(2-Cl,3-OCF₃,5-OCF₂CF₂H) Ph(2-Cl,3-OCF₃,5-OC₂F₅) Ph(2-Cl,3-OCF₃,5-SO₂Me) Ph(2-Cl,3-OCF₃,5-TMS) Ph(2-Cl,3-OCF₃,5-CN) Ph(2-Cl,3-OCHF₂,5-Cl) Ph(2-Cl,3-OCHF₂,5-F) Ph(2-Cl,3-OCHF₂,5-Br) Ph(2-Cl,3-OCHF₂,5-I) Ph(2-Cl,3-OCHF₂,5-Me) Ph(2-Cl,3-OCHF₂,5-Et) Ph(2-Cl,3-OCHF₂,5-n-Pr) Ph(2-Cl,3-OCHF₂,5-t-Bu) Ph(2-Cl,3-OCHF₂,5-i-Pr) Ph(2-Cl,3-OCHF₂,5-c-Pr) Ph(2-Cl,3-OCHF₂CF₃,5-CF₃) Ph(2-Cl,3-OC₂F₅,5-C₂F₅) Ph(2-Cl,3-OCHF₂,5-CF₂CF₂H) Ph(2-Cl,3-OCHF₂,5-CF₂H) Ph(2-Cl,3-OCHF₂,5-OMe) Ph(2-Cl,3-OCHF₂,5-OCF₃) Ph(2-Cl,3,5-di-OCHF₂) Ph(2-Cl,3-OCHF₂,5-OCF₂CF₂H) Ph(2-Cl,3-OCHF₂,5-OC₂F₅) Ph(2-Cl,3-OCHF₂,5-SO₂Me) Ph(2-Cl,3-OCHF₂,5-TMS) Ph(2-Cl,3-OCHF₂,5-CN) Ph(2-Cl,3-OCF₂CF₂H,5-Cl) Ph(2-Cl,3-OCF₂CF₂H,5-F) Ph(2-Cl,3-OCF₂CF₂H,5-Br) Ph(2-Cl,3-OCF₂CF₂H,5-I) Ph(2-Cl,3-OCF₂CF₂H,5-Me) Ph(2-Cl,3-OCF₂CF₂H,5-Et) Ph(2-Cl,3-OCF₂CF₂H,5-n-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-t-Bu) Ph(2-Cl,3-OCF₂CF₂H,5-i-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-c-Pr) Ph(2-Cl,3-OCF₂CF₂H,5-CF₃) Ph(2-Cl,3-OCF₂CF₂H,5-C₂F₅) Ph(2-Cl,3-OCF₂CF₂H,5- CF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-OMe) Ph(2-Cl,3-OCF₂CF₂H,5-OCF₃) Ph(2-Cl,3-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,3,5-di-OCF₂CF₂H) Ph(2-Cl,3-OCF₂CF₂H,5-OC₂F₅) Ph(2-Cl,3-OCF₂CF₂H,5-SO₂Me) Ph(2-Cl,3-OCF₂CF₂H,5-TMS) Ph(2-Cl,3-OCF₂CF₂H,5-CN) Ph(2-Cl,3-OC₂F₅,5-Cl) Ph(2-Cl,3-OC₂F₅,5-F) Ph(2-Cl,3-OC₂F₅,5-Br) Ph(2-Cl,3-OC₂F₅,54) Ph(2-Cl,3-OC₂F₅,5-Me) Ph(2-Cl,3-OC₂F₅,5-Et) Ph(2-Cl,3-OC₂F₅,5-n-Pr) Ph(2-Cl,3-OC₂F₅,5-t-Bu) Ph(2-Cl,3-OC₂F₅,5-i-Pr) Ph(2-Cl,3-OC₂F₅,5-c-Pr) Ph(2-Cl,3-OC₂F₅CF3,5-CF₃) Ph(2-Cl,3-OC₂F₅,5-CF₂CF₂H) Ph(2-Cl,3-OC₂F₅,5-CF₂H) Ph(2-Cl,3-OC₂F₅,5-OMe) Ph(2-Cl,3-OC₂F₅,5-OCF₃) Ph(2-Cl,3-OC₂F₅,5-OCHF₂) Ph(2-Cl,3-OC₂F₅,5-OCF₂CF₂H) Ph(2-Cl,3,5-di-OC₂F₅) Ph(2-Cl,3-OC₂F₅,5-SO₂Me) Ph(2-Cl,3-OC₂F₅,5-TMS) Ph(2-Cl,3-OC₂F₅,5-CN) Ph(2-Cl,3-SO₂Me,5-Cl) Ph(2-Cl,3-SO₂Me,5-F) Ph(2-Cl,3-SO₂Me,5-Br) Ph(2-Cl,3-SO₂Me,5-I) Ph(2-Cl,3-SO₂Me,5-Me) Ph(2-Cl,3-SO₂Me,5-Et) Ph(2-Cl,3-SO₂Me,5-n-Pr) Ph(2-Cl,3-SO₂Me,5-t-Bu) Ph(2-Cl,3-SO₂Me,5-i-Pr) Ph(2-Cl,3-SO₂Me,5-c-Pr) Ph(2-Cl,3-SO₂MeCF3,5-CF₃) Ph(2-Cl,3-SO₂Me,5-C₂F₅) Ph(2-Cl,3-SO₂Me,5-CF₂CF₂H) Ph(2-Cl,3-SO₂Me,5-CF₂H) Ph(2-Cl,3-SO₂Me,5-OMe) Ph(2-Cl,3-SO₂Me,5-OCF₃) Ph(2-Cl,3-SO₂Me,5-OCHF₂) Ph(2-Cl,3-SO₂Me,5-OCF₂CF₂H) Ph(2-Cl,3-SO₂Me,5-OC₂F₅) Ph(2-Cl,3,5-di-SO₂Me) Ph(2-Cl,3-SO₂Me,5-TMS) Ph(2-Cl,3-SO₂Me,5-CN) Ph(2-Cl,3-TMS,5-Cl) Ph(2-Cl,3-TMS,5-F) Ph(2-Cl,3-TMS,5-Br) Ph(2-Cl,3-TMS,54) Ph(2-Cl,3-TMS,5-Me) Ph(2-Cl,3-TMS,5-Et) Ph(2-Cl,3-TMS,5-n-Pr) Ph(2-Cl,3-TMS,5-t-Bu) Ph(2-Cl,3-TMS,5-i-Pr) Ph(2-Cl,3-TMS,5-c-Pr) Ph(2-Cl,3-TMS,5-CF₃) Ph(2-Cl,3-TMS,5-C₂F₅) Ph(2-Cl,3-TMS,5-CF₂CF₂H) Ph(2-Cl,3-TMS,5-CF₂H) Ph(2-Cl,3-TMS,5-OMe) Ph(2-Cl,3-TMS,5-OCF₃) Ph(2-Cl,3-TMS,5-OCHF₂) Ph(2-Cl,3-TMS,5-OCF₂CF₂H) Ph(2-Cl,3-TMS,5-OC₂F₅) Ph(2-Cl,3-TMS,5-SO₂Me) Ph(2-Cl,3,5-di-TMS) Ph(2-Cl,3-TMS,5-CN) Ph(2-Cl,3-CN,5-Cl) Ph(2-Cl,3-CN,5-F) Ph(2-Cl,3-CN,5-Br) Ph(2-Cl,3-CN,5-I) Ph(2-Cl,3-CN,5-Me) Ph(2-Cl,3-CN,5-Et) Ph(2-Cl,3-CN,5-n-Pr) Ph(2-Cl,3-CN,5-t-Bu) Ph(2-Cl,3-CN,5-i-Pr) Ph(2-Cl,3-CN,5-c-Pr) Ph(2-Cl,3-CN,5-CF₃) Ph(2-Cl,3-CN,5-C₂F₅) Ph(2-Cl,3-CN,5-CF₂CF₂H) Ph(2-Cl,3-CN,5-CF₂H) Ph(2-Cl,3-CN,5-OMe) Ph(2-Cl,3-CN,5-OCF₃) Ph(2-Cl,3-CN,5-OCHF₂) Ph(2-Cl,3-CN,5-OCF₂CF₂H) Ph(2-Cl,3-CN,5-OC₂F₅) Ph(2-Cl,3-CN,5-SO₂Me) Ph(2-Cl,3-CN,5-TMS) Ph(2-Cl,3,5-di-CN) Ph(2,4,5-tri-Cl) Ph(2-Cl,4-Cl,5-F) Ph(2-Cl,4-Cl,5-Br) Ph(2-Cl,4-Cl,5-I) Ph(2-Cl,4-Cl,5-Me) Ph(2-Cl,4-Cl,5-Et) Ph(2-Cl,4-Cl,5-n-Pr) Ph(2-Cl,4-Cl,5-t-Bu) Ph(2-Cl,4-Cl,5-i-Pr) Ph(2-Cl,4-Cl,5-c-Pr) Ph(2-Cl,4-Cl,5-CF₃) Ph(2-Cl,4-Cl,5-C₂F₅) Ph(2-Cl,4-Cl,5-CF₂CF₂H) Ph(2-Cl,4-Cl,5-CF₂H) Ph(2-Cl,4-Cl,5-OMe) Ph(2-Cl,4-Cl,5-OCF₃) Ph(2-Cl,4-Cl,5-OCHF₂) Ph(2-Cl,4-Cl,5-OCF₂CF₂H) Ph(2-Cl,4-Cl,5-OC₂F₅) Ph(2-Cl,4-Cl,5-SO₂Me) Ph(2-Cl,4-Cl,5-TMS) Ph(2-Cl,4-Cl,5-CN) Ph(2-Cl,4-F,5-Cl) Ph(2-Cl,4,5-di-F) Ph(2-Cl,4-F,5-Br) Ph(2-Cl,4-F,5-I) Ph(2-Cl,4-F,5-Me) Ph(2-Cl,4-F,5-Et) Ph(2-Cl,4-F,5-n-Pr) Ph(2-Cl,4-F,5-t-Bu) Ph(2-Cl,4-F,5-i-Pr) Ph(2-Cl,4-F,5-c-Pr) Ph(2-Cl,4-F,5-CF₃) Ph(2-Cl,4-F,5-C₂F₅) Ph(2-Cl,4-F,5-CF₂CF₂H) Ph(2-Cl,4-F,5-CF₂H) Ph(2-Cl,4-F,5-OMe) Ph(2-Cl,4-F,5-OCF₃) Ph(2-Cl,4-F,5-OCHF₂) Ph(2-Cl,4-F,5-OCF₂CF₂H) Ph(2-Cl,4-F,5-OC₂F₅) Ph(2-Cl,4-F,5-SO₂Me) Ph(2-Cl,4-F,5-TMS) Ph(2-Cl,4-F,5-CN) Ph(2-Cl,4-Br,5-Cl) Ph(2-Cl,4-Br,5-F) Ph(2-Cl,4,5-di-Br) Ph(2-Cl,4-Br,5-I) Ph(2-Cl,4-Br,5-Me) Ph(2-Cl,4-Br,5-Et) Ph(2-Cl,4-Br,5-n-Pr) Ph(2-Cl,4-Br,5-t-Bu) Ph(2-Cl,4-Br,5-i-Pr) Ph(2-Cl,4-Br,5-c-Pr) Ph(2-Cl,4-Br,5-CF₃) Ph(2-Cl,4-Br,5-C₂F₅) Ph(2-Cl,4-Br,5-CF₂CF₂H) Ph(2-Cl,4-Br,5-CF₂H) Ph(2-Cl,4-Br,5-OMe) Ph(2-Cl,4-Br,5-OCF₃) Ph(2-Cl,4-Br,5-OCHF₂) Ph(2-Cl,4-Br,5-OCF₂CF₂H) Ph(2-Cl,4-Br,5-OC₂F₅) Ph(2-Cl,4-Br,5-SO₂Me) Ph(2-Cl,4-Br,5-TMS) Ph(2-Cl,4-Br,5-CN) Ph(2-Cl,4-I,5-Cl) Ph(2-Cl,4-I,5-F) Ph(2-Cl,4-I,5-Br) Ph(2-Cl,4,5-di-I) Ph(2-Cl,4-I,5-Me) Ph(2-Cl,4-I,5-Et) Ph(2-Cl,4-I,5-n-Pr) Ph(2-Cl,4-I,5-t-Bu) Ph(2-Cl,4-I,5-i-Pr) Ph(2-Cl,4-I,5-c-Pr) Ph(2-Cl,4-I,5-CF₃) Ph(2-Cl,4-I,5-C₂F₅) Ph(2-Cl,4-I,5-CF₂CF₂H) Ph(2-Cl,4-I,5-CF₂H) Ph(2-Cl,4-I,5-OMe) Ph(2-Cl,4-I,5-OCF₃) Ph(2-Cl,4-I,5-OCHF₂) Ph(2-Cl,4-I,5-OCF₂CF₂H) Ph(2-Cl,4-I,5-OC₂F₅) Ph(2-Cl,4-I,5-SO₂Me) Ph(2-Cl,4-I,5-TMS) Ph(2-Cl,4-I,5-CN) Ph(2-Cl,4-Me,5-Cl) Ph(2-Cl,4-Me,5-F) Ph(2-Cl,4-Me,5-Br) Ph(2-Cl,4-Me,5-I) Ph(2-Cl,4,5-di-Me) Ph(2-Cl,4-Me,5-Et) Ph(2-Cl,4-Me,5-n-Pr) Ph(2-Cl,4-Me,5-t-Bu) Ph(2-Cl,4-Me,5-i-Pr) Ph(2-Cl,4-Me,5-c-Pr) Ph(2-Cl,4-Me,5-CF₃) Ph(2-Cl,4-Me,5-C₂F₅) Ph(2-Cl,4-Me,5-CF₂CF₂H) Ph(2-Cl,4-Me,5-CF₂H) Ph(2-Cl,4-Me,5-OMe) Ph(2-Cl,4-Me,5-OCF₃) Ph(2-Cl,4-Me,5-OCHF₂) Ph(2-Cl,4-Me,5-OCF₂CF₂H) Ph(2-Cl,4-Me,5-OC₂F₅) Ph(2-Cl,4-Me,5-SO₂Me) Ph(2-Cl,4-Me,5-TMS) Ph(2-Cl,4-Me,5-CN) Ph(2-Cl,4-Et,5-Cl) Ph(2-Cl,4-Et,5-F) Ph(2-Cl,4-Et,5-Br) Ph(2-Cl,4-Et,5-I) Ph(2-Cl,4-Et,5-Me) Ph(2-Cl,4,5-di-Et) Ph(2-Cl,4-Et,5-n-Pr) Ph(2-Cl,4-Et,5-t-Bu) Ph(2-Cl,4-Et,5-i-Pr) Ph(2-Cl,4-Et,5-c-Pr) Ph(2-Cl,4-Et,5-CF₃) Ph(2-Cl,4-Et,5-C₂F₅) Ph(2-Cl,4-Et,5-CF₂CF₂H) Ph(2-Cl,4-Et,5-CF₂H) Ph(2-Cl,4-Et,5-OMe) Ph(2-Cl,4-Et,5-OCF₃) Ph(2-Cl,4-Et,5-OCHF₂) Ph(2-Cl,4-Et,5-OCF₂CF₂H) Ph(2-Cl,4-Et,5-OC₂F₅) Ph(2-Cl,4-Et,5-SO₂Me) Ph(2-Cl,4-Et,5-TMS) Ph(2-Cl,4-Et,5-CN) Ph(2-Cl,4-n-Pr,5-Cl) Ph(2-Cl,4-n-Pr,5-F) Ph(2-Cl,4-n-Pr,5-Br) Ph(2-Cl,4-n-Pr,5-I) Ph(2-Cl,4-n-Pr,5-Me) Ph(2-Cl,4-n-Pr,5-Et) Ph(2-Cl,4,5-di-n-Pr) Ph(2-Cl,4-n-Pr,5-t-Bu) Ph(2-Cl,4-n-Pr,5-i-Pr) Ph(2-Cl,4-n-Pr,5-c-Pr) Ph(2-Cl,4-n-Pr,5-CF₃) Ph(2-Cl,4-n-Pr,5-C₂F₅) Ph(2-Cl,4-n-Pr,5-CF₂CF₂H) Ph(2-Cl,4-n-Pr,5-CF₂H) Ph(2-Cl,4-n-Pr,5-OMe) Ph(2-Cl,4-n-Pr,5-OCF₃) Ph(2-Cl,4-n-Pr,5-OCHF₂) Ph(2-Cl,4-n-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-n-Pr,5-OC₂F₅) Ph(2-Cl,4-n-Pr,5-SO₂Me) Ph(2-Cl,4-n-Pr,5-TMS) Ph(2-Cl,4-n-Pr,5-CN) Ph(2-Cl,4-t-Bu,5-Cl) Ph(2-Cl,4-t-Bu,5-F) Ph(2-Cl,4-t-Bu,5-Br) Ph(2-Cl,4-t-Bu,5-I) Ph(2-Cl,4-t-Bu,5-Me) Ph(2-Cl,4-t-Bu,5-Et) Ph(2-Cl,4-t-Bu,5-n-Pr) Ph(2-Cl,4,5-di-t-Bu) Ph(2-Cl,4-t-Bu,5-i-Pr) Ph(2-Cl,4-t-Bu,5-c-Pr) Ph(2-Cl,4-t-Bu,5-CF₃) Ph(2-Cl,4-t-Bu,5-C₂F₅) Ph(2-Cl,4-t-Bu,5-CF₂CF₂H) Ph(2-Cl,4-t-Bu,5-CF₂H) Ph(2-Cl,4-t-Bu,5-OMe) Ph(2-Cl,4-t-Bu,5-OCF₃) Ph(2-Cl,4-t-Bu,5-OCHF₂) Ph(2-Cl,4-t-Bu,5-OCF₂CF₂H) Ph(2-Cl,4-t-Bu,5-OC₂F₅) Ph(2-Cl,4-t-Bu,5-SO₂Me) Ph(2-Cl,4-t-Bu,5-TMS) Ph(2-Cl,4-t-Bu,5-CN) Ph(2-Cl,4-i-Pr,5-Cl) Ph(2-Cl,4-i-Pr,5-F) Ph(2-Cl,4-i-Pr,5-Br) Ph(2-Cl,4-i-Pr,5-I) Ph(2-Cl,4-i-Pr,5-Me) Ph(2-Cl,4-i-Pr,5-Et) Ph(2-Cl,4-i-Pr,5-n-Pr) Ph(2-Cl,4-i-Pr,5-t-Bu) Ph(2-Cl,4,5-di-i-Pr) Ph(2-Cl,4-i-Pr,5-c-Pr) Ph(2-Cl,4-i-Pr,5-CF₃) Ph(2-Cl,4-i-Pr,5-C₂F₅) Ph(2-Cl,4-i-Pr,5-CF₂CF₂H) Ph(2-Cl,4-i-Pr,5-CF₂H) Ph(2-Cl,4-i-Pr,5-OMe) Ph(2-Cl,4-i-Pr,5-OCF₃) Ph(2-Cl,4-i-Pr,5-OCHF₂) Ph(2-Cl,4-i-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-i-Pr,5-OC₂F₅) Ph(2-Cl,4-i-Pr,5-SO₂Me) Ph(2-Cl,4-i-Pr,5-TMS) Ph(2-Cl,4-i-Pr,5-CN) Ph(2-Cl,4-c-Pr,5-Cl) Ph(2-Cl,4-c-Pr,5-F) Ph(2-Cl,4-c-Pr,5-Br) Ph(2-Cl,4-c-Pr,5-I) Ph(2-Cl,4-c-Pr,5-Me) Ph(2-Cl,4-c-Pr,5-Et) Ph(2-Cl,4-c-Pr,5-n-Pr) Ph(2-Cl,4-c-Pr,5-t-Bu) Ph(2-Cl,4-c-Pr,5-i-Pr) Ph(2-Cl,4,5-di-c-Pr) Ph(2-Cl,4-c-Pr,5-CF₃) Ph(2-Cl,4-c-Pr,5-C₂F₅) Ph(2-Cl,4-c-Pr,5-CF₂CF₂H) Ph(2-Cl,4-c-Pr,5-CF₂H) Ph(2-Cl,4-c-Pr,5-OMe) Ph(2-Cl,4-c-Pr,5-OCF₃) Ph(2-Cl,4-c-Pr,5-OCHF₂) Ph(2-Cl,4-c-Pr,5-OCF₂CF₂H) Ph(2-Cl,4-c-Pr,5-OC₂F₅) Ph(2-Cl,4-c-Pr,5-SO₂Me) Ph(2-Cl,4-c-Pr,5-TMS) Ph(2-Cl,4-c-Pr,5-CN) Ph(2-Cl,4-CF3,5-Cl) Ph(2-Cl,4-CF₃,5-F) Ph(2-Cl,4-CF₃,5-Br) Ph(2-Cl,4-CF₃,5-I) Ph(2-Cl,4-CF₃,5-Me) Ph(2-Cl,4-CF₃,5-Et) Ph(2-Cl,4-CF₃,5-n-Pr) Ph(2-Cl,4-CF₃,5-t-Bu) Ph(2-Cl,4-CF₃,5-i-Pr) Ph(2-Cl,4-CF₃,5-c-Pr) Ph(2-Cl,4,5-di-CF₃) Ph(2-Cl,4-CF₃,5-C₂F₅) Ph(2-Cl,4-CF₃,5-CF₂CF₂H) Ph(2-Cl,4-CF₃,5-CF₂H) Ph(2-Cl,4-CF₃,5-OMe) Ph(2-Cl,4-CF₃,5-OCF₃) Ph(2-Cl,4-CF₃,5-OCHF₂) Ph(2-Cl,4-CF₃,5-OCF₂CF₂H) Ph(2-Cl,4-CF₃,5-OC₂F₅) Ph(2-Cl,4-CF₃,5-SO₂Me) Ph(2-Cl,4-CF₃,5-TMS) Ph(2-Cl,4-CF₃,5-CN) Ph(2-Cl,4-CF₂CF₃,5-Cl) Ph(2-Cl,4-CF₂CF₃,5-F) Ph(2-Cl,4-CF₂CF₃,5-Br) Ph(2-Cl,4-CF₂CF₃,54) Ph(2-Cl,4-CF₂CF₃,5-Me) Ph(2-Cl,4-CF₂CF₃,5-Et) Ph(2-Cl,4-CF₂CF₃,5-n-Pr) Ph(2-Cl,4-CF₂CF₃,5-t-Bu) Ph(2-Cl,4-CF₂CF₃,5-i-Pr) Ph(2-Cl,4-CF₂CF₃,5-c-Pr) Ph(2-Cl,4-C₂F₅CF₃,5-CF₃) Ph(2-Cl,4,5-di-C₂F₅) Ph(2-Cl,4-CF₂CF₃,5-CF₂CF₂H) Ph(2-Cl,4-CF₂CF₃,5-CF₂H) Ph(2-Cl,4-CF₂CF₃,5-OMe) Ph(2-Cl,4-CF₂CF₃,5-OCF₃) Ph(2-Cl,4-CF₂CF₃,5-OCHF₂) Ph(2-Cl,4-CF₂CF₃,5- OCF₂CF₂H) Ph(2-Cl,4-CF₂CF₃,5-OC₂F₅) Ph(2-Cl,4-CF₂CF₃,5-SO₂Me) Ph(2-Cl,4-CF₂CF₃,5-TMS) Ph(2-Cl,4-CF₂CF₃,5-CN) Ph(2-Cl,4-CF₂CF₂H,5-Cl) Ph(2-Cl,4-CF₂CF₂H,5-F) Ph(2-Cl,4-CF₂CF₂H,5-Br) Ph(2-Cl,4-CF₂CF₂H,5-I) Ph(2-Cl,4-CF₂CF₂H,5-Me) Ph(2-Cl,4-CF₂CF₂H,5-Et) Ph(2-Cl,4-CF₂CF₂H,5-n-Pr) Ph(2-Cl,4-CF₂CF₂H,5-t-Bu) Ph(2-Cl,4-CF₂CF₂H,5-i-Pr) Ph(2-Cl,4-CF₂CF₂H,5-c-Pr) Ph(2-Cl,4-CF₂CF₂CF₃H,5-CF₃) Ph(2-Cl,4-CF₂CF₂H,5-C₂F₅) Ph(2-Cl,4,5-di-CF₂CF₂H) Ph(2-Cl,4-CF₂CF₂H,5-CF₂H) Ph(2-Cl,4-CF₂CF₂H,5-OMe) Ph(2-Cl,4-CF₂CF₂H,5-OCF₃) Ph(2-Cl,4-CF₂CF₂H,5-OCHF₂) Ph(2-Cl,4-CF₂CF₂H,5- OCF₂CF₂H) Ph(2-Cl,4-CF₂CF₂H,5-OC₂F₅) Ph(2-Cl,4-CF₂CF₂H,5-SO₂Me) Ph(2-Cl,4-CF₂CF₂H,5-TMS) Ph(2-Cl,4-CF₂CF₂H,5-CN) Ph(2-Cl,4-CF₂H,5-Cl) Ph(2-Cl,4-CF₂H,5-F) Ph(2-Cl,4-CF₂H,5-Br) Ph(2-Cl,4-CF₂H,5-I) Ph(2-Cl,4-CF₂H,5-Me) Ph(2-Cl,4-CF₂H,5-Et) Ph(2-Cl,4-CF₂H,5-n-Pr) Ph(2-Cl,4-CF₂H,5-t-Bu) Ph(2-Cl,4-CF₂H,5-i-Pr) Ph(2-Cl,4-CF₂H,5-c-Pr) Ph(2-Cl,4-CF₂H,5-CF₃) Ph(2-Cl,4-CF₂H,5-C₂F₅) Ph(2-Cl,4-CF₂H,5-CF₂CF₂H) Ph(2-Cl,4,5-di-CF₂H) Ph(2-Cl,4-CF₂H,5-OMe) Ph(2-Cl,4-CF₂H,5-OCF₃) Ph(2-Cl,4-CF₂H,5-OCHF₂) Ph(2-Cl,4-CF₂H,5-OCF₂CF₂H) Ph(2-Cl,4-CF₂H,5-OC₂F₅) Ph(2-Cl,4-CF₂H,5-SO₂Me) Ph(2-Cl,4-CF₂H,5-TMS) Ph(2-Cl,4-CF₂H,5-CN) Ph(2-Cl,4-OMe,5-Cl) Ph(2-Cl,4-OMe,5-F) Ph(2-Cl,4-OMe,5-Br) Ph(2-Cl,4-OMe,5-I) Ph(2-Cl,4-OMe,5-Me) Ph(2-Cl,4-OMe,5-Et) Ph(2-Cl,4-OMe,5-n-Pr) Ph(2-Cl,4-OMe,5-t-Bu) Ph(2-Cl,4-OMe,5-i-Pr) Ph(2-Cl,4-OMe,5-c-Pr) Ph(2-Cl,4-OMeCF₃,5-CF₃) Ph(2-Cl,4-OMe,5-C₂F₅) Ph(2-Cl,4-OMe,5-CF₂CF₂H) Ph(2-Cl,4-OMe,5-CF₂H) Ph(2-Cl,4,5-di-OMe) Ph(2-Cl,4-OMe,5-OCF₃) Ph(2-Cl,4-OMe,5-OCHF₂) Ph(2-Cl,4-OMe,5-OCF₂CF₂H) Ph(2-Cl,4-OMe,5-OC₂F₅) Ph(2-Cl,4-OMe,5-SO₂Me) Ph(2-Cl,4-OMe,5-TMS) Ph(2-Cl,4-OMe,5-CN) Ph(2-Cl,4-OCF₃,5-Cl) Ph(2-Cl,4-OCF₃,5-F) Ph(2-Cl,4-OCF₃,5-Br) Ph(2-Cl,4-OCF₃,54) Ph(2-Cl,4-OCF₃,5-Me) Ph(2-Cl,4-OCF₃,5-Et) Ph(2-Cl,4-OCF₃,5-n-Pr) Ph(2-Cl,4-OCF₃,5-t-Bu) Ph(2-Cl,4-OCF₃,5-i-Pr) Ph(2-Cl,4-OCF₃,5-c-Pr) Ph(2-Cl,4-OCF₃,5-CF₃) Ph(2-Cl,4-OCF₃,5-C₂F₅) Ph(2-Cl,4-OCF₃,5-CF₂CF₂H) Ph(2-Cl,4-OCF₃,5-CF₂H) Ph(2-Cl,4-OCF₃,5-OMe) Ph(2-Cl,4,5-di-OCF₃) Ph(2-Cl,4-OCF₃,5-OCHF₂) Ph(2-Cl,4-OCF₃,5-OCF₂CF₂H) Ph(2-Cl,4-OCF₃,5-OC₂F₅) Ph(2-Cl,4-OCF₃,5-SO₂Me) Ph(2-Cl,4-OCF₃,5-TMS) Ph(2-Cl,4-OCF₃,5-CN) Ph(2-Cl,4-OCHF₂,5-Cl) Ph(2-Cl,4-OCHF₂,5-F) Ph(2-Cl,4-OCHF₂,5-Br) Ph(2-Cl,4-OCHF₂,5-I) Ph(2-Cl,4-OCHF₂,5-Me) Ph(2-Cl,4-OCHF₂,5-Et) Ph(2-Cl,4-OCHF₂,5-n-Pr) Ph(2-Cl,4-OCHF₂,5-t-Bu) Ph(2-Cl,4-OCHF₂,5-i-Pr) Ph(2-Cl,4-OCHF₂,5-c-Pr) Ph(2-Cl,4-OCHF₂CF₃,5-CF₃) Ph(2-Cl,4-OCF₂CF₃,5-C₂F₅) Ph(2-Cl,4-OCHF₂,5-CF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-CF₂H) Ph(2-Cl,4-OCHF₂,5-OMe) Ph(2-Cl,4-OCHF₂,5-OCF₃) Ph(2-Cl,4,5-di-OCHF₂) Ph(2-Cl,4-OCHF₂,5-OCF₂CF₂H) Ph(2-Cl,4-OCHF₂,5-OC₂F₅) Ph(2-Cl,4-OCHF₂,5-SO₂Me) Ph(2-Cl,4-OCHF₂,5-TMS) Ph(2-Cl,4-OCHF₂,5-CN) Ph(2-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,4-OCF₂CF₂H,5-F) Ph(2-Cl,4-OCF₂CF₂H,5-Br) Ph(2-Cl,4-OCF₂CF₂H,5-I) Ph(2-Cl,4-OCF₂CF₂H,5-Me) Ph(2-Cl,4-OCF₂CF₂H,5-Et) Ph(2-Cl,4-OCF₂CF₂H,5-n-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-t-Bu) Ph(2-Cl,4-OCF₂CF₂H,5-i-Pr) Ph(2-Cl,4-OCF₂CF₂H,5-c-Pr) Ph(2-Cl,4-OCF₂CF₂CF₃H,5- CF₃) Ph(2-Cl,4-OCF₂CF₂H,5-C₂F₅) Ph(2-Cl,4-OCF₂CF₂H,5- CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H,5-CF₂H) Ph(2-Cl,4-OCF₂CF₂H,5-OMe) Ph(2-Cl,4-OCF₂CF₂H,5-OCF₃) Ph(2-Cl,4-OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,4,5-di-OCF₂CF₂H) Ph(2-Cl,4-OCF₂CF₂H,5-OC₂F₅) Ph(2-Cl,4-OCF₂CF₂H,5-SO₂Me) Ph(2-Cl,4-OCF₂CF₂H,5-TMS) Ph(2-Cl,4-OCF₂CF₂H,5-CN) Ph(2-Cl,4-OCF₂CF₃,5-Cl) Ph(2-Cl,4-OCF₂CF₃,5-F) Ph(2-Cl,4-OCF₂CF₃,5-Br) Ph(2-Cl,4-OCF₂CF₃,5-I) Ph(2-Cl,4-OCF₂CF₃,5-Me) Ph(2-Cl,4-OCF₂CF₃,5-Et) Ph(2-Cl,4-OCF₂CF₃,5-n-Pr) Ph(2-Cl,4-OCF₂CF₃,5-t-Bu) Ph(2-Cl,4-OCF₂CF₃,5-i-Pr) Ph(2-Cl,4-OCF₂CF₃,5-c-Pr) Ph(2-Cl,4-OC₂F₅CF₃,5-CF₃) Ph(2-Cl,4-OCF₂CF₃,5- CF₂CF₂H) Ph(2-Cl,4-OCF₂CF₃,5-CF₂H) Ph(2-Cl,4-OCF₂CF₃,5-OMe) Ph(2-Cl,4-OCF₂CF₃,5-OCF₃) Ph(2-Cl,4-OCF₂CF₃,5-OCHF₂) Ph(2-Cl,4-OCF₂CF₃,5- OCF₂CF₂H) Ph(2-Cl,4,5-di-OC₂F₅) Ph(2-Cl,4-OCF₂CF₃,5-SO₂Me) Ph(2-Cl,4-OCF₂CF₃,5-TMS) Ph(2-Cl,4-OCF₂CF₃,5-CN) Ph(2-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,4-SO₂Me,5-F) Ph(2-Cl,4-SO₂Me,5-Br) Ph(2-Cl,4-SO₂Me,5-I) Ph(2-Cl,4-SO₂Me,5-Me) Ph(2-Cl,4-SO₂Me,5-Et) Ph(2-Cl,4-SO₂Me,5-n-Pr) Ph(2-Cl,4-SO₂Me,5-t-Bu) Ph(2-Cl,4-SO₂Me,5-i-Pr) Ph(2-Cl,4-SO₂Me,5-c-Pr) Ph(2-Cl,4-SO₂MeCF₃,5-CF₃) Ph(2-Cl,4-SO₂Me,5-C₂F₅) Ph(2-Cl,4-SO₂Me,5-CF₂CF₂H) Ph(2-Cl,4-SO₂Me,5-CF₂H) Ph(2-Cl,4-SO₂Me,5-OMe) Ph(2-Cl,4-SO₂Me,5-OCF₃) Ph(2-Cl,4-SO₂Me,5-OCHF₂) Ph(2-Cl,4-SO₂Me,5-OCF₂CF₂H) Ph(2-Cl,4-SO₂Me,5-OC₂F₅) Ph(2-Cl,4,5-di-SO₂Me) Ph(2-Cl,4-SO₂Me,5-TMS) Ph(2-Cl,4-SO₂Me,5-CN) Ph(2-Cl,4-TMS,5-Cl) Ph(2-Cl,4-TMS,5-F) Ph(2-Cl,4-TMS,5-Br) Ph(2-Cl,4-TMS,5-I) Ph(2-Cl,4-TMS,5-Me) Ph(2-Cl,4-TMS,5-Et) Ph(2-Cl,4-TMS,5-n-Pr) Ph(2-Cl,4-TMS,5-t-Bu) Ph(2-Cl,4-TMS,5-i-Pr) Ph(2-Cl,4-TMS,5-c-Pr) Ph(2-Cl,4-TMS,5-CF₃) Ph(2-Cl,4-TMS,5-C₂F₅) Ph(2-Cl,4-TMS,5-CF₂CF₂H) Ph(2-Cl,4-TMS,5-CF₂H) Ph(2-Cl,4-TMS,5-OMe) Ph(2-Cl,4-TMS,5-OCF₃) Ph(2-Cl,4-TMS,5-OCHF₂) Ph(2-Cl,4-TMS,5-OCF₂CF₂H) Ph(2-Cl,4-TMS,5-OC₂F₅) Ph(2-Cl,4-TMS,5-SO₂Me) Ph(2-Cl,4,5-di-TMS) Ph(2-Cl,4-TMS,5-CN) Ph(2-Cl,4-CN,5-Cl) Ph(2-Cl,4-CN,5-F) Ph(2-Cl,4-CN,5-Br) Ph(2-Cl,4-CN,5-I) Ph(2-Cl,4-CN,5-Me) Ph(2-Cl,4-CN,5-Et) Ph(2-Cl,4-CN,5-n-Pr) Ph(2-Cl,4-CN,5-t-Bu) Ph(2-Cl,4-CN,5-i-Pr) Ph(2-Cl,4-CN,5-c-Pr) Ph(2-Cl,4-CN,5-CF₃) Ph(2-Cl,4-CN,5-C₂F₅) Ph(2-Cl,4-CN,5-CF₂CF₂H) Ph(2-Cl,4-CN,5-CF₂H) Ph(2-Cl,4-CN,5-OMe) Ph(2-Cl,4-CN,5-OCF₃) Ph(2-Cl,4-CN,5-OCHF₂) Ph(2-Cl,4-CN,5-OCF₂CF₂H) Ph(2-Cl,4-CN,5-OC₂F₅) Ph(2-Cl,4-CN,5-SO₂Me) Ph(2-Cl,4-CN,5-TMS) Ph(2-Cl,4,5-di-CN) Ph(2-F,3,4-di-Cl) Ph(2-F,3-Cl,4-I) Ph(2-F,3-Cl,4-Me) Ph(2-F,3-Cl,4-Et) Ph(2-F,3-Cl,4-n-Pr) Ph(2-F,3-Cl,4-i-Pr) Ph(2-F,3-Cl,4-CF₃) Ph(2-F,3-Cl,4-C₂F₅) Ph(2-F,3-Cl,4-CF₂CF₂H) Ph(2-F,3-Cl,4-CF₂H) Ph(2-F,3-Cl,4-OMe) Ph(2-F,3-Cl,4-OCHF₂) Ph(2-F,3-Cl,4-OCF₂CF₂H) Ph(2-F,3-Cl,4-OC₂F₅) Ph(2,3,4-tri-F) Ph(2-F,3-F,4-Br) Ph(2-F,3-F,4-I) Ph(2-F,3-F,4-Et) Ph(2-F,3-F,4-n-Pr) Ph(2-F,3-F,4-t-Bu) Ph(2-F,3-F,4-i-Pr) Ph(2-F,3-F,4-CF₃) Ph(2-F,3-F,4-C₂F₅) Ph(2-F,3-F,4-CF₂CF₂H) Ph(2-F,3-F,4-CF₂H) Ph(2-F,3-F,4-OMe) Ph(2-F,3-F,4-OCHF₂) Ph(2-F,3-F,4-OCF₂CF₂H) Ph(2-F,3-F,4-OC₂F₅) Ph(2-F,3-Br,4-Cl) Ph(2-F,3,4-di-Br) Ph(2-F,3-Br,4-I) Ph(2-F,3-Br,4-Me) Ph(2-F,3-Br,4-Et) Ph(2-F,3-Br,4-n-Pr) Ph(2-F,3-Br,4-t-Bu) Ph(2-F,3-Br,4-i-Pr) Ph(2-F,3-Br,4-CF₃) Ph(2-F,3-Br,4-C₂F₅) Ph(2-F,3-Br,4-CF₂CF₂H) Ph(2-F,3-Br,4-CF₂H) Ph(2-F,3-Br,4-OMe) Ph(2-F,3-Br,4-OCF₂CF₂H) Ph(2-F,3-Br,4-OC₂F5) Ph(2-F,3-I,4-Cl) Ph(2-F,3-I,4-F) Ph(2-F,3-I,4-Br) Ph(2-F,3,4-di-I) Ph(2-F,3-I,4-Me) Ph(2-F,3-I,4-Et) Ph(2-F,3-I,4-n-Pr) Ph(2-F,3-I,4-t-Bu) Ph(2-F,3-I,4-i-Pr) Ph(2-F,3-I,4-c-Pr) Ph(2-F,3-I,4-CF₃) Ph(2-F,3-I,4-C₂F₅) Ph(2-F,3-I,4-CF₂CF₂H) Ph(2-F,3-I,4-CF₂H) Ph(2-F,3-I,4-OMe) Ph(2-F,3-I,4-OCF₃) Ph(2-F,3-I,4-OCHF₂) Ph(2-F,3-I,4-OCF₂CF₂H) Ph(2-F,3-I,4-OC₂F₅) Ph(2-F,3-I,4-SO₂Me) Ph(2-F,3-I,4-TMS) Ph(2-F,3-I,4-CN) Ph(2-F,3-Me,4-I) Ph(2-F,3,4-di-Me) Ph(2-F,3-Me,4-Et) Ph(2-F,3-Me,4-n-Pr) Ph(2-F,3-Me,4-i-Pr) Ph(2-F,3-Me,4-c-Pr) Ph(2-F,3-Me,4-C₂F₅) Ph(2-F,3-Me,4-CF₂CF₂H) Ph(2-F,3-Me,4-CF₂H) Ph(2-F,3-Me,4-OMe) Ph(2-F,3-Me,4-OCF₂CF₂H) Ph(2-F,3-Me,4-OC₂F₅) Ph(2-F,3-Et,4-Cl) Ph(2-F,3-Et,4-F) Ph(2-F,3-Et,4-Br) Ph(2-F,3-Et,4-I) Ph(2-F,3-Et,4-Me) Ph(2-F,3,4-di-Et) Ph(2-F,3-Et,4-n-Pr) Ph(2-F,3-Et,4-t-Bu) Ph(2-F,3-Et,4-i-Pr) Ph(2-F,3-Et,4-c-Pr) Ph(2-F,3-Et,4-CF₃) Ph(2-F,3-Et,4-C₂F₅) Ph(2-F,3-Et,4-CF₂CF₂H) Ph(2-F,3-Et,4-CF₂H) Ph(2-F,3-Et,4-OMe) Ph(2-F,3-Et,4-OCF₃) Ph(2-F,3-Et,4-OCHF₂) Ph(2-F,3-Et,4-OCF₂CF₂H) Ph(2-F,3-Et,4-OC₂F₅) Ph(2-F,3-Et,4-SO₂Me) Ph(2-F,3-Et,4-TMS) Ph(2-F,3-Et,4-CN) Ph(2-F,3-n-Pr,4-Cl) Ph(2-F,3-n-Pr,4-F) Ph(2-F,3-n-Pr,4-Br) Ph(2-F,3-n-Pr,4-I) Ph(2-F,3-n-Pr,4-Me) Ph(2-F,3-n-Pr,4-Et) Ph(2-F,3,4-di-n-Pr) Ph(2-F,3-n-Pr,4-t-Bu) Ph(2-F,3-n-Pr,4-i-Pr) Ph(2-F,3-n-Pr,4-c-Pr) Ph(2-F,3-n-Pr,4-CF₃) Ph(2-F,3-n-Pr,4-C₂F₅) Ph(2-F,3-n-Pr,4-CF₂CF₂H) Ph(2-F,3-n-Pr,4-CF₂H) Ph(2-F,3-n-Pr,4-OMe) Ph(2-F,3-n-Pr,4-OCF₃) Ph(2-F,3-n-Pr,4-OCHF₂) Ph(2-F,3-n-Pr,4-OCF₂CF₂H) Ph(2-F,3-n-Pr,4-OC₂F₅) Ph(2-F,3-n-Pr,4-SO₂Me) Ph(2-F,3-n-Pr,4-TMS) Ph(2-F,3-n-Pr,4-CN) Ph(2-F,3-t-Bu,4-I) Ph(2-F,3-t-Bu,4-Et) Ph(2-F,3-t-Bu,4-n-Pr) Ph(2-F,3,4-di-t-Bu) Ph(2-F,3-t-Bu,4-i-Pr) Ph(2-F,3-t-Bu,4-C₂F₅) Ph(2-F,3-t-Bu,4-CF₂CF₂H) Ph(2-F,3-t-Bu,4-CF₂H) Ph(2-F,3-t-Bu,4-OMe) Ph(2-F,3-t-Bu,4-OCF₂CF₂H) Ph(2-F,3-t-Bu,4-OC₂F₅) Ph(2-F,3-i-Pr,4-Cl) Ph(2-F,3-i-Pr,4-F) Ph(2-F,3-i-Pr,4-Br) Ph(2-F,3-i-Pr,4-I) Ph(2-F,3-i-Pr,4-Me) Ph(2-F,3-i-Pr,4-Et) Ph(2-F,3-i-Pr,4-n-Pr) Ph(2-F,3-i-Pr,4-t-Bu) Ph(2-F,3,4-di-i-Pr) Ph(2-F,3-i-Pr,4-c-Pr) Ph(2-F,3-i-Pr,4-CF₃) Ph(2-F,3-i-Pr,4-C₂F₅) Ph(2-F,3-i-Pr,4-CF₂CF₂H) Ph(2-F,3-i-Pr,4-CF₂H) Ph(2-F,3-i-Pr,4-OMe) Ph(2-F,3-i-Pr,4-OCF₃) Ph(2-F,3-i-Pr,4-OCHF₂) Ph(2-F,3-i-Pr,4-OCF₂CF₂H) Ph(2-F,3-i-Pr,4-OC₂F₅) Ph(2-F,3-i-Pr,4-SO₂Me) Ph(2-F,3-i-Pr,4-TMS) Ph(2-F,3-i-Pr,4-CN) Ph(2-F,3-c-Pr,4-I) Ph(2-F,3-c-Pr,4-Et) Ph(2-F,3-c-Pr,4-n-Pr) Ph(2-F,3-c-Pr,4-i-Pr) Ph(2-F,3-c-Pr,4-C₂F₅) Ph(2-F,3-c-Pr,4-CF₂CF₂H) Ph(2-F,3-c-Pr,4-CF₂H) Ph(2-F,3-c-Pr,4-OMe) Ph(2-F,3-c-Pr,4-OCF₂CF₂H) Ph(2-F,3-c-Pr,4-OC₂F₅) Ph(2-F,3-CF₃,4-I) Ph(2-F,3-CF₃,4-Et) Ph(2-F,3-CF₃,4-n-Pr) Ph(2-F,3-CF₃,4-i-Pr) Ph(2-F,3,4-di-CF₃) Ph(2-F,3-CF₃,4-C₂F₅) Ph(2-F,3-CF₃,4-CF₂CF₂H) Ph(2-F,3-CF₃,4-CF₂H) Ph(2-F,3-CF₃,4-OMe) Ph(2-F,3-CF₃,4-OCF₃) Ph(2-F,3-CF₃,4-OCHF₂) Ph(2-F,3-CF₃,4-OCF₂CF₂H) Ph(2-F,3-CF₃,4-OC₂F₅) Ph(2-F,3-CF₃,4-TMS) Ph(2-F,3-CF₃,4-CN) Ph(2-F,3-C₂F₅,4-Cl) Ph(2-F,3-C₂F₅,4-F) Ph(2-F,3-C₂F₅,4-Br) Ph(2-F,3-C₂F₅,4-I) Ph(2-F,3-C₂F₅,4-Me) Ph(2-F,3-C₂F₅,4-Et) Ph(2-F,3-C₂F₅,4-n-Pr) Ph(2-F,3-C₂F₅,4-t-Bu) Ph(2-F,3-C₂F₅,4-i-Pr) Ph(2-F,3-C₂F₅,4-c-Pr) Ph(2-F,3-C₂F₅CF3,4-CF₃) Ph(2-F,3,4-di-C₂F₅) Ph(2-F,3-C₂F₅,4-CF₂CF₂H) Ph(2-F,3-C₂F₅,4-CF₂H) Ph(2-F,3-C₂F₅,4-OMe) Ph(2-F,3-C₂F₅,4-OCF₃) Ph(2-F,3-C₂F₅,4-OCHF₂) Ph(2-F,3-C₂F₅,4-OCF₂CF₂H) Ph(2-F,3-C₂F₅,4-OC₂F₅) Ph(2-F,3-C₂F₅,4-SO₂Me) Ph(2-F,3-C₂F₅,4-TMS) Ph(2-F,3-C₂F₅,4-CN) Ph(2-F,3-CF₂CF₂H,4-Cl) Ph(2-F,3-CF₂CF₂H,4-F) Ph(2-F,3-CF₂CF₂H,4-Br) Ph(2-F,3-CF₂CF₂H,4-I) Ph(2-F,3-CF₂CF₂H,4-Me) Ph(2-F,3-CF₂CF₂H,4-Et) Ph(2-F,3-CF₂CF₂H,4-n-Pr) Ph(2-F,3-CF₂CF₂H,4-t-Bu) Ph(2-F,3-CF₂CF₂H,4-i-Pr) Ph(2-F,3-CF₂CF₂H,4-c-Pr) Ph(2-F,3-CF₂CF₂H,4-CF₃) Ph(2-F,3-CF₂CF₂H,4-C₂F₅) Ph(2-F,3,4-di-CF₂CF₂H) Ph(2-F,3-CF₂CF₂H,4-CF₂H) Ph(2-F,3-CF₂CF₂H,4-OMe) Ph(2-F,3-CF₂CF₂H,4-OCF₃) Ph(2-F,3-CF₂CF₂H,4-OCHF₂) Ph(2-F,3-CF₂CF₂H,4- OCF₂CF₂H) Ph(2-F,3-CF₂CF₂H,4-OC₂F₅) Ph(2-F,3-CF₂CF₂H,4-SO₂Me) Ph(2-F,3-CF₂CF₂H,4-TMS) Ph(2-F,3-CF₂CF₂H,4-CN) Ph(2-F,3-CF₂H,4-Cl) Ph(2-F,3-CF₂H,4-F) Ph(2-F,3-CF₂H,4-Br) Ph(2-F,3-CF₂H,4-I) Ph(2-F,3-CF₂H,4-Me) Ph(2-F,3-CF₂H,4-Et) Ph(2-F,3-CF₂H,4-n-Pr) Ph(2-F,3-CF₂H,4-t-Bu) Ph(2-F,3-CF₂H,4-i-Pr) Ph(2-F,3-CF₂H,4-c-Pr) Ph(2-F,3-CF₂H,4-CF₃) Ph(2-F,3-CF₂H,4-C₂F₅) Ph(2-F,3-CF₂H,4-CF₂CF₂H) Ph(2-F,3,4-di-CF₂H) Ph(2-F,3-CF₂H,4-OMe) Ph(2-F,3-CF₂H,4-OCF₃) Ph(2-F,3-CF₂H,4-OCHF₂) Ph(2-F,3-CF₂H,4-OCF₂CF₂H) Ph(2-F,3-CF₂H,4-OC₂F₅) Ph(2-F,3-CF₂H,4-SO₂Me) Ph(2-F,3-CF₂H,4-TMS) Ph(2-F,3-CF₂H,4-CN) Ph(2-F,3-OMe,4-Cl) Ph(2-F,3-OMe,4-F) Ph(2-F,3-OMe,4-Br) Ph(2-F,3-OMe,4-I) Ph(2-F,3-OMe,4-Me) Ph(2-F,3-OMe,4-Et) Ph(2-F,3-OMe,4-n-Pr) Ph(2-F,3-OMe,4-t-Bu) Ph(2-F,3-OMe,4-i-Pr) Ph(2-F,3-OMe,4-c-Pr) Ph(2-F,3-OMe,4-CF₃) Ph(2-F,3-OMe,4-C₂F₅) Ph(2-F,3-OMe,4-CF₂CF₂H) Ph(2-F,3-OMe,4-CF₂H) Ph(2-F,3,4-di-OMe) Ph(2-F,3-OMe,4-OCF₃) Ph(2-F,3-OMe,4-OCHF₂) Ph(2-F,3-OMe,4-OCF₂CF₂H) Ph(2-F,3-OMe,4-OC₂F₅) Ph(2-F,3-OMe,4-SO₂Me) Ph(2-F,3-OMe,4-TMS) Ph(2-F,3-OMe,4-CN) Ph(2-F,3-OCF₃,4-Cl) Ph(2-F,3-OCF₃,4-F) Ph(2-F,3-OCF₃,4-Br) Ph(2-F,3-OCF₃,4-I) Ph(2-F,3-OCF₃,4-Me) Ph(2-F,3-OCF₃,4-Et) Ph(2-F,3-OCF₃,4-n-Pr) Ph(2-F,3-OCF₃,4-t-Bu) Ph(2-F,3-OCF₃,4-i-Pr) Ph(2-F,3-OCF₃,4-CF₃) Ph(2-F,3-OCF₃,4-C₂F₅) Ph(2-F,3-OCF₃,4-CF₂CF₂H) Ph(2-F,3-OCF₃,4-CF₂H) Ph(2-F,3-OCF₃,4-OMe) Ph(2-F,3,4-di-OCF₃) Ph(2-F,3-OCF₃,4-OCF₂CF₂H) Ph(2-F,3-OCF₃,4-OC₂F₅) Ph(2-F,3-OCHF₂,4-Cl) Ph(2-F,3-OCHF₂,4-F) Ph(2-F,3-OCHF₂,4-Br) Ph(2-F,3-OCHF₂,4-I) Ph(2-F,3-OCHF₂,4-Me) Ph(2-F,3-OCHF₂,4-Et) Ph(2-F,3-OCHF₂,4-n-Pr) Ph(2-F,3-OCHF₂,4-t-Bu) Ph(2-F,3-OCHF₂,4-i-Pr) Ph(2-F,3-OCHF₂,4-c-Pr) Ph(2-F,3-OCHF₂CF₃,4-CF₃) Ph(2-F,3-OC₂F₅,4-C₂F₅) Ph(2-F,3-OCHF₂,4-CF₂CF₂H) Ph(2-F,3-OCHF₂,4-CF₂H) Ph(2-F,3-OCHF₂,4-OMe) Ph(2-F,3-OCHF₂,4-OCF₃) Ph(2-F,3,4-di-OCHF₂) Ph(2-F,3-OCHF₂,4-OCF₂CF₂H) Ph(2-F,3-OCHF₂,4-OC₂F₅) Ph(2-F,3-OCHF₂,4-SO₂Me) Ph(2-F,3-OCHF₂,4-TMS) Ph(2-F,3-OCHF₂,4-CN) Ph(2-F,3-OCF₂CF₂H,4-Cl) Ph(2-F,3-OCF₂CF₂H,4-F) Ph(2-F,3-OCF₂CF₂H,4-Br) Ph(2-F,3-OCF₂CF₂H,4-I) Ph(2-F,3-OCF₂CF₂H,4-Me) Ph(2-F,3-OCF₂CF₂H,4-Et) Ph(2-F,3-OCF₂CF₂H,4-n-Pr) Ph(2-F,3-OCF₂CF₂H,4-t-Bu) Ph(2-F,3-OCF₂CF₂H,4-i-Pr) Ph(2-F,3-OCF₂CF₂H,4-c-Pr) Ph(2-F,3-OCF₂CF₂H,4-CF₃) Ph(2-F,3-OCF₂CF₂H,4-C₂F₅) Ph(2-F,3-OCF₂CF₂H,4- CF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,4-CF₂H) Ph(2-F,3-OCF₂CF₂H,4-OMe) Ph(2-F,3-OCF₂CF₂H,4-OCF₃) Ph(2-F,3-OCF₂CF₂H,4-OCHF₂) Ph(2-F,3,4-di-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,4-OC₂F₅) Ph(2-F,3-OCF₂CF₂H,4-SO₂Me) Ph(2-F,3-OCF₂CF₂H,4-TMS) Ph(2-F,3-OCF₂CF₂H,4-CN) Ph(2-F,3-OC₂F₅,4-Cl) Ph(2-F,3-OC₂F₅,4-F) Ph(2-F,3-OC₂F₅,4-Br) Ph(2-F,3-OC₂F₅,4-I) Ph(2-F,3-OC₂F₅,4-Me) Ph(2-F,3-OC₂F₅,4-Et) Ph(2-F,3-OC₂F₅,4-n-Pr) Ph(2-F,3-OC₂F₅,4-t-Bu) Ph(2-F,3-OC₂F₅,4-i-Pr) Ph(2-F,3-OC₂F₅,4-c-Pr) Ph(2-F,3-OC₂F₅CF₃,4-CF₃) Ph(2-F,3-OC₂F₅,4-CF₂CF₂H) Ph(2-F,3-OC₂F₅,4-CF₂H) Ph(2-F,3-OC₂F₅,4-OMe) Ph(2-F,3-OC₂F₅,4-OCF₃) Ph(2-F,3-OC₂F₅,4-OCHF₂) Ph(2-F,3-OC₂F₅,4-OCF₂CF₂H) Ph(2-F,3,4-di-OC₂F₅) Ph(2-F,3-OC₂F₅,4-SO₂Me) Ph(2-F,3-OC₂F₅,4-TMS) Ph(2-F,3-OC₂F₅,4-CN) Ph(2-F,3-SO₂Me,4-Cl) Ph(2-F,3-SO₂Me,4-Br) Ph(2-F,3-SO₂Me,4-I) Ph(2-F,3-SO₂Me,4-Me) Ph(2-F,3-SO₂Me,4-Et) Ph(2-F,3-SO₂Me,4-n-Pr) Ph(2-F,3-SO₂Me,4-t-Bu) Ph(2-F,3-SO₂Me,4-i-Pr) Ph(2-F,3-SO₂MeCF₃,4-CF₃) Ph(2-F,3-SO₂Me,4-C₂F₅) Ph(2-F,3-SO₂Me,4-CF₂CF₂H) Ph(2-F,3-SO₂Me,4-CF₂H) Ph(2-F,3-SO₂Me,4-OMe) Ph(2-F,3-SO₂Me,4-OCHF₂) Ph(2-F,3-SO₂Me,4-OCF₂CF₂H) Ph(2-F,3-SO₂Me,4-OC₂F₅) Ph(2-F,3-TMS,4-Cl) Ph(2-F,3-TMS,4-F) Ph(2-F,3-TMS,4-Br) Ph(2-F,3-TMS,4-I) Ph(2-F,3-TMS,4-Me) Ph(2-F,3-TMS,4-Et) Ph(2-F,3-TMS,4-n-Pr) Ph(2-F,3-TMS,4-t-Bu) Ph(2-F,3-TMS,4-i-Pr) Ph(2-F,3-TMS,4-c-Pr) Ph(2-F,3-TMS,4-CF₃) Ph(2-F,3-TMS,4-C₂F₅) Ph(2-F,3-TMS,4-CF₂CF₂H) Ph(2-F,3-TMS,4-CF₂H) Ph(2-F,3-TMS,4-OMe) Ph(2-F,3-TMS,4-OCF₃) Ph(2-F,3-TMS,4-OCHF₂) Ph(2-F,3-TMS,4-OCF₂CF₂H) Ph(2-F,3-TMS,4-OC₂F₅) Ph(2-F,3-TMS,4-SO₂Me) Ph(2-F,3,4-di-TMS) Ph(2-F,3-TMS,4-CN) Ph(2-F,3-CN,4-F) Ph(2-F,3-CN,4-Br) Ph(2-F,3-CN,4-I) Ph(2-F,3-CN,4-Me) Ph(2-F,3-CN,4-Et) Ph(2-F,3-CN,4-n-Pr) Ph(2-F,3-CN,4-t-Bu) Ph(2-F,3-CN,4-i-Pr) Ph(2-F,3-CN,4-c-Pr) Ph(2-F,3-CN,4-CF₃) Ph(2-F,3-CN,4-C₂F₅) Ph(2-F,3-CN,4-CF₂CF₂H) Ph(2-F,3-CN,4-CF₂H) Ph(2-F,3-CN,4-OMe) Ph(2-F,3-CN,4-OCF₃) Ph(2-F,3-CN,4-OCHF₂) Ph(2-F,3-CN,4-OCF₂CF₂H) Ph(2-F,3-CN,4-OC₂F₅) Ph(2-F,3-CN,4-TMS) Ph(2-F,3,4-di-CN) Ph(2-F,3,5-di-Cl) Ph(2-F,3-Cl,5-F) Ph(2-F,3-Cl,5-Br) Ph(2-F,3-Cl,5-I) Ph(2-F,3-Cl,5-Me) Ph(2-F,3-Cl,5-Et) Ph(2-F,3-Cl,5-n-Pr) Ph(2-F,3-Cl,5-t-Bu) Ph(2-F,3-Cl,5-i-Pr) Ph(2-F,3-Cl,5-c-Pr) Ph(2-F,3-Cl,5-CF₃) Ph(2-F,3-Cl,5-C₂F₅) Ph(2-F,3-Cl,5-CF₂CF₂H) Ph(2-F,3-Cl,5-CF₂H) Ph(2-F,3-Cl,5-OMe) Ph(2-F,3-Cl,5-OCF₃) Ph(2-F,3-Cl,5-OCHF₂) Ph(2-F,3-Cl,5-OCF₂CF₂H) Ph(2-F,3-Cl,5-OC₂F₅) Ph(2-F,3-Cl,5-SO₂Me) Ph(2-F,3-Cl,5-TMS) Ph(2-F,3-Cl,5-CN) Ph(2-F,3-F,5-Cl) Ph(2,3,5-tri-F) Ph(2-F,3-F,5-Br) Ph(2-F,3-F,5-I) Ph(2-F,3-F,5-Me) Ph(2-F,3-F,5-Et) Ph(2-F,3-F,5-n-Pr) Ph(2-F,3-F,5-t-Bu) Ph(2-F,3-F,5-i-Pr) Ph(2-F,3-F,5-c-Pr) Ph(2-F,3-F,5-CF₃) Ph(2-F,3-F,5-C₂F₅) Ph(2-F,3-F,5-CF₂CF₂H) Ph(2-F,3-F,5-CF₂H) Ph(2-F,3-F,5-OMe) Ph(2-F,3-F,5-OCF₃) Ph(2-F,3-F,5-OCHF₂) Ph(2-F,3-F,5-OCF₂CF₂H) Ph(2-F,3-F,5-OC₂F₅) Ph(2-F,3-F,5-SO₂Me) Ph(2-F,3-F,5-TMS) Ph(2-F,3-F,5-CN) Ph(2-F,3-Br,5-Cl) Ph(2-F,3-Br,5-F) Ph(2-F,3,5-di-Br) Ph(2-F,3-Br,5-I) Ph(2-F,3-Br,5-Me) Ph(2-F,3-Br,5-Et) Ph(2-F,3-Br,5-n-Pr) Ph(2-F,3-Br,5-t-Bu) Ph(2-F,3-Br,5-i-Pr) Ph(2-F,3-Br,5-c-Pr) Ph(2-F,3-Br,5-CF₃) Ph(2-F,3-Br,5-C₂F₅) Ph(2-F,3-Br,5-CF₂CF₂H) Ph(2-F,3-Br,5-CF₂H) Ph(2-F,3-Br,5-OMe) Ph(2-F,3-Br,5-OCF₃) Ph(2-F,3-Br,5-OCHF₂) Ph(2-F,3-Br,5-OCF₂CF₂H) Ph(2-F,3-Br,5-OC₂F₅) Ph(2-F,3-Br,5-SO₂Me) Ph(2-F,3-Br,5-TMS) Ph(2-F,3-Br,5-CN) Ph(2-F,3-I,5-Cl) Ph(2-F,3-I,5-F) Ph(2-F,3-I,5-Br) Ph(2-F,3,5-di-I) Ph(2-F,3-I,5-Me) Ph(2-F,3-I,5-Et) Ph(2-F,3-I,5-n-Pr) Ph(2-F,3-I,5-t-Bu) Ph(2-F,3-I,5-i-Pr) Ph(2-F,3-I,5-c-Pr) Ph(2-F,3-I,5-CF₃) Ph(2-F,3-I,5-C₂F₅) Ph(2-F,3-I,5-CF₂CF₂H) Ph(2-F,3-I,5-CF₂H) Ph(2-F,3-I,5-OMe) Ph(2-F,3-I,5-OCF₃) Ph(2-F,3-I,5-OCHF₂) Ph(2-F,3-I,5-OCF₂CF₂H) Ph(2-F,3-I,5-OC₂F₅) Ph(2-F,3-I,5-SO₂Me) Ph(2-F,3-I,5-TMS) Ph(2-F,3-I,5-CN) Ph(2-F,3-Me,5-Cl) Ph(2-F,3-Me,5-F) Ph(2-F,3-Me,5-Br) Ph(2-F,3-Me,5-I) Ph(2-F,3,5-di-Me) Ph(2-F,3-Me,5-Et) Ph(2-F,3-Me,5-n-Pr) Ph(2-F,3-Me,5-t-Bu) Ph(2-F,3-Me,5-i-Pr) Ph(2-F,3-Me,5-c-Pr) Ph(2-F,3-Me,5-CF₃) Ph(2-F,3-Me,5-C₂F₅) Ph(2-F,3-Me,5-CF₂CF₂H) Ph(2-F,3-Me,5-CF₂H) Ph(2-F,3-Me,5-OMe) Ph(2-F,3-Me,5-OCF₃) Ph(2-F,3-Me,5-OCHF₂) Ph(2-F,3-Me,5-OCF₂CF₂H) Ph(2-F,3-Me,5-OC₂F₅) Ph(2-F,3-Me,5-SO₂Me) Ph(2-F,3-Me,5-TMS) Ph(2-F,3-Me,5-CN) Ph(2-F,3-Et,5-Cl) Ph(2-F,3-Et,5-F) Ph(2-F,3-Et,5-Br) Ph(2-F,3-Et,5-I) Ph(2-F,3-Et,5-Me) Ph(2-F,3,5-di-Et) Ph(2-F,3-Et,5-n-Pr) Ph(2-F,3-Et,5-t-Bu) Ph(2-F,3-Et,5-i-Pr) Ph(2-F,3-Et,5-c-Pr) Ph(2-F,3-Et,5-CF₃) Ph(2-F,3-Et,5-C₂F₅) Ph(2-F,3-Et,5-CF₂CF₂H) Ph(2-F,3-Et,5-CF₂H) Ph(2-F,3-Et,5-OMe) Ph(2-F,3-Et,5-OCF₃) Ph(2-F,3-Et,5-OCHF₂) Ph(2-F,3-Et,5-OCF₂CF₂H) Ph(2-F,3-Et,5-OC₂F₅) Ph(2-F,3-Et,5-SO₂Me) Ph(2-F,3-Et,5-TMS) Ph(2-F,3-Et,5-CN) Ph(2-F,3-n-Pr,5-Cl) Ph(2-F,3-n-Pr,5-F) Ph(2-F,3-n-Pr,5-Br) Ph(2-F,3-n-Pr,5-I) Ph(2-F,3-n-Pr,5-Me) Ph(2-F,3-n-Pr,5-Et) Ph(2-F,3,5-di-n-Pr) Ph(2-F,3-n-Pr,5-t-Bu) Ph(2-F,3-n-Pr,5-i-Pr) Ph(2-F,3-n-Pr,5-c-Pr) Ph(2-F,3-n-Pr,5-CF₃) Ph(2-F,3-n-Pr,5-C₂F₅) Ph(2-F,3-n-Pr,5-CF₂CF₂H) Ph(2-F,3-n-Pr,5-CF₂H) Ph(2-F,3-n-Pr,5-OMe) Ph(2-F,3-n-Pr,5-OCF₃) Ph(2-F,3-n-Pr,5-OCHF₂) Ph(2-F,3-n-Pr,5-OCF₂CF₂H) Ph(2-F,3-n-Pr,5-OC₂F₅) Ph(2-F,3-n-Pr,5-SO₂Me) Ph(2-F,3-n-Pr,5-TMS) Ph(2-F,3-n-Pr,5-CN) Ph(2-F,3-t-Bu,5-Cl) Ph(2-F,3-t-Bu,5-F) Ph(2-F,3-t-Bu,5-Br) Ph(2-F,3-t-Bu,5-I) Ph(2-F,3-t-Bu,5-Me) Ph(2-F,3-t-Bu,5-Et) Ph(2-F,3-t-Bu,5-n-Pr) Ph(2-F,3,5-di-t-Bu) Ph(2-F,3-t-Bu,5-i-Pr) Ph(2-F,3-t-Bu,5-c-Pr) Ph(2-F,3-t-Bu,5-CF₃) Ph(2-F,3-t-Bu,5-C₂F₅) Ph(2-F,3-t-Bu,5-CF₂CF₂H) Ph(2-F,3-t-Bu,5-CF₂H) Ph(2-F,3-t-Bu,5-OMe) Ph(2-F,3-t-Bu,5-OCF₃) Ph(2-F,3-t-Bu,5-OCHF₂) Ph(2-F,3-t-Bu,5-OCF₂CF₂H) Ph(2-F,3-t-Bu,5-OC₂F₅) Ph(2-F,3-t-Bu,5-SO₂Me) Ph(2-F,3-t-Bu,5-TMS) Ph(2-F,3-t-Bu,5-CN) Ph(2-F,3-i-Pr,5-Cl) Ph(2-F,3-i-Pr,5-F) Ph(2-F,3-i-Pr,5-Br) Ph(2-F,3-i-Pr,5-I) Ph(2-F,3-i-Pr,5-Me) Ph(2-F,3-i-Pr,5-Et) Ph(2-F,3-i-Pr,5-n-Pr) Ph(2-F,3-i-Pr,5-t-Bu) Ph(2-F,3,5-di-i-Pr) Ph(2-F,3-i-Pr,5-c-Pr) Ph(2-F,3-i-Pr,5-CF₃) Ph(2-F,3-i-Pr,5-C₂F₅) Ph(2-F,3-i-Pr,5-CF₂CF₂H) Ph(2-F,3-i-Pr,5-CF₂H) Ph(2-F,3-i-Pr,5-OMe) Ph(2-F,3-i-Pr,5-OCF₃) Ph(2-F,3-i-Pr,5-OCHF₂) Ph(2-F,3-i-Pr,5-OCF₂CF₂H) Ph(2-F,3-i-Pr,5-OC₂F₅) Ph(2-F,3-i-Pr,5-SO₂Me) Ph(2-F,3-i-Pr,5-TMS) Ph(2-F,3-i-Pr,5-CN) Ph(2-F,3-c-Pr,5-Cl) Ph(2-F,3-c-Pr,5-F) Ph(2-F,3-c-Pr,5-Br) Ph(2-F,3-c-Pr,5-I) Ph(2-F,3-c-Pr,5-Me) Ph(2-F,3-c-Pr,5-Et) Ph(2-F,3-c-Pr,5-n-Pr) Ph(2-F,3-c-Pr,5-t-Bu) Ph(2-F,3-c-Pr,5-i-Pr) Ph(2-F,3,5-di-c-Pr) Ph(2-F,3-c-Pr,5-CF₃) Ph(2-F,3-c-Pr,5-C₂F₅) Ph(2-F,3-c-Pr,5-CF₂CF₂H) Ph(2-F,3-c-Pr,5-CF₂H) Ph(2-F,3-c-Pr,5-OMe) Ph(2-F,3-c-Pr,5-OCF₃) Ph(2-F,3-c-Pr,5-OCHF₂) Ph(2-F,3-c-Pr,5-OCF₂CF₂H) Ph(2-F,3-c-Pr,5-OC₂F₅) Ph(2-F,3-c-Pr,5-SO₂Me) Ph(2-F,3-c-Pr,5-TMS) Ph(2-F,3-c-Pr,5-CN) Ph(2-F,3-CF3,5-Cl) Ph(2-F,3-CF3,5-F) Ph(2-F,3-CF3,5-Br) Ph(2-F,3-CF3,5-I) Ph(2-F,3-CF3,5-Me) Ph(2-F,3-CF3,5-Et) Ph(2-F,3-CF3,5-n-Pr) Ph(2-F,3-CF3,5-t-Bu) Ph(2-F,3-CF3,5-i-Pr) Ph(2-F,3-CF3,5-c-Pr) Ph(2-F,3,5-di-CF₃) Ph(2-F,3-CF₃,5-C₂F₅) Ph(2-F,3-CF₃,5-CF₂CF₂H) Ph(2-F,3-CF₃,5-CF₂H) Ph(2-F,3-CF₃,5-OMe) Ph(2-F,3-CF₃,5-OCF₃) Ph(2-F,3-CF₃,5-OCHF₂) Ph(2-F,3-CF₃,5-OCF₂CF₂H) Ph(2-F,3-CF₃,5-OC₂F₅) Ph(2-F,3-CF₃,5-SO₂Me) Ph(2-F,3-CF₃,5-TMS) Ph(2-F,3-CF₃,5-CN) Ph(2-F,3-C₂F₅,5-Cl) Ph(2-F,3-C₂F₅,5-F) Ph(2-F,3-C₂F₅,5-Br) Ph(2-F,3-C₂F₅,5-I) Ph(2-F,3-C₂F₅,5-Me) Ph(2-F,3-C₂F₅,5-Et) Ph(2-F,3-C₂F₅,5-n-Pr) Ph(2-F,3-C₂F₅,5-t-Bu) Ph(2-F,3-C₂F₅,5-i-Pr) Ph(2-F,3-C₂F₅,5-c-Pr) Ph(2-F,3-C₂F₅CF3,5-CF₃) Ph(2-F,3,5-di-C₂F₅) Ph(2-F,3-C₂F₅,5-CF₂CF₂H) Ph(2-F,3-C₂F₅,5-CF₂H) Ph(2-F,3-C₂F₅,5-OMe) Ph(2-F,3-C₂F₅,5-OCF₃) Ph(2-F,3-C₂F₅,5-OCHF₂) Ph(2-F,3-C₂F₅,5-OCF₂CF₂H) Ph(2-F,3-C₂F₅,5-OC₂F₅) Ph(2-F,3-C₂F₅,5-SO₂Me) Ph(2-F,3-C₂F₅,5-TMS) Ph(2-F,3-C₂F₅,5-CN) Ph(2-F,3-CF₂CF₂H,5-Cl) Ph(2-F,3-CF₂CF₂H,5-F) Ph(2-F,3-CF₂CF₂H,5-Br) Ph(2-F,3-CF₂CF₂H,54) Ph(2-F,3-CF₂CF₂H,5-Me) Ph(2-F,3-CF₂CF₂H,5-Et) Ph(2-F,3-CF₂CF₂H,5-n-Pr) Ph(2-F,3-CF₂CF₂H,5-t-Bu) Ph(2-F,3-CF₂CF₂H,5-i-Pr) Ph(2-F,3-CF₂CF₂H,5-c-Pr) Ph(2-F,3-CF₂CF₂H,5-CF₃) Ph(2-F,3-CF₂CF₂H,5-C₂F₅) Ph(2-F,3,5-di-CF₂CF₂H) Ph(2-F,3-CF₂CF₂H,5-CF₂H) Ph(2-F,3-CF₂CF₂H,5-OMe) Ph(2-F,3-CF₂CF₂H,5-OCF₃) Ph(2-F,3-CF₂CF₂H,5-OCHF₂) Ph(2-F,3-CF₂CF₂H,5- OCF₂CF₂H) Ph(2-F,3-CF₂CF₂H,5-OC₂F₅) Ph(2-F,3-CF₂CF₂H,5-SO₂Me) Ph(2-F,3-CF₂CF₂H,5-TMS) Ph(2-F,3-CF₂CF₂H,5-CN) Ph(2-F,3-CF₂H,5-Cl) Ph(2-F,3-CF₂H,5-F) Ph(2-F,3-CF₂H,5-Br) Ph(2-F,3-CF₂H,54) Ph(2-F,3-CF₂H,5-Me) Ph(2-F,3-CF₂H,5-Et) Ph(2-F,3-CF₂H,5-n-Pr) Ph(2-F,3-CF₂H,5-t-Bu) Ph(2-F,3-CF₂H,5-i-Pr) Ph(2-F,3-CF₂H,5-c-Pr) Ph(2-F,3-CF₂H,5-CF₃) Ph(2-F,3-CF₂H,5-C₂F₅) Ph(2-F,3-CF₂H,5-CF₂CF₂H) Ph(2-F,3,5-di-CF₂H) Ph(2-F,3-CF₂H,5-OMe) Ph(2-F,3-CF₂H,5-OCF₃) Ph(2-F,3-CF₂H,5-OCHF₂) Ph(2-F,3-CF₂H,5-OCF₂CF₂H) Ph(2-F,3-CF₂H,5-OC₂F₅) Ph(2-F,3-CF₂H,5-SO₂Me) Ph(2-F,3-CF₂H,5-TMS) Ph(2-F,3-CF₂H,5-CN) Ph(2-F,3-OMe,5-Cl) Ph(2-F,3-OMe,5-F) Ph(2-F,3-OMe,5-Br) Ph(2-F,3-OMe,5-I) Ph(2-F,3-OMe,5-Me) Ph(2-F,3-OMe,5-Et) Ph(2-F,3-OMe,5-n-Pr) Ph(2-F,3-OMe,5-t-Bu) Ph(2-F,3-OMe,5-i-Pr) Ph(2-F,3-OMe,5-c-Pr) Ph(2-F,3-OMe,5-CF₃) Ph(2-F,3-OMe,5-C₂F₅) Ph(2-F,3-OMe,5-CF₂CF₂H) Ph(2-F,3-OMe,5-CF₂H) Ph(2-F,3,5-di-OMe) Ph(2-F,3-OMe,5-OCF₃) Ph(2-F,3-OMe,5-OCHF₂) Ph(2-F,3-OMe,5-OCF₂CF₂H) Ph(2-F,3-OMe,5-OC₂F₅) Ph(2-F,3-OMe,5-SO₂Me) Ph(2-F,3-OMe,5-TMS) Ph(2-F,3-OMe,5-CN) Ph(2-F,3-OCF₃,5-Cl) Ph(2-F,3-OCF₃,5-F) Ph(2-F,3-OCF₃,5-Br) Ph(2-F,3-OCF₃,54) Ph(2-F,3-OCF₃,5-Me) Ph(2-F,3-OCF₃,5-Et) Ph(2-F,3-OCF₃,5-n-Pr) Ph(2-F,3-OCF₃,5-t-Bu) Ph(2-F,3-OCF₃,5-i-Pr) Ph(2-F,3-OCF₃,5-c-Pr) Ph(2-F,3-OCF₃,5-CF₃) Ph(2-F,3-OCF₃,5-C₂F₅) Ph(2-F,3-OCF₃,5-CF₂CF₂H) Ph(2-F,3-OCF₃,5-CF₂H) Ph(2-F,3-OCF₃,5-OMe) Ph(2-F,3,5-di-OCF₃) Ph(2-F,3-OCF₃,5-OCHF₂) Ph(2-F,3-OCF₃,5-OCF₂CF₂H) Ph(2-F,3-OCF₃,5-OC₂F₅) Ph(2-F,3-OCF₃,5-SO₂Me) Ph(2-F,3-OCF₃,5-TMS) Ph(2-F,3-OCF₃,5-CN) Ph(2-F,3-OCHF₂,5-Cl) Ph(2-F,3-OCHF₂,5-F) Ph(2-F,3-OCHF₂,5-Br) Ph(2-F,3-OCHF₂,5-I) Ph(2-F,3-OCHF₂,5-Me) Ph(2-F,3-OCHF₂,5-Et) Ph(2-F,3-OCHF₂,5-n-Pr) Ph(2-F,3-OCHF₂,5-t-Bu) Ph(2-F,3-OCHF₂,5-i-Pr) Ph(2-F,3-OCHF₂,5-c-Pr) Ph(2-F,3-OCHF₂CF₃,5-CF₃) Ph(2-F,3-OC₂F₅,5-C₂F₅) Ph(2-F,3-OCHF₂,5-CF₂CF₂H) Ph(2-F,3-OCHF₂,5-CF₂H) Ph(2-F,3-OCHF₂,5-OMe) Ph(2-F,3-OCHF₂,5-OCF₃) Ph(2-F,3,5-di-OCHF₂) Ph(2-F,3-OCHF₂,5-OCF₂CF₂H) Ph(2-F,3-OCHF₂,5-OC₂F₅) Ph(2-F,3-OCHF₂,5-SO₂Me) Ph(2-F,3-OCHF₂,5-TMS) Ph(2-F,3-OCHF₂,5-CN) Ph(2-F,3-OCF₂CF₂H,5-Cl) Ph(2-F,3-OCF₂CF₂H,5-F) Ph(2-F,3-OCF₂CF₂H,5-Br) Ph(2-F,3-OCF₂CF₂H,5-I) Ph(2-F,3-OCF₂CF₂H,5-Me) Ph(2-F,3-OCF₂CF₂H,5-Et) Ph(2-F,3-OCF₂CF₂H,5-n-Pr) Ph(2-F,3-OCF₂CF₂H,5-t-Bu) Ph(2-F,3-OCF₂CF₂H,5-i-Pr) Ph(2-F,3-OCF₂CF₂H,5-c-Pr) Ph(2-F,3-OCF₂CF₂H,5-CF₃) Ph(2-F,3-OCF₂CF₂H,5-C₂F₅) Ph(2-F,3-OCF₂CF₂H,5- CF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,5-CF₂H) Ph(2-F,3-OCF₂CF₂H,5-OMe) Ph(2-F,3-OCF₂CF₂H,5-OCF₃) Ph(2-F,3-OCF₂CF₂H,5-OCHF₂) Ph(2-F,3,5-di-OCF₂CF₂H) Ph(2-F,3-OCF₂CF₂H,5-OC₂F₅) Ph(2-F,3-OCF₂CF₂H,5-SO₂Me) Ph(2-F,3-OCF₂CF₂H,5-TMS) Ph(2-F,3-OCF₂CF₂H,5-CN) Ph(2-F,3-OC₂F₅,5-Cl) Ph(2-F,3-OC₂F₅,5-F) Ph(2-F,3-OC₂F₅,5-Br) Ph(2-F,3-OC₂F₅,5-I) Ph(2-F,3-OC₂F₅,5-Me) Ph(2-F,3-OC₂F₅,5-Et) Ph(2-F,3-OC₂F₅,5-n-Pr) Ph(2-F,3-OC₂F₅,5-t-Bu) Ph(2-F,3-OC₂F₅,5-i-Pr) Ph(2-F,3-OC₂F₅,5-c-Pr) Ph(2-F,3-OC₂F₅CF₃,5-CF₃) Ph(2-F,3-OC₂F₅,5-CF₂CF₂H) Ph(2-F,3-OC₂F₅,5-CF₂H) Ph(2-F,3-OC₂F₅,5-OMe) Ph(2-F,3-OC₂F₅,5-OCF₃) Ph(2-F,3-OC₂F₅,5-OCHF₂) Ph(2-F,3-OC₂F₅,5-OCF₂CF₂H) Ph(2-F,3,5-di-OC₂F₅) Ph(2-F,3-OC₂F₅,5-SO₂Me) Ph(2-F,3-OC₂F₅,5-TMS) Ph(2-F,3-OC₂F₅,5-CN) Ph(2-F,3-SO₂Me,5-Cl) Ph(2-F,3-SO₂Me,5-F) Ph(2-F,3-SO₂Me,5-Br) Ph(2-F,3-SO₂Me,5-I) Ph(2-F,3-SO₂Me,5-Me) Ph(2-F,3-SO₂Me,5-Et) Ph(2-F,3-SO₂Me,5-n-Pr) Ph(2-F,3-SO₂Me,5-t-Bu) Ph(2-F,3-SO₂Me,5-i-Pr) Ph(2-F,3-SO₂Me,5-c-Pr) Ph(2-F,3-SO₂MeCF₃,5-CF₃) Ph(2-F,3-SO₂Me,5-C₂F5) Ph(2-F,3-SO₂Me,5-CF₂CF₂H) Ph(2-F,3-SO₂Me,5-CF₂H) Ph(2-F,3-SO₂Me,5-OMe) Ph(2-F,3-SO₂Me,5-OCF₃) Ph(2-F,3-SO₂Me,5-OCHF₂) Ph(2-F,3-SO₂Me,5-OCF₂CF₂H) Ph(2-F,3-SO₂Me,5-OC₂F₅) Ph(2-F,3,5-di-SO₂Me) Ph(2-F,3-SO₂Me,5-TMS) Ph(2-F,3-SO₂Me,5-CN) Ph(2-F,3-TMS,5-Cl) Ph(2-F,3-TMS,5-F) Ph(2-F,3-TMS,5-Br) Ph(2-F,3-TMS,5-I) Ph(2-F,3-TMS,5-Me) Ph(2-F,3-TMS,5-Et) Ph(2-F,3-TMS,5-n-Pr) Ph(2-F,3-TMS,5-t-Bu) Ph(2-F,3-TMS,5-i-Pr) Ph(2-F,3-TMS,5-c-Pr) Ph(2-F,3-TMS,5-CF₃) Ph(2-F,3-TMS,5-C₂F₅) Ph(2-F,3-TMS,5-CF₂CF₂H) Ph(2-F,3-TMS,5-CF₂H) Ph(2-F,3-TMS,5-OMe) Ph(2-F,3-TMS,5-OCF₃) Ph(2-F,3-TMS,5-OCHF₂) Ph(2-F,3-TMS,5-OCF₂CF₂H) Ph(2-F,3-TMS,5-OC₂F₅) Ph(2-F,3-TMS,5-SO₂Me) Ph(2-F,3,5-di-TMS) Ph(2-F,3-TMS,5-CN) Ph(2-F,3-CN,5-Cl) Ph(2-F,3-CN,5-F) Ph(2-F,3-CN,5-Br) Ph(2-F,3-CN,5-I) Ph(2-F,3-CN,5-Me) Ph(2-F,3-CN,5-Et) Ph(2-F,3-CN,5-n-Pr) Ph(2-F,3-CN,5-t-Bu) Ph(2-F,3-CN,5-i-Pr) Ph(2-F,3-CN,5-c-Pr) Ph(2-F,3-CN,5-CF₃) Ph(2-F,3-CN,5-C₂F₅) Ph(2-F,3-CN,5-CF₂CF₂H) Ph(2-F,3-CN,5-CF₂H) Ph(2-F,3-CN,5-OMe) Ph(2-F,3-CN,5-OCF₃) Ph(2-F,3-CN,5-OCHF2) Ph(2-F,3-CN,5-OCF₂CF₂H) Ph(2-F,3-CN,5-OC₂F₅) Ph(2-F,3-CN,5-SO₂Me) Ph(2-F,3-CN,5-TMS) Ph(2-F,3,5-di-CN) Ph(2-F,4,5-di-Cl) Ph(2-F,4-Cl,5-F) Ph(2-F,4-Cl,5-Br) Ph(2-F,4-Cl,5-I) Ph(2-F,4-Cl,5-Me) Ph(2-F,4-Cl,5-Et) Ph(2-F,4-Cl,5-n-Pr) Ph(2-F,4-Cl,5-t-Bu) Ph(2-F,4-Cl,5-i-Pr) Ph(2-F,4-Cl,5-c-Pr) Ph(2-F,4-Cl,5-CF₃) Ph(2-F,4-Cl,5-C₂F₅) Ph(2-F,4-Cl,5-CF₂CF₂H) Ph(2-F,4-Cl,5-CF₂H) Ph(2-F,4-Cl,5-OMe) Ph(2-F,4-Cl,5-OCF₃) Ph(2-F,4-Cl,5-OCHF₂) Ph(2-F,4-Cl,5-OCF₂CF₂H) Ph(2-F,4-Cl,5-OC₂F₅) Ph(2-F,4-Cl,5-SO₂Me) Ph(2-F,4-Cl,5-TMS) Ph(2-F,4-Cl,5-CN) Ph(2-F,4-F,5-Cl) Ph(2,4,5-tri-F) Ph(2-F,4-F,5-Br) Ph(2-F,4-F,5-I) Ph(2-F,4-F,5-Me) Ph(2-F,4-F,5-Et) Ph(2-F,4-F,5-n-Pr) Ph(2-F,4-F,5-t-Bu) Ph(2-F,4-F,5-i-Pr) Ph(2-F,4-F,5-c-Pr) Ph(2-F,4-F,5-CF₃) Ph(2-F,4-F,5-C₂F₅) Ph(2-F,4-F,5-CF₂CF₂H) Ph(2-F,4-F,5-CF₂H) Ph(2-F,4-F,5-OMe) Ph(2-F,4-F,5-OCF₃) Ph(2-F,4-F,5-OCHF₂) Ph(2-F,4-F,5-OCF₂CF₂H) Ph(2-F,4-F,5-OC₂F₅) Ph(2-F,4-F,5-SO₂Me) Ph(2-F,4-F,5-TMS) Ph(2-F,4-F,5-CN) Ph(2-F,4-Br,5-Cl) Ph(2-F,4-Br,5-F) Ph(2-F,4,5-di-Br) Ph(2-F,4-Br,5-I) Ph(2-F,4-Br,5-Me) Ph(2-F,4-Br,5-Et) Ph(2-F,4-Br,5-n-Pr) Ph(2-F,4-Br,5-t-Bu) Ph(2-F,4-Br,5-i-Pr) Ph(2-F,4-Br,5-c-Pr) Ph(2-F,4-Br,5-CF₃) Ph(2-F,4-Br,5-C₂F₅) Ph(2-F,4-Br,5-CF₂CF₂H) Ph(2-F,4-Br,5-CF₂H) Ph(2-F,4-Br,5-OMe) Ph(2-F,4-Br,5-OCF₃) Ph(2-F,4-Br,5-OCHF₂) Ph(2-F,4-Br,5-OCF₂CF₂H) Ph(2-F,4-Br,5-OC₂F₅) Ph(2-F,4-Br,5-SO₂Me) Ph(2-F,4-Br,5-TMS) Ph(2-F,4-Br,5-CN) Ph(2-F,4-I,5-Cl) Ph(2-F,4-I,5-F) Ph(2-F,4-I,5-Br) Ph(2-F,4,5-di-I) Ph(2-F,4-I,5-Me) Ph(2-F,4-I,5-Et) Ph(2-F,4-I,5-n-Pr) Ph(2-F,4-I,5-t-Bu) Ph(2-F,4-I,5-i-Pr) Ph(2-F,4-I,5-c-Pr) Ph(2-F,4-I,5-CF₃) Ph(2-F,4-I,5-C₂F₅) Ph(2-F,4-I,5-CF₂CF₂H) Ph(2-F,4-I,5-CF₂H) Ph(2-F,4-I,5-OMe) Ph(2-F,4-I,5-OCF₃) Ph(2-F,4-I,5-OCHF₂) Ph(2-F,4-I,5-OCF₂CF₂H) Ph(2-F,4-I,5-OC₂F₅) Ph(2-F,4-I,5-SO₂Me) Ph(2-F,4-I,5-TMS) Ph(2-F,4-I,5-CN) Ph(2-F,4-Me,5-Cl) Ph(2-F,4-Me,5-F) Ph(2-F,4-Me,5-Br) Ph(2-F,4-Me,5-I) Ph(2-F,4,5-di-Me) Ph(2-F,4-Me,5-Et) Ph(2-F,4-Me,5-n-Pr) Ph(2-F,4-Me,5-t-Bu) Ph(2-F,4-Me,5-i-Pr) Ph(2-F,4-Me,5-c-Pr) Ph(2-F,4-Me,5-CF₃) Ph(2-F,4-Me,5-C₂F₅) Ph(2-F,4-Me,5-CF₂CF₂H) Ph(2-F,4-Me,5-CF₂H) Ph(2-F,4-Me,5-OMe) Ph(2-F,4-Me,5-OCF₃) Ph(2-F,4-Me,5-OCHF₂) Ph(2-F,4-Me,5-OCF₂CF₂H) Ph(2-F,4-Me,5-OC₂F₅) Ph(2-F,4-Me,5-SO₂Me) Ph(2-F,4-Me,5-TMS) Ph(2-F,4-Me,5-CN) Ph(2-F,4-Et,5-Cl) Ph(2-F,4-Et,5-F) Ph(2-F,4-Et,5-Br) Ph(2-F,4-Et,5-I) Ph(2-F,4-Et,5-Me) Ph(2-F,4,5-di-Et) Ph(2-F,4-Et,5-n-Pr) Ph(2-F,4-Et,5-t-Bu) Ph(2-F,4-Et,5-i-Pr) Ph(2-F,4-Et,5-c-Pr) Ph(2-F,4-Et,5-CF₃) Ph(2-F,4-Et,5-C₂F₅) Ph(2-F,4-Et,5-CF₂CF₂H) Ph(2-F,4-Et,5-CF₂H) Ph(2-F,4-Et,5-OMe) Ph(2-F,4-Et,5-OCF₃) Ph(2-F,4-Et,5-OCHF₂) Ph(2-F,4-Et,5-OCF₂CF₂H) Ph(2-F,4-Et,5-OC₂F₅) Ph(2-F,4-Et,5-SO₂Me) Ph(2-F,4-Et,5-TMS) Ph(2-F,4-Et,5-CN) Ph(2-F,4-n-Pr,5-Cl) Ph(2-F,4-n-Pr,5-F) Ph(2-F,4-n-Pr,5-Br) Ph(2-F,4-n-Pr,5-I) Ph(2-F,4-n-Pr,5-Me) Ph(2-F,4-n-Pr,5-Et) Ph(2-F,4,5-di-n-Pr) Ph(2-F,4-n-Pr,5-t-Bu) Ph(2-F,4-n-Pr,5-i-Pr) Ph(2-F,4-n-Pr,5-c-Pr) Ph(2-F,4-n-Pr,5-CF₃) Ph(2-F,4-n-Pr,5-C₂F₅) Ph(2-F,4-n-Pr,5-CF₂CF₂H) Ph(2-F,4-n-Pr,5-CF₂H) Ph(2-F,4-n-Pr,5-OMe) Ph(2-F,4-n-Pr,5-OCF₃) Ph(2-F,4-n-Pr,5-OCHF₂) Ph(2-F,4-n-Pr,5-OCF₂CF₂H) Ph(2-F,4-n-Pr,5-OC₂F₅) Ph(2-F,4-n-Pr,5-SO₂Me) Ph(2-F,4-n-Pr,5-TMS) Ph(2-F,4-n-Pr,5-CN) Ph(2-F,4-t-Bu,5-Cl) Ph(2-F,4-t-Bu,5-F) Ph(2-F,4-t-Bu,5-Br) Ph(2-F,4-t-Bu,5-I) Ph(2-F,4-t-Bu,5-Me) Ph(2-F,4-t-Bu,5-Et) Ph(2-F,4-t-Bu,5-n-Pr) Ph(2-F,4,5-di-t-Bu) Ph(2-F,4-t-Bu,5-i-Pr) Ph(2-F,4-t-Bu,5-c-Pr) Ph(2-F,4-t-Bu,5-CF₃) Ph(2-F,4-t-Bu,5-C₂F₅) Ph(2-F,4-t-Bu,5-CF₂CF₂H) Ph(2-F,4-t-Bu,5-CF₂H) Ph(2-F,4-t-Bu,5-OMe) Ph(2-F,4-t-Bu,5-OCF₃) Ph(2-F,4-t-Bu,5-OCHF₂) Ph(2-F,4-t-Bu,5-OCF₂CF₂H) Ph(2-F,4-t-Bu,5-OC₂F₅) Ph(2-F,4-t-Bu,5-SO₂Me) Ph(2-F,4-t-Bu,5-TMS) Ph(2-F,4-t-Bu,5-CN) Ph(2-F,4-i-Pr,5-Cl) Ph(2-F,4-i-Pr,5-F) Ph(2-F,4-i-Pr,5-Br) Ph(2-F,4-i-Pr,5-I) Ph(2-F,4-i-Pr,5-Me) Ph(2-F,4-i-Pr,5-Et) Ph(2-F,4-i-Pr,5-n-Pr) Ph(2-F,4-i-Pr,5-t-Bu) Ph(2-F,4,5-di-i-Pr) Ph(2-F,4-i-Pr,5-c-Pr) Ph(2-F,4-i-Pr,5-CF₃) Ph(2-F,4-i-Pr,5-C₂F₅) Ph(2-F,4-i-Pr,5-CF₂CF₂H) Ph(2-F,4-i-Pr,5-CF₂H) Ph(2-F,4-i-Pr,5-OMe) Ph(2-F,4-i-Pr,5-OCF₃) Ph(2-F,4-i-Pr,5-OCHF₂) Ph(2-F,4-i-Pr,5-OCF₂CF₂H) Ph(2-F,4-i-Pr,5-OC₂F₅) Ph(2-F,4-i-Pr,5-SO₂Me) Ph(2-F,4-i-Pr,5-TMS) Ph(2-F,4-i-Pr,5-CN) Ph(2-F,4-c-Pr,5-Cl) Ph(2-F,4-c-Pr,5-F) Ph(2-F,4-c-Pr,5-Br) Ph(2-F,4-c-Pr,5-I) Ph(2-F,4-c-Pr,5-Me) Ph(2-F,4-c-Pr,5-Et) Ph(2-F,4-c-Pr,5-n-Pr) Ph(2-F,4-c-Pr,5-t-Bu) Ph(2-F,4-c-Pr,5-i-Pr) Ph(2-F,4,5-di-c-Pr) Ph(2-F,4-c-Pr,5-CF₃) Ph(2-F,4-c-Pr,5-C₂F₅) Ph(2-F,4-c-Pr,5-CF₂CF₂H) Ph(2-F,4-c-Pr,5-CF₂H) Ph(2-F,4-c-Pr,5-OMe) Ph(2-F,4-c-Pr,5-OCF₃) Ph(2-F,4-c-Pr,5-OCHF₂) Ph(2-F,4-c-Pr,5-OCF₂CF₂H) Ph(2-F,4-c-Pr,5-OC₂F₅) Ph(2-F,4-c-Pr,5-SO₂Me) Ph(2-F,4-c-Pr,5-TMS) Ph(2-F,4-c-Pr,5-CN) Ph(2-F,4-CF₃,5-Cl) Ph(2-F,4-CF₃,5-F) Ph(2-F,4-CF₃,5-Br) Ph(2-F,4-CF₃,5-I) Ph(2-F,4-CF₃,5-Me) Ph(2-F,4-CF₃,5-Et) Ph(2-F,4-CF₃,5-n-Pr) Ph(2-F,4-CF₃,5-t-Bu) Ph(2-F,4-CF₃,5-i-Pr) Ph(2-F,4-CF₃,5-c-Pr) Ph(2-F,4,5-di-CF₃) Ph(2-F,4-CF₃,5-C₂F₅) Ph(2-F,4-CF₃,5-CF₂CF₂H) Ph(2-F,4-CF₃,5-CF₂H) Ph(2-F,4-CF₃,5-OMe) Ph(2-F,4-CF₃,5-OCF₃) Ph(2-F,4-CF₃,5-OCHF₂) Ph(2-F,4-CF₃,5-OCF₂CF₂H) Ph(2-F,4-CF₃,5-OC₂F₅) Ph(2-F,4-CF₃,5-SO₂Me) Ph(2-F,4-CF₃,5-TMS) Ph(2-F,4-CF₃,5-CN) Ph(2-F,4-CF₂CF₃,5-Cl) Ph(2-F,4-CF₂CF₃,5-F) Ph(2-F,4-CF₂CF₃,5-Br) Ph(2-F,4-CF₂CF₃,5-I) Ph(2-F,4-CF₂CF₃,5-Me) Ph(2-F,4-CF₂CF₃,5-Et) Ph(2-F,4-CF₂CF₃,5-n-Pr) Ph(2-F,4-CF₂CF₃,5-t-Bu) Ph(2-F,4-CF₂CF₃,5-i-Pr) Ph(2-F,4-CF₂CF₃,5-c-Pr) Ph(2-F,4-C₂F₅CF₃,5-CF₃) Ph(2-F,4,5-di-C₂F₅) Ph(2-F,4-CF₂CF₃,5-CF₂CF₂H) Ph(2-F,4-CF₂CF₃,5-CF₂H) Ph(2-F,4-CF₂CF₃,5-OMe) Ph(2-F,4-CF₂CF₃,5-OCF₃) Ph(2-F,4-CF₂CF₃,5-OCHF₂) Ph(2-F,4-CF₂CF₃,5-OCF₂CF₂H) Ph(2-F,4-CF₂CF₃,5-OC₂F₅) Ph(2-F,4-CF₂CF₃,5-SO₂Me) Ph(2-F,4-CF₂CF₃,5-TMS) Ph(2-F,4-CF₂CF₃,5-CN) Ph(2-F,4-CF₂CF₂H,5-Cl) Ph(2-F,4-CF₂CF₂H,5-F) Ph(2-F,4-CF₂CF₂H,5-Br) Ph(2-F,4-CF₂CF₂H,5-I) Ph(2-F,4-CF₂CF₂H,5-Me) Ph(2-F,4-CF₂CF₂H,5-Et) Ph(2-F,4-CF₂CF₂H,5-n-Pr) Ph(2-F,4-CF₂CF₂H,5-t-Bu) Ph(2-F,4-CF₂CF₂H,5-i-Pr) Ph(2-F,4-CF₂CF₂H,5-c-Pr) Ph(2-F,4-CF₂CF₂CF₃H,5-CF₃) Ph(2-F,4-CF₂CF₂H,5-C₂F₅) Ph(2-F,4,5-di-CF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-CF₂H) Ph(2-F,4-CF₂CF₂H,5-OMe) Ph(2-F,4-CF₂CF₂H,5-OCF₃) Ph(2-F,4-CF₂CF₂H,5-OCHF₂) Ph(2-F,4-CF₂CF₂H,5- OCF₂CF₂H) Ph(2-F,4-CF₂CF₂H,5-OC₂F₅) Ph(2-F,4-CF₂CF₂H,5-SO₂Me) Ph(2-F,4-CF₂CF₂H,5-TMS) Ph(2-F,4-CF₂CF₂H,5-CN) Ph(2-F,4-CF₂H,5-Cl) Ph(2-F,4-CF₂H,5-F) Ph(2-F,4-CF₂H,5-Br) Ph(2-F,4-CF₂H,5-I) Ph(2-F,4-CF₂H,5-Me) Ph(2-F,4-CF₂H,5-Et) Ph(2-F,4-CF₂H,5-n-Pr) Ph(2-F,4-CF₂H,5-t-Bu) Ph(2-F,4-CF₂H,5-i-Pr) Ph(2-F,4-CF₂H,5-c-Pr) Ph(2-F,4-CF₂H,5-CF₃) Ph(2-F,4-CF₂H,5-C₂F₅) Ph(2-F,4-CF₂H,5-CF₂CF₂H) Ph(2-F,4,5-di-CF₂H) Ph(2-F,4-CF₂H,5-OMe) Ph(2-F,4-CF₂H,5-OCF₃) Ph(2-F,4-CF₂H,5-OCHF₂) Ph(2-F,4-CF₂H,5-OCF₂CF₂H) Ph(2-F,4-CF₂H,5-OC₂F₅) Ph(2-F,4-CF₂H,5-SO₂Me) Ph(2-F,4-CF₂H,5-TMS) Ph(2-F,4-CF₂H,5-CN) Ph(2-F,4-OMe,5-Cl) Ph(2-F,4-OMe,5-F) Ph(2-F,4-OMe,5-Br) Ph(2-F,4-OMe,5-I) Ph(2-F,4-OMe,5-Me) Ph(2-F,4-OMe,5-Et) Ph(2-F,4-OMe,5-n-Pr) Ph(2-F,4-OMe,5-t-Bu) Ph(2-F,4-OMe,5-i-Pr) Ph(2-F,4-OMe,5-c-Pr) Ph(2-F,4-OMe,5-CF₃) Ph(2-F,4-OMe,5-C₂F₅) Ph(2-F,4-OMe,5-CF₂CF₂H) Ph(2-F,4-OMe,5-CF₂H) Ph(2-F,4,5-di-OMe) Ph(2-F,4-OMe,5-OCF₃) Ph(2-F,4-OMe,5-OCHF₂) Ph(2-F,4-OMe,5-OCF₂CF₂H) Ph(2-F,4-OMe,5-OC₂F₅) Ph(2-F,4-OMe,5-SO₂Me) Ph(2-F,4-OMe,5-TMS) Ph(2-F,4-OMe,5-CN) Ph(2-F,4-OCF₃,5-Cl) Ph(2-F,4-OCF₃,5-F) Ph(2-F,4-OCF₃,5-Br) Ph(2-F,4-OCF₃,5-I) Ph(2-F,4-OCF₃,5-Me) Ph(2-F,4-OCF₃,5-Et) Ph(2-F,4-OCF₃,5-n-Pr) Ph(2-F,4-OCF₃,5-t-Bu) Ph(2-F,4-OCF₃,5-i-Pr) Ph(2-F,4-OCF₃,5-c-Pr) Ph(2-F,4-OCF₃,5-CF₃) Ph(2-F,4-OCF₃,5-C₂F₅) Ph(2-F,4-OCF₃,5-CF₂CF₂H) Ph(2-F,4-OCF₃,5-CF₂H) Ph(2-F,4-OCF₃,5-OMe) Ph(2-F,4,5-di-OCF₃) Ph(2-F,4-OCF₃,5-OCHF₂) Ph(2-F,4-OCF₃,5-OCF₂CF₂H) Ph(2-F,4-OCF₃,5-OC₂F₅) Ph(2-F,4-OCF₃,5-SO₂Me) Ph(2-F,4-OCF₃,5-TMS) Ph(2-F,4-OCF₃,5-CN) Ph(2-F,4-OCHF₂,5-Cl) Ph(2-F,4-OCHF₂,5-F) Ph(2-F,4-OCHF₂,5-Br) Ph(2-F,4-OCHF₂,5-I) Ph(2-F,4-OCHF₂,5-Me) Ph(2-F,4-OCHF₂,5-Et) Ph(2-F,4-OCHF₂,5-n-Pr) Ph(2-F,4-OCHF₂,5-t-Bu) Ph(2-F,4-OCHF₂,5-i-Pr) Ph(2-F,4-OCHF₂,5-c-Pr) Ph(2-F,4-OCHF₂CF₃,5-CF₃) Ph(2-F,4-OCF₂CF₃,5-C₂F₅) Ph(2-F,4-OCHF₂,5-CF₂CF₂H) Ph(2-F,4-OCHF₂,5-CF₂H) Ph(2-F,4-OCHF₂,5-OMe) Ph(2-F,4-OCHF₂,5-OCF₃) Ph(2-F,4,5-di-OCHF₂) Ph(2-F,4-OCHF₂,5-OCF₂CF₂H) Ph(2-F,4-OCHF₂,5-OC₂F₅) Ph(2-F,4-OCHF₂,5-SO₂Me) Ph(2-F,4-OCHF₂,5-TMS) Ph(2-F,4-OCHF₂,5-CN) Ph(2-F,4-OCF₂CF₂H,5-Cl) Ph(2-F,4-OCF₂CF₂H,5-F) Ph(2-F,4-OCF₂CF₂H,5-Br) Ph(2-F,4-OCF₂CF₂H,5-I) Ph(2-F,4-OCF₂CF₂H,5-Me) Ph(2-F,4-OCF₂CF₂H,5-Et) Ph(2-F,4-OCF₂CF₂H,5-n-Pr) Ph(2-F,4-OCF₂CF₂H,5-t-Bu) Ph(2-F,4-OCF₂CF₂H,5-i-Pr) Ph(2-F,4-OCF₂CF₂H,5-c-Pr) Ph(2-F,4-OCF₂CF₂CF₃H,5-CF₃) Ph(2-F,4-OCF₂CF₂H,5-C₂F₅) Ph(2-F,4-OCF₂CF₂H,5- CF₂CF₂H) Ph(2-F,4-OCF₂CF₂H,5-CF₂H) Ph(2-F,4-OCF₂CF₂H,5-OMe) Ph(2-F,4-OCF₂CF₂H,5-OCF₃) Ph(2-F,4-OCF₂CF₂H,5-OCHF₂) Ph(2-F,4,5-di-OCF₂CF₂H) Ph(2-F,4-OCF₂CF₂H,5-OC₂F₅) Ph(2-F,4-OCF₂CF₂H,5-SO₂Me) Ph(2-F,4-OCF₂CF₂H,5-TMS) Ph(2-F,4-OCF₂CF₂H,5-CN) Ph(2-F,4-OCF₂CF₃,5-Cl) Ph(2-F,4-OCF₂CF₃,5-F) Ph(2-F,4-OCF₂CF₃,5-Br) Ph(2-F,4-OCF₂CF₃,5-I) Ph(2-F,4-OCF₂CF₃,5-Me) Ph(2-F,4-OCF₂CF₃,5-Et) Ph(2-F,4-OCF₂CF₃,5-n-Pr) Ph(2-F,4-OCF₂CF₃,5-t-Bu) Ph(2-F,4-OCF₂CF₃,5-i-Pr) Ph(2-F,4-OCF₂CF₃,5-c-Pr) Ph(2-F,4-OC₂F₅CF₃,5-CF₃) Ph(2-F,4-OCF₂CF₃,5-CF₂CF₂H) Ph(2-F,4-OCF₂CF₃,5-CF₂H) Ph(2-F,4-OCF₂CF₃,5-OMe) Ph(2-F,4-OCF₂CF₃,5-OCF₃) Ph(2-F,4-OCF₂CF₃,5-OCHF₂) Ph(2-F,4-OCF₂CF₃,5- OCF₂CF₂H) Ph(2-F,4,5-di-OC₂F₅) Ph(2-F,4-OCF₂CF₃,5-SO₂Me) Ph(2-F,4-OCF₂CF₃,5-TMS) Ph(2-F,4-OCF₂CF₃,5-CN) Ph(2-F,4-SO₂Me,5-Cl) Ph(2-F,4-SO₂Me,5-F) Ph(2-F,4-SO₂Me,5-Br) Ph(2-F,4-SO₂Me,54) Ph(2-F,4-SO₂Me,5-Me) Ph(2-F,4-SO₂Me,5-Et) Ph(2-F,4-SO₂Me,5-n-Pr) Ph(2-F,4-SO₂Me,5-t-Bu) Ph(2-F,4-SO₂Me,5-i-Pr) Ph(2-F,4-SO₂Me,5-c-Pr) Ph(2-F,4-SO₂MeCF₃,5-CF₃) Ph(2-F,4-SO₂Me,5-C₂F₅) Ph(2-F,4-SO₂Me,5-CF₂CF₂H) Ph(2-F,4-SO₂Me,5-CF₂H) Ph(2-F,4-SO₂Me,5-OMe) Ph(2-F,4-SO₂Me,5-OCF₃) Ph(2-F,4-SO₂Me,5-OCHF₂) Ph(2-F,4-SO₂Me,5-OCF₂CF₂H) Ph(2-F,4-SO₂Me,5-OC₂F₅) Ph(2-F,4,5-di-SO₂Me) Ph(2-F,4-SO₂Me,5-TMS) Ph(2-F,4-SO₂Me,5-CN) Ph(2-F,4-TMS,5-Cl) Ph(2-F,4-TMS,5-F) Ph(2-F,4-TMS,5-Br) Ph(2-F,4-TMS,5-I) Ph(2-F,4-TMS,5-Me) Ph(2-F,4-TMS,5-Et) Ph(2-F,4-TMS,5-n-Pr) Ph(2-F,4-TMS,5-t-Bu) Ph(2-F,4-TMS,5-i-Pr) Ph(2-F,4-TMS,5-c-Pr) Ph(2-F,4-TMS,5-CF₃) Ph(2-F,4-TMS,5-C₂F₅) Ph(2-F,4-TMS,5-CF₂CF₂H) Ph(2-F,4-TMS,5-CF₂H) Ph(2-F,4-TMS,5-OMe) Ph(2-F,4-TMS,5-OCF₃) Ph(2-F,4-TMS,5-OCHF2) Ph(2-F,4-TMS,5-OCF₂CF₂H) Ph(2-F,4-TMS,5-OC₂F₅) Ph(2-F,4-TMS,5-SO₂Me) Ph(2-F,4,5-di-TMS) Ph(2-F,4-TMS,5-CN) Ph(2-F,4-CN,5-Cl) Ph(2-F,4-CN,5-F) Ph(2-F,4-CN,5-Br) Ph(2-F,4-CN,5-I) Ph(2-F,4-CN,5-Me) Ph(2-F,4-CN,5-Et) Ph(2-F,4-CN,5-n-Pr) Ph(2-F,4-CN,5-t-Bu) Ph(2-F,4-CN,5-i-Pr) Ph(2-F,4-CN,5-c-Pr) Ph(2-F,4-CN,5-CF₃) Ph(2-F,4-CN,5-C₂F₅) Ph(2-F,4-CN,5-CF₂CF₂H) Ph(2-F,4-CN,5-CF₂H) Ph(2-F,4-CN,5-OMe) Ph(2-F,4-CN,5-OCF₃) Ph(2-F,4-CN,5-OCHF₂) Ph(2-F,4-CN,5-OCF₂CF₂H) Ph(2-F,4-CN,5-OC₂F₅) Ph(2-F,4-CN,5-SO₂Me) Ph(2-F,4-CN,5-TMS) Ph(2-F,4,5-di-CN) Ph(3,4,5-tri-Cl) Ph(3-Cl,4-F,5-Cl) Ph(3-Cl,4-Br,5-Cl) Ph(3-Cl,4-I,5-Cl) Ph(3-Cl,4-Me,5-Cl) Ph(3-Cl,4-Et,5-Cl) Ph(3-Cl,4-n-Pr,5-Cl) Ph(3-Cl,4-t-Bu,5-Cl) Ph(3-Cl,4-i-Pr,5-Cl) Ph(3-Cl,4-c-Pr,5-Cl) Ph(3-Cl,4-CF₃,5-Cl) Ph(3-Cl,4-C₂F₅,5-Cl) Ph(3-Cl,4-CF₂CF₂H,5-Cl) Ph(3-Cl,4-CF₂H,5-Cl) Ph(3-Cl,4-OMe,5-Cl) Ph(3-Cl,4-OCF₃,5-Cl) Ph(3-Cl,4-OCHF₂,5-Cl) Ph(3-Cl,4-OCF₂CF₂H,5-Cl) Ph(3-Cl,4-OC₂F₅,5-Cl) Ph(3-Cl,4-SO₂Me,5-Cl) Ph(3-Cl,4-TMS,5-Cl) Ph(3-Cl,4-CN,5-Cl) Ph(3-F,4-Cl,5-F) Ph(3,4,5-tri-F) Ph(3-F,4-Br,5-F) Ph(3-F,4-I,5-F) Ph(3-F,4-Me,5-F) Ph(3-F,4-Et,5-F) Ph(3-F,4-n-Pr,5-F) Ph(3-F,4-t-Bu,5-F) Ph(3-F,4-i-Pr,5-F) Ph(3-F,4-c-Pr,5-F) Ph(3-F,4-CF₃,5-F) Ph(3-F,4-C₂F₅,5-F) Ph(3-F,4-CF₂CF₂H,5-F) Ph(3-F,4-CF₂H,5-F) Ph(3-F,4-OMe,5-F) Ph(3-F,4-OCF₃,5-F) Ph(3-F,4-OCHF₂,5-F) Ph(3-F,4-OCF₂CF₂H,5-F) Ph(3-F,4-OC₂F5,5-F) Ph(3-F,4-SO₂Me,5-F) Ph(3-F,4-TMS,5-F) Ph(3-F,4-CN,5-F) Ph(3-Br,4-Cl,5-Br) Ph(3-Br,4-F,5-Br) Ph(3,4,5-tri-Br) Ph(3-Br,4-I,5-Br) Ph(3-Br,4-Me,5-Br) Ph(3-Br,4-Et,5-Br) Ph(3-Br,4-n-Pr,5-Br) Ph(3-Br,4-t-Bu,5-Br) Ph(3-Br,4-i-Pr,5-Br) Ph(3-Br,4-c-Pr,5-Br) Ph(3-Br,4-CF₃,5-Br) Ph(3-Br,4-C₂F₅,5-Br) Ph(3-Br,4-CF₂CF₂H,5-Br) Ph(3-Br,4-CF₂H,5-Br) Ph(3-Br,4-OMe,5-Br) Ph(3-Br,4-OCF₃,5-Br) Ph(3-Br,4-OCHF₂,5-Br) Ph(3-Br,4-OCF₂CF₂H,5-Br) Ph(3-Br,4-OC₂F₅,5-Br) Ph(3-Br,4-SO₂Me,5-Br) Ph(3-Br,4-TMS,5-Br) Ph(3-Br,4-CN,5-Br) Ph(3-Me,4-Cl,5-Me) Ph(3-Me,4-F,5-Me) Ph(3-Me,4-Br,5-Me) Ph(3-Me,4-I,5-Me) Ph(3,4-tri-Me) Ph(3-Me,4-Et,5-Me) Ph(3-Me,4-n-Pr,5-Me) Ph(3-Me,4-t-Bu,5-Me) Ph(3-Me,4-i-Pr,5-Me) Ph(3-Me,4-c-Pr,5-Me) Ph(3-Me,4-CF₃,5-Me) Ph(3-Me,4-C₂F₅,5-Me) Ph(3-Me,4-CF₂CF₂H,5-Me) Ph(3-Me,4-CF₂H,5-Me) Ph(3-Me,4-OMe,5-Me) Ph(3-Me,4-OCF₃,5-Me) Ph(3-Me,4-OCHF₂,5-Me) Ph(3-Me,4-OCF₂CF₂H,5-Me) Ph(3-Me,4-OC₂F₅,5-Me) Ph(3-Me,4-SO₂Me,5-Me) Ph(3-Me,4-TMS,5-Me) Ph(3-Me,4-CN,5-Me) Ph(3-CF₃,4-Cl,5-CF₃) Ph(3-CF₃,4-F,5-CF₃) Ph(3-CF₃,4-Br,5-CF₃) Ph(3-CF₃,4-I,5-CF₃) Ph(3-CF₃,4-Me,5-CF₃) Ph(3-CF₃,4-Et,5-CF₃) Ph(3-CF₃,4-n-Pr,5-CF₃) Ph(3-CF₃,4-t-Bu,5-CF₃) Ph(3-CF₃,4-i-Pr,5-CF₃) Ph(3-CF₃,4-c-Pr,5-CF₃) Ph(3,4,5-tri-CF₃) Ph(3-CF₃,4-C₂F₅,5-CF₃) Ph(3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(3-CF₃,4-CF₂H,5-CF₃) Ph(3-CF₃,4-OMe,5-CF₃) Ph(3-CF₃,4-OCF₃,5-CF₃) Ph(3-CF₃,4-OCHF₂,5-CF₃) Ph(3-CF₃,4-OCF₂CF₂H,5-CF₃) Ph(3,5-di-CF₃,4-OC₂F5) Ph(3-CF₃,4-SO₂Me,5-CF₃) Ph(3-CF₃,4-TMS,5-CF₃) Ph(3-CF₃,4-CN,5-CF3) Ph(3-OCHF₂,4-Cl,5-OCHF₂) Ph(3-OCHF₂,4-F,5-OCHF₂) Ph(3-OCHF₂,4-Br,5-OCHF₂) Ph(3-OCHF₂,4-I,5-OCHF₂) Ph(3-OCHF₂,4-Me,5-OCHF2) Ph(3-OCHF₂,4-Et,5-OCHF₂) Ph(3-OCHF2,4-n-Pr,5-OCHF₂) Ph(3-OCHF2,4-t-Bu,5-OCHF₂) Ph(3-OCHF₂,4-i-Pr,5-OCHF₂) Ph(3-OCHF₂,4-c-Pr,5-OCHF₂) Ph(3,5-di-OCHF₂CF₃,4-CF₃,) Ph(3-OC₂F₅,4-C₂F₅,5-OCHF₂) Ph(3,5-di-OCHF₂,4-CF₂CF₂H) Ph(3-OCHF₂,4-CF₂H,5-OCHF₂) Ph(3-OCHF₂,4-OMe,5-OCHF₂) Ph(3-OCHF₂,4-OCF₃,5-OCHF₂) Ph(3,4,5-tri-OCHF₂) Ph(3,5-di-OCHF₂,4-OCF₂CF₂H) Ph(3,5-di-OCHF₂,4-OC₂F₅) Ph(3,5-di-OCHF₂,4-SO₂Me) Ph(3-OCHF₂,4-TMS,5-OCHF₂) Ph(3-OCHF₂,4-CN,5-OCHF₂) Ph(2,3,4,5-tetra-Cl) Ph(2-Cl,3-Cl,4-F,5-Cl) Ph(2-Cl,3-Cl,4-Br,5-Cl) Ph(2-Cl,3-Cl,4-I,5-Cl) Ph(2-Cl,3-Cl,4-Me,5-Cl) Ph(2-Cl,3-Cl,4-Et,5-Cl) Ph(2-Cl,3-Cl,4-n-Pr,5-Cl) Ph(2-Cl,3-Cl,4-t-Bu,5-Cl) Ph(2-Cl,3-Cl,4-i-Pr,5-Cl) Ph(2-Cl,3-Cl,4-c-Pr,5-Cl) Ph(2-Cl,3-Cl,4-CF₃,5-Cl) Ph(2-Cl,3,5-di-Cl,4-C₂F₅) Ph(2-Cl,3-Cl,4-CF₂CF₂H,5-Cl) Ph(2-Cl,3-Cl,4-CF₂H,5-Cl) Ph(2-Cl,3-Cl,4-OMe,5-Cl) Ph(2-Cl,3-Cl,4-OCF₃,5-Cl) Ph(2-Cl,3-Cl,4-OCHF₂,5-Cl) Ph(2-Cl,3-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-Cl,3,5-di-Cl,4-OC₂F₅) Ph(2-Cl,3-Cl,4-SO₂Me,5-Cl) Ph(2-Cl,3-Cl,4-TMS,5-Cl) Ph(2-Cl,3-Cl,4-CN,5-Cl) Ph(2-Cl,3-F,4-Cl,5-F) Ph(2-Cl,3,4,5-tri-F) Ph(2-Cl,3-F,4-Br,5-F) Ph(2-Cl,3-F,4-I,5-F) Ph(2-Cl,3-F,4-Me,5-F) Ph(2-Cl,3-F,4-Et,5-F) Ph(2-Cl,3-F,4-n-Pr,5-F) Ph(2-Cl,3-F,4-t-Bu,5-F) Ph(2-Cl,3-F,4-i-Pr,5-F) Ph(2-Cl,3-F,4-c-Pr,5-F) Ph(2-Cl,3-F,4-CF₃,5-F) Ph(2-Cl,3-F,4-C₂F₅,5-F) Ph(2-Cl,3-F,4-CF₂CF₂H,5-F) Ph(2-Cl,3-F,4-CF₂H,5-F) Ph(2-Cl,3-F,4-OMe,5-F) Ph(2-Cl,3-F,4-OCF₃,5-F) Ph(2-Cl,3-F,4-OCHF₂,5-F) Ph(2-Cl,3-F,4-OCF₂CF₂H,5-F) Ph(2-Cl,3,5-di-F,4-OC₂F₅,) Ph(2-Cl,3-F,4-SO₂Me,5-F) Ph(2-Cl,3-F,4-TMS,5-F) Ph(2-Cl,3-F,4-CN,5-F) Ph(2-Cl,3-Br,4-Cl,5-Br) Ph(2-Cl,3-Br,4-F,5-Br) Ph(2-Cl,3,4,5-tri-Br) Ph(2-Cl,3-Br,4-I,5-Br) Ph(2-Cl,3-Br,4-Me,5-Br) Ph(2-Cl,3-Br,4-Et,5-Br) Ph(2-Cl,3-Br,4-n-Pr,5-Br) Ph(2-Cl,3-Br,4-t-Bu,5-Br) Ph(2-Cl,3-Br,4-i-Pr,5-Br) Ph(2-Cl,3-Br,4-c-Pr,5-Br) Ph(2-Cl,3-Br,4-CF₃,5-Br) Ph(2-Cl,3,5-di-Br,4-C₂F₅) Ph(2-Cl,3-Br,4-CF₂CF₂H,5-Br) Ph(2-Cl,3-Br,4-CF₂H,5-Br) Ph(2-Cl,3-Br,4-OMe,5-Br) Ph(2-Cl,3-Br,4-OCF₃,5-Br) Ph(2-Cl,3-Br,4-OCHF₂,5-Br) Ph(2-Cl,3-Br,4-OCF₂CF₂H,5-Br) Ph(2-Cl,3,5-di-Br,4-OC₂F₅) Ph(2-Cl,3-Br,4-SO₂Me,5-Br) Ph(2-Cl,3-Br,4-TMS,5-Br) Ph(2-Cl,3-Br,4-CN,5-Br) Ph(2-Cl,3-Me,4-Cl,5-Me) Ph(2-Cl,3-Me,4-F,5-Me) Ph(2-Cl,3-Me,4-Br,5-Me) Ph(2-Cl,3-Me,4-I,5-Me) Ph(2-Cl,3,4-tri-Me) Ph(2-Cl,3-Me,4-Et,5-Me) Ph(2-Cl,3-Me,4-n-Pr,5-Me) Ph(2-Cl,3-Me,4-t-Bu,5-Me) Ph(2-Cl,3-Me,4-i-Pr,5-Me) Ph(2-Cl,3-Me,4-c-Pr,5-Me) Ph(2-Cl,3-Me,4-CF₃,5-Me) Ph(2-Cl,3,5-di-Me,4-C₂F₅) Ph(2-Cl,3-Me,4-CF₂CF₂H,5-Me) Ph(2-Cl,3-Me,4-CF₂H,5-Me) Ph(2-Cl,3-Me,4-OMe,5-Me) Ph(2-Cl,3-Me,4-OCF₃,5-Me) Ph(2-Cl,3-Me,4-OCHF₂,5-Me) Ph(2-Cl,3,5-di-Me,4-OCF₂CF₂H) Ph(2-Cl,3-Me,4-OC₂F₅,5-Me) Ph(2-Cl,3,5-di-Me,4-SO₂Me) Ph(2-Cl,3-Me,4-TMS,5-Me) Ph(2-Cl,3-Me,4-CN,5-Me) Ph(2-Cl,3-CF₃,4-Cl,5-CF₃) Ph(2-Cl,3-CF₃,4-F,5-CF₃) Ph(2-Cl,3-CF₃,4-Br,5-CF₃) Ph(2-Cl,3-CF₃,4-I,5-CF₃) Ph(2-Cl,3-CF₃,4-Me,5-CF₃) Ph(2-Cl,3-CF₃,4-Et,5-CF₃) Ph(2-Cl,3-CF₃,4-n-Pr,5-CF₃) Ph(2-Cl,3-CF₃,4-t-Bu,5-CF₃) Ph(2-Cl,3-CF₃,4-i-Pr,5-CF₃) Ph(2-Cl,3-CF₃,4-c-Pr,5-CF₃) Ph(2-Cl,3,4,5-tri-CF₃) Ph(2-Cl,3,5-di-CF₃,4-C₂F₅) Ph(2-Cl,3,5-di-CF₃,4-CF₂CF₂H) Ph(2-Cl,3-CF₃,4-CF₂H,5-CF₃) Ph(2-Cl,3-CF₃,4-OMe,5-CF₃) Ph(2-Cl,3-CF₃,4-OCF₃,5-CF₃) Ph(2-Cl,3-CF₃,4-OCHF₂,5-CF₃) Ph(2-Cl,3,5-di-CF₃,4- OCF₂CF₂H-) Ph(2-Cl,3,5-di-CF₃,4-OC₂F₅) Ph(2-Cl,3,5-di-CF₃,4-SO₂Me) Ph(2-Cl,3,5-di-CF₃,4-TMS) Ph(2-Cl,3-CF₃,4-CN,5-CF₃) Ph(2-Cl,3,5-di-OCHF₂,4-Cl) Ph(2-Cl,3-OCHF₂,4-F,5-OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4-Br) Ph(2-Cl,3-OCHF₂,4-I,5-OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4-Me) Ph(2-Cl,3,5-di-OCHF₂,4-Et) Ph(2-Cl,3,5-di-OCHF₂,4-n-Pr) Ph(2-Cl,3,5-di-OCHF₂,4-t-Bu) Ph(2-Cl,3,5-di-OCHF₂,4-i-Pr) Ph(2-Cl,3,5-di-OCHF₂,4-c-Pr) Ph(2-Cl,3,5-di-OCHF₂CF₃,4- CF₃) Ph(2-Cl,3-OC₂F₅,4-C₂F₅,5- OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4- CF₂CF₂H) Ph(2-Cl,3-OCHF₂,4-CF₂H,5- OCHF₂) Ph(2-Cl,3,5-di OCHF₂,4-OMe) Ph(2-Cl,3,5-di-OCHF₂,4-OCF₃) Ph(2-Cl,3,4,5-tri-OCHF₂) Ph(2-Cl,3-OCHF₂,4- OCF₂CF₂H,5-OCHF₂) Ph(2-Cl,3-OCHF₂,4-OC₂F₅,5- OCHF₂) Ph(2-Cl,3,5-di-OCHF₂,4-SO₂Me) Ph(2-Cl,3,5-di-OCHF₂,4-TMS) Ph(2-Cl,3,5-di-OCHF₂,4-CN) Ph(2-F,3,4,5-tri-Cl) Ph(2-F,3-Cl,4-F,5-Cl) Ph(2-F,3-Cl,4-Br,5-Cl) Ph(2-F,3-Cl,4-I,5-Cl) Ph(2-F,3-Cl,4-Me,5-Cl) Ph(2-F,3-Cl,4-Et,5-Cl) Ph(2-F,3-Cl,4-n-Pr,5-Cl) Ph(2-F,3-Cl,4-t-Bu,5-Cl) Ph(2-F,3-Cl,4-i-Pr,5-Cl) Ph(2-F,3-Cl,4-c-Pr,5-Cl) Ph(2-F,3-Cl,4-CF₃,5-Cl) Ph(2-F,3-Cl,4-C₂F₅,5-Cl) Ph(2-F,3-Cl,4-CF₂CF₂H,5-Cl) Ph(2-F,3-Cl,4-CF₂H,5-Cl) Ph(2-F,3-Cl,4-OMe,5-Cl) Ph(2-F,3-Cl,4-OCF₃,5-Cl) Ph(2-F,3-Cl,4-OCHF₂,5-Cl) Ph(2-F,3-Cl,4-OCF₂CF₂H,5-Cl) Ph(2-F,3,5-di-Cl,4-OC₂F₅) Ph(2-F,3-Cl,4-SO₂Me,5-Cl) Ph(2-F,3-Cl,4-TMS,5-Cl) Ph(2-F,3-Cl,4-CN,5-Cl) Ph(2-F,3-F,4-Cl,5-F) Ph(2,3,4,5-tetra-F) Ph(2-F,3-F,4-Br,5-F) Ph(2-F,3-F,4-I,5-F) Ph(2-F,3-F,4-Me,5-F) Ph(2-F,3-F,4-Et,5-F) Ph(2-F,3-F,4-n-Pr,5-F) Ph(2-F,3-F,4-t-Bu,5-F) Ph(2-F,3-F,4-i-Pr,5-F) Ph(2-F,3-F,4-c-Pr,5-F) Ph(2-F,3-F,4-CF₃,5-F) Ph(2-F,3-F,4-C₂F₅,5-F) Ph(2-F,3-F,4-CF₂CF₂H,5-F) Ph(2-F,3-F,4-CF₂H,5-F) Ph(2-F,3-F,4-OMe,5-F) Ph(2-F,3-F,4-OCF₃,5-F) Ph(2-F,3-F,4-OCHF₂,5-F) Ph(2-F,3-F,4-OCF₂CF₂H,5-F) Ph(2-F,3-F,4-OC₂F₅,5-F) Ph(2-F,3-F,4-SO₂Me,5-F) Ph(2-F,3-F,4-TMS,5-F) Ph(2-F,3-F,4-CN,5-F) Ph(2-F,3-Br,4-Cl,5-Br) Ph(2-F,3-Br,4-F,5-Br) Ph(2-F,3,4,5-tri-Br) Ph(2-F,3-Br,4-I,5-Br) Ph(2-F,3-Br,4-Me,5-Br) Ph(2-F,3-Br,4-Et,5-Br) Ph(2-F,3-Br,4-n-Pr,5-Br) Ph(2-F,3-Br,4-t-Bu,5-Br) Ph(2-F,3-Br,4-i-Pr,5-Br) Ph(2-F,3-Br,4-c-Pr,5-Br) Ph(2-F,3-Br,4-CF₃,5-Br) Ph(2-F,3,5-di-Br,4-C₂F₅) Ph(2-F,3-Br,4-CF₂CF₂H,5-Br) Ph(2-F,3-Br,4-CF₂H,5-Br) Ph(2-F,3-Br,4-OMe,5-Br) Ph(2-F,3-Br,4-OCF₃,5-Br) Ph(2-F,3-Br,4-OCHF₂,5-Br) Ph(2-F,3-Br,4-OCF₂CF₂H,5-Br) Ph(2-F,3-Br,4-OC₂F₅,5-Br) Ph(2-F,3-Br,4-SO₂Me,5-Br) Ph(2-F,3-Br,4-TMS,5-Br) Ph(2-F,3-Br,4-CN,5-Br) Ph(2-F,3-Me,4-Cl,5-Me) Ph(2-F,3-Me,4-F,5-Me) Ph(2-F,3-Me,4-Br,5-Me) Ph(2-F,3-Me,4-I,5-Me) Ph(2-F,3,4-tri-Me) Ph(2-F,3-Me,4-Et,5-Me) Ph(2-F,3-Me,4-n-Pr,5-Me) Ph(2-F,3-Me,4-t-Bu,5-Me) Ph(2-F,3-Me,4-i-Pr,5-Me) Ph(2-F,3-Me,4-c-Pr,5-Me) Ph(2-F,3-Me,4-CF₃,5-Me) Ph(2-F,3-Me,4-C₂F₅,5-Me) Ph(2-F,3-Me,4-CF₂CF₂H,5-Me) Ph(2-F,3-Me,4-CF₂H,5-Me) Ph(2-F,3-Me,4-OMe,5-Me) Ph(2-F,3-Me,4-OCF₃,5-Me) Ph(2-F,3-Me,4-OCHF₂,5-Me) Ph(2-F,3-Me,4-OCF₂CF₂H,5-Me) Ph(2-F,3-Me,4-OC₂F₅,5-Me) Ph(2-F,3-Me,4-SO₂Me,5-Me) Ph(2-F,3-Me,4-TMS,5-Me) Ph(2-F,3-Me,4-CN,5-Me) Ph(2-F,3-CF₃,4-Cl,5-CF₃) Ph(2-F,3-CF₃,4-F,5-CF₃) Ph(2-F,3-CF₃,4-Br,5-CF₃) Ph(2-F,3-CF₃,4-I,5-CF₃) Ph(2-F,3-CF₃,4-Me,5-CF₃) Ph(2-F,3-CF₃,4-Et,5-CF₃) Ph(2-F,3-CF₃,4-n-Pr,5-CF₃) Ph(2-F,3-CF₃,4-t-Bu,5-CF₃) Ph(2-F,3-CF₃,4-i-Pr,5-CF₃) Ph(2-F,3-CF₃,4-c-Pr,5-CF₃) Ph(2-F,3,4,5-tri-CF₃) Ph(2-F,3-CF₃,4-C₂F₅,5-CF₃) Ph(2-F,3-CF₃,4-CF₂CF₂H,5-CF₃) Ph(2-F,3-CF₃,4-CF₂H,5-CF₃) Ph(2-F,3-CF₃,4-OMe,5-CF₃) Ph(2-F,3-CF₃,4-OCF₃,5-CF₃) Ph(2-F,3-CF₃,4-OCHF₂,5-CF₃) Ph(2-F,3-CF₃,4-OCF₂CF₂H,5- CF₃) Ph(2-F,3-CF₃,4-OC₂F₅,5-CF₃) Ph(2-F,3-CF₃,4-SO₂Me,5-CF₃) Ph(2-F,3-CF₃,4-TMS,5-CF₃) Ph(2-F,3-CF₃,4-CN,5-CF₃) Ph(2-F,3-OCHF₂,4-Cl,5-OCHF₂) Ph(2-F,3-OCHF₂,4-F,5-OCHF₂) Ph(2-F,3-OCHF₂,4-Br,5-OCHF₂) Ph(2-F,3-OCHF₂,4-I,5-OCHF₂) Ph(2-F,3-OCHF₂,4-Me,5- OCHF₂) Ph(2-F,3-OCHF₂,4-Et,5-OCHF₂) Ph(2-F,3-OCHF₂,4-n-Pr,5- OCHF₂) Ph(2-F,3-OCHF₂,4-t-Bu,5- OCHF₂) Ph(2-F,3-OCHF₂,4-i-Pr,5- OCHF₂) Ph(2-F,3,5-di-OCHF₂,4-c-Pr) Ph(2-F,3-OCHF₂CF₃,4-CF₃,5- OCHF₂) Ph(2-F,3-OC₂F₅,4-C₂F₅,5- OCHF₂) Ph(2-F,3,5-di-OCHF₂,4- CF₂CF₂H) Ph(2-F,3-OCHF₂,4-CF₂H,5- OCHF₂) Ph(2-F,3-OCHF₂,4-OMe,5- OCHF₂) Ph(2-F,3-OCHF₂,4-OCF₃,5- OCHF₂) Ph(2-F,3,4,5-tri-OCHF₂) Ph(2-F,3-OCHF₂,4- OCF₂CF₂H,5-OCHF₂) Ph(2-F,3-OCHF₂,4-OC₂F₅,5- OCHF₂) Ph(2-F,3-OCHF₂,4-SO₂Me,5- OCHF₂) Ph(2-F,3-OCHF₂,4-TMS,5- OCHF₂) Ph(2-F,3-OCHF₂,4-CN,5- OCHF₂) 1H-Imidazol-2-yl(1-CF₂CF₂H,5- Cl) 1H-Imidazol-2-yl(1-CF₂CF₂H,5- F) 1H-Imidazol-2-yl(1-CH₂CF₃,5- Cl) 1H-Imidazol-2-yl(1-CH₂CF₃,5-F) 1H-Imidazol-2-yl(1-Me,5-CF₂H) 1H-Imidazol-2-yl(1-CF₂CF₂H,5- CF₂H) 1H-Imidazol-2-yl(1-CH₂CF₃,5- CF₂H) 1H-Imidazol-2-yl(1-Me,5-CF₃) 1H-Imidazol-2-yl(1-CF₂CF₂H,5- CF₃) 1H-Imidazol-2-yl(1-CH₂CF₃,5- CF₃) 1,3-Benzodioxo1-4-yl 1,3-Benzodioxo1-4-yl(2,2-di-Me) 1,4-Benzodioxo1-4-yl(2,3- dihydro) 1,4-Benzodioxo1-4-yl(2,2,3,3- tetrafluoro) 1H-Pyrazol-3-yl(1-CH₂CF₃,4-F) 1H-Pyrazol-3-yl(1-CH₂CF₃,4-Cl) 1H-Pyrazol-3-yl(1-CF₂CF₂H,4-F) 1H-Pyrazol-3-yl(1-CF₂CF₂H,4- Cl) 1,3-Benzodioxo1-4-yl(2,2-di-F)

Table 2 is constructed in the same manner except that the Row Heading “Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is” is replaced with the Row Heading listed for Table 2 below (i.e. “Y¹ is O; Y¹ is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-F); and Q¹ is”). Therefore the first entry in Table 2 is a compound of Formula 1 wherein Y¹ is O, R² is H, R⁴ is H, R⁵ is H, Q² is Ph(2,3-F); and Q¹ is Ph(3-Cl) (i.e. 3-chlorophenyl).

Tables 3 through 1699 are constructed similarly. Table Row Heading 2 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 3 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 4 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 5 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 6 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 7 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 8 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 9 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 10 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 11 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 12 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 13 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 14 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 15 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 16 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 17 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 18 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 19 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 20 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 21 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 22 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 23 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 24 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 25 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 26 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 27 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 28 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 29 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 30 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 31 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 32 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 33 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 34 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 35 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 36 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 37 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 38 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 39 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 40 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 41 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 42 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 43 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 44 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 45 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 46 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 47 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 48 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 49 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 50 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 51 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 52 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 53 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 54 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 55 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 56 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 57 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 58 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 59 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 60 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 61 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 62 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 63 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 64 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 65 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 66 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 67 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 68 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 69 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 70 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 71 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 72 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 73 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 74 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 75 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 76 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 77 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 78 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 79 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 80 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 81 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 82 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 83 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 84 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 85 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 86 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 87 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 88 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 89 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 90 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 91 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 92 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 93 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 94 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 95 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 96 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 97 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 98 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 99 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 100 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 101 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 102 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 103 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 104 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 105 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 106 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 107 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 108 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 109 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 110 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 111 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 112 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 113 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 114 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 115 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 116 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 117 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 118 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 119 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 120 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 121 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 122 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 123 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 124 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 125 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 126 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 127 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 128 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 129 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 130 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 131 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 132 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 133 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 134 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 135 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 136 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 137 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 138 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 139 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 140 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 141 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 142 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 143 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 144 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 145 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 146 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 147 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 148 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 149 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 150 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 151 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 152 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 153 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 154 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 155 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 156 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 157 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 158 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 159 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 160 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 161 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 162 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 163 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 164 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 165 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 166 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 167 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 168 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 169 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 170 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 171 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is 172 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 173 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 174 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 175 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 176 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 177 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 178 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 179 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 180 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 181 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 182 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 183 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 184 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 185 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 186 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 187 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 188 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 189 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 190 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 191 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 192 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 193 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 194 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 195 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 196 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 197 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 198 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 199 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 200 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 201 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 202 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 203 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 204 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 205 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 206 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 207 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 208 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 209 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 210 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 211 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 212 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 213 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 214 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 215 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 216 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 217 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 218 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 219 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 220 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 221 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 222 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 223 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 224 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 225 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 226 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 227 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 228 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 229 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 230 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 231 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 232 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 233 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 234 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 235 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 236 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 237 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 238 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 239 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 240 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 241 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 242 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 243 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 244 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 245 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 246 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 247 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 248 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 249 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 250 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 251 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 252 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 253 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 254 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 255 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 256 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 257 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 258 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 259 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 260 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 261 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 262 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 263 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 264 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 265 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 266 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 267 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 268 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 269 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 270 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 271 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 272 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 273 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 274 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 275 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 276 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 277 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 278 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 279 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 280 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 281 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 282 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 283 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 284 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 285 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 286 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 287 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 288 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 289 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 290 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 291 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 292 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 293 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 294 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 295 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 296 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 297 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 298 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 299 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 300 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 301 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 302 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 303 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 304 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 305 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 306 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 307 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 308 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 309 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 310 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 311 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 312 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 313 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 314 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 315 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 316 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 317 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 318 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 319 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 320 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 321 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 322 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 323 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 324 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 325 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 326 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 327 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 328 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 329 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 330 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 331 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 332 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 333 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 334 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 335 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 336 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 337 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 338 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 339 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 340 Y¹ is S; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 341 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is 342 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 343 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 344 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 345 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 346 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 347 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 348 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 349 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 350 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 351 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 352 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 353 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 354 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 355 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 356 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 357 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 358 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 359 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 360 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 361 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 362 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 363 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 364 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 365 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 366 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 367 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 368 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 369 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 370 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 371 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 372 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 373 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 374 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 375 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 376 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 377 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 378 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 379 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 380 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 381 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 382 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 383 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 384 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 385 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 386 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 387 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 388 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 389 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 390 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 391 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 392 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 393 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 394 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 395 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 396 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 397 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 398 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 399 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 400 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 401 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 402 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 403 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 404 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 405 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 406 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 407 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 408 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 409 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 410 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 411 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 412 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 413 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 414 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 415 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 416 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 417 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 418 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 419 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 420 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 421 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 422 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 423 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 424 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 425 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 426 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 427 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 428 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 429 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 430 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 431 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 432 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 433 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 434 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 435 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 436 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 437 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 438 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 439 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 440 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 441 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 442 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 443 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 444 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 445 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 446 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 447 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 448 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 449 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 450 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 451 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 452 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 453 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 454 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 455 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 456 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 457 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 458 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 459 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 460 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 461 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 462 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 463 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 464 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 465 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 466 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 467 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 468 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 469 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 470 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 471 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 472 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 473 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 474 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 475 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 476 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 477 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 478 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 479 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 480 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 481 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 482 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 483 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 484 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 485 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 486 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 487 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 488 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 489 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 490 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 491 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 492 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 493 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 494 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 495 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 496 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 497 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 498 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 499 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 500 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 501 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 502 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 503 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 504 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 505 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 506 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 507 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 508 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 509 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 510 Y¹ is O; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 511 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is 512 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 513 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 514 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 515 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 516 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 517 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 518 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 519 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 520 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 521 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 522 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 523 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 524 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 525 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 526 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 527 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 528 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 529 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 530 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 531 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 532 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 533 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 534 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 535 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 536 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 537 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 538 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 539 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 540 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 541 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 542 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 543 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 544 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 545 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 546 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 547 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 548 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 549 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 550 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 551 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 552 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 553 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 554 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 555 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 556 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 557 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 558 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 559 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 560 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 561 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 562 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 563 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 564 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 565 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 566 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 567 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 568 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 569 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 570 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 571 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 572 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 573 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 574 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 575 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 576 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 577 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 578 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 579 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 580 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 581 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 582 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 583 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 584 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 585 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 586 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 587 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 588 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 589 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 590 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 591 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 592 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 593 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 594 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 595 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 596 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 597 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 598 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 599 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 600 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 601 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 602 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 603 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 604 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 605 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 606 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 607 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 608 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 609 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 610 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 611 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 612 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 613 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 614 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 615 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 616 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 617 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 618 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 619 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 620 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 621 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 622 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 623 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 624 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 625 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 626 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 627 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 628 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 629 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 630 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 631 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 632 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 633 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 634 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 635 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 636 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 637 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 638 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 639 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 640 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 641 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 642 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 643 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 644 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 645 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 646 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 647 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 648 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 649 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 650 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 651 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 652 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 653 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 654 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 655 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 656 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 657 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 658 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 659 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 660 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 661 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 662 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 663 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 664 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 665 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 666 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 667 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 668 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 669 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 670 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 671 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 672 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 673 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 674 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 675 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 676 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 677 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 678 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 679 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 680 Y¹ is S; Y² is S; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 681 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is 682 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 683 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 684 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 685 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 686 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 687 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 688 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 689 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 690 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 691 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 692 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 693 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 694 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 695 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 696 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 697 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 698 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 699 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 700 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 701 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 702 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 703 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 704 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 705 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 706 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 707 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 708 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 709 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 710 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 711 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 712 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 713 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 714 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 715 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 716 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 717 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 718 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 719 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 720 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 721 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 722 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 723 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 724 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 725 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 726 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 727 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 728 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 729 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 730 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 731 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 732 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 733 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 734 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 735 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 736 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 737 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 738 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 739 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 740 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 741 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 742 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 743 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 744 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 745 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 746 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 747 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 748 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 749 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 750 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 751 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 752 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 753 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 754 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 755 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 756 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 757 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 758 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 759 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 760 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 761 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 762 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 763 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 764 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 765 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 766 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 767 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 768 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 769 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 770 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 771 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 772 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 773 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 774 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 775 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 776 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 777 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 778 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 779 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 780 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 781 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 782 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 783 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 784 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 785 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 786 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 787 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 788 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 789 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 790 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 791 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 792 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 793 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 794 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 795 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 796 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 797 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 798 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 799 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 800 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 801 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 802 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 803 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 804 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 805 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 806 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 807 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 808 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 809 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 810 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 811 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 812 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 813 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 814 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 815 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 816 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 817 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 818 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 819 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 820 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 821 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 822 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 823 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 824 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 825 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 826 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 827 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 828 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 829 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 830 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 831 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 832 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 833 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 834 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 835 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 836 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 837 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 838 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 839 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 840 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 841 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 842 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 843 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 844 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 845 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 846 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 847 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 848 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 849 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 850 Y¹ is NH; Y² is O; R² is H; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 851 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F); and Q¹ is 852 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 853 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 854 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 855 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 856 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 857 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 858 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 859 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 860 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 861 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 862 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 863 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 864 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 865 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 866 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 867 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 868 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 869 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 870 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 871 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 872 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 873 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 874 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 875 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 876 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 877 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 878 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 879 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 880 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 881 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 882 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 883 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 884 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 885 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 886 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 887 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 888 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 889 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 890 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 891 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 892 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 893 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 894 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 895 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 896 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 897 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 898 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 899 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 900 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 901 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 902 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 903 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 904 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 905 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 906 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 907 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 908 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 909 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 910 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 911 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 912 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 913 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 914 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 915 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 916 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 917 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 918 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 919 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 920 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 921 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 922 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 923 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 924 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 925 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 926 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 927 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 928 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 929 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 930 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 931 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 932 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 933 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 934 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 935 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 936 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 937 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 938 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 939 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 940 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 941 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 942 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 943 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 944 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 945 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 946 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 947 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 948 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 949 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-I); and Q¹ is 950 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 951 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 952 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 953 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 954 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 955 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 956 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 957 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 958 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 959 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 960 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 961 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 962 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 963 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 964 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 965 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 966 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 967 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 968 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 969 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 970 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 971 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 972 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 973 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 974 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 975 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 976 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 977 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 978 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 979 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 980 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 981 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 982 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-F); and Q¹ is 983 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 984 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 985 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 986 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 987 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 988 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 989 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 990 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 991 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 992 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 993 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 994 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 995 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 996 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 997 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 998 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 999 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1000 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 1001 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 1002 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 1003 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 1004 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 1005 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 1006 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 1007 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 1008 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 1009 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 1010 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 1011 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1012 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 1013 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(4-F); and Q¹ is 1014 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 1015 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1016 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1017 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1018 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 1019 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 1020 Y¹ is O; Y² is O; R² is Me; R⁴ is H; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1021 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F); and Q¹ is 1022 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 1023 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 1024 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 1025 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 1026 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 1027 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1028 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 1029 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 1030 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1031 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 1032 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1033 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 1034 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 1035 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 1036 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1037 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 1038 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 1039 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 1040 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 1041 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1042 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 1043 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1044 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 1045 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 1046 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1047 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1048 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 1049 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 1050 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 1051 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 1052 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1053 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1054 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 1055 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 1056 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 1057 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1058 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1059 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1060 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 1061 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 1062 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 1063 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 1064 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 1065 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 1066 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 1067 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 1068 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1069 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 1070 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 1071 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 1072 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 1073 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1074 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 1075 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 1076 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 1077 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 1078 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 1079 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 1080 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1081 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1082 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 1083 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 1084 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 1085 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1086 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1087 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 1088 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 1089 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 1090 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 1091 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1092 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 1093 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 1094 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 1095 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 1096 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1097 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 1098 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 1099 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 1100 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 1101 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 1102 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 1103 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 1104 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 1105 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 1106 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 1107 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 1108 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1109 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1110 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 1111 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 1112 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1113 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 1114 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1115 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 1116 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 1117 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 1118 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 1119 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-I); and Q¹ is 1120 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 1121 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 1122 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 1123 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 1124 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 1125 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 1126 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 1127 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 1128 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 1129 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 1130 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 1131 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 1132 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 1133 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1134 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 1135 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 1136 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1137 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 1138 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1139 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 1140 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 1141 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1142 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1143 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 1144 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 1145 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1146 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 1147 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1148 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 1149 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 1150 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1151 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1152 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-F); and Q¹ is 1153 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 1154 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 1155 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 1156 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 1157 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 1158 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 1159 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1160 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 1161 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 1162 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 1163 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1164 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1165 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 1166 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 1167 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 1168 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1169 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1170 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 1171 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 1172 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 1173 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 1174 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 1175 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 1176 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 1177 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 1178 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 1179 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 1180 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 1181 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1182 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 1183 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(4-F); and Q¹ is 1184 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 1185 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1186 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1187 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1188 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 1189 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 1190 Y¹ is O; Y² is O; R² is H; R⁴ is Br; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1191 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F); and Q¹ is 1192 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3-di-F); and Q¹ is 1193 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,4-di-F); and Q¹ is 1194 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,5-di-F); and Q¹ is 1195 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3,4-tri-F); and Q¹ is 1196 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3,5-tri-F); and Q¹ is 1197 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1198 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 1199 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 1200 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1201 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Me); and Q¹ is 1202 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1203 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 1204 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-Cl); and Q¹ is 1205 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,4-Cl); and Q¹ is 1206 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1207 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,4-Br); and Q¹ is 1208 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-OMe); and Q¹ is 1209 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 1210 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 1211 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1212 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-CF₃); and Q¹ is 1213 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1214 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-NO₂); and Q¹ is 1215 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 1216 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1217 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1218 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃); and Q¹ is 1219 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,3-F); and Q¹ is 1220 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,3-Me); and Q¹ is 1221 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,4-F); and Q¹ is 1222 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1223 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1224 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 1225 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H); and Q¹ is 1226 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,3-F); and Q¹ is 1227 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1228 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1229 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1230 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 1231 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 1232 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me); and Q¹ is 1233 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3-di-Me); and Q¹ is 1234 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-F); and Q¹ is 1235 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-Cl); and Q¹ is 1236 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-CF₃); and Q¹ is 1237 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 1238 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1239 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,4-Cl); and Q¹ is 1240 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,4-F); and Q¹ is 1241 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,5-F); and Q¹ is 1242 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 1243 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1244 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et); and Q¹ is 1245 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,3-F); and Q¹ is 1246 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,3-Cl); and Q¹ is 1247 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,4-F); and Q¹ is 1248 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 1249 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr); and Q¹ is 1250 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1251 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1252 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr,4-F); and Q¹ is 1253 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 1254 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr); and Q¹ is 1255 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1256 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1257 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr,4-F); and Q¹ is 1258 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 1259 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂); and Q¹ is 1260 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,3-F); and Q¹ is 1261 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1262 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,4-F); and Q¹ is 1263 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 1264 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₃); and Q¹ is 1265 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₃,3-F); and Q¹ is 1266 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1267 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl); and Q¹ is 1268 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3-Me); and Q¹ is 1269 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 1270 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,3-di-Cl); and Q¹ is 1271 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2,4-di-Cl); and Q¹ is 1272 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3-F); and Q¹ is 1273 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,4-F); and Q¹ is 1274 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,5-F); and Q¹ is 1275 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 1276 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 1277 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H); and Q¹ is 1278 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1279 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1280 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 1281 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 1282 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1283 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 1284 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1285 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Br); and Q¹ is 1286 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Br,3-F); and Q¹ is 1287 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Br,4-F); and Q¹ is 1288 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 1289 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-I); and Q¹ is 1290 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-I,3-F); and Q¹ is 1291 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-I,4-F); and Q¹ is 1292 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-I,3,4-di-F); and Q¹ is 1293 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN); and Q¹ is 1294 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,3-Me); and Q¹ is 1295 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,3-F); and Q¹ is 1296 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,4-F); and Q¹ is 1297 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,3-Cl); and Q¹ is 1298 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,4-Cl); and Q¹ is 1299 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 1300 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl; and Q¹ is 1301 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,3-F; and Q¹ is 1302 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,4-F; and Q¹ is 1303 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1304 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 1305 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 1306 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1307 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me); and Q¹ is 1308 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1309 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 1310 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 1311 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1312 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1313 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 1314 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 1315 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1316 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂); and Q¹ is 1317 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1318 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 1319 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 1320 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1321 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1322 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-F); and Q¹ is 1323 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,4-di-F); and Q¹ is 1324 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,5-di-F); and Q¹ is 1325 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,4,5-tri-F); and Q¹ is 1326 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-F,4-Cl); and Q¹ is 1327 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃); and Q¹ is 1328 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,4-F); and Q¹ is 1329 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1330 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,5-F); and Q¹ is 1331 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 1332 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me); and Q¹ is 1333 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1334 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1335 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 1336 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 1337 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂); and Q¹ is 1338 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1339 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1340 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 1341 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 1342 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me); and Q¹ is 1343 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,4-F); and Q¹ is 1344 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,4-Cl); and Q¹ is 1345 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,5-F); and Q¹ is 1346 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 1347 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Cl); and Q¹ is 1348 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Cl,4-F); and Q¹ is 1349 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,4-di-Cl); and Q¹ is 1350 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Cl,5-F); and Q¹ is 1351 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1352 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(3,5-di-Cl); and Q¹ is 1353 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(4-F); and Q¹ is 1354 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is Ph(4-Cl); and Q¹ is 1355 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1356 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1357 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1358 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 1359 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 1360 Y¹ is O; Y² is O; R² is H; R⁴ is Cl; R⁵ is H; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1361 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F); and Q¹ is 1362 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3-di-F); and Q¹ is 1363 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,4-di-F); and Q¹ is 1364 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,5-di-F); and Q¹ is 1365 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3,4-tri-F); and Q¹ is 1366 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3,5-tri-F); and Q¹ is 1367 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1368 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 1369 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 1370 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1371 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Me); and Q¹ is 1372 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1373 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 1374 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-Cl); and Q¹ is 1375 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,4-Cl); and Q¹ is 1376 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1377 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,4-Br); and Q¹ is 1378 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-OMe); and Q¹ is 1379 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 1380 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 1381 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1382 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-CF₃); and Q¹ is 1383 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1384 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-NO₂); and Q¹ is 1385 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 1386 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1387 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1388 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃); and Q¹ is 1389 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3-F); and Q¹ is 1390 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3-Me); and Q¹ is 1391 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,4-F); and Q¹ is 1392 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1393 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1394 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 1395 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H); and Q¹ is 1396 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3-F); and Q¹ is 1397 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1398 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1399 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1400 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 1401 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 1402 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me); and Q¹ is 1403 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3-di-Me); and Q¹ is 1404 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3-F); and Q¹ is 1405 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3-Cl); and Q¹ is 1406 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3-CF₃); and Q¹ is 1407 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 1408 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1409 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,4-Cl); and Q¹ is 1410 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,4-F); and Q¹ is 1411 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,5-F); and Q¹ is 1412 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 1413 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1414 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et); and Q¹ is 1415 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,3-F); and Q¹ is 1416 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,3-Cl); and Q¹ is 1417 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,4-F); and Q¹ is 1418 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 1419 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr); and Q¹ is 1420 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1421 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1422 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr,4-F); and Q¹ is 1423 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 1424 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr); and Q¹ is 1425 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1426 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1427 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr,4-F); and Q¹ is 1428 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 1429 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂); and Q¹ is 1430 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂,3-F); and Q¹ is 1431 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1432 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂,4-F); and Q¹ is 1433 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 1434 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₃); and Q¹ is 1435 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₃,3-F); and Q¹ is 1436 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1437 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl); and Q¹ is 1438 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3-Me); and Q¹ is 1439 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 1440 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,3-di-Cl); and Q¹ is 1441 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2,4-di-Cl); and Q¹ is 1442 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3-F); and Q¹ is 1443 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,4-F); and Q¹ is 1444 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,5-F); and Q¹ is 1445 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 1446 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 1447 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H); and Q¹ is 1448 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1449 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1450 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 1451 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 1452 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1453 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 1454 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1455 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Br); and Q¹ is 1456 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Br,3-F); and Q¹ is 1457 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Br,4-F); and Q¹ is 1458 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 1459 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-I); and Q¹ is 1460 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-I,3-F); and Q¹ is 1461 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-I,4-F); and Q¹ is 1462 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-I,3,4-di-F); and Q¹ is 1463 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN); and Q¹ is 1464 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3-Me); and Q¹ is 1465 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3-F); and Q¹ is 1466 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,4-F); and Q¹ is 1467 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3-Cl); and Q¹ is 1468 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,4-Cl); and Q¹ is 1469 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 1470 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl; and Q¹ is 1471 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,3-F; and Q¹ is 1472 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,4-F; and Q¹ is 1473 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1474 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 1475 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 1476 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1477 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me); and Q¹ is 1478 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1479 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 1480 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 1481 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1482 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1483 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 1484 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 1485 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1486 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂); and Q¹ is 1487 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1488 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 1489 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 1490 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1491 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1492 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-F); and Q¹ is 1493 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3,4-di-F); and Q¹ is 1494 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3,5-di-F); and Q¹ is 1495 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3,4,5-tri-F); and Q¹ is 1496 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-F,4-Cl); and Q¹ is 1497 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃); and Q¹ is 1498 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃,4-F); and Q¹ is 1499 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1500 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃,5-F); and Q¹ is 1501 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 1502 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me); and Q¹ is 1503 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1504 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1505 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 1506 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 1507 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂); and Q¹ is 1508 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1509 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1510 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 1511 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 1512 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me); and Q¹ is 1513 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,4-F); and Q¹ is 1514 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,4-Cl); and Q¹ is 1515 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,5-F); and Q¹ is 1516 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 1517 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Cl); and Q¹ is 1518 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Cl,4-F); and Q¹ is 1519 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3,4-di-Cl); and Q¹ is 1520 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Cl,5-F); and Q¹ is 1521 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1522 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(3,5-di-Cl); and Q¹ is 1523 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(4-F); and Q¹ is 1524 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is Ph(4-Cl); and Q¹ is 1525 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1526 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1527 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1528 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 1529 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 1,3-benzodioxol-4-yl; and Q¹ is 1530 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Br; Q² is 1,3-benzodioxol-5-yl; and Q¹ is 1531 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F); and Q¹ is 1532 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3-di-F); and Q¹ is 1533 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,4-di-F); and Q¹ is 1534 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,5-di-F); and Q¹ is 1535 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3,4-tri-F); and Q¹ is 1536 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3,5-tri-F); and Q¹ is 1537 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3,4,5-tetra-F); and Q¹ is 1538 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Cl,4-Br); and Q¹ is 1539 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Cl,4-F); and Q¹ is 1540 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Br,4-F); and Q¹ is 1541 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Me); and Q¹ is 1542 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Me,4-F); and Q¹ is 1543 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Me,4-Cl); and Q¹ is 1544 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-Cl); and Q¹ is 1545 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,4-Cl); and Q¹ is 1546 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3,4-di-Cl); and Q¹ is 1547 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,4-Br); and Q¹ is 1548 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-OMe); and Q¹ is 1549 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-OMe,4-F); and Q¹ is 1550 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-OMe,4-Cl); and Q¹ is 1551 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-CF₂H); and Q¹ is 1552 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-CF₃); and Q¹ is 1553 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-CF₃,4-F); and Q¹ is 1554 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-NO₂); and Q¹ is 1555 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-NO₂,4-F); and Q¹ is 1556 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-SO₂Me); and Q¹ is 1557 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-F,3-SO₂Me,4-F); and Q¹ is 1558 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃); and Q¹ is 1559 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,3-F); and Q¹ is 1560 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,3-Me); and Q¹ is 1561 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,4-F); and Q¹ is 1562 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,3-Cl); and Q¹ is 1563 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,4-Cl); and Q¹ is 1564 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₃,3,4-di-F); and Q¹ is 1565 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H); and Q¹ is 1566 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,3-F); and Q¹ is 1567 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,3-Me); and Q¹ is 1568 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,4-F); and Q¹ is 1569 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,3-Cl); and Q¹ is 1570 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,4-Cl); and Q¹ is 1571 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CF₂H,3,4-di-F); and Q¹ is 1572 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me); and Q¹ is 1573 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3-di-Me); and Q¹ is 1574 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-F); and Q¹ is 1575 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-Cl); and Q¹ is 1576 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-CF₃); and Q¹ is 1577 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3,4-di-Cl); and Q¹ is 1578 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3-Cl,4-F); and Q¹ is 1579 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,4-Cl); and Q¹ is 1580 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,4-F); and Q¹ is 1581 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,5-F); and Q¹ is 1582 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3,4-di-F); and Q¹ is 1583 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Me,3,5-di-F); and Q¹ is 1584 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et); and Q¹ is 1585 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,3-F); and Q¹ is 1586 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,3-Cl); and Q¹ is 1587 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,4-F); and Q¹ is 1588 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Et,3,4-di-F); and Q¹ is 1589 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr); and Q¹ is 1590 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr,3-F); and Q¹ is 1591 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr,3-Cl); and Q¹ is 1592 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr,4-F); and Q¹ is 1593 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-i-Pr,3,4-di-F); and Q¹ is 1594 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr); and Q¹ is 1595 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr,3-F); and Q¹ is 1596 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr,3-Cl); and Q¹ is 1597 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr,4-F); and Q¹ is 1598 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-c-Pr,3,4-di-F); and Q¹ is 1599 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂); and Q¹ is 1600 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,3-F); and Q¹ is 1601 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,3-Cl); and Q¹ is 1602 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,4-F); and Q¹ is 1603 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-NO₂,3,4-di-F); and Q¹ is 1604 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₃); and Q¹ is 1605 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₃,3-F); and Q¹ is 1606 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₃,4-F); and Q¹ is 1607 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl); and Q¹ is 1608 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3-Me); and Q¹ is 1609 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3-Me,4-F); and Q¹ is 1610 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,3-di-Cl); and Q¹ is 1611 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2,4-di-Cl); and Q¹ is 1612 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3-F); and Q¹ is 1613 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,4-F); and Q¹ is 1614 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,5-F); and Q¹ is 1615 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3,4-di-F); and Q¹ is 1616 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Cl,3,5-di-F); and Q¹ is 1617 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H); and Q¹ is 1618 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,3-Me); and Q¹ is 1619 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,3-Cl); and Q¹ is 1620 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,3-F); and Q¹ is 1621 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂H,4-F); and Q¹ is 1622 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂CF₂H); and Q¹ is 1623 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂CF₂H,3-F); and Q¹ is 1624 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-OCF₂CF₂H,4-F); and Q¹ is 1625 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br); and Q¹ is 1626 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br,3-F); and Q¹ is 1627 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br,4-F); and Q¹ is 1628 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-Br,3,4-di-F); and Q¹ is 1629 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-I); and Q¹ is 1630 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-I,3-F); and Q¹ is 1631 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-I,4-F); and Q¹ is 1632 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-I,3,4-di-F); and Q¹ is 1633 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN); and Q¹ is 1634 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,3-Me); and Q¹ is 1635 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,3-F); and Q¹ is 1636 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,4-F); and Q¹ is 1637 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,3-Cl); and Q¹ is 1638 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,4-Cl); and Q¹ is 1639 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-CN,3,4-di-F); and Q¹ is 1640 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl; and Q¹ is 1641 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,3-F; and Q¹ is 1642 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,4-F; and Q¹ is 1643 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,3,4-di-F; and Q¹ is 1644 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,3-Cl; and Q¹ is 1645 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,4-Cl; and Q¹ is 1646 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2-Pyridinyl,3-Cl,4-F; and Q¹ is 1647 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me); and Q¹ is 1648 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-F); and Q¹ is 1649 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-Me); and Q¹ is 1650 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,4-F); and Q¹ is 1651 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,5-F); and Q¹ is 1652 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3,4-di-F); and Q¹ is 1653 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-Cl); and Q¹ is 1654 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,4-Cl); and Q¹ is 1655 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂Me,3-Cl,4-F); and Q¹ is 1656 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂); and Q¹ is 1657 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,3-F); and Q¹ is 1658 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,3-Cl); and Q¹ is 1659 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,4-F); and Q¹ is 1660 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,5-F); and Q¹ is 1661 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(2-SO₂NH₂,3,4-di-F); and Q¹ is 1662 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-F); and Q¹ is 1663 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,4-di-F); and Q¹ is 1664 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,5-di-F); and Q¹ is 1665 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,4,5-tri-F); and Q¹ is 1666 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-F,4-Cl); and Q¹ is 1667 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃); and Q¹ is 1668 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,4-F); and Q¹ is 1669 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,4-Cl); and Q¹ is 1670 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,5-F); and Q¹ is 1671 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-CF₃,4,5-di-F); and Q¹ is 1672 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me); and Q¹ is 1673 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,4-Cl); and Q¹ is 1674 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,4-F); and Q¹ is 1675 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,4,5-di-F); and Q¹ is 1676 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂Me,5-F); and Q¹ is 1677 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂); and Q¹ is 1678 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,4-F); and Q¹ is 1679 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,4,5-di-F); and Q¹ is 1680 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,4-Cl); and Q¹ is 1681 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-SO₂NH₂,5-F); and Q¹ is 1682 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me); and Q¹ is 1683 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,4-F); and Q¹ is 1684 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,4-Cl); and Q¹ is 1685 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,5-F); and Q¹ is 1686 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Me,4,5-di-F); and Q¹ is 1687 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Cl); and Q¹ is 1688 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Cl,4-F); and Q¹ is 1689 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,4-di-Cl); and Q¹ is 1690 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Cl,5-F); and Q¹ is 1691 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3-Cl,4,5-di-F); and Q¹ is 1692 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(3,5-di-Cl); and Q¹ is 1693 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(4-F); and Q¹ is 1694 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is Ph(4-Cl); and Q¹ is 1695 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2,2-di-F-1,3-benzodioxol-4-yl; and Q¹ is 1696 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2,2-di-F-1,3-benzodioxol-5-yl; and Q¹ is 1697 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2,2-di-Me-1,3-benzodioxol-4-yl; and Q¹ is 1698 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 2,2-di-Me-1,3-benzodioxol-5-yl; and Q¹ is 1699 Y¹ is O; Y² is O; R² is H; R⁴ is H; R⁵ is Cl; Q² is 1,3-benzodioxol-4-yl; and Q¹ is

Table 1700

Table 1700 is constructed the same way as Table 1 above, except the structure is replaced with the following:

Tables 1701 through 3399

This disclosure also includes Tables 1701 through 3399, each Table is constructed in the same fashion as Tables 2 through 1699 above, except that the structure is replaced with the structure in Table 1700 above.

Table 3400

Table 3400 is constructed the same way as Table 1 above, except the structure is replaced with the following:

Tables 3401 through 5099

This disclosure also includes Tables 3401 through 5099, each Table is constructed in the same fashion as Tables 2 through 1699 above, except that the structure is replaced with the structure in Table 3400 above.

Table 5100

Table 5100 is constructed the same way as Table 1 above, except the structure is replaced with the following:

Tables 5101 through 6799

This disclosure also includes Tables 5101 through 6799, each Table is constructed in the same fashion as Tables 2 through 1699 above, except that the structure is replaced with the structure in Table 5100 above.

TABLE I

The present disclosure also includes the intermediate compounds listed in Table I. Table 1 is constructed using the above Table I structure, combined with the individual values listed for Q¹ from Table 1.

TABLE II

The present disclosure also includes the intermediate compounds listed in Table II. Table II is constructed using the above Table II structure, combined with the individual values listed for Q¹ from Table 1.

TABLE III

The present disclosure also includes the intermediate compounds listed in Table III. Table III is constructed using the above Table III structure, combined with the individual values listed for Q¹ from Table 1.

TABLE IV

The present disclosure also includes the intermediate compounds listed in Table IV. Table IV is constructed using the above Table IV structure, combined with the individual values listed for Q¹ from Table 1.

Formulation/Utility

A compound of this invention will generally be used as a herbicidal active ingredient in a composition, i.e. formulation, with at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, which serves as a carrier. The formulation or composition ingredients are selected to be consistent with the physical properties of the active ingredient, mode of application and environmental factors such as soil type, moisture and temperature.

Useful formulations include both liquid and solid compositions. Liquid compositions include solutions (including emulsifiable concentrates), suspensions, emulsions (including microemulsions, oil-in-water emulsions, flowable concentrates and/or suspoemulsions) and the like, which optionally can be thickened into gels. The general types of aqueous liquid compositions are soluble concentrate, suspension concentrate, capsule suspension, concentrated emulsion, microemulsion, oil-in-water emulsion, flowable concentrate and suspo-emulsion. The general types of nonaqueous liquid compositions are emulsifiable concentrate, microemulsifiable concentrate, dispersible concentrate and oil dispersion.

The general types of solid compositions are dusts, powders, granules, pellets, prills, pastilles, tablets, filled films (including seed coatings) and the like, which can be water-dispersible (“wettable”) or water-soluble. Films and coatings formed from film-forming solutions or flowable suspensions are particularly useful for seed treatment. Active ingredient can be (micro)encapsulated and further formed into a suspension or solid formulation; alternatively the entire formulation of active ingredient can be encapsulated (or “overcoated”). Encapsulation can control or delay release of the active ingredient. An emulsifiable granule combines the advantages of both an emulsifiable concentrate formulation and a dry granular formulation. High-strength compositions are primarily used as intermediates for further formulation.

Sprayable formulations are typically extended in a suitable medium before spraying. Such liquid and solid formulations are formulated to be readily diluted in the spray medium, usually water, but occasionally another suitable medium like an aromatic or paraffinic hydrocarbon or vegetable oil. Spray volumes can range from about from about one to several thousand liters per hectare, but more typically are in the range from about ten to several hundred liters per hectare. Sprayable formulations can be tank mixed with water or another suitable medium for foliar treatment by aerial or ground application, or for application to the growing medium of the plant. Liquid and dry formulations can be metered directly into drip irrigation systems or metered into the furrow during planting.

The formulations will typically contain effective amounts of active ingredient, diluent and surfactant within the following approximate ranges which add up to 100 percent by weight.

Weight Percent Active Ingredient Diluent Surfactant Water-Dispersible and Water- 0.001-90 0-99.999 0-15 soluble Granules, Tablets and Powders Oil Dispersions, Suspensions,    1-50 40-99    0-50 Emulsions, Solutions (including Emulsifiable Concentrates) Dusts    1-25 70-99    0-5  Granules and Pellets 0.001-99 5-99.999 0-15 High Strength Compositions   90-99 0-10    0-2 

Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, gypsum, cellulose, titanium dioxide, zinc oxide, starch, dextrin, sugars (e.g., lactose, sucrose), silica, talc, mica, diatomaceous earth, urea, calcium carbonate, sodium carbonate and bicarbonate, and sodium sulfate. Typical solid diluents are described in Watkins et al., Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, N.J.

Liquid diluents include, for example, water, N,N-dimethylalkanamides (e.g., N,N-dimethylformamide), limonene, dimethyl sulfoxide, N-alkylpyrrolidones (e.g., N-methylpyrrolidinone), alkyl phosphates (e.g., triethyl phosphate), ethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, propylene carbonate, butylene carbonate, paraffins (e.g., white mineral oils, normal paraffins, isoparaffins), alkylbenzenes, alkylnaphthalenes, glycerine, glycerol triacetate, sorbitol, aromatic hydrocarbons, dearomatized aliphatics, alkylbenzenes, alkylnaphthalenes, ketones such as cyclohexanone, 2-heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, acetates such as isoamyl acetate, hexyl acetate, heptyl acetate, octyl acetate, nonyl acetate, tridecyl acetate and isobornyl acetate, other esters such as alkylated lactate esters, dibasic esters, alkyl and aryl benzoates and γ-butyrolactone, and alcohols, which can be linear, branched, saturated or unsaturated, such as methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, isobutyl alcohol, n-hexanol, 2-ethylhexanol, n-octanol, decanol, isodecyl alcohol, isooctadecanol, cetyl alcohol, lauryl alcohol, tridecyl alcohol, oleyl alcohol, cyclohexanol, tetrahydrofurfuryl alcohol, diacetone alcohol, cresol and benzyl alcohol. Liquid diluents also include glycerol esters of saturated and unsaturated fatty acids (typically C₆-C₂₂), such as plant seed and fruit oils (e.g., oils of olive, castor, linseed, sesame, corn (maize), peanut, sunflower, grapeseed, safflower, cottonseed, soybean, rapeseed, coconut and palm kernel), animal-sourced fats (e.g., beef tallow, pork tallow, lard, cod liver oil, fish oil), and mixtures thereof. Liquid diluents also include alkylated fatty acids (e.g., methylated, ethylated, butylated) wherein the fatty acids may be obtained by hydrolysis of glycerol esters from plant and animal sources, and can be purified by distillation. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950.

The solid and liquid compositions of the present invention often include one or more surfactants. When added to a liquid, surfactants (also known as “surface-active agents”) generally modify, most often reduce, the surface tension of the liquid. Depending on the nature of the hydrophilic and lipophilic groups in a surfactant molecule, surfactants can be useful as wetting agents, dispersants, emulsifiers or defoaming agents.

Surfactants can be classified as nonionic, anionic or cationic. Nonionic surfactants useful for the present compositions include, but are not limited to: alcohol alkoxylates such as alcohol alkoxylates based on natural and synthetic alcohols (which may be branched or linear) and prepared from the alcohols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof amine ethoxylates, alkanolamides and ethoxylated alkanolamides; alkoxylated triglycerides such as ethoxylated soybean, castor and rapeseed oils; alkylphenol alkoxylates such as octylphenol ethoxylates, nonylphenol ethoxylates, dinonyl phenol ethoxylates and dodecyl phenol ethoxylates (prepared from the phenols and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); block polymers prepared from ethylene oxide or propylene oxide and reverse block polymers where the terminal blocks are prepared from propylene oxide; ethoxylated fatty acids; ethoxylated fatty esters and oils; ethoxylated methyl esters; ethoxylated tristyrylphenol (including those prepared from ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); fatty acid esters, glycerol esters, lanolin-based derivatives, polyethoxylate esters such as polyethoxylated sorbitan fatty acid esters, polyethoxylated sorbitol fatty acid esters and polyethoxylated glycerol fatty acid esters; other sorbitan derivatives such as sorbitan esters; polymeric surfactants such as random copolymers, block copolymers, alkyd peg (polyethylene glycol) resins, graft or comb polymers and star polymers; polyethylene glycols (pegs); polyethylene glycol fatty acid esters; silicone-based surfactants; and sugar-derivatives such as sucrose esters, alkyl polyglycosides and alkyl polysaccharides.

Useful anionic surfactants include, but are not limited to: alkylaryl sulfonic acids and their salts; carboxylated alcohol or alkylphenol ethoxylates; diphenyl sulfonate derivatives; lignin and lignin derivatives such as lignosulfonates; maleic or succinic acids or their anhydrides; olefin sulfonates; phosphate esters such as phosphate esters of alcohol alkoxylates, phosphate esters of alkylphenol alkoxylates and phosphate esters of styryl phenol ethoxylates; protein-based surfactants; sarcosine derivatives; styryl phenol ether sulfate; sulfates and sulfonates of oils and fatty acids; sulfates and sulfonates of ethoxylated alkylphenols; sulfates of alcohols; sulfates of ethoxylated alcohols; sulfonates of amines and amides such as N,N-alkyltaurates; sulfonates of benzene, cumene, toluene, xylene, and dodecyl and tridecylbenzenes; sulfonates of condensed naphthalenes; sulfonates of naphthalene and alkyl naphthalene; sulfonates of fractionated petroleum; sulfosuccinamates; and sulfosuccinates and their derivatives such as dialkyl sulfosuccinate salts.

Useful cationic surfactants include, but are not limited to: amides and ethoxylated amides; amines such as N-alkyl propanediamines, tripropylenetriamines and dipropylenetetramines, and ethoxylated amines, ethoxylated diamines and propoxylated amines (prepared from the amines and ethylene oxide, propylene oxide, butylene oxide or mixtures thereof); amine salts such as amine acetates and diamine salts; quaternary ammonium salts such as quaternary salts, ethoxylated quaternary salts and diquaternary salts; and amine oxides such as alkyldimethylamine oxides and bis-(2-hydroxyethyl)-alkylamine oxides.

Also useful for the present compositions are mixtures of nonionic and anionic surfactants or mixtures of nonionic and cationic surfactants. Nonionic, anionic and cationic surfactants and their recommended uses are disclosed in a variety of published references including McCutcheon's Emulsifiers and Detergents, annual American and International Editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964; and A. S. Davidson and B. Milwidsky, Synthetic Detergents, Seventh Edition, John Wiley and Sons, New York, 1987.

Compositions of this invention may also contain formulation auxiliaries and additives, known to those skilled in the art as formulation aids (some of which may be considered to also function as solid diluents, liquid diluents or surfactants). Such formulation auxiliaries and additives may control: pH (buffers), foaming during processing (antifoams such polyorganosiloxanes), sedimentation of active ingredients (suspending agents), viscosity (thixotropic thickeners), in-container microbial growth (antimicrobials), product freezing (antifreezes), color (dyes/pigment dispersions), wash-off (film formers or stickers), evaporation (evaporation retardants), and other formulation attributes. Film formers include, for example, polyvinyl acetates, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohols, polyvinyl alcohol copolymers and waxes. Examples of formulation auxiliaries and additives include those listed in McCutcheon's Volume 2: Functional Materials, annual International and North American editions published by McCutcheon's Division, The Manufacturing Confectioner Publishing Co.; and PCT Publication WO 03/024222.

The compound of Formula 1 and any other active ingredients are typically incorporated into the present compositions by dissolving the active ingredient in a solvent or by grinding in a liquid or dry diluent. Solutions, including emulsifiable concentrates, can be prepared by simply mixing the ingredients. If the solvent of a liquid composition intended for use as an emulsifiable concentrate is water-immiscible, an emulsifier is typically added to emulsify the active-containing solvent upon dilution with water. Active ingredient slurries, with particle diameters of up to 2,000 μm can be wet milled using media mills to obtain particles with average diameters below 3 μm. Aqueous slurries can be made into finished suspension concentrates (see, for example, U.S. Pat. No. 3,060,084) or further processed by spray drying to form water-dispersible granules. Dry formulations usually require dry milling processes, which produce average particle diameters in the 2 to 10 μm range. Dusts and powders can be prepared by blending and usually grinding (such as with a hammer mill or fluid-energy mill). Granules and pellets can be prepared by spraying the active material upon preformed granular carriers or by agglomeration techniques. See Browning, “Agglomeration”, Chemical Engineering, Dec. 4, 1967, pp 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8-57 and following, and WO 91/13546. Pellets can be prepared as described in U.S. Pat. No. 4,172,714. Water-dispersible and water-soluble granules can be prepared as taught in U.S. Pat. Nos. 4,144,050, 3,920,442 and DE 3,246,493. Tablets can be prepared as taught in U.S. Pat. Nos. 5,180,587, 5,232,701 and 5,208,030. Films can be prepared as taught in GB 2,095,558 and U.S. Pat. No. 3,299,566.

For further information regarding the art of formulation, see T. S. Woods, “The Formulator's Toolbox—Product Forms for Modern Agriculture” in Pesticide Chemistry and Bioscience, The Food-Environment Challenge, T. Brooks and T. R. Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. See also U.S. 3,235,361, Col. 6, line 16 through Col. 7, line 19 and Examples 10-41; U.S. 3,309,192, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182; U.S. Pat. No. 2,891,855, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; Hance et al., Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989; and Developments in formulation technology, PJB Publications, Richmond, UK, 2000.

In the following Examples, all percentages are by weight and all formulations are prepared in conventional ways. Compound numbers refer to compounds in Index Tables A-C. Without further elaboration, it is believed that one skilled in the art using the preceding description can utilize the present invention to its fullest extent. The following Examples are, therefore, to be construed as merely illustrative, and not limiting of the disclosure in any way whatsoever. Percentages are by weight except where otherwise indicated.

EXAMPLE A

High Strength Concentrate Compound 17 98.5% silica aerogel 0.5% synthetic amorphous fine silica 1.0%

EXAMPLE B

Wettable Powder Compound 79 65.0% dodecylphenol polyethylene glycol ether 2.0% sodium ligninsulfonate 4.0% sodium silicoaluminate 6.0% montmorillonite (calcined) 23.0%

EXAMPLE C

Granule Compound 80 10.0% attapulgite granules (low volatile matter, 90.0% 0.71/0.30 mm; U.S.S. No. 25-50 sieves)

EXAMPLE D

Extruded Pellet Compound 5 25.0% anhydrous sodium sulfate 10.0% crude calcium ligninsulfonate 5.0% sodium alkylnaphthalenesulfonate 1.0% calcium/magnesium bentonite 59.0%

EXAMPLE E

Emulsifiable Concentrate Compound 17 10.0% polyoxyethylene sorbitol hexoleate 20.0% C₆-C₁₀fatty acid methyl ester 70.0%

EXAMPLE F

Microemulsion Compound 79 5.0% polyvinylpyrrolidone-vinyl acetate copolymer 30.0% alkylpolyglycoside 30.0% glyceryl monooleate 15.0% water 20.0%

EXAMPLE G

Suspension Concentrate Compound 80  35% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% water 53.7% 

EXAMPLE H

Emulsion in Water Compound 5 10.0% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon 20.0 water 58.7%

EXAMPLE I

Oil Dispersion Compound 17 25% polyoxyethylene sorbitol hexaoleate 15% organically modified bentonite clay 2.5%  fatty acid methyl ester 57.5% 

EXAMPLE J

Suspoemulsion Compound 79 10.0% imidacloprid 5.0% butyl polyoxyethylene/polypropylene block copolymer 4.0% stearic acid/polyethylene glycol copolymer 1.0% styrene acrylic polymer 1.0% xanthan gum 0.1% propylene glycol 5.0% silicone based defoamer 0.1% 1,2-benzisothiazolin-3-one 0.1% aromatic petroleum based hydrocarbon 20.0% water 53.7%

Test results indicate that the compounds of the present invention are highly active preemergent and/or postemergent herbicides and/or plant growth regulants. The compounds of the invention generally show highest activity for early postemergence weed control (i.e.

applied soon after weed seedlings emerge from the soil) and preemergence weed control (i.e. applied before weed seedlings emerge from the soil). Many of them have utility for broad-spectrum pre- and/or postemergence weed control in areas where complete control of all vegetation is desired such as around fuel storage tanks, industrial storage areas, parking lots, drive-in theaters, air fields, river banks, irrigation and other waterways, around billboards and highway and railroad structures. Many of the compounds of this invention, by virtue of selective metabolism in crops versus weeds, or by selective activity at the locus of physiological inhibition in crops and weeds, or by selective placement on or within the environment of a mixture of crops and weeds, are useful for the selective control of grass and broadleaf weeds within a crop/weed mixture. One skilled in the art will recognize that the preferred combination of these selectivity factors within a compound or group of compounds can readily be determined by performing routine biological and/or biochemical assays. Compounds of this invention may show tolerance to important agronomic crops including, but is not limited to, alfalfa, barley, cotton, wheat, rape, sugar beets, corn (maize), sorghum, soybeans, rice, oats, peanuts, vegetables, tomato, potato, perennial plantation crops including coffee, cocoa, oil palm, rubber, sugarcane, citrus, grapes, fruit trees, nut trees, banana, plantain, pineapple, hops, tea and forests such as eucalyptus and conifers (e.g., loblolly pine), and turf species (e.g., Kentucky bluegrass, St. Augustine grass, Kentucky fescue and Bermuda grass). Compounds of this invention can be used in crops genetically transformed or bred to incorporate resistance to herbicides, express proteins toxic to invertebrate pests (such as Bacillus thuringiensis toxin), and/or express other useful traits. Those skilled in the art will appreciate that not all compounds are equally effective against all weeds. Alternatively, the subject compounds are useful to modify plant growth.

As the compounds of the invention have (both preemergent and postemergent herbicidal) activity, to control undesired vegetation by killing or injuring the vegetation or reducing its growth, the compounds can be usefully applied by a variety of methods involving contacting a herbicidally effective amount of a compound of the invention, or a composition comprising said compound and at least one of a surfactant, a solid diluent or a liquid diluent, to the foliage or other part of the undesired vegetation or to the environment of the undesired vegetation such as the soil or water in which the undesired vegetation is growing or which surrounds the seed or other propagule of the undesired vegetation.

A herbicidally effective amount of the compounds of this invention is determined by a number of factors. These factors include: formulation selected, method of application, amount and type of vegetation present, growing conditions, etc. In general, a herbicidally effective amount of compounds of this invention is about 0.005 to 20 kg/ha with a preferred range of about 0.01 to 1 kg/ha. One skilled in the art can easily determine the herbicidally effective amount necessary for the desired level of weed control.

Compounds of the invention are useful in treating all plants and plant parts. Plant varieties and cultivars can be obtained by conventional propagation and breeding methods or by genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgene) has been stably integrated into the plant's genome. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

Genetically modified plant cultivars which can be treated according to the invention include those that are resistant against one or more biotic stresses (pests such as nematodes, insects, mites, fungi, etc.) or abiotic stresses (drought, cold temperature, soil salinity, etc.), or that contain other desirable characteristics. Plants can be genetically modified to exhibit traits of, for example, herbicide tolerance, insect-resistance, modified oil profiles or drought tolerance. Useful genetically modified plants containing single gene transformation events or combinations of transformation events are listed in Table 3. Additional information for the genetic modifications listed in Table 3 can be obtained from publicly available databases maintained, for example, by the U.S. Department of Agriculture.

The following abbreviations, T1 through T37, are used in Table 3 for traits. A “−” means the entry is not available.

Trait Description T1 Glyphosate tolerance T2 High lauric acid oil T3 Glufosinate tolerance T4 Phytate breakdown T5 Oxynil tolerance T6 Disease resistance T7 Insect resistance T9 Modified flower color T11 ALS Herbicide Tol. T12 Dicamba Tolerance T13 Anti-allergy T14 Salt tolerance T15 Cold tolerance T16 Imidazolinone herb. tol. T17 Modified alpha-amylase T18 Pollination control T19 2,4-D tolerance T20 Increased lysine T21 Drought tolerance T22 Delayed ripening/senescence T23 Modified product quality T24 High cellulose T25 Modified starch/carbohydrate T26 Insect & disease resist. T27 High tryptophan T28 Erect leaves semidwarf T29 Semidwarf T30 Low iron tolerance T31 Modified oil/fatty acid T32 HPPD tolerance T33 High oil T34 Aryloxyalkanoate tol. T35 Mesotrione tolerance T36 Reduced nicotine T37 Modified product

TABLE 3 Crop Event Name Event Code Trait(s) Gene(s) Alfalfa J101 MON-00101-8 T1 cp4 epsps (aroA:CP4) Alfalfa J163 MON-ØØ163-7 T1 cp4 epsps (aroA:CP4) Canola* 23-18-17 (Event 18) CGN-89465-2 T2 te Canola* 23-198 (Event 23) CGN-89465-2 T2 te Canola* 61061 DP-Ø61Ø61-7 T1 gat4621 Canola* 73496 DP-Ø73496-4 T1 gat4621 Canola* GT200 (RT200) MON-89249-2 T1 cp4 epsps (aroA:CP4); goxv247 Canola* GT73 (RT73) MON-ØØØ73-7 T1 cp4 epsps (aroA:CP4); goxv247 Canola* HCN10 (Topas 19/2) — T3 bar Canola* HCN28 (T45) ACS-BNØØ8-2 T3 pat (syn) Canola* HCN92 (Topas 19/2) ACS-BNØØ7-1 T3 bar Canola* MON88302 MON-883Ø2-9 T1 cp4 epsps (aroA:CP4) Canola* MPS961 — T4 phyA Canola* MPS962 — T4 phyA Canola* MPS963 — T4 phyA Canola* MPS964 — T4 phyA Canola* MPS965 — T4 phyA Canola* MS1 (B91-4) ACS-BNØØ4-7 T3 bar Canola* MS8 ACS-BNØØ5-8 T3 bar Canola* OXY-235 ACS-BNØ11-5 T5 bxn Canola* PHY14 — T3 bar Canola* PHY2 3 — T3 bar Canola* PHY35 — T3 bar Canola* PHY36 — T3 bar Canola* RF1 (B93-101) ACS-BNØØ1-4 T3 bar Canola* RF2 (B94-2) ACS-BNØØ2-5 T3 bar Canola* RF3 ACS-BNØØ3-6 T3 bar Bean EMBRAPA 5.1 EMB-PV051-1 T6 ac1 (sense and antisense) Brinjal # EE-1 — T7 cry1Ac Cotton 19-51a DD-Ø1951A-7 T11 S4-HrA Cotton 281-24-236 DAS-24236-5 T3, T7 pat (syn); cry1F Cotton 3006-210-23 DAS-21Ø23-5 T3, T7 pat (syn); cry1Ac Cotton 31707 — T5, T7 bxn; cry1Ac Cotton 31803 — T5, T7 bxn; cry1Ac Cotton 31807 — T5, T7 bxn; cry1Ac Cotton 31808 — T5, T7 bxn; cry1Ac Cotton 42317 — T5, T7 bxn; cry1Ac Cotton BNLA-601 — T7 cry1Ac Cotton BXN10211 BXN10211-9 T5 bxn; cry1Ac Cotton BXN10215 BXN10215-4 T5 bxn; cry1Ac Cotton BXN10222 BXN10222-2 T5 bxn; cry1Ac Cotton BXN10224 BXN10224-4 T5 bxn; cry1Ac Cotton COT102 SYN-IR102-7 T7 vip3A(a) Cotton COT67B SYN-IR67B-1 T7 cry1Ab Cotton COT202 — T7 vip3A Cotton Event 1 — T7 cry1Ac Cotton GMF Cry1A GTL-GMF311-7 T7 cry1Ab-Ac Cotton GHB119 BCS-GH005-8 T7 crY2 Ae Cotton GHB614 BCS-GH002-5 T1 2mepsps Cotton GK12 — T7 cry1Ab-Ac Cotton LLCotton25 ACS-GH001-3 T3 bar Cotton MLS 9124 — T7 cry1C Cotton MON1076 MON-89924-2 T7 cry1Ac Cotton MON1445 MON-01445-2 T1 cp4 epsps (aroA:CP4) Cotton MON15985 MON-15985-7 T7 cry1Ac; crY2 Ab2 Cotton MON1698 MON-89383-1 T7 cp4 epsps (aroA:CP4) Cotton MON531 MON-00531-6 T7 cry1Ac Cotton MON757 MON-00757-7 T7 cry1Ac Cotton MON88913 MON-88913-8 T1 cp4 epsps (aroA:CP4) Cotton Nqwe Chi 6 Bt — T7 — Cotton SKG321 — T7 cry1A; CpTI Cotton T303-3 BCS-GH003-6 T3, T7 cry1Ab; bar Cotton T304-40 BCS-GH004-7 T3, T7 cry1Ab; bar Cotton CE43-67B — T7 cry1Ab Cotton CE46-02A — T7 cry1Ab Cotton CE44-69D — T7 cry1Ab Cotton 1143-14A — T7 cry1Ab Cotton 1143-51B — T7 cry1Ab Cotton T342-142 — T7 cry1Ab Cotton PV-GHGT07 (1445) — T1 cp4 epsps (aroA:CP4) Cotton EE-GH3 — T1 mepsps Cotton EE-GH5 — T7 cry1Ab Cotton MON88701 MON-88701-3 T3, T12 Modified dmo; bar Cotton OsCr11 — T13 Modified Cry j Flax FP967 CDC-FL001-2 T11 als Lentil RH44 — T16 als Maize 3272 SYN-E3272-5 T17 amy797E Maize 5307 SYN-05307-1 T7 ecry3.1Ab Maize 59122 DAS-59122-7 T3, T7 cry34Ab1; cry35Ab1; pat Maize 676 PH-000676-7 T3, T18 pat; dam Maize 678 PH-000678-9 T3, T18 pat; dam Maize 680 PH-000680-2 T3, T18 pat; dam Maize 98140 DP-098140-6 T1, T11 gat4621; zm-hra Maize Bt10 — T3, T7 cry1Ab; pat Maize Bt176 (176) SYN-EV176-9 T3, T7 cry1Ab; bar Maize BVLA430101 — T4 phyA2 Maize CBH-351 ACS-ZM004-3 T3, T7 cry9C; bar Maize DAS40278-9 DAS40278-9 T19 aad-1 Maize DBT418 DKB-89614-9 T3, T7 cry1Ac; pinII; bar Maize DLL25 (B16) DKB-89790-5 T3 bar Maize GA21 MON-00021-9 T1 mepsps Maize GG25 — T1 mepsps Maize GJ11 — T1 mepsps Maize Fl117 — T1 mepsps Maize GAT-ZM1 — T3 pat Maize LY038 REN-00038-3 T20 cordapA Maize MIR162 SYN-IR162-4 T7 vip3Aa20 Maize MIR604 SYN-IR604-5 T7 mcry3A Maize MON801 (MON80100) MON801 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON802 MON-80200-7 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON809 PH-MON-809-2 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON810 MON-00810-6 T1, T7 cry1Ab; cp4 epsps (aroA:CP4); goxv247 Maize MON832 — T1 cp4 epsps (aroA:CP4); goxv247 Maize MON863 MON-00863-5 T7 cry3Bb1 Maize MON87427 MON-87427-7 T1 cp4 epsps (aroA:CP4) Maize MON87460 MON-87460-4 T21 cspB Maize MON88017 MON-88017-3 T1, T7 cry3Bb1; cp4 epsps (aroA:CP4) Maize MON89034 MON-89034-3 T7 crY2 Ab2; cry1A.105 Maize MS3 ACS-ZM001-9 T3, T18 bar; barnase Maize MS6 ACS-ZM005-4 T3, T18 bar; barnase Maize NK603 MON-00603-6 T1 cp4 epsps (aroA:CP4) Maize T14 ACS-ZM002-1 T3 pat (syn) Maize T25 ACS-ZM003-2 T3 pat (syn) Maize TC1507 DAS-01507-1 T3, T7 cry1Fa2; pat Maize TC6275 DAS-06275-8 T3, T7 mocry1F; bar Maize VIP1034 — T3, T7 vip3A; pat Maize 43A47 DP-043A47-3 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Maize 40416 DP-040416-8 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Maize 32316 DP-032316-8 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Maize 4114 DP-004114-3 T3, T7 cry1F; cry34Ab1; cry35Ab1; pat Melon Melon A — T22 sam-k Melon Melon B — T22 sam-k Papaya 55-1 CUH-CP551-8 T6 prsv cp Papaya 63-1 CUH-CP631-7 T6 prsv cp Papaya Huanong No. 1 — T6 prsv rep Papaya X17-2 UFL-X17CP-6 T6 prsv cp Plum C-5 ARS-PLMC5-6 T6 ppv cp Canola** ZSR5 00 — T1 cp4 epsps (aroA:CP4); goxv247 Canola** ZSR5 02 — T1 cp4 epsps (aroA:CP4); goxv247 Canola** ZSR5 03 — T1 cp4 epsps (aroA:CP4); goxv247 Rice 7Crp#242-95-7 — T13 7crp Rice 7Crp#10 — T13 7crp Rice GM Shanyou 63 — T7 cry1Ab; cry1Ac Rice Huahui-1/TT51-1 — T7 cry1Ab; cry1Ac Rice LLRICE06 ACS-OS001-4 T3 bar Rice LLRICE601 BCS-OS003-7 T3 bar Rice LLRICE62 ACS-OS002-5 T3 bar Rice Tarom molaii + cry1Ab — T7 cry1Ab (truncated) Rice GAT-OS2 — T3 bar Rice GAT-OS3 — T3 bar Rice PE-7 — T7 Cry1Ac Rice 7Crp#10 — T13 7crp Rice KPD627-8 — T27 OASA1D Rice KPD722-4 — T27 OASA1D Rice KA317 — T27 OASA1D Rice HW5 — T27 OASA1D Rice HW1 — T27 OASA1D Rice B-4-1-18 — T28 Δ OsBRI1 Rice G-3-3-22 — T29 OSGA2ox1 Rice AD77 — T6 DEF Rice AD51 — T6 DEF Rice AD48 — T6 DEF Rice AD41 — T6 DEF Rice 13pNasNa800725atAprt1 — T30 HvNAS1; HvNAAT-A; APRT Rice 13pAprt1 — T30 APRT Rice gHvNAS1-gHvNAAT-1 — T30 HvNAS1; HvNAAT-A; HvNAAT-B Rice gHvIDS3-1 — T30 HvIDS3 Rice gHvNAAT1 — T30 HvNAAT-A; HvNAAT-B Rice gHvNAS1-1 — T30 HvNAS1 Rice NIA-OS006-4 — T6 WRKY45 Rice NIA-OS005-3 — T6 WRKY45 Rice NIA-OS004-2 — T6 WRKY45 Rice NIA-OS003-1 — T6 WRKY45 Rice NIA-OS002-9 — T6 WRKY45 Rice NIA-OS001-8 — T6 WRKY45 Rice OsCr11 — T13 Modified Cry j Rice 17053 — T1 cp4 epsps (aroA:CP4) Rice 17314 — T1 cp4 epsps (aroA:CP4) Rose WKS82/130-4-1 IFD-52401-4 T9 5AT; bp40 (f3'5'h) Rose WKS92/130-9-1 IFD-52901-9 T9 5AT; bp40 (f3'5'h) Soybean 260-05 (G94-1, G94-19, — T9 gm-fad2-1 (silencing locus) G168) Soybean A2704-12 ACS-GM005-3 T3 pat Soybean A2704-21 ACS-GM004-2 T3 pat Soybean A5547-127 ACS-GM006-4 T3 pat Soybean A5547-35 ACS-GM008-6 T3 pat Soybean CV127 BPS-CV127-9 T16 csr1-2 Soybean DAS68416-4 DAS68416-4 T3 pat Soybean DP305423 DP-305423-1 T11, T31 gm-fad2-1 (silencing locus); gm-hra Soybean DP356043 DP-356043-5 T1, T31 gm-fad2-1 (silencing locus); gat4601 Soybean FG72 MST-FG072-3 T32, T1 2mepsps; hppdPF W336 Soybean GTS 40-3-2 (40-3-2) MON-04032-6 T1 cp4 epsps (aroA:CP4) Soybean GU262 ACS-GM003-1 T3 pat Soybean MON87701 MON-87701-2 T7 cry1Ac Soybean MON87705 MON-87705-6 T1, T31 fatb1-A (sense & antisense); fad2- 1A (sense & antisense); cp4 epsps (aroA:CP4) Soybean MON87708 MON-87708-9 T1, T12 dmo; cp4 epsps (aroA:CP4) Soybean MON87769 MON-87769-7 T1, T31 Pj.D6D; Nc.Fad3; cp4 epsps (aroA:CP4) Soybean MON89788 MON-89788-1 T1 cp4 epsps (aroA:CP4) Soybean W62 ACS-GM002-9 T3 bar Soybean W98 ACS-GM001-8 T3 bar Soybean MON87754 MON-87754-1 T33 dgat2A Soybean DAS21606 DAS-21606 T34, T3 Modified aad-12; pat Soybean DAS44406 DAS-44406-6 T1, T3, T34 Modified aad-12; 2mepsps; pat Soybean SYHT04R SYN-0004R-8 T35 Modified avhppd Soybean 9582.814.19.1 — T3, T7 cry1Ac, cry1F, PAT Squash CZW3 SEM-ØCZW3-2 T6 cmv cp, zymv cp, wmv cp Squash ZW20 SEM-0ZW20-7 T6 zymv cp, wmv cp Sugar Beet GTSB77 (T9100152) SY-GTSB77-8 T1 cp4 epsps (aroA:CP4); goxv247 Sugar Beet H7-1 KM-000H71-4 T1 cp4 epsps (aroA:CP4) Sugar Beet T120-7 ACS-BV001-3 T3 pat Sugar Beet T227-1 — T1 cp4 epsps (aroA:CP4) Sugarcane NXI-1T — T21 EcbetA Sunflower X81359 — T16 als Pepper PK-SP01 — T6 cmv cp Tobacco C/F/93/08-02 — T5 bxn Tobacco Vector 21-41 — T36 NtQPT1 (antisense) Sunflower X81359 — T16 als Wheat MON71800 MON-718ØØ-3 T1 cp4 epsps (aroA:CP4) *Argentine (Brassica napus), **Polish (B. rapa), # Eggplant

Treatment of genetically modified plants with compounds of the invention may result in super-additive or synergistic effects. For example, reduction in application rates, broadening of the activity spectrum, increased tolerance to biotic/abiotic stresses or enhanced storage stability may be greater than expected from just simple additive effects of the application of compounds of the invention on genetically modified plants.

Compounds of this invention can also be mixed with one or more other biologically active compounds or agents including herbicides, herbicide safeners, fungicides, insecticides, nematocides, bactericides, acaricides, growth regulators such as insect molting inhibitors and rooting stimulants, chemosterilants, semiochemicals, repellents, attractants, pheromones, feeding stimulants, plant nutrients, other biologically active compounds or entomopathogenic bacteria, virus or fungi to form a multi-component pesticide giving an even broader spectrum of agricultural protection. Mixtures of the compounds of the invention with other herbicides can broaden the spectrum of activity against additional weed species, and suppress the proliferation of any resistant biotypes. Thus the present invention also pertains to a composition comprising a compound of Formula 1 (in a herbicidally effective amount) and at least one additional biologically active compound or agent (in a biologically effective amount) and can further comprise at least one of a surfactant, a solid diluent or a liquid diluent. The other biologically active compounds or agents can be formulated in compositions comprising at least one of a surfactant, solid or liquid diluent.

For mixtures of the present invention, one or more other biologically active compounds or agents can be formulated together with a compound of Formula 1, to form a premix, or one or more other biologically active compounds or agents can be formulated separately from the compound of Formula 1, and the formulations combined together before application (e.g., in a spray tank) or, alternatively, applied in succession.

A mixture of one or more of the following herbicides with a compound of this invention may be particularly useful for weed control: acetochlor, acifluorfen and its sodium salt, aclonifen, acrolein (2-propenal), alachlor, alloxydim, ametryn, amicarbazone, amidosulfuron, aminocyclopyrachlor and its esters (e.g., methyl, ethyl) and salts (e.g., sodium, potassium), aminopyralid, amitrole, ammonium sulfamate, anilofos, asulam, atrazine, azimsulfuron, beflubutamid, benazolin, benazolin-ethyl, bencarbazone, benfluralin, benfuresate, bensulfuron-methyl, bensulide, bentazone, benzobicyclon, benzofenap, bicyclopyrone, bifenox, bilanafos, bispyribac and its sodium salt, bromacil, bromobutide, bromofenoxim, bromoxynil, bromoxynil octanoate, butachlor, butafenacil, butamifos, butralin, butroxydim, butylate, cafenstrole, carbetamide, carfentrazone-ethyl, catechin, chlomethoxyfen, chloramben, chlorbromuron, chlorflurenol-methyl, chloridazon, chlorimuron-ethyl, chlorotoluron, chlorpropham, chlorsulfuron, chlorthal-dimethyl, chlorthiamid, cinidon-ethyl, cinmethylin, cinosulfuron, clacyfos, clefoxydim, clethodim, cyclopyrimorate, clodinafop-propargyl, clomazone, clomeprop, clopyralid, clopyralid-olamine, cloransulam-methyl, cumyluron, cyanazine, cycloate, cyclopyrimorate, cyclosulfamuron, cycloxydim, cyhalofop-butyl, 2,4-D and its butotyl, butyl, isoctyl and isopropyl esters and its dimethylammonium, diolamine and trolamine salts, daimuron, dalapon, dalapon-sodium, dazomet, 2,4-DB and its dimethylammonium, potassium and sodium salts, desmedipham, desmetryn, dicamba and its diglycolammonium, dimethylammonium, potassium and sodium salts, dichlobenil, dichlorprop, diclofop-methyl, diclosulam, difenzoquat metilsulfate, diflufenican, diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, dimethylarsinic acid and its sodium salt, dinitramine, dinoterb, diphenamid, diquat dibromide, dithiopyr, diuron, DNOC, endothal, EPTC, esprocarb, ethalfluralin, ethametsulfuron-methyl, ethiozin, ethofumesate, ethoxyfen, ethoxysulfuron, etobenzanid, fenoxaprop-ethyl, fenoxaprop-P-ethyl, fenoxasulfone, fenquinotrione, fentrazamide, fenuron, fenuron-TCA, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, florasulam, fluazifop-butyl, fluazifop-P-butyl, fluazolate, flucarbazone, flucetosulfuron, fluchloralin, flufenacet, flufenpyr, flufenpyr-ethyl, flumetsulam, flumiclorac-pentyl, flumioxazin, fluometuron, fluoroglycofen-ethyl, flupoxam, flupyrsulfuron-methyl and its sodium salt, flurenol, flurenol-butyl, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiacet-methyl, fomesafen, foramsulfuron, fosamine-ammonium, glufosinate, glufosinate-ammonium, glufosinate-P, glyphosate and its salts such as ammonium, isopropylammonium, potassium, sodium (including sesquisodium) and trimesium (alternatively named sulfosate), halauxifen, halauxifen-methyl, halosulfuron-methyl, haloxyfop-etotyl, haloxyfop-methyl, hexazinone, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin, imazaquin-ammonium, imazethapyr, imazethapyr-ammonium, imazosulfuron, indanofan, indaziflam, iofensulfuron, iodosulfuron-methyl, ioxynil, ioxynil octanoate, ioxynil-sodium, ipfencarbazone, isoproturon, isouron, isoxaben, isoxaflutole, isoxachlortole, lactofen, lenacil, linuron, maleic hydrazide, MCPA and its salts (e.g., MCPA-dimethylammonium, MCPA-potassium and MCPA-sodium, esters (e.g., MCPA-2-ethylhexyl, MCPA-butotyl) and thioesters (e.g., MCPA-thioethyl), MCPB and its salts (e.g., MCPB-sodium) and esters (e.g., MCPB-ethyl), mecoprop, mecoprop-P, mefenacet, mefluidide, mesosulfuron-methyl, mesotrione, metam-sodium, metamifop, metamitron, metazachlor, metazosulfuron, methabenzthiazuron, methylarsonic acid and its calcium, monoammonium, monosodium and disodium salts, methyldymron, metobenzuron, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron-methyl, molinate, monolinuron, naproanilide, napropamide, napropamide-M, naptalam, neburon, nicosulfuron, norflurazon, orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxasulfuron, oxaziclomefone, oxyfluorfen, paraquat dichloride, pebulate, pelargonic acid, pendimethalin, penoxsulam, pentanochlor, pentoxazone, perfluidone, pethoxamid, pethoxyamid, phenmedipham, picloram, picloram-potassium, picolinafen, pinoxaden, piperophos, pretilachlor, primisulfuron-methyl, prodiamine, profoxydim, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propyrisulfuron, propyzamide, prosulfocarb, prosulfuron, pyraclonil, pyraflufen-ethyl, pyrasulfotole, pyrazogyl, pyrazolynate, pyrazoxyfen, pyrazosulfuron-ethyl, pyribenzoxim, pyributicarb, pyridate, pyriftalid, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quizalofop-ethyl, quizalofop-P-ethyl, quizalofop-P-tefuryl, rimsulfuron, saflufenacil, sethoxydim, siduron, simazine, simetryn, sulcotrione, sulfentrazone, sulfometuron-methyl, sulfosulfuron, 2,3,6-TBA, TCA, TCA-sodium, tebutam, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbumeton, terbuthylazine, terbutryn, thenylchlor, thiazopyr, thiencarbazone, thifensulfuron-methyl, thiobencarb, tiafenacil, tiocarbazil, topramezone, tralkoxydim, tri-allate, triafamone, triasulfuron, triaziflam, tribenuron-methyl, triclopyr, triclopyr-butotyl, triclopyr-triethylammonium, tridiphane, trietazine, trifloxysulfuron, trifluralin, triflusulfuron-methyl, tritosulfuron, vernolate, 3-(2-chloro-3,6-difluorophenyl)-4-hydroxy-1-methyl-1,5-naphthyridin-2(1H)-one, 5-chloro-3-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-1-(4-methoxyphenyl)-2(1H)-quinoxalinone, 2-chloro-N-(1-methyl-1H-tetrazol-5-yl-6-(trifluoromethyl)-3-pyridinecarboxamide, 7-(3,5-dichloro-4-pyridinyl)-5-(2,2-difluoroethyl)-8-hydroxypyrido [2,3-b]pyrazin-6(5H)-one), 4-(2,6-diethyl-4-methylphenyl)--hydroxy-2,6-dimethyl-3(2H)-pyridazinone), 5-[[(2,6-difluorophenyl)methoxy]methyl]-4,5-dihydro-5-methyl-3-(3-methyl-2-thienyl)isoxazole (previously methioxolin), 3-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2H-1,4-benzoxazin-6-yl]dihydro-1,5-dimethyl-6-thioxo-1,3,5-triazine-2,4(1H,3H)-dione, 4-(4-fluorophenyl)-6-[(2-hydroxy-6-oxo-1-cyclohexen-1-yl)carbonyl]-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione, methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-2-pyridinecarboxylate, 2-methyl-3-(methylsulfonyl)-N-(1-methyl-1H-tetrazol-5-yl-4-(trifluoromethyl)benzamide, and 2-methyl-N-(4-methyl-1,2,5-oxadiazol-3-yl-3-(methylsulfinyl)-4-(trifluoromethy enzamide. Other herbicides also include bioherbicides such as Alternaria destruens Simmons, Colletotrichum gloeosporiodes (Penz.) Penz. & Sacc., Drechsiera monoceras (MTB-951), Myrothecium verrucaria (Albertini & Schweinitz) Ditmar: Fries, Phytophthora palmivora (Butl.) Butl. and Puccinia thlaspeos Schub.

Compounds of this invention can also be used in combination with plant growth regulators such as aviglycine, N-(phenylmethyl)-1H-purin-6-amine, epocholeone, gibberellic acid, gibberellin A₄ and A₇, harpin protein, mepiquat chloride, prohexadione calcium, prohydrojasmon, sodium nitrophenolate and trinexapac-methyl, and plant growth modifying organisms such as Bacillus cereus strain BP01.

General references for agricultural protectants (i.e. herbicides, herbicide safeners, insecticides, fungicides, nematocides, acaricides and biological agents) include The Pesticide Manual, 13th Edition, C. D. S. Tomlin, Ed., British Crop Protection Council, Farnham, Surrey, U.K., 2003 and The BioPesticide Manual, 2nd Edition, L. G. Copping, Ed., British Crop Protection Council, Farnham, Surrey, U.K., 2001.

For embodiments where one or more of these various mixing partners are used, the weight ratio of these various mixing partners (in total) to the compound of Formula 1 is typically between about 1:3000 and about 3000:1. Of note are weight ratios between about 1:300 and about 300:1 (for example ratios between about 1:30 and about 30:1). One skilled in the art can easily determine through simple experimentation the biologically effective amounts of active ingredients necessary for the desired spectrum of biological activity. It will be evident that including these additional components may expand the spectrum of weeds controlled beyond the spectrum controlled by the compound of Formula 1 alone.

In certain instances, combinations of a compound of this invention with other biologically active (particularly herbicidal) compounds or agents (i.e. active ingredients) can result in a greater-than-additive (i.e. synergistic) effect on weeds and/or a less-than-additive effect (i.e. safening) on crops or other desirable plants. Reducing the quantity of active ingredients released in the environment while ensuring effective pest control is always desirable. Ability to use greater amounts of active ingredients to provide more effective weed control without excessive crop injury is also desirable. When synergism of herbicidal active ingredients occurs on weeds at application rates giving agronomically satisfactory levels of weed control, such combinations can be advantageous for reducing crop production cost and decreasing environmental load. When safening of herbicidal active ingredients occurs on crops, such combinations can be advantageous for increasing crop protection by reducing weed competition.

Of note is a combination of a compound of the invention with at least one other herbicidal active ingredient. Of particular note is such a combination where the other herbicidal active ingredient has different site of action from the compound of the invention. In certain instances, a combination with at least one other herbicidal active ingredient having a similar spectrum of control but a different site of action will be particularly advantageous for resistance management. Thus, a composition of the present invention can further comprise (in a herbicidally effective amount) at least one additional herbicidal active ingredient having a similar spectrum of control but a different site of action.

Compounds of this invention can also be used in combination with herbicide safeners such as allidochlor, benoxacor, cloquintocet-mexyl, cumyluron, cyometrinil, cyprosulfonamide, daimuron, dichlormid, dicyclonon, dietholate, dimepiperate, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen-ethyl, mefenpyr-diethyl, mephenate, methoxyphenone naphthalic anhydride (1,8-naphthalic anhydride), oxabetrinil, N-(aminocarbonyl)-2-methylbenzenesulfonamide, N-(aminocarbonyl)-2-fluorobenzenesulfonamide, 1-bromo-4-[(chloromethyl)sulfonyl]benzene (BCS), 4-(dichloroacetyl)-1-oxa-4-azospiro[4.5]decane (MON 4660), 2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG 191), ethyl 1,6-dihydro-1-(2-methoxyphenyl)-6-oxo-2-phenyl-5-pyrimidinecarboxylate, 2-hydroxy-N,N-dimethyl-6-(trifluoromethyl)pyridine-3-carboxamide, and 3-oxo-1-cyclohexen-1-yl 1-(3,4-dimethylphenyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate to increase safety to certain crops. Antidotally effective amounts of the herbicide safeners can be applied at the same time as the compounds of this invention, or applied as seed treatments. Therefore an aspect of the present invention relates to a herbicidal mixture comprising a compound of this invention and an antidotally effective amount of a herbicide safener. Seed treatment is particularly useful for selective weed control, because it physically restricts antidoting to the crop plants. Therefore a particularly useful embodiment of the present invention is a method for selectively controlling the growth of undesired vegetation in a crop comprising contacting the locus of the crop with a herbicidally effective amount of a compound of this invention wherein seed from which the crop is grown is treated with an antidotally effective amount of safener. Antidotally effective amounts of safeners can be easily determined by one skilled in the art through simple experimentation.

Of note is a composition comprising a compound of the invention (in a herbicidally effective amount), at least one additional active ingredient selected from the group consisting of other herbicides and herbicide safeners (in an effective amount), and at least one component selected from the group consisting of surfactants, solid diluents and liquid diluents.

Preferred for better control of undesired vegetation (e.g., lower use rate such as from synergism, broader spectrum of weeds controlled, or enhanced crop safety) or for preventing the development of resistant weeds are mixtures of a compound of this invention with another herbicide. Table A1 lists particular combinations of Component (a) (i.e. a specific compound of the present invention) with another herbicide as Component (b) illustrative of the mixtures, compositions and methods of the present invention. Compound 17 in the Component (a) column is identified in Index Table A. The second column of Table A1 lists the specific Component (b) compound (e.g., “2,4-D” in the first line). The third, fourth and fifth columns of Table A1 lists ranges of weight ratios for rates at which the Component (a) compound is typically applied to a field-grown crop relative to Component (b) (i.e. (a):(b)). Thus, for example, the first line of Table A1 specifically discloses the combination of Component (a) (i.e. Compound 17 in Index Table A) with 2,4-D is typically applied in a weight ratio between 1:192-6:1. The remaining lines of Table A1 are to be construed similarly.

TABLE A1 Component (a) Typical More Typical Most Typical (Compound #) Component (b) Weight Ratio Weight Ratio Weight Ratio 17 2,4-D 1:192-6:1 1:64-2:1 1:24-1:3 17 Acetochlor 1:768-2:1 1:256-1:2   1:96-1:11 17 Acifluorfen  1:96-12:1 1:32-4:1 1:12-1:2 17 Aclonifen 1:857-2:1 1:285-1:3  1:107-1:12 17 Alachlor 1:768-2:1 1:256-1:2   1:96-1:11 17 Ametryn 1:384-3:1 1:128-1:1  1:48-1:6 17 Amicarbazone 1:192-6:1 1:64-2:1 1:24-1:3 17 Amidosulfuron   1:6-168:1  1:2-56:1  1:1-11:1 17 Aminocyclopyrachlor  1:48-24:1 1:16-8:1  1:6-2:1 17 Aminopyralid  1:20-56:1  1:6-19:1  1:2-4:1 17 Amitrole 1:768-2:1 1:256-1:2   1:96-1:11 17 Anilofos  1:96-12:1 1:32-4:1 1:12-1:2 17 Asulam 1:960-2:1 1:320-1:3  1:120-1:14 17 Atrazine 1:192-6:1 1:64-2:1 1:24-1:3 17 Azimsulfuron   1:6-168:1  1:2-56:1  1:1-11:1 17 Beflubutamid 1:342-4:1 1:114-2:1  1:42-1:5 17 Benfuresate 1:617-2:1 1:205-1:2  1:77-1:9 17 Bensulfuron-methyl  1:25-45:1  1:8-15:1  1:3-3:1 17 Bentazone 1:192-6:1 1:64-2:1 1:24-1:3 17 Benzobicyclon  1:85-14:1 1:28-5:1 1:10-1:2 17 Benzofenap 1:257-5:1 1:85-2:1 1:32-1:4 17 Bicyclopyrone  1:42-27:1 1:14-9:1  1:5-2:1 17 Bifenox 1:257-5:1 1:85-2:1 1:32-1:4 17 Bispyribac-sodium   1:10-112:1  1:3-38:1  1:1-7:1 17 Bromacil 1:384-3:1 1:128-1:1  1:48-1:6 17 Bromobutide 1:384-3:1 1:128-1:1  1:48-1:6 17 Bromoxynil  1:96-12:1 1:32-4:1 1:12-1:2 17 Butachlor 1:768-2:1 1:256-1:2   1:96-1:11 17 Butafenacil  1:42-27:1 1:14-9:1  1:5-2:1 17 Butylate 1:1542-1:2  1:514-1:5  1:192-1:22 17 Cafenstrole 1:192-6:1 1:64-2:1 1:24-1:3 17 Carfentrazone-ethyl 1:128-9:1 1:42-3:1 1:16-1:2 17 Chlorimuron-ethyl   1:8-135:1  1:2-45:1  1:1-9:1 17 Chlorotoluron 1:768-2:1 1:256-1:2   1:96-1:11 17 Chlorsulfuron   1:6-168:1  1:2-56:1  1:1-11:1 17 Cinosulfuron  1:17-68:1  1:5-23:1  1:2-5:1 17 Cinidon-ethyl 1:384-3:1 1:128-1:1  1:48-1:6 17 Cinmethylin  1:34-34:1  1:11-12:1  1:4-3:1 17 Clacyfos  1:34-34:1  1:11-12:1  1:4-3:1 17 Clethodim  1:48-24:1 1:16-8:1  1:6-2:1 17 Clodinafop-propargyl  1:20-56:1  1:6-19:1  1:2-4:1 17 Clomazone 1:384-3:1 1:128-1:1  1:48-1:6 17 Clomeprop 1:171-7:1 1:57-3:1 1:21-1:3 17 Clopyralid 1:192-6:1 1:64-2:1 1:24-1:3 17 Cloransulam-methyl  1:12-96:1  1:4-32:1  1:1-6:1 17 Cumyluron 1:384-3:1 1:128-1:1  1:48-1:6 17 Cyanazine 1:384-3:1 1:128-1:1  1:48-1:6 17 Cyclopyrimorate  1:17-68:1  1:5-23:1  1:2-5:1 17 Cyclosulfamuron  1:17-68:1  1:5-23:1  1:2-5:1 17 Cycloxydim  1:96-12:1 1:32-4:1 1:12-1:2 17 Cyhalofop  1:25-45:1  1:8-15:1  1:3-3:1 17 Daimuron 1:192-6:1 1:64-2:1 1:24-1:3 17 Desmedipham 1:322-4:1 1:107-2:1  1:40-1:5 17 Dicamba 1:192-6:1 1:64-2:1 1:24-1:3 17 Dichlobenil 1:1371-1:2  1:457-1:4  1:171-1:20 17 Dichlorprop 1:925-2:1 1:308-1:3  1:115-1:13 17 Diclofop-methyl 1:384-3:1 1:128-1:1  1:48-1:6 17 Diclosulam   1:10-112:1  1:3-38:1  1:1-7:1 17 Difenzoquat 1:288-4:1 1:96-2:1 1:36-1:4 17 Diflufenican 1:857-2:1 1:285-1:3  1:107-1:12 17 Diflufenzopyr  1:12-96:1  1:4-32:1  1:1-6:1 17 Dimethachlor 1:768-2:1 1:256-1:2   1:96-1:11 17 Dimethametryn 1:192-6:1 1:64-2:1 1:24-1:3 17 Dimethenamid-P 1:384-3:1 1:128-1:1  1:48-1:6 17 Dithiopyr 1:192-6:1 1:64-2:1 1:24-1:3 17 Diuron 1:384-3:1 1:128-1:1  1:48-1:6 17 EPTC 1:768-2:1 1:256-1:2   1:96-1:11 17 Esprocarb 1:1371-1:2  1:457-1:4  1:171-1:20 17 Ethalfluralin 1:384-3:1 1:128-1:1  1:48-1:6 17 Ethametsulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 17 Ethoxyfen   1:8-135:1  1:2-45:1  1:1-9:1 17 Ethoxysulfuron  1:20-56:1  1:6-19:1  1:2-4:1 17 Etobenzanid 1:257-5:1 1:85-2:1 1:32-1:4 17 Fenoxaprop-ethyl  1:120-10:1 1:40-4:1 1:15-1:2 17 Fenoxasulfone  1:85-14:1 1:28-5:1 1:10-1:2 17 Fenquinotrione  1:17-68:1  1:5-23:1  1:2-5:1 17 Fentrazamide  1:17-68:1  1:5-23:1  1:2-5:1 17 Flazasulfuron  1:17-68:1  1:5-23:1  1:2-5:1 17 Florasulam   1:2-420:1   1:1-140:1  2:1-27:1 17 Fluazifop-butyl 1:192-6:1 1:64-2:1 1:24-1:3 17 Flucarbazone   1:8-135:1  1:2-45:1  1:1-9:1 17 Flucetosulfuron   1:8-135:1  1:2-45:1  1:1-9:1 17 Flufenacet 1:257-5:1 1:85-2:1 1:32-1:4 17 Flumetsulam  1:24-48:1  1:8-16:1  1:3-3:1 17 Flumiclorac-pentyl   1:10-112:1  1:3-38:1  1:1-7:1 17 Flumioxazin  1:25-45:1  1:8-15:1  1:3-3:1 17 Fluometuron 1:384-3:1 1:128-1:1  1:48-1:6 17 Flupyrsulfuron-methyl   1:3-336:1   1:1-112:1  2:1-21:1 17 Fluridone 1:384-3:1 1:128-1:1  1:48-1:6 17 Fluroxypyr  1:96-12:1 1:32-4:1 1:12-1:2 17 Flurtamone 1:857-2:1 1:285-1:3  1:107-1:12 17 Fluthiacet-methyl  1:48-42:1  1:16-14:1  1:3-3:1 17 Fomesafen  1:96-12:1 1:32-4:1 1:12-1:2 17 Foramsulfuron  1:13-84:1  1:4-28:1  1:1-6:1 17 Glufosinate 1:288-4:1 1:96-2:1 1:36-1:4 17 Glyphosate 1:288-4:1 1:96-2:1 1:36-1:4 17 Halauxifen  1:20-56:1  1:6-19:1  1:2-4:1 17 Halauxifen-methyl  1:20-56:1  1:6-19:1  1:2-4:1 17 Halosulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 17 Haloxyfop-methyl  1:34-34:1  1:11-12:1  1:4-3:1 17 Hexazinone 1:192-6:1 1:64-2:1 1:24-1:3 17 Imazamox  1:13-84:1  1:4-28:1  1:1-6:1 17 Imazapic  1:20-56:1  1:6-19:1  1:2-4:1 17 Imazapyr  1:85-14:1 1:28-5:1 1:10-1:2 17 Imazaquin  1:34-34:1  1:11-12:1  1:4-3:1 17 Imazethabenz-methyl 1:171-7:1 1:57-3:1 1:21-1:3 17 Imazethapyr  1:24-48:1  1:8-16:1  1:3-3:1 17 Imazosulfuron  1:27-42:1  1:9-14:1  1:3-3:1 17 Indanofan 1:342-4:1 1:114-2:1  1:42-1:5 17 Indaziflam  1:25-45:1  1:8-15:1  1:3-3:1 17 Iodosulfuron-methyl   1:3-336:1   1:1-112:1  2:1-21:1 17 Ioxynil 1:192-6:1 1:64-2:1 1:24-1:3 17 Ipfencarbazone  1:85-14:1 1:28-5:1 1:10-1:2 17 Isoproturon 1:384-3:1 1:128-1:1  1:48-1:6 17 Isoxaben 1:288-4:1 1:96-2:1 1:36-1:4 17 Isoxaflutole  1:60-20:1 1:20-7:1  1:7-2:1 17 Lactofen  1:42-27:1 1:14-9:1  1:5-2:1 17 Lenacil 1:384-3:1 1:128-1:1  1:48-1:6 17 Linuron 1:384-3:1 1:128-1:1  1:48-1:6 17 MCPA 1:192-6:1 1:64-2:1 1:24-1:3 17 MCPB 1:288-4:1 1:96-2:1 1:36-1:4 17 Mecoprop 1:768-2:1 1:256-1:2   1:96-1:11 17 Mefenacet 1:384-3:1 1:128-1:1  1:48-1:6 17 Mefluidide 1:192-6:1 1:64-2:1 1:24-1:3 17 Mesosulfuron-methyl   1:5-224:1  1:1-75:1  1:1-14:1 17 Mesotrione  1:42-27:1 1:14-9:1  1:5-2:1 17 Metamifop  1:42-27:1 1:14-9:1  1:5-2:1 17 Metazachlor 1:384-3:1 1:128-1:1  1:48-1:6 17 Metazosulfuron  1:25-45:1  1:8-15:1  1:3-3:1 17 Methabenzthiazuron 1:768-2:1 1:256-1:2   1:96-1:11 17 Metolachlor 1:768-2:1 1:256-1:2   1:96-1:11 17 Metosulam   1:8-135:1  1:2-45:1  1:1-9:1 17 Metribuzin 1:192-6:1 1:64-2:1 1:24-1:3 17 Metsulfuron-methyl   1:2-560:1   1:1-187:1  3:1-35:1 17 Molinate 1:1028-2:1  1:342-1:3  1:128-1:15 17 Napropamide 1:384-3:1 1:128-1:1  1:48-1:6 17 Napropamide-M 1:192-6:1 1:64-2:1 1:24-1:3 17 Naptalam 1:192-6:1 1:64-2:1 1:24-1:3 17 Nicosulfuron  1:12-96:1  1:4-32:1  1:1-6:1 17 Norflurazon 1:1152-1:1  1:384-1:3  1:144-1:16 17 Orbencarb 1:1371-1:2  1:457-1:4  1:171-1:20 17 Orthosulfamuron  1:20-56:1  1:6-19:1  1:2-4:1 17 Oryzalin 1:514-3:1 1:171-1:2  1:64-1:8 17 Oxadiargyl 1:384-3:1 1:128-1:1  1:48-1:6 17 Oxadiazon 1:548-3:1 1:182-1:2  1:68-1:8 17 Oxasulluron  1:27-42:1  1:9-14:1  1:3-3:1 17 Oxaziclomefone  1:42-27:1 1:14-9:1  1:5-2:1 17 Oxyfluorfen 1:384-3:1 1:128-1:1  1:48-1:6 17 Paraquat 1:192-6:1 1:64-2:1 1:24-1:3 17 Pendimethalin 1:384-3:1 1:128-1:1  1:48-1:6 17 Penoxsulam   1:10-112:1  1:3-38:1  1:1-7:1 17 Penthoxamid 1:384-3:1 1:128-1:1  1:48-1:6 17 Pentoxazone  1:102-12:1 1:34-4:1 1:12-1:2 17 Phenmedipham  1:102-12:1 1:34-4:1 1:12-1:2 17 Picloram  1:96-12:1 1:32-4:1 1:12-1:2 17 Picolinafen  1:34-34:1  1:11-12:1  1:4-3:1 17 Pinoxaden  1:25-45:1  1:8-15:1  1:3-3:1 17 Pretilachlor 1:192-6:1 1:64-2:1 1:24-1:3 17 Primisulfuron-methyl   1:8-135:1  1:2-45:1  1:1-9:1 17 Prodiamine 1:384-3:1 1:128-1:1  1:48-1:6 17 Profoxydim  1:42-27:1 1:14-9:1  1:5-2:1 17 Prometryn 1:384-3:1 1:128-1:1  1:48-1:6 17 Propachlor 1:1152-1:1  1:384-1:3  1:144-1:16 17 Propanil 1:384-3:1 1:128-1:1  1:48-1:6 17 Propaquizafop  1:48-24:1 1:16-8:1  1:6-2:1 17 Propoxycarbazone  1:17-68:1  1:5-23:1  1:2-5:1 17 Propyrisulfuron  1:17-68:1  1:5-23:1  1:2-5:1 17 Propyzamide 1:384-3:1 1:128-1:1  1:48-1:6 17 Prosulfocarb 1:1200-1:2  1:400-1:4  1:150-1:17 17 Prosulfuron   1:6-168:1  1:2-56:1  1:1-11:1 17 Pyraclonil  1:42-27:1 1:14-9:1  1:5-2:1 17 Pyraflufen-ethyl   1:5-224:1  1:1-75:1  1:1-14:1 17 Pyrasulfotole  1:13-84:1  1:4-28:1  1:1-6:1 17 Pyrazolynate 1:857-2:1 1:285-1:3  1:107-1:12 17 Pyrazosulfuron-ethyl   1:10-112:1  1:3-38:1  1:1-7:1 17 Pyrazoxyfen   1:5-224:1  1:1-75:1  1:1-14:1 17 Pyribenzoxim   1:10-112:1  1:3-38:1  1:1-7:1 17 Pyributicarb 1:384-3:1 1:128-1:1  1:48-1:6 17 Pyridate 1:288-4:1 1:96-2:1 1:36-1:4 17 Pyriftalid   1:10-112:1  1:3-38:1  1:1-7:1 17 Pyriminobac-methyl  1:20-56:1  1:6-19:1  1:2-4:1 17 Pyrimisulfan  1:17-68:1  1:5-23:1  1:2-5:1 17 Pyrithiobac  1:24-48:1  1:8-16:1  1:3-3:1 17 Pyroxasulfone  1:85-14:1 1:28-5:1 1:10-1:2 17 Pyroxsulam   1:5-224:1  1:1-75:1  1:1-14:1 17 Quinclorac 1:192-6:1 1:64-2:1 1:24-1:3 17 Quizalofop-ethyl  1:42-27:1 1:14-9:1  1:5-2:1 17 Rimsulfuron  1:13-84:1  1:4-28:1  1:1-6:1 17 Saflufenacil  1:25-45:1  1:8-15:1  1:3-3:1 17 Sethoxydim  1:96-12:1 1:32-4:1 1:12-1:2 17 Simazine 1:384-3:1 1:128-1:1  1:48-1:6 17 Sulcotrione  1:120-10:1 1:40-4:1 1:15-1:2 17 Sulfentrazone 1:147-8:1 1:49-3:1 1:18-1:3 17 Sulfometuron-methyl  1:34-34:1  1:11-12:1  1:4-3:1 17 Sulfosulfuron   1:8-135:1  1:2-45:1  1:1-9:1 17 Tebuthiuron 1:384-3:1 1:128-1:1  1:48-1:6 17 Tefmyltrione  1:42-27:1 1:14-9:1  1:5-2:1 17 Tembotrione  1:31-37:1  1:10-13:1  1:3-3:1 17 Tepraloxydim  1:25-45:1  1:8-15:1  1:3-3:1 17 Terbacil 1:288-4:1 1:96-2:1 1:36-1:4 17 Terbuthylazine 1:857-2:1 1:285-1:3  1:107-1:12 17 Terbutryn 1:192-6:1 1:64-2:1 1:24-1:3 17 Thenylchlor  1:85-14:1 1:28-5:1 1:10-1:2 17 Thiazopyr 1:384-3:1 1:128-1:1  1:48-1:6 17 Thiencarbazone   1:3-336:1   1:1-112:1  2:1-21:1 17 Thifensulfuron-methyl   1:5-224:1  1:1-75:1  1:1-14:1 17 Tiafenacil  1:17-68:1  1:5-23:1  1:2-5:1 17 Thiobencarb 1:768-2:1 1:256-1:2   1:96-1:11 17 Topramezone   1:6-168:1  1:2-56:1  1:1-11:1 17 Tralkoxydim  1:68-17:1 1:22-6:1  1:8-2:1 17 Triallate 1:768-2:1 1:256-1:2   1:96-1:11 17 Triasulfuron   1:5-224:1  1:1-75:1  1:1-14:1 17 Triaziflam 1:171-7:1 1:57-3:1 1:21-1:3 17 Tribenuron-methyl   1:3-336:1   1:1-112:1  2:1-21:1 17 Triclopyr 1:192-6:1 1:64-2:1 1:24-1:3 17 Trifloxysulfuron   1:2-420:1   1:1-140:1  2:1-27:1 17 Trifluralin 1:288-4:1 1:96-2:1 1:36-1:4 17 Triflusulfuron-methyl  1:17-68:1  1:5-23:1  1:2-5:1 17 Tritosulfuron  1:13-84:1  1:4-28:1  1:1-6:1

Table A2 is constructed the same as Table A1 above except that entries below the “Component (a)” column heading are replaced with the respective Component (a) Column Entry shown below. Compound 79 in the Component (a) column is identified in Index Table A. Thus, for example, in Table A2 the entries below the “Component (a)” column heading all recite “Compound 79” (i.e. Compound 79 identified in Index Table A), and the first line below the column headings in Table A2 specifically discloses a mixture of Compound 79 with 2,4-D. Tables A3 and A4 are constructed similarly.

Table Number Component (a) Column Entries A2 Compound 79 A3 Compound 80 A4 Compound 5 A5 Compound 3 A6 Compound 5 A7 Compound 80 A8 Compound 101 A9 Compound 103 A10 Compound 156 A11 Compound 202 A12 Compound 204 A13 Compound 206 A14 Compound 232 A15 Compound 263 A16 Compound 271 A17 Compound 304 A18 Compound 306 A19 Compound 315 A20 Compound 319 A21 Compound 323 A22 Compound 351

Preferred for better control of undesired vegetation (e.g., lower use rate such as from synergism, broader spectrum of weeds controlled, or enhanced crop safety) or for preventing the development of resistant weeds are mixtures of a compound of this invention with a herbicide selected from the group consisting of chlorimuron-ethyl, nicosulfuron, mesotrione, thifensulfuron-methyl, flupyrsulfuron-methyl, tribenuron, pyroxasulfone, pinoxaden, tembotrione, pyroxsulam, metolachlor and S-metolachlor.

The following Tests demonstrate the control efficacy of compounds of this invention on specific pathogens. The pathogen control protection afforded by the compounds is not limited, however, to these species. See Index Tables A-C for compound descriptions. The following abbreviations are used in the Index Tables which follow: Me is methyl, Ph is phenyl, OMe is methoxy, —CN is cyano, —NO₂ is nitro, t-Boc is tertiary-butoxycarbonyl, and TMS is trimethylsilyl. The abbreviation “Ex.” stands for “Example” and is followed by a number indicating in which example the compound is prepared. Mass spectra are reported as the molecular weight of the highest isotopic abundance parent ion (M+1) formed by addition of H⁺ (molecular weight of 1) to the molecule, or (M−1) formed by the loss of H⁺ (molecular weight of 1) from the molecule, observed by using liquid chromatography coupled to a mass spectrometer (LCMS) using either atmospheric pressure chemical ionization (AP⁺) or electrospray ionization (ESI⁺).

TABLE A ⁽¹⁾ INDEX

Cmpd. No. Q¹ Q² m.p. (° C.) M − 1 M + 1 1 Ph(3-F) Ph(2-F) 317 2 Ph(3-F) Ph(2-CF₃) 367 3 Ph(3-CF₃) Ph(2-F) 367 4 Ph(3-CF₃) Ph(2-CF₃) 417 5 Ph(3,4-di-F) Ph(2-F) 335 6 Ph(3,4-di-F) Ph(2-CF₃) 385 12 Ph(3,4-di-F) Ph(3-F) 335 13 Ph(3,4-di-F) Ph(3-CF₃) 385 14 Ph(3,4-di-Cl) Ph(2-F) 367 15 Ph(3,4-di-Cl) Ph(2-CN) 376 16 Ph(4-F) Ph(2-F) 317 17 Ph(3,4-di-F) Ph(2,3-di-F) 198-200 18 Ph(3,4-di-F) Ph(3-Cl) 165-167 19 Ph(3,4-di-F) Ph(2-Me) 158-160 20 Ph(3,4-di-F) Ph(2-NO₂) 173-175 21 Ph(3,4-di-F) Ph(2-SO₂Me) 203-205 22 Ph(3,4-di-F) 4-pyridinyl(2-F) 210-212 23 Ph(3,4-di-F) Ph(2,4-di-F) 188-190 25 Ph(3,4-di-Cl) Ph(2,3-di-F) 171-173 26 Ph(3,4-di-Cl) Ph(2-CF₃) 170-172 27 Ph(3,4-di-Cl) Ph(3-F) 174-176 28 3-thienyl Ph(2-CF₃) 146-148 29 3-thienyl Ph(2-F) ** 30 Ph(3,4-di-F) Ph 184-186 31 Ph(3,4-di-F) 1H-pyrazol-3-yl(1-Me) 181-183 32 Ph(3,4-di-Cl) Ph(2-OCF₃) 432 33 Ph(3,4,5-tri-F) Ph(2-CF₃) 160-162 34 Ph(3,4,5-tri-F) Ph(2-F) 196-198 35 Ph(3,4,5-tri-F) Ph(2-Me) 170-172 36 Ph(3-OMe) Ph(2-F) 329 38 Ph(3-Me) Ph(2-F) 313 39 Ph(3,4-di-Cl) Ph(2-NO₂) 178-180 40 Ph(3,4-di-Cl) Ph(2-Me) 194-196 41 pyridin-3-yl(6-Cl) Ph(2-F) 200-204 42 pyridin-3-yl(6-Cl) Ph(2-CF₃) 43 Ph(3,4-di-Cl) Ph(2-SO₂Me) 219-221 45 Ph(3,4-di-F) 2-pyridinyl 316 318 46 Ph(3,4-di-F) 3-pyridinyl(2-OMe) 346 348 47 Ph(3,4-di-F) 2-pyridinyl(1-oxido) 334 48 Ph(3,4,5-tri-F) Ph(2,3-di-F) 371 49 Ph(3,4,5-tri-F) Ph(3-NO₂) 380 50 Ph(2,4,5-tri-F) Ph(2,3-di-F) 371 51 Ph(2,4,5-tri-F) Ph(2-F) 353 52 Ph(3-F,4-Cl) Ph(2,3-di-F) 369 53 Ph(3-F,4-Cl) Ph(2-F) 351 54 Ph(3,4-di-F) Ph(2-OCF₃) 399 401 55 Ph(3,4-di-F) Ph(2-Br) 393 395 56 Ph(3,4-di-F) Ph(3-Me) 329 331 57 Ph(3,4-di-F) 1,3-benzodioxol- 395 397 4-yl(2,2-di-F) 58 Ph(3,4-di-F) 2-pyridinyl(6-OMe) 346 348 59 Ph(3-Cl,4-F) Ph(2,3-di-F) 369 60 Ph(3-Cl,4-F) Ph(2-F) 351 62 1,3-benzodioxol- Ph(2,3-di-F) 397 5-yl(2,2-di-F) 63 1,3-benzodioxol- Ph(2-F) 379 5-yl(2,2-di-F) 64 Ph(3-Br) Ph(2,3-di-F) 395 65 Ph Ph(2,3-di-F) 317 66 Ph(3-Br) Ph(2-F) 377 67 Ph(3,4-di-F) Ph(2-CF₃,3-F) 401 403 68 Ph(3-OCF₃) Ph(2,3-di-F) 401 69 Ph(3-OCF₃) Ph(2-F) 383 70 Ph(3-NH-t-Boc) Ph(2,3-di-F) 432 72 Ph(3-CN) Ph(2-F) 324 73 Ph(3-CN) Ph(2,3-di-F) 342 74 (Ex. 1) Ph(3-Cl,4-F) Ph(2-CF₃) 401 75 1,3-benzodioxol- Ph(2-CF₃) 429 5-yl(2,2-di-F) 76 Ph(3-CF₃,4-F) Ph(2-F) 385 77 Ph(3-CF₃,4-F) Ph(2,3-di-F) 403 78 Ph(3-CF₃,4-F) Ph(2-CF₃) 435 79 Ph(4-CF₃) Ph(2-F) 367 80 Ph(4-CF₃) Ph(2,3-di-F) 385 81 Ph Ph(2-F) 158-159 82 Ph Ph(2-CF₃) 159-160 83 Ph Ph(2-Cl) 154-155 84 Ph Ph(2-F,4-Br) 184-186 85 Ph(2-F) Ph(2-F) ** 86 Ph Ph(2-CN) ** 87 Ph(4-Cl) Ph(2-F) 189-192 88 Ph(2-Cl) Ph(2-F) 163-165 89 Ph(3-Cl) Ph(2-F) 164-166 90 Ph(3,5-di-Cl) Ph(2-F) 199-203 91 Ph(2,4-di-Cl) Ph(2-F) 192-194 96 Ph(3,4-F) 2-pyridin-6-one 334 97 Ph(3,4-F) 3-pyridin-2-one 334 98 Ph(3,4-F) 3-pyridinyl(2-CF₃) 170-173 99 Ph(3,4-F) Ph(2-Cl) 155-158 100 Ph(3,4-F) Ph(3-Cl,2-Me) 198-201 101 Ph(3,4-F) Ph(2,3-di-F) 170-172 102(3S,4R) Ph(3,4-F) Ph(2-F) 180-182 103(3R,4S) Ph(3,4-F) Ph(2-F) 179-181 104 Ph(3,4-F) Ph(3-Cl,2-F) 196-198 105 Ph(3,4-F) 3-pyridinyl(2-F) 171-174 106 Ph(3,4-F) Ph(3-F,2-Me) 200-202 107 Ph(3,4-F) Ph(2,3-di-F) 171-173 108 Ph(3,4-F) Ph(2-Cl,3-F) 219-223 109 Ph(3-CF₃) Ph(2-Me) 163-165 110 Ph(3-CF₃) 2-pyridinyl 175-177 111 Ph(3-CF₃) 1,3,4-thiadiazol-2-yl 357.3 112 Ph(3-CF₃) 1,3,4-thiadiazol-2-yl(5- 425.3 CF₃) 113 Ph(3-CF₃) 1,3-thiazol-2-yl(5-Cl) 390.3 114 Ph(3-CF₃) oxazol-2-yl(4-CF₃) 408.4 115 2-naphthyl Ph(2-F) 349 116 2-naphthyl Ph(2,3-di-F) 367 117 2-naphthyl Ph(2-CF₃) 399 118 Ph(4-F) Ph(2-OCHF₂) 363.3 119 Ph(4-F) Ph(2,3-di-F) 335.3 120 Ph(4-F) Ph(2,3,4-tri-F) 353.5 121 Ph(3-OCF₂CHF₂) Ph(2-F) 415 122 Ph(3-OCF₂CHF₂) Ph(2,4-di-F) 433 123 Ph(3-OCF₂CHF₂) Ph(2,3-di-F) 433 124 Ph(3-OCF₂CHF₂) Ph(2,3,4-tri-F) 451 125 Ph(3-OCF₂CHF₂) Ph(2-Cl) 431 126 Ph(OCH₂CF₃) Ph(2-F) 397 127 Ph(OCH₂CF₃) Ph(2,4-di-F) 415 128 Ph(OCH₂CF₃) Ph(2,3-di-F) 415 129 Ph(OCH₂CF₃) Ph(2,3,4-tri-F) 433 130 Ph(OCH₂CF₃) Ph(2-Cl) 413 131 Ph(3-OMe,4-F) Ph(2,4-di-F) 365 132 Ph(3-OMe,4-F) Ph(2,3,4-tri-F) 383 133 Ph(3-OMe,4-F) Ph(2-Cl) 363 134 Ph(3-SO₂Me) Ph(2-F) 377 135 Ph(3-SO₂Me) Ph(2,4-di-F) 395 136 Ph(3-SO₂Me) Ph(2,3-di-F) 395 137 Ph(3-SO₂Me) Ph(2,3,4-tri-F) 413 138 Ph(3-SO₂Me) Ph(2-Cl) 393 139 Ph(4-F,3-Me) Ph(2-F) 331 140 Ph(4-F,3-Me) Ph(2,4-di-F) 349 141 Ph(4-F,3-Me) Ph(2,3-di-F) 349 142 Ph(4-F,3-Me) Ph(2,3,4-tri-F) 367 143 Ph(4-F,3-Me) Ph(2-Cl) 347 144 Ph(3-F,4-Me) Ph(2-F) 331 145 Ph(3-F,4-Me) Ph(2,4-di-F) 349 146 Ph(3-F,4-Me) Ph(2,3-di-F) 349 147 Ph(3-F,4-Me) Ph(2,3,4-tri-F) 367 148 Ph(3-F,4-Me) Ph(2-Cl) 347 149 Ph(4-Me) Ph(2-F) 313 150 Ph(4-Me) Ph(2,4-di-F) 331 151 Ph(4-Me) Ph(2,3-di-F) 331 152 Ph(4-Me) Ph(2-Cl) 329 153 Ph(4-Me) Ph(3-F) 313 154 Ph(3-CF₃) Ph(2-Cl) 397.5 155 Ph(3,5-di-F) Ph(2-F) 335 156 Ph(3,5-di-F) Ph(2,4-di-F) 353 157 Ph(3,5-di-F) Ph(2,3-di-F) 353 158 Ph(3,5-di-F) Ph(2,3,4-tri-F) 371 159 Ph(3,5-di-F) Ph(2-Cl) 351 160 Ph(3-CF₃) Ph(2-SO₂Me) 427 161 1,3-benzodioxo1-5-yl(2,2- Ph(2-F) 379 di-F) 162 1,3-benzodioxo1-5-yl(2,2- Ph(2,3,4-tri-F) 415 di-F) 163 Ph(3-CHF₂) Ph(2-F) 349 164 Ph(3-CHF₂) Ph(2,3-di-F) 367 165 Ph(3-CHF₂) Ph(2,3,4-tri-F) 385 166 Ph(3-c-Pr) Ph(2-F) 339 167 Ph(3-c-Pr) Ph(2,3-di-F) 357 168 Ph(3-c-Pr) Ph(2,3,4-tri-F) 375 169 Ph(3-Et) Ph(2-F) 327 170 Ph(3-Et) Ph(2,3-di-F) 345 171 Ph(3-Et) Ph(2,3,4-tri-F) 363 172 Ph(4-OCF₂CHF₂) Ph(2,3-di-F) 433 173 Ph(4-OCF₂CHF₂) Ph(2,4-di-F) 433 174 Ph(4-OCF₂CHF₂) Ph(2,3,4-di-F) 451 176 Ph(4-Cl) Ph(2,3-di-F) 351 177 Ph(4-Cl) Ph(2,4-di-F) 351 178 Ph(4-Cl) Ph(2-F) 333 179 Ph(4-Cl) Ph(3-F) 333 180 Ph(4-Cl) Ph(2-Cl) 350 183 Ph(3-CF₃) Ph(2-F,5-Me) 381 184 Ph(3-CF₃) Ph(2-F,3-Me) 381 185 Ph(3-CF₃) Ph(4-F,3-Me) 381 186 Ph(3-CF₃) Ph(5-CF₃,4-Me) 431 187 Ph(3-CF₃) Ph(4-OMe,2-F) 397 188 Ph(3-CF₃) Ph(4-OMe,3-F) 397 189 Ph(3-CF₃) Ph(2-Cl) 383 190 Ph(3-CF₃) Ph(2-Br) 428.9 191 1H-pyrazol-3-yl(1-Me) Ph(2-CF₃) 141-143 192 1H-pyrazol-3-yl(1-Me) Ph(2,3-di-F) 188-190 193 Ph(3,4-di-F) Ph(4-F) 162-164 194 Ph(3-OMe,4-F) Ph(2-F) 347 195 Ph(3-OMe,4-F) Ph(2,3-di-F) 365 196 Ph(3-OMe,4-F) Ph(2-CF₃) 397 197 Ph(4-OMe,3-F) Ph(2-F) 347 198 Ph(4-OMe,3-F) Ph(2,3-di-F) 365 199 Ph(4-OMe,3-F) Ph(2-CF₃) 397 200 Ph(3-t-Bu) Ph(2,3-di-F) 373 201 Ph(3-t-Bu) Ph(2-CF₃) 405 202 Ph(4-CF₃) Ph(2,3-di-F) 385.5 203(3S,4R) Ph(3-CF₃) Ph(2-F) 138-140 204(3R,4S) Ph(3-CF₃) Ph(2-F) 135-137 205(3S,4R) Ph(3-CF₃) Ph(2,3-di-F) 121-123 206(3R,4S) Ph(3-CF₃) Ph(2,3-di-F) 120-122 207 Ph(3-CF₃) Ph(2,4-di-F) 164-166 208 Ph(3-CF₃) Ph(3-F) 123-125 209 Ph(3-CF₃,4-OCH₃) Ph(2-F) 397 210 Ph(3-CHF₂) Ph(2-F) 349 211 Ph(3-CHF₂) Ph(2,3-di-F) 367 212 Ph(3-CHF₂) Ph(2-CF₃) 399 213 Ph(3-SF₅) Ph(2-F) 425 214 Ph(3-SF₅) Ph(2,3-di-F) 443 215 Ph(3-SF₅) Ph(2-CF₃) 475 216 naphthalen-1-yl Ph(2-F) 349 217 Ph(4-Cl) Ph(2-F) 333 218 Ph(4-Cl) Ph(2,3-di-F) 351 219 Ph(4-Cl) Ph(2-CF₃) 383 220 Ph(4-Cl) Ph(2-Cl) 349 221 Ph(4-Cl) Ph(2,3-di-Cl) 383 222 Ph(3-OCHF₂) Ph(2-CF₃) 415.1 223 Ph(3-OCHF₂) Ph(2-F) 365.1 224 Ph(3-OCHF₂) Ph(2,3-di-F) 383.1 225 Ph(4-OCHF₂) Ph(2-Br) 427 226 Ph(4-OCHF₂) Ph(2-Cl) 381 227 Ph(4-OCHF₂) Ph(2-Me) 361.1 228 Ph(3-OCHF₂) Ph(2-Br) 427 229 Ph(3-OCHF₂) Ph(2-Cl) 381.1 230 Ph(3-OCHF₂) Ph(2-Me) 361.1 231(3R,4S) Ph(4-CF₃) Ph(2-F) 367.5 232 Ph(4-CF₃) Ph(2,3,4-tri-F) 403.5 233 Ph(4-CF₃) Ph(2-Cl) 383.5 234 Ph(3-CF₃,4-OMe) Ph(2,3-di-F) 415 235 Ph(4-Ph(2-F)) Ph(2,3-di-F) 131.6-136.5 236 Ph(4-Ph(2-CF₃)) Ph(2,3-di-F) 177.9-191.1 237 Ph(3-Ph(2-CF₃)) Ph(2-CF₃) 57.1-66.2 238 Ph(3-Ph(2-F)) Ph(2-CF₃) 152.7-157.5 239 Ph(4-F) Ph(2-F) 317.4 240 Ph(3-CF₃,4-OMe) Ph(2-CF₃) 447 241 Ph(3-CF₃) Ph(2,3-di-F) 385 242 Ph(3-CF₃) Ph(2-CF₃,3-F) 436 244 Ph(3,4-di-F) 2-pyridinyl(6-F) 337.3 245 Ph(3,4-di-F) 2-pyridinyl(6-CF₃) 386.4 246 Ph(4-CF₃,3-F) Ph(2-F) 385 247 Ph(4-CF₃,3-F) Ph(2,3-di-F) 403 248 Ph(4-CF₃,3-F) Ph(2-CF₃) 435 249 Ph(4-CF₃,3-Cl) Ph(2-F) 401 250 Ph(4-CF₃,3-Cl) Ph(2,3-di-F) 419 251 Ph(4-CF₃,3-Cl) Ph(2-CF₃) 451 252 1H-imidazol-2-yl(1-Me) Ph(2,3-di-F) 170-174 253 1H-pyrazol-4-yl(1-Me) Ph(2,3-di-F) 165-168 254 1H-pyrazol-4-yl(1-Me) Ph(2-F) 189-193 255 1H-imidazol-2-yl(1-Me) Ph(2-F) 167-170 256 Ph(4-OCF₃) Ph(2-F) 383 257 Ph(4-OCF₃) Ph(2,3-di-F) 401 258 Ph(4-OCF₃) Ph(2-CF₃) 433 259 Ph(4-CF₃,2-F) Ph(2-F) 385 260 Ph(4-CF₃,2-F) Ph(2,3-di-F) 403 261 Ph(4-CF₃,2-F) Ph(2-CF₃) 435 262 3-pyridinyl(6-CF₃) Ph(2-F) 368 263 3-pyridinyl(6-CF₃) Ph(2,3-di-F) 386 264 3-pyridinyl(6-CF₃) Ph(2-CF₃) 418 267 Ph(3-CF₃,4-Cl) Ph(2-F) 401 268 Ph(3-CF₃,4-Cl) Ph(2,3-di-F) 419 269 Ph(3-CF₃,4-Cl) Ph(2-CF₃) 451 272 Ph(3,4-di-Cl) Ph(2,4-di-F) 385 273 Ph(3,4-di-Cl) Ph(2-Cl) 383 275 Ph(3-Cl) Ph(2,3-di-F) 351.4 278 Ph(3,5-di-F) Ph(2,4-di-F) 353 279 Ph(3,5-di-F) Ph(2,3-di-F) 353 280 Ph(3,5-di-F) Ph(2-Cl) 351 281 2-benzofuranyl Ph(2-F) 339 282 2-benzofuranyl Ph(2,3-di-F) 357 283 2-benzofuranyl Ph(2-CF₃) 389 284 2-furanyl(5-Cl) Ph(2-F) 323 285 2-furanyl(5-Cl) Ph(2,3-di-F) 341 286 Ph(3,4-di-Cl) Ph(2,3,4-tri-F) 403 287 Ph(3-SMe) Ph(2-F) 345 288 Ph(3-SMe) Ph(2,4-di-F) 363 289 Ph(3-SMe) Ph(2,3-di-F) 363 290 Ph(3-SMe) Ph(2,3,4-tri-F) 381 291 Ph(3-SMe) Ph(2-Cl) 361 292 2-thienyl(5-Cl) Ph(2-F) 339 293 2-thienyl(5-Cl) Ph(2-CF₃) 389 294 2-thienyl(5-Cl) Ph(2,3-di-F) 357 295 2-benzothiophenyl Ph(2-F) 355 296 2-benzothiophenyl Ph(2,3-di-F) 373 297 2-benzothiophenyl Ph(2-CF₃) 405 298 1H-pyrazol-4-yl(1- Ph(2-F) 371 CH₂CF₃) 299 1H-pyrazol-4-yl(1- Ph(2,3-di-F) 389 CH₂CF₃) 300 1H-pyrazol-4-yl(1- Ph(2-CF₃) 421 CH₂CF₃) 307 Ph(3-Br) Ph(2-F) 378 308 Ph(3-Br) Ph(2,4-di-F) 394 309 Ph(3-Br) Ph(2,3-di-F) 396 310 Ph(3-Br) Ph(2,3,4-tri-F) 412 311 Ph(3-Br) Ph(2-Cl) 394 312 Ph(3-CF₃) Ph(2-Cl) 383 313 Ph(3-CF₃) Ph(3-CF₃) 417 314 Ph(3-CF₃) Ph(2,5-di-F) 385 315 Ph(3-CF₃) Ph(2,3,4-tri-F) 403 316 Ph(3-CF₃) Ph(3-Cl,2-F) 401 317 Ph(3-CF₃) Ph(3-Me) 363 318 Ph(3-i-Pr) Ph(2-F) 341 319 Ph(3-i-Pr) Ph(2,3-di-F) 359 320 Ph(3-i-Pr) Ph(2-CF₃) 391 321 Ph(4-SCF₃) Ph(2-F) 399 322 Ph(4-SCF₃) Ph(2,3,4-tri-F) 435 323 Ph(3-OCHF₂) Ph(2-F) 365 324 Ph(3-OCHF₂) Ph(2,3-di-F) 383 325 Ph(3-OCHF₂) Ph(2,3,4-tri-F) 401 326 Ph(3-(1H-pyrazol-1-yl(3- Ph(2,3-di-F) 190.8-193.9 CF₃))) 327 Ph(3-I) Ph(2,3-di-F) 152.7-160.9 328 Ph(3-I) Ph(2-CF₃) 106.8-110.4 329 Ph(3-(1H-pyrazol-1-yl(3- Ph(2-CF₃) 174.8-179.8 CF₃))) 330 Ph(3-OPh) Ph(2-F) 391 331 Ph(3-OPh) Ph(2,4-di-F) 409 332 Ph(3-OPh) Ph(2,3-di-F) 409 333 Ph(3-OPh) Ph(2,3,4-tri-F) 427 334 Ph(3-OPh) Ph(2-Cl) 407 337 Ph(3-(1H-pyrazol-1-yl)) Ph(2,3-di-F) 383.5 338 Ph(3-(1H-pyrazol-1-yl)) Ph(2-CF₃) 415.5 339 Ph(3,4-di-Br) Ph(2-F) 457 340 Ph(3,4-di-Br) Ph(2,4-di-F) 475 341 Ph(3,4-di-Br) Ph(2,3-di-F) 475 342 Ph(3,4-di-Br) Ph(2,3,4-tri-F) 493 343 Ph(3,4-di-Br) Ph(2-Cl) 473 344 Ph(3-CF₃) Ph(3-Cl,2-F) 155-156 345 Ph(3-CF₃) Ph(2,3,4-tri-F) 156158 346 Ph(3,4-di-F) Ph(2,3,4-tri-F) 205-207 347 Ph(3-t-Bu) Ph(2-F) 355 348 Ph(4-OCHF₂) Ph(2-CF₃) 143-144 349 Ph(4-OCHF₂) Ph(2-F) 161-162 350 Ph(4-OCHF₂) Ph(2,3-di-F) 167-168 ⁽¹⁾ Substituents in the 3 and 4 positions of the pyrrolidinone ring, i.e. C(O)N(Q²)(R⁶) and Q¹, respectively, are predominately in the trans configuration. In some instances the presence of minor amounts of the cis isomer can be detected by NMR. * See synthesis example for ¹H NMR data. ** See Index Table D for ¹H NMR data.

INDEX TABLE B

Cmpd. No. R² R³ Q¹ Q² M + 1 7(Diastereomer Mixture A) Me H Ph(3,4-di-F) Ph(2-F) 349 8(Diastereomer Mixture B) Me H Ph(3,4-di-F) Ph(2-F) 349 9(Diastereomer Mixture A) Me H Ph(3,4-di-F) Ph(2-CF₃) 399 10(Diastereomer Mixture B) Me H Ph(3,4-di-F) Ph(2-CF₃) 399 11 Me Me Ph(3,4-di-F) Ph(2-F) 363

TABLE C INDEX

Cmpd. No. R¹ Q¹ R⁴ R⁵ R⁶ Q² Y¹ m.p. (° C.) M − 1 M + 1  24 H Ph(3,4-di-F) H H Me Ph(2-F) O 171-172  37 t-Boc Ph(3-Me) H H H Ph(2-F) O 70.2-73.4 44 (Ex. 3) OH Ph(3,4-di-F) H H H Ph(2-F) O 351  61 H Ph(3-Cl,4-F) H Me H Ph(2,3-di-F) O 383  71 H Ph(3,4-di-F) H H OH Ph O 331 92 (Ex. 2) H Ph H Br H Ph(2-F) O * 93 (Ex. 2) H Ph Br H H Ph(2-F) O *  94 H Ph H Br H Ph(2-F,4-Br) O ** 95 (Ex. 4) H Ph(3,4-di-F) H H H Ph(2-F) NH * 175 H Ph(3,4-F) H H OMe Ph(2-F,5-NO₂) O 170-175 181 n-Pr Ph(4-CF₃) H H H Ph(2-F) O 409.5 182 n-Pr Ph(4-CF₃) H H H Ph(2,3-di-F) O 427.5 243 H Ph(3,4-di-F) H H OMe Ph(2-NO₂) O 155-159 265 H Ph(3,4-di-F) H H propargyl Ph(2-NO₂) O 226-230 266 H Ph(3,4-di-F) H H allyl Ph(2-NO₂) O 206-210 270 Me Ph(4-F) H H H Ph(2-F) O 331 271 Me Ph(4-F) H H H Ph(2,3-di-F) O 349 274 H Ph(3-CF₃) H H H Ph(2-F) S 383 276 i-Pr Ph(4-F) H H H Ph(2,3-di-F) O 377.5 277 Me Ph(3-CF₃) H H H Ph(2-F) O 381.5 301 H Ph CH₃ H H Ph(2-F) O 313.1 302 Me Ph(3,4-di-F) H H H Ph(2-F) O 349.3 303 Me Ph(3,4-di-F) H H H Ph(2,3-di-F) O 367.3 304 Me Ph(4-CF₃) H H H Ph(2-F) O 381.5 305 Me Ph(3-CF₃) H H H Ph(2,3-di-F) O 399.5 306 Me Ph(4-CF₃) H H H Ph(2,3-di-F) O 399.5 335 Et Ph(4-CF₃) H H H Ph(2-F) O 395 336 Et Ph(4-CF₃) H H H Ph(2,3-di-F) O 413 351(3S,4S)(Ex. 6) Me Ph(3-CF₃) H H H Ph(2-F) O * *See synthesis example for ¹H NMR data. **See Index Table D for ¹H NMR data.

INDEX TABLE D ¹H NMR Data (CDCl₃ Cmpd. No. solution unless indicated otherwise)^(a) 29 δ 9.65 (br s, 1H), 8.28 (m, 1H), 7.37 (m, 1H), 7.25 (m, 1H), 7.10 (m, 4H), 6.18 (br s, 1H), 4.36 (m, 1H), 3.84 (m, 1H), 3.53 (m, 2H). 85 δ 9.80 (br s, 1H), 8.25 (t, 1H), 7.40 (t, 1H), 7.25 (m, 1H), 7.15 (m, 1H), 7.05 (m, 4H), 6.35 (br s, 1H), 4.10 (q, 1H), 3.80 (m, 2H), 3.50 (t, 1H). 86 δ 10.3 (br s, 1H), 8.20 (br s, 1H), 7.80 (d, 1H), 7.70 (d, 1H), 7.65 (t, 1H), 7.40-7.20 (m, 6H), 4.00 (q, 1H), 3.85 (d, 1H), 3.70 (t, 1H), 3.30 (t, 1H) 94 δ 9.55 (br s, 1H), 8.25 (t, 1H), 7.48 (d, 2H), 7.38 (m, 3H), 7.11 (m, 3H), 6.85 (br s, 1H), 4.45 (m, 1H), 3.77 (m, 1H), 3.65 (m, 1H). ^(a1)H NMR data are in ppm downfield from tetramethylsilane. Couplings are designated by (s)-singlet, (d)-doublet, (t)-triplet, (m)-multiplet, (br s)-broad singlet.

Biological Examples of the Invention Test A

Seeds of plant species selected from barnyardgrass (Echinochloa crus-galli), Kochia (Kochia scoparia), ragweed (common ragweed, Ambrosia elation), ryegrass, Italian (Italian ryegrass, Lolium multiflorum), crabgrass, large (large crabgrass Digitaria sanguinalis), giant foxtail (Setaria faberii), morningglory (Ipomoea spp.), pigweed (Amaranthus retroflexus), velvetleaf (Abutilon theophrasti), wheat (Triticum aestivum), and corn (Zea mays) were planted into a blend of loam soil and sand and treated preemergence with a directed soil spray using test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant.

At the same time, plants selected from these crop and weed species and also blackgrass (Alopecurus myosuroides), and galium (catchweed bedstraw, Galium aparine) were planted in pots containing the same blend of loam soil and sand and treated with postemergence applications of test chemicals formulated in the same manner. Plants ranged in height from 2 to 10 cm and were in the one- to two-leaf stage for the postemergence treatment. Treated plants and untreated controls were maintained in a greenhouse for approximately 10 days, after which time all treated plants were compared to untreated controls and visually evaluated for injury. Plant response ratings, summarized in Table A, are based on a 0 to 100 scale where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

TABLE A 1000 g ai/ha Compounds Postemergence 17 18 19 20 21 22 23 24 25 26 27 30 31 33 Barnyardgrass 90 50  90 80  90 0 90  0 80 70  70  90  60  90 Blackgrass — — — — — — — — — — — — — — Corn 60 0  0 0  0 0 0 0  0 0 0 0 30  40 Crabgrass, Large 90 70  90 90  80 0 80  30  80 60  70  80  20  90 Foxtail, Giant 90 70  80 80  80 0 80  0 90 70  60  80  20  90 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory  0 0  0 0  0 0 0 0 10 0 0 0 0 20 Pigweed 40 0  0 0 — 0 0 0  0 0 0 0 0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 50 0 10 0 60 0 40  0 10 0 0 0 0 20 Wheat 60 0 30 20  30 0 0 0  0 0 0 0 0 60 1000 g ai/ha Compounds Postemergence 34 35 39 40 43 44 71 96 98 99 100 104 105 106 Barnyardgrass 90 90 50 80 40 60  50  0 50 90 80 80  90 90 Blackgrass — — — — — — — — — — — — — — Corn 50 20  0 20  0 0 0 0  0 20 40 0  0 50 Crabgrass, Large 90 90 80 90 20 50  80  0 90 90 90 80  90 90 Foxtail, Giant 90 90 70 90 50 30  60  0 60 90 80 70  80 90 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 20  0 10 10 10 0 — 0  0 10  0 0 10 20 Pigweed  0  0 50  0 20 0 0 0  0  0  0 0  0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 20  0 10  0 30 0 0 0 10 10  0 10  10 40 Wheat 70 40 40 20  0 0 0 0 20 20 30 0  0 30 1000 g ai/ha Compounds Postemergence 108 191 192 193 237 238 243 252 253 254 255 265 266 274 Barnyardgrass 90 0 0 90  20  30  60  0 0 0 0 0 0 90 Blackgrass — — — — 0 20  — — — — — — — 50 Corn  0 0 0 0 0 0 0 0 0 0 0 0 0 70 Crabgrass, Large 90 0 0 90  — — 0 0 20  0 0 0 0 — Foxtail, Giant 80 0 0 80  0 30  20  0 20  0 0 0 0 90 Galium — — — — 0 20  — — — — — — —  0 Kochia — — — — 0 0 — — — — — — — 40 Morningglory 10 0 0 0 — — 0 0 10  0 0 0 0 — Pigweed  0 0 0 0 0 0 0 0 0 0 0 0 0 20 Ragweed — — — — 0 0 — — — — — — — 30 Ryegrass, Italian — — — — 0 0 — — — — — — — 20 Velvetleaf 10 0 0 0 — — 0 0 0 0 0 0 0 — Wheat  0 0 0 0 0 0 0 0 0 0 0 0 0 40 500 g ai/ha Compounds Postemergence 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Barnyardgrass 80  60  80 70 90  80 70  60  50  40  50  90 30  80  Blackgrass — — — — — — — — — — — — — — Corn 0 0 60 50 0  0 0 0 0 0 0  0 0 0 Crabgrass, Large 80  70  80 80 80  80 80  70  70  60  50  90 60  90  Foxtail, Giant 60  60  80 70 80  80 50  50  70  30  — 80 0 80  Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 30 30 10   0 0 0 0 0 0  0 0 0 Pigweed 0 0 50 50 0 10 0 0 0 0 0  0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0  0  0 0 10 0 0 0 0 0 20 0 90  Wheat 0 0 50 50 0  0 0 0 0 0 0 20 0 0 500 g ai/ha Compounds Postemergence 15 16 28 29 32 36 37 38 41 42 45 46 47 48 Barnyardgrass 0 90 0 0 0 80  50  30  50  40  80 0 0 90 Blackgrass — — — — — — — — — — — — — — Corn 0 30 0 0 0 0 0 0 0 0 — — — 50 Crabgrass, Large 0 90 40  0 30  20  20  50  60  70  80 60  0 80 Foxtail, Giant 0 90 0 0 40  20  20  20  0 20  70 40  0 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 10 0 0 0 0 0 0 0 0 50 0 20  20 Pigweed 0  0 0 0 0 0 0 0 30  0  0 0 0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0  0 0 0 0 0 0 0 30  50   0 0 0 20 Wheat 0 50 0 0 0 0 0 0 0 0  0 0 0 40 500 g ai/ha Compounds Postemergence 49 50 51 52 53 54 55 56 57 58 59 60 61 62 Barnyardgrass 20  80  20  80 80  0 90  50  80  0 90 90 20  80 Blackgrass — — — — — — — — — — — — — — Corn 0 0 0 30 0 0 0 0 0 0 30 60 0 70 Crabgrass, Large 70  80  80  80 80  80  80  80  70  80  90 90 70  90 Foxtail, Giant 40  80  30  80 80  70  80  60  60  70  80 80 30  80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 0  0 0 0 0 0 0 0  0  0 0  0 Pigweed 0 0 0 40 0 0 0 0 0 0 40  0 0 70 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0  0 0 0 0 0 0 0  0  0 0  0 Wheat 0 0 0 30 0 0 0 0 0 0 60 50 0 60 500 g ai/ha Compounds Postemergence 63 64 65 66 67 68 69 70 72 73 74 75 76 77 Barnyardgrass 80 80 70 80 60  80 80 60 60  80 80 70 90 80 Blackgrass — — — — — — — — — — — — — — Corn 50 40 20 80 0 90 90  0 0  0 50  0 70 70 Crabgrass, Large 90 80 90 80 90  90 90 70 70  80 90 80 90 80 Foxtail, Giant 90 80 90 80 90  80 80 80 50  80 90 80 80 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory  0  0 20  0 0  0  0  0 10  20  0  0 40 30 Pigweed  0 30  0  0 20  60 30 20 0  0  0  0 60 50 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf  0 30 30  0 0 20 30 20 0 30 50 20 60 40 Wheat 30 40 20 30 0 20 40 40 0  0 60 30 60 60 500 g ai/ha Compounds Postemergence 78 79 80 81 82 83 84 85 86 87 88 89 90 91 Barnyardgrass 70 90 80 80  50 60  0 20  20  80 40  80 70 20  Blackgrass — — — — — — — — — — — — — — Corn 50 70 60 0  0 0 0 0 0  0 0 30 30 0 Crabgrass, Large 80 90 90 80  70 70  20  50  60  80 60  80 70 50  Foxtail, Giant 80 80 80 70  70 50  0 0 10  80 0 80 70 20  Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory  0 10  0 0 10 0 0 0 0 10 0 10  0 0 Pigweed 50 70 70 0  0 0 0 0 0 20 0 20 20 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 60 60 60 0 20 0 0 0 0  0 0  0  0 0 Wheat 50 50 50 0 10 0 0 0 0 20 0 20  0 0 500 g ai/ha Compounds Postemergence 92 93 94 95 97 101 102 103 107 109 110 111 112 113 Barnyardgrass 70  60  0 90  0 90 0 90 80 90 90 0 0 0 Blackgrass — — — — — — — — — 80 70 0 0 0 Corn 0 0 0 0 0 50 0 20  0 80 20 0 0 0 Crabgrass, Large 70  80  0 90  0 80 0 90 70 — — — — — Foxtail, Giant 10  60  0 80  0 90 0 90 70 90 90 0 0 0 Galium — — — — — — — — — 60 40 0 0 0 Kochia — — — — — — — — —  0  0 0 0 0 Morningglory 0 0 0 0 0 60 0  0 40 — — — — — Pigweed 0 0 0 0 0 70 0 20 30  0  0 0 0 0 Ragweed — — — — — — — — —  0  0 0 0 0 Ryegrass, Italian — — — — — — — — — 30 40 0 0 0 Velvetleaf 0 0 0 0 0 70 0  0 20 — — — — — Wheat 0 0 0 0 0 60 0 20  0 60 20 0 0 0 500 g ai/ha Compounds Postemergence 114 115 116 117 118 119 120 121 122 123 124 125 126 127 Barnyardgrass 60 50  40  30  60  90 90 80 80 80 70 70 80  70 Blackgrass 30 — — — 0 50 50 70 70 70 70 50 30  40 Corn 20 0 20  20  0 70 80 70 60 80 50  0 0 20 Crabgrass, Large — 50  30  60  — — — — — — — — — — Foxtail, Giant 70 10  20  50  80  90 90 90 80 90 90 80 80  80 Galium 20 — — — 60  50 60 70 80 70 80 60 30  60 Kochia 20 — — — 50  50 70 60 70 70 80 60 0 60 Morningglory — 0 0 0 — — — — — — — — — — Pigweed  0 0 0 0 0 30 50  0 80 90 70 20 0  0 Ragweed  0 — — — 0 30 50 30 70 70 70  0 0  0 Ryegrass, Italian 60 — — — 0 40 50 50 40 50 50  0 0  0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat 20 0 0 0 0 70 60 60 60 60 50  0 0  0 500 g ai/ha Compounds Postemergence 128 129 130 131 132 133 139 140 141 142 143 144 145 146 Barnyardgrass 60 70 70  60  80  80  90  80  90 90 90  90 90 90 Blackgrass 50 50 0 0 0 0 20  20  50 30 0 30 30 70 Corn 20 30 0 0 0 0 0 0 50  0 0 20  0 50 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 80 80 70  50  70  50  30  50  50 50 30  70 70 70 Galium  0 60 0 0 0 0 30  30  50 40 40  70 50 70 Kochia  0  0 0 0 10  0 0 0 20  0 0  0 20 70 Morningglory — — — — — — — — — — — — — — Pigweed 50  0 0 0 0 0 0 0  0  0 0  0  0  0 Ragweed  0  0 0 0 0 0 0 0 40  0 0  0 20 60 Ryegrass, Italian  0 50 0 0 0 0 0 0 40 20 0 40  0 60 Velvetleaf — — — — — — — — — — — — — — Wheat 40 40 0 0 0 0 0 0 30 20 0  0  0 70 500 g ai/ha Compounds Postemergence 147 148 149 150 151 152 153 154 156 157 160 161 162 163 Barnyardgrass 90 90  80 80 90 80 80 80 80 80 80 90 90 90 Blackgrass 60 0 40 10 70 50 30 70 20 30 70 50 50 60 Corn 50 0 70 30 50  0  0 70 30 80 70 60 60 40 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 70 30  70 70 70 60 60 80 80 80 90 90 90 80 Galium 60 40  60 60 70 70 60 60 30 40 70 60 70 60 Kochia 60 0 60 60 80 60 60 50 20 30 80 60 70  0 Morningglory — — — — — — — — — — — — — — Pigweed 10 0  0 20 60 20 50 30 20 30 80 60 70 20 Ragweed 50 0 40 20 70 50 10  0 30 40 60 30 40 20 Ryegrass, Italian 50 0 50  0 50 50  0 50 30 30 10 50 50 30 Velvetleaf — — — — — — — — — — — — — — Wheat 40 0 20  0 60  0  0 50 40 70 50 40 50 60 500 g ai/ha Compounds Postemergence 164 165 166 167 168 169 170 171 172 174 175 181 182 183 Barnyardgrass 90 90 80 90 90 90 90 90 20  20  0 0 0 0 Blackgrass 70 70 60 60 60 60 60 60 0 0 0 50  0 0 Corn 80 80 80 70 70 50 70 70 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 90 90 90 90 90 80 30  30  0 0 10  0 Galium 60 50 60 60 70 50 60 70 0 0 0 0 0 0 Kochia 70 70 70 50 60 40 50 30 0 0 0 70  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 60 50 50  0 40  0 30 40 0 0 0 50  0 0 Ragweed 50 50  0 50 20  0 50 30 0 0 0 0 0 0 Ryegrass, Italian 50 50 50 40 50 40 60 30 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat 80 70 50 50 40 50 60 50 0 0 0 0 0 0 500 g ai/ha Compounds Postemergence 184 185 186 188 189 190 194 195 196 197 198 199 200 201 Barnyardgrass 80 80  0 0 90  90 80  90  80  70  80  70  90  30  Blackgrass 20 20  0 0 — — — — — — — — 0 0 Corn 20 20  0 0 60  40 0 0 0 0 0 0 20  0 Crabgrass, Large — — — — 80  90 80  80  80  70  80  80  — — Foxtail, Giant 80 80  0 0 90  80 50  70  70  40  60  50  40  0 Galium 20 0 0 0 — — — — — — — — 0 0 Kochia  0 0 0 0 — — — — — — — — 0 0 Morningglory — — — — 0 10 0 0 0 10  0 0 — — Pigweed  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Ragweed  0 0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 20 0 0 0 — — — — — — — — 0 0 Velvetleaf — — — — 0 10 0 0 0 0 0 40  — — Wheat 40 20  0 0 0  0 0 30  0 0 0 0 20  0 500 g ai/ha Compounds Postemergence 202 203 204 205 206 207 208 209 210 211 212 213 214 215 Barnyardgrass 90 80  90 70 90 90 80 80  90 90 90 70 70 60 Blackgrass 50 30  80 70 80 70 60 20  60 70 60 60 70 50 Corn 90 0 80  0 80 70 50 0 60 70 50 50 50  0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 70  90 90 90 90 90 70  90 90 90 90 90 80 Galium 60 0 60 60 80 50 50 0 60 70 60  0 70 60 Kochia 90 0 60 40 70  0 60 0 60 60 20  0 40  0 Morningglory — — — — — — — — — — — — — — Pigweed 80 0 20 30 70  0  0 0 20 50  0  0 50 60 Ragweed 50 20   0  0 50  0 20 0  0 30 20 30  0 10 Ryegrass, Italian 40 0 50  0 60 50 40 20  50 60  0 50 30  0 Velvetleaf — — — — — — — — — — — — — — Wheat 50 20  80 40 80 60 40 0 50 80 70 50 50  0 500 g ai/ha Compounds Postemergence 216 217 218 219 220 221 222 223 224 225 226 227 228 229 Barnyardgrass 0 90 90 50  80 0 90 80 90 60 80 80  80 80 Blackgrass 0 50 40 50  40 0 60 70 70 30 30 40  40 70 Corn 0 30 30 0 20 0 60 50 80 20  0 0 30  0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 10  90 90 80  80 30  90 90 80 70 80 80  90 90 Galium 0 50 60 60  30 0 60 60 70 30 20 0 40 70 Kochia 0 70 60 10  40 0 40 70 90  0 50 40  30 60 Morningglory — — — — — — — — — — — — — — Pigweed 0  0 40 0  0 0 20 60 80  0  0 0  0  0 Ragweed 0 30 50 0  0 0 40 30 60  0  0 0 20 60 Ryegrass, Italian 0 30 30 0 20 0 30 40 60  0 20 20  20 40 Velvetleaf — — — — — — — — — — — — — — Wheat 0 30 50 0 20 0 30 50 60 20  0 0 20  0 500 g ai/ha Compounds Postemergence 230 231 232 233 234 235 236 239 240 241 242 244 245 246 Barnyardgrass 90 90 90 90 90 20 0 90 90  90 80 90 50 70 Blackgrass 50 60 50 60 30 20 0 20 0 — — — — — Corn 40 40 80 20 60 20 0  0 20  80 70 20  0 30 Crabgrass, Large — — — — — — — — — 80 80 80 30 60 Foxtail, Giant 90 90 90 90 80 50 0 90 80  90 80 80 30 80 Galium 50 50 60 50 50 70 0 30 0 — — — — — Kochia 40 90 90 80 30 20 0 20 0 — — — — — Morningglory — — — — — — — — — 30 30  0  0  0 Pigweed  0 40 90 20  0 50 0  0 0 20 20 40 40  0 Ragweed 30 50 50 50  0  0 0  0 0 — — — — — Ryegrass, Italian 20 40 50 40 30  0 0 20 0 — — — — — Velvetleaf — — — — — — — — — 20 20 30 40  0 Wheat 20 30 50 20 40  0 0 20 20  70 20 20 40 30 500 g ai/ha Compounds Postemergence 247 248 249 250 251 256 257 258 259 260 261 262 263 264 Barnyardgrass 80 50  50  50  30  20  80 80 70  80 50 70  80 80 Blackgrass — — — — — — — — — — — — — — Corn 20 20  0 0 0 0 20 20 0  0  0 0 60  0 Crabgrass, Large 70 70  40  40  30  90  90 90 90  90 80 80  90 90 Foxtail, Giant 80 50  40  50  20  70  90 80 70  90 60 70  90 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory  0 0 0 0 0 0  0  0 0 50  0 0 60  0 Pigweed  0 0 0 0 20  0  0  0 0 70 40 0 70 60 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf  0 0 0 0 0 0  0  0 0 — 30 — — 30 Wheat 30 0 0 0 0 20  30 30 0  0  0 0 60  0 500 g ai/ha Compounds Postemergence 267 268 269 270 271 272 273 275 276 277 278 279 280 281 Barnyardgrass 80 70 70 90 90 80 30  90 0 90 90  90 90  70  Blackgrass — — — 20 60 30 0 60 0 50 60  70 0 0 Corn 70 40 20 30 60 10 0 90 0 90 0 70 0 0 Crabgrass, Large 90 80 80 — — — — — — — — — — — Foxtail, Giant 80 90 80 90 90 80 70  90 0 90 80  90 80  0 Galium — — — 50 70 50 50  70 0 70 50  50 0 0 Kochia — — — 30 80 60 0 80 0 30 0 40 0 0 Morningglory 60  0  0 — — — — — — — — — — — Pigweed 60 80 60  0 20 20 0 40 0 30 10   0 0 0 Ragweed — — —  0 60  0 0 30 0 30 0  0 0 0 Ryegrass, Italian — — — 20 40  0 0 50 0 40 0  0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat  0  0  0 20 80  0 0 70 0 70 0 60 0 0 500 g ai/ha Compounds Postemergence 282 283 284 285 286 287 288 289 290 291 292 293 294 295 Barnyardgrass 90  60  50  70  60  80  80  70  80  60  70  70  90 50  Blackgrass 20  0 0 0 0 0 0 0 0 0 0 10  30 0 Corn 0 0 0 0 0 0 0 0 0 0 0 0  0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 30  10  10  0 70  0 30  60  60  50  60  70  80 0 Galium 40  0 60  0 0 0 0 0 0 0 20  60  30 10  Kochia 0 0 0 0 20  0 20  0 0 0 0 0 50 0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 10  0 0 0  0 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 0 20 0 Ryegrass, Italian 0 0 0 0 20  0 0 0 0 0 0 0 20 0 Velvetleaf — — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 20 0 500 g ai/ha Compounds Postemergence 296 297 298 299 300 301 302 303 304 305 306 307 308 309 Barnyardgrass 20  0 0 70  0 0 90 90 90 90 80 90  70  90 Blackgrass 0 10  0 0 0 0 60 70 70 70 60 70  70  70 Corn 0 0 0 0 0 0 40 70 70 70 70 60  10  80 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 0 0 0 50  0 0 80 80 80 80 80 80  80  90 Galium 0 0 0 0 0 0 60 70 60 70 70 0 0 70 Kochia 0 0 0 0 0 0 60 80 80 70 70 0 0  0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 10 60 60 70 80 0 0  0 Ragweed 0 0 0 0 0 0  0 40 20  0 40 0 0  0 Ryegrass, Italian 0 0 0 0 0 0 60 60 50 70 60 0 0 30 Velvetleaf — — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 50 60 60 70 60 30  20  60 500 g ai/ha Compounds Postemergence 310 311 312 313 314 315 316 317 318 319 320 321 322 323 Barnyardgrass 90 80  90 80  80  90 90 90  90 90 90 50  60  90 Blackgrass 50 30  50 0 0 50 40 20  40 50 20 0 0 60 Corn 50 0 80 0 0 80 80 20  50 80  0 0 20  90 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 70  90 70  80  90 90 90  70 90 70 50  60  90 Galium 20 0 50 0 0 50 40 0 40 50  0 0 0 60 Kochia 30 0 40 0 0 70 40 0 30 50 20 0 0 90 Morningglory — — — — — — — — — — — — — — Pigweed  0 0 30 0 0 50 20 0 20 20  0 0 0 30 Ragweed 30 0 40 0 0 40 30 0 30 40 30 0 0 20 Ryegrass, Italian 30 0 40 0 0 50 30 0 40 50 30 0 0 30 Velvetleaf — — — — — — — — — — — — — — Wheat 50 0 70 0 0 70 40 20  30 50  0 0 0 80 500 g ai/ha Compounds Postemergence 324 325 326 327 328 329 330 331 332 333 334 335 336 337 Barnyardgrass 90 90 20  80 80 0 60  70  50 60 0 60  60  50  Blackgrass 70 50 0 40 40 0 0 30   0 30 0 20  0 0 Corn 90 80 0 30  0 0 0 0  0 20 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 50  80 80 30  80  80  80 80 10  90  70  40  Galium 60 60 0 60 50 0 30  30  20 40 0 0 0 0 Kochia 80 80 30  40 20 0 0 20  20 20 0 0 0 30  Morningglory — — — — — — — — — — — — — — Pigweed 70 50 0 20  0 0 0 0  0 20 0 0 0 0 Ragweed 50 60 0 20  0 0 0 0  0 20 0 0 0 0 Ryegrass, Italian 50 50 0 20 20 0 0 0 20 30 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat 80 80 0 20  0 0 0 0 20 20 0 20  0 0 500 g ai/ha Compounds Postemergence 338 339 340 341 342 343 344 345 346 347 348 349 350 Barnyardgrass 30  60  50 50 60 30  90  90 90 50  50 90 90 Blackgrass 0 0 20  0  0 0 0 60 50 0 30 40 50 Corn 0 0  0 30 40 0 0 90 40 0  0 20 40 Crabgrass, Large — — — — — — — — — — — — — Foxtail, Giant 60  60  90 70 50 60  90  90 90 20  90 90 90 Galium 0 0 30 30 20 0 0 70 50 0 40 50 70 Kochia 0 0 30 70 70 20  0 70  0 0 40 60 80 Morningglory — — — — — — — — — — — — — Pigweed 0 0 20 50 50 0 0 70 20 0 20 20 70 Ragweed 0 0  0 20  0 0 0 30 20 0  0 20 30 Ryegrass, Italian 0 0 20 20  0 0 0 70 30 0  0  0 30 Velvetleaf — — — — — — — — — — — — — Wheat 0 0  0 20 20 0 0 70 40 0 20 30 50 125 g ai/ha Compounds Postemergence 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Barnyardgrass 50  30  70  60 60  40  20  20  30  0 0 60  0 60  Blackgrass — — — — — — — — — — — — — — Corn 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 30  50  70  60 70  60  30  60  40  20  0 80  0 80  Foxtail, Giant 20  30  60  60 80  70  0 0 0 0 0 60  0 60  Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 30  20 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0 0 40 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 30 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 15 16 28 29 32 36 37 38 41 42 45 46 47 48 Barnyardgrass 0 70  0 0 0 0 0 0 0 0 50 0 0 80  Blackgrass — — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0 0 — — — 0 Crabgrass, Large 0 90  20  0 0 0 0 0 30  0 60 30  0 80  Foxtail, Giant 0 60  0 0 0 0 0 0 0 0 20 0 0 80  Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 40 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0  0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 — 0 0 0 0 0 0 30   0 0 0 0 Wheat 0 20  0 0 0 0 0 0 0 0  0 0 0 20  125 g ai/ha Compounds Postemergence 49 50 51 52 53 54 55 56 57 58 59 60 61 62 Barnyardgrass 0 80  0 80  30  0 30  0 70  0 70  80  0 70 Blackgrass — — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 40 Crabgrass, Large 20  80  20  80  80  70  80  50  50  40  70  80  0 80 Foxtail, Giant 0 80  0 80  30  60  70  20  50  20  80  80  0 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 0 0 0  0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 30 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0  0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 20 125 g ai/ha Compounds Postemergence 63 64 65 66 67 68 69 70 72 73 74 75 76 77 Barnyardgrass 60  60  20  80  40  70 70 20  20  70  60  40  80 70 Blackgrass — — — — — — — — — — — — — — Corn 0 30  0 20  0 20 20 0 0 0 0 0 40 50 Crabgrass, Large 80  80  90  80  50  90 70 20  30  50  80  60  90 80 Foxtail, Giant 70  70  50  70  80  80 80 20  10  30  80  70  80 80 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0  0  0 0 0 0 0 0 20  0 Pigweed 0 0 0 0 0 40 20 0 0 — 0 0 50 40 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 20 20 0 0 0 30  10  20 20 Wheat 0 0 0 0 0  0  0 0 0 0 0 0 50 50 125 g ai/ha Compounds Postemergence 78 79 80 81 82 83 84 85 86 87 88 89 90 91 Barnyardgrass 50 80 80 30  0 — 0 0 0 50  0 60  30  0 Blackgrass — — — — — — — — — — — — — — Corn 20 20 30 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 70 80 80 50  50  20  0 0 0 60  0 60  50  30  Foxtail, Giant 80 80 80 20  0 0 0 0 0 50  0 60  40  0 Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory  0  0  0 0 0 0 0 0 0 0 0 0 0 0 Pigweed 50 70 60 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 20 10 10 0 0 0 0 0 0 0 0 0 0 0 Wheat 40 30 40 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 92 93 94 95 97 101 102 103 107 109 110 111 112 113 Barnyardgrass 20  10  0 80  0 80 0 90 50  90 50  0 0 0 Blackgrass — — — — — — — — — 50 0 0 0 0 Corn 0 0 0 0 0  0 0 20 0 50 0 0 0 0 Crabgrass, Large 20  50  0 80  0 80 0 90 60  — — — — — Foxtail, Giant 0 10  0 70  0 80 0 90 10  90 80  0 0 0 Galium — — — — — — — — — 30 20  0 0 0 Kochia — — — — — — — — —  0 0 0 0 0 Morningglory 0 0 0 0 0 30 0  0 0 — — — — — Pigweed 0 0 0 0 0 20 0 20 0  0 0 0 0 0 Ragweed — — — — — — — — —  0 0 0 0 0 Ryegrass, Italian — — — — — — — — — 20 20  0 0 0 Velvetleaf 0 0 0 0 0 50 0  0 0 — — — — — Wheat 0 0 0 0 0 50 0  0 0 20 0 0 0 0 125 g ai/ha Compounds Postemergence 114 115 116 117 118 119 120 121 122 123 124 125 126 127 Barnyardgrass 20  10  — 0 0 90 80 70 70 70 60 60  60  60  Blackgrass 20  — — — 0 30 40 60 50 60 40 20  0 30  Corn 0 0 0 0 0 30 20 50 40 50  0 0 0 0 Crabgrass, Large — 0 20  30  — — — — — — — — — — Foxtail, Giant 40  0 0 20  50  90 80 80 80 80 80 70  70  70  Galium 0 — — — 50  30 50 60 70 60 70 0 0 20  Kochia 0 — — — 10  40 60 50 70 60 70 20  0 20  Morningglory — 0 0 0 — — — — — — — — — — Pigweed 0 0 0 0 0 30 20  0 60 80 60 0 0 0 Ragweed 0 — — — 0 20 30  0 30 50 40 0 0 0 Ryegrass, Italian 0 — — — 0 20 30 40  0 40 30 0 0 0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat 0 0 0 0 0 20 20 50 50 50 30 0 0 0 125 g ai/ha Compounds Postemergence 128 129 130 131 132 133 139 140 141 142 143 144 145 146 Barnyardgrass 50  60  50  50  60  30  80  70  80  80  50  90  70  90  Blackgrass 30  30  0 0 0 0 0 0 0 0 0 0 0 30  Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 70  70  60  50  50  20  30  0 0 0 20  40  40  0 Galium 0 40  0 0 0 0 0 0 20  0 0 10  20  40  Kochia 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 30  0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ryegrass, Italian 0 30  0 0 0 0 0 0 0 0 0 0 0 20  Velvetleaf — — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 147 148 149 150 151 152 153 154 156 157 160 161 162 163 Barnyardgrass 90 50  70 80  80 70 60  70 80  70 70 90 70 90 Blackgrass 40 0 30 0 40  0 40  60 0 30 60 50 50 50 Corn  0 0 10 0  0  0 0 60 20  50 40 10 30 10 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 40 20  40 30  60 50 50  80 80  80 80 90 90 70 Galium 50 0 50 50  60 60 0  0 20  40 60 50 30 20 Kochia 40 0 50 30  70 50 60  40 0 20 70 20 40  0 Morningglory — — — — — — — — — — — — — — Pigweed  0 0  0 0 50  0 40  20 0  0 60 20 20  0 Ragweed  0 0 30 0 60 40 0  0 0 20 50  0  0  0 Ryegrass, Italian 20 0 10 0 30 10 0 30 20  30  0 20  0  0 Velvetleaf — — — — — — — — — — — — — — Wheat  0 0  0 0  0  0 0  0 0 40  0 20  0 20 125 g ai/ha Compounds Postemergence 164 165 166 167 168 169 170 171 172 174 175 181 182 183 Barnyardgrass 90 90 80 90 90 90  90 90 0 0 0 0 0 0 Blackgrass 50 60 50 50 40 30  50 50 0 0 0 40  0 0 Corn 50 60 30  0 30 0 20 20 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 70 70 80 90 90 60  60 60 0 20  0 0 0 0 Galium 50 40 20 50 60 20  60 50 0 0 0 0 0 0 Kochia 60 50 30 30 40 0 20  0 0 0 0 10  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 20 30 40  0  0 0 20  0 0 0 0 0 0 0 Ragweed 20 20  0 20  0 0 20  0 0 0 0 0 0 0 Ryegrass, Italian 40 40  0 20 20 20  20 20 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat 40 30 20  0  0 0  0  0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 184 185 186 188 189 190 194 195 196 197 198 199 200 201 Barnyardgrass 70  40  0 0 90  70  50  80  30  30  50  50  70  0 Blackgrass 0 0 0 0 — — — — — — — — 0 0 Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — 60  70  60  80  70  50  50  60  — — Foxtail, Giant 70  20  0 0 70  70  10  30  20  0 10  0 20  0 Galium 0 0 0 0 — — — — — — — — 0 0 Kochia 0 0 0 0 — — — — — — — — 0 0 Morningglory — — — — 0 0 0 0 0 0 0 0 — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 0 0 0 0 — — — — — — — — 0 0 Velvetleaf — — — — 0 0 0 0 0 0 0 0 — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 202 203 204 205 206 207 208 209 210 211 212 213 214 215 Barnyardgrass 80 40  90 40  90 80  50  60  80  90 60  60  60 50  Blackgrass 50 0 70 0 70 70  20  0 30  50 40  50  40 30  Corn 80 0 60 0 60 50  0 0 0 30 0 0 30 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 50  90 70  90 90  90  40  50  70 60  80  80 80  Galium 60 0 50 30  70 0 0 0 30  60 50  0 40 40  Kochia 80 0 20 0 70 0 0 0 20  40 0 0  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 70 0  0 0 50 0 0 0 0  0 0 0  0 50  Ragweed 30 0  0 0  0 0 0 0 0  0 0 0  0 0 Ryegrass, Italian 30 0 30 0 50 0 0 0 0 30 0 40  10 0 Velvetleaf — — — — — — — — — — — — — — Wheat 40 0 60 0 70 0 0 0 0 30 0 0  0 0 125 g ai/ha Compounds Postemergence 216 217 218 219 220 221 222 223 224 225 226 227 228 229 Barnyardgrass 0 70 60 40  40  0 70 80 80 30  30  20  60 70 Blackgrass 0 20 20 40  0 0 30 60 60 0 20  0 20 40 Corn 0 20 20 0 0 0 20  0 60 0 0 0 20  0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 0 80 60 60  50  0 80 80 80 40  70  30  70 80 Galium 0 30 40 30  0 0 30 50 70 20  20  0 30 60 Kochia 0 20 50 0 0 0  0 50 80 0 30  0 20 10 Morningglory — — — — — — — — — — — — — — Pigweed 0  0  0 0 0 0  0 40 60 0 0 0  0  0 Ragweed 0  0  0 0 0 0  0  0 40 0 0 0  0 20 Ryegrass, Italian 0  0  0 0 0 0 20  0 50 0 0 0  0 30 Velvetleaf — — — — — — — — — — — — — — Wheat 0 20 20 0 0 0 20 40 50 0 0 0  0  0 125 g ai/ha Compounds Postemergence 230 231 232 233 234 235 236 239 240 241 242 244 245 246 Barnyardgrass 60 80 80 70 60  10  0 50  30  80 70  80 30 70  Blackgrass 20 40 50 60 0 0 0 20  0 — — — — — Corn 20 30 80 20 0 0 0 0 0 50 0  0  0 20  Crabgrass, Large — — — — — — — — — 70 70  80 20 50  Foxtail, Giant 70 70 90 90 40  10  0 50  40  80 80  80 20 40  Galium 20 40 60 20 30  50  0 0 0 — — — — — Kochia  0 70 80 60 0 0 0 0 0 — — — — — Morningglory — — — — — — — — — 20 0 20  0 0 Pigweed  0  0 80  0 0 0 0 0 0  0 0 20 40 0 Ragweed  0 20 20 30 0 0 0 0 0 — — — — — Ryegrass, Italian  0 20 40 20 20  0 0 0 0 — — — — — Velvetleaf — — — — — — — — —  0 0 30 20 0 Wheat 20 20 30  0 0 0 0 0 0 30 0 20  0 0 125 g ai/ha Compounds Postemergence 247 248 249 250 251 256 257 258 259 260 261 262 263 264 Barnyardgrass 60  20  30  30  0 0 50  40  50  70 0 60  70 30  Blackgrass — — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0  0 0 0 40 0 Crabgrass, Large 50  50  0 0 0 70  90  80  80  90 70  70  80 80  Foxtail, Giant 50  30  20  30  0 40  80  60  50  80 0 60  80 60  Galium — — — — — — — — — — — — — — Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0  0 0 0 20 0 Pigweed 0 0 0 0 0 0 0 0 0 60 0 0 40 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 — 0 — — 30  Wheat 0 0 0 0 0 0 20  0 0  0 0 0 40 0 125 g ai/ha Compounds Postemergence 267 268 269 270 271 272 273 275 276 277 278 279 280 281 Barnyardgrass 70 50 50 90  90 50  10  90 0 90 80  80 80  40  Blackgrass — — — 0 50 0 0 50 0 50 30  60 0 0 Corn 40  0  0 0 20 0 0 40 0 90 0 40 0 0 Crabgrass, Large 80 70 60 — — — — — — — — — — — Foxtail, Giant 70 80 70 60  90 60  20  90 0 90 80  80 70  0 Galium — — — 20  40 30  0 60 0 70 40  40 0 0 Kochia — — — 0 60 20  0 50 0 30 0  0 0 0 Morningglory 20  0  0 — — — — — — — — — — — Pigweed 50 70 40 0  0 0 0 30 0 30 0  0 0 0 Ragweed — — — 0 40 0 0 30 0 30 0  0 0 0 Ryegrass, Italian — — — 0  0 0 0 30 0 30 0  0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat  0  0  0 0  0 0 0 40 0 60 0 40 0 0 125 g ai/ha Compounds Postemergence 282 283 284 285 286 287 288 289 290 291 292 293 294 295 Barnyardgrass 50  0 0 20  60  50  20  50  50  40  50  50  60  0 Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 20  0 Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 0 0 0 0 60  0 20  30  30  20  50  50  30  0 Galium 0 0 0 0 0 0 0 0 0 20  10  20  0 0 Kochia 0 0 0 0 0 0 0 0 0 0 0 0 30  0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 0 0 0 0 0 20  0 125 g ai/ha Compounds Postemergence 296 297 298 299 300 301 302 303 304 305 306 307 308 309 Barnyardgrass 0 0 0 30  0 0 90  80 80 80 80 70  70  80 Blackgrass 0 0 0 0 0 0 40  60 50 60 50 30  50  60 Corn 0 0 0 0 0 0 0 50 30 70 50 0 0 30 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 0 0 0 0 0 0 80  80 80 80 80 70  70  80 Galium 0 0 0 0 0 0 60  60 20 50 60 0 0 60 Kochia 0 0 0 0 0 0 10  50 10 30 30 0 0  0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 40 40 60 70 0 0  0 Ragweed 0 0 0 0 0 0 0 20  0  0 20 0 0  0 Ryegrass, Italian 0 0 0 0 0 0 0 40 50 60 50 0 0 10 Velvetleaf — — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 50 40 60 50 0 0 40 125 g ai/ha Compounds Postemergence 310 311 312 313 314 315 316 317 318 319 320 321 322 323 Barnyardgrass 90 60  80 20  30  90 80 80  90 90 50  0 0 90 Blackgrass 30 0 40 0 0 40 30 0 30 40 0 0 0 40 Corn 20 0 60 0 0 70 60 0 20 40 0 0 0 70 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 60  80 40  60  90 90 80  40 50 30  0 0 90 Galium 20 0 30 0 0 40 20 0 30 30 0 0 0 40 Kochia 30 0 20 0 0 50 30 0 20 30 20  0 0 40 Morningglory — — — — — — — — — — — — — — Pigweed  0 0 20 0 0 30  0 0 20  0 0 0 0 20 Ragweed 20 0 20 0 0 20 20 0  0 20 0 0 0  0 Ryegrass, Italian 30 0 20 0 0 20 20 0 20 30 0 0 0 30 Velvetleaf — — — — — — — — — — — — — — Wheat 30 0 40 0 0 60 20 0 20 20 0 0 0 40 125 g ai/ha Compounds Postemergence 324 325 326 327 328 329 330 331 332 333 334 335 336 337 Barnyardgrass 90 90 0 40 30  0 60  20  40  20  0 20  30  0 Blackgrass 60 50 0 30 30  0 0 0 0 0 0 0 0 0 Corn 50 80 0  0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 20  40 70  0 80  20  30  50  0 70  70  0 Galium 40 50 0 40 20  0 20  0 0 0 0 0 0 0 Kochia 50 60 0 30 0 0 0 0 0 0 0 0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 40 40 0  0 0 0 0 0 0 0 0 0 0 0 Ragweed 20 20 0  0 0 0 0 0 0 0 0 0 0 0 Ryegrass, Italian 30 30 0 20 0 0 0 0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat 30 60 0  0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Postemergence 338 339 340 341 342 343 344 345 346 347 348 349 350 Barnyardgrass 0 40  30  30  30  0 60  70 80 50  20  80  70 Blackgrass 0 0 0 0 0 0 0 50 20 0 20  20  50 Corn 0 0 0 0 0 0 0 80 20 0 0 0 20 Crabgrass, Large — — — — — — — — — — — — — Foxtail, Giant 20  60  30  50  40  30  80  90 80 20  70  60  80 Galium 0 0 0 0 0 0 0 60 30 0 0 20  60 Kochia 0 0 0 0 20  0 0 50  0 0 20  40  70 Morningglory — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 20  0 0 0 0 20 Ragweed 0 0 0 0 0 0 0  0  0 0 0 0  0 Ryegrass, Italian 0 0 0 0 0 0 0 50 20 0 0 0  0 Velvetleaf — — — — — — — — — — — — — Wheat 0 0 0 0 0 0 0 50  0 0 0 0 20 1000 g ai/ha Compounds Preemergence 17 18 19 20 21 22 23 24 25 26 27 30 31 33 Barnyardgrass 90 80  90  90 90 0 90 0 80  70  70  90  50 90 Corn 60 0 0 0  0 0  0 0 0 0 0 0 20  0 Crabgrass, Large 90 80  90  90 90 70  90 70  90  90  90  90  80 90 Foxtail, Giant 90 80  90  90 90 30  90 40  90  90  90  90  80 90 Kochia — — — — — — — — — — — — — — Morningglory 30 0 0 0 40 0  0 0 0 0 0 0 — — Pigweed 50 0 0 0 40 — — 0 0 0 0 0  0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 40 0 0 30 50 0 40 60  0 0 0 0  0  0 Wheat 70 0 0 0 20 0  0 0 0 0 0 0 50 50 1000 g ai/ha Compounds Preemergence 34 35 39 40 43 44 71 96 98 99 100 104 105 106 Barnyardgrass 90 90 70  90 20  40  50  0 50 90 90 80 90  90 Corn 30 20 0 30 0 0 0 0 20 20 20 20 0 30 Crabgrass, Large 90 90 90  90 90  90  80  0 90 90 90 90 90  90 Foxtail, Giant 90 90 80  90 80  70  60  0 90 90 90 90 90  90 Kochia — — — — — — — — — — — — — — Morningglory — 0 0  0 0 0 — 0 0  0  0  0 0  0 Pigweed  0 0 0  0 0 0 0 0 0  0  0  0 0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf  0 0 0  0 0 0 0 0 0  0  0  0 0  0 Wheat 60 0 0 20 0 0 0 0 0 20 20 20 0 50 1000 g ai/ha Compounds Preemergence 108 191 192 193 237 238 243 252 253 254 255 265 266 274 Barnyardgrass 90  0 0 80  60  50  80  20  0 0 60  0 0 90 Corn 0 0 0 0 — — 0 0 0 0 0 0 0 — Crabgrass, Large 90  0 0 100  — — 90  40  0 70  90  0 0 — Foxtail, Giant 90  0 0 90  80  90  90  20  0 40  70  0 0 90 Kochia — — — — 0 0 — — — — — — — 40 Morningglory 0 0 0 0 — — 0 0 0 0 0 0 0 — Pigweed 0 0 0 0 0 0 0 — 0 0 0 0 0  0 Ragweed — — — — 0 0 — — — — — — — 20 Ryegrass, Italian — — — — 0 0 — — — — — — — 40 Velvetleaf 0 0 0 0 — — 0 0 0 0 0 0 0 — Wheat 0 0 0 0 — — 0 0 0 0 0 0 0 — 500 g ai/ha Compounds Preemergence 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Barnyardgrass 90 60  80 80 90  80  80  60 60  40  20  90 50  90 Corn 20 0 50 0 0 0 0 20 0 0 0 0 0 0 Crabgrass, Large 90 90  90 90 90  90  90  90 90  90  90  90 80  90 Foxtail, Giant 90 90  90 90 100  90  90  90 90  90  50  90 30  90 Kochia — — — — — — — — — — — — — — Morningglory 0 0  0 0 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0  0 0 0 0 0 0 0 0 0 0 0 20 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0  0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 60 70 0 0 0 0 0 0 0 20 0 0 500 g ai/ha Compounds Preemergence 15 16 28 29 32 36 37 38 41 42 45 46 47 48 Barnyardgrass 0 90 20  50  0 80 80 80  60  60 80  50  0 90 Corn 0 30 0 0 0 0 0 0 0  0 0 0 0 20 Crabgrass, Large 80  90 80  70  80  80 80 80  90  90 90  90  60  90 Foxtail, Giant 50  90 20  0 80  70 20 30  70  80 80  80  0 90 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 — — 0 0 0  0 Pigweed 0 0 0 0 0 0 0 0 0 30 0 0 0  0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0  0 0 0 0  0 Wheat 0 0 0 0 0 20 30 0 0  0 0 0 0 50 500 g ai/ha Compounds Preemergence 49 50 51 52 53 54 55 56 57 58 59 60 61 62 Barnyardgrass 20  90  0 90 90 20 80  40  80  20  90  90  0 80 Corn 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90  90  90  90 90 90 90  90  90  90  90  90  80  90 Foxtail, Giant 70  90  90  90 90 90 90  50  80  80  90  90  0 90 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0  0 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0 0 40 0 0 0 0 0 0 0 0 0 30 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 20 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0  0 20 20 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Preemergence 63 64 65 66 67 68 69 70 72 73 74 75 76 77 Barnyardgrass 80  90 90  90 70  90 90 90 50  80  90 70 80 90 Corn 0 20 0 20 0  0  0 0 0 0 0 0 40 30 Crabgrass, Large 90  90 90  90 90  90 90 90 90  90  90 90 90 90 Foxtail, Giant 90  90 90  90 90  90 90 90 80  90  90 90 90 90 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0  0 0  0  0 0 0 0 0 0 50 60 Pigweed 0 0 0  0 0 30 20 0 0 0 50 0 50 70 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0  0 0  0  0 0 0 0 0 0  0  0 Wheat 0 0 0 20 0 20 20 20 0 0 0 30  0 30 500 g ai/ha Compounds Preemergence 78 79 80 81 82 83 84 85 86 87 88 89 90 91 Barnyardgrass 90 90 80 80 50  50  0 30  40 80 50 80 70  20  Corn  0  0  0  0 0 0 0 0 20 0 0 0 0 0 Crabgrass, Large 90 90 90 90 90  90  50  80  80 90 80 90 80  60  Foxtail, Giant 90 90 90 90 70  70  0 50  60 90 30 90 70  40  Kochia — — — — — — — — — — — — — — Morningglory  0  0  0 20 0 0 0 0 0 0 0 0 0 0 Pigweed 60 80 80  0 0 0 0 0 0 0 30 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 30 30 30  0 0 0 0 0 0 0 0 0 0 0 Wheat  0 20 20 20 0 0 0 0 0 10 0 10 0 0 500 g ai/ha Compounds Preemergence 92 93 94 95 97 101 102 103 107 109 110 111 112 113 Barnyardgrass 90  90  0 90  0 90 0 90 70 90  90  0 0 0 Corn 0 0 0 0 0  0 0 0 0 — — — — — Crabgrass, Large 90  90  50  90  0 100  0 100 90 — — — — — Foxtail, Giant 90  90  0 90  0 90 0 90 80 90  90  0 0 0 Kochia — — — — — — — — — 0 0 0 0 0 Morningglory 0 0 0 0 0 50 0 0 0 — — — — — Pigweed 0 0 — 0 0 70 0 20 20 0 0 0 0 0 Ragweed — — — — — — — — — 0 0 0 0 0 Ryegrass, Italian — — — — — — — — — 50  0 0 0 0 Velvetleaf 0 0 — 0 0 40 0 0 0 — — — — — Wheat 0 0 0 0 0 70 0 0 0 — — — — — 500 g ai/ha Compounds Preemergence 114 115 116 117 118 119 120 121 122 123 124 125 126 127 Barnyardgrass 50  50  50  20  70  90 90 90 90 90 80 90 90  90  Corn — 0 0 0 — — — — — — — — — — Crabgrass, Large — 80  80  80  — — — — — — — — — — Foxtail, Giant 70  20  30  70  90  90 90 90 90 90 90 90 90  90  Kochia 0 — — — 0 60 80 70 70 90 70 70 10  60  Morningglory — 0 0 0 — — — — — — — — — — Pigweed 0 0 0 0 0 40 40 70 80 80 80  0 0 0 Ragweed 0 — — — 0 80 80 70 60 80 50  0 0 0 Ryegrass, Italian 30  — — — 0 60 50  0  0 60 40 20 0 0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat — 0 0 0 — — — — — — — — — — 500 g ai/ha Compounds Preemergence 128 129 130 131 132 133 139 140 141 142 143 144 145 146 Barnyardgrass 80 80 70  60  90  30  90 90  90 90  90  90  90  90 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 90  60  80  90  90 90  90 90  90  80  90  90 Kochia 60 70 0 0 0 0 30 0 20 0 30  0 0 30 Morningglory — — — — — — — — — — — — — — Pigweed  0  0 0 0 0 0 20 0  0 0 0 0 0  0 Ragweed —  0 0 0 0 0  0 0  0 0 0 0 0 30 Ryegrass, Italian  0 60 0 0 0 0  0 0 20 0 0 20  0 40 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 147 148 149 150 151 152 153 154 156 157 160 161 162 163 Barnyardgrass 90 90  90 90 90 90 90 80 90 90 90 90 90 90 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90  90 90 90 90 80 90 90 90 90 90 90 90 Kochia 80 30  70 90 90 60 80 70 40 70 90 60 60 50 Morningglory — — — — — — — — — — — — — — Pigweed  0 0  0  0  0 10  0 30  0 50 90 70 80 40 Ragweed 50 0 80 50 90 70 80  0  0 50 80 70 60 40 Ryegrass, Italian 40 0 70 50 60 30  0 50 30 60 70 50 50  0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 164 165 166 167 168 169 170 171 172 174 175 181 182 183 Barnyardgrass 90 90 90 90 90 90 90 90 20  20  0 0 0 0 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 90 90 90 90 90 90 30  50  0 70  70  0 Kochia 80 70 70 60 60 60 70 70 30  20  0 80  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 70 70 10 50 50 20 50 40 0 0 0 0 0 0 Ragweed 60 80 50 50 50 20 60 30 0 0 0 0 0 0 Ryegrass, Italian 50 20 60 70 40 20 50 30 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 184 185 186 188 189 190 194 195 196 197 198 199 200 201 Barnyardgrass 90  70 0 0 90 90 80  90  70  70  90  60  90  20  Corn — — — — 0 0 0 0 0 0 0 0 — — Crabgrass, Large — — — — 90 90 100  90  100  100  100  100  — — Foxtail, Giant 90  90 0 0 90 90 90  90  90  80  80  90  80  30  Kochia 20  40 0 0 — — — — — — — — 0 0 Morningglory — — — — 0 0 0 0 0 0 0 0 — — Pigweed 0 20 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0  0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 0 20 0 0 — — — — — — — — 0 0 Velvetleaf — — — — 0 0 0 0 0 0 0 0 — — Wheat — — — — 20 30 0 0 0 0 0 0 — — 500 g ai/ha Compounds Preemergence 202 203 204 205 206 207 208 209 210 211 212 213 214 215 Barnyardgrass 90 60  90 80 90 90 90 60 90 90 90 80  80 80 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 80  90 90 90 90 90 90 90 90 90 90  90 90 Kochia 80 0 80 50 80 30 20 20 30 70 20 0 80  0 Morningglory — — — — — — — — — — — — — — Pigweed 70 0 50 20 80 20  0 20 50 70  0 0 70 50 Ragweed 90 0 80 30 70 20  0  0 30 80 50 0  0  0 Ryegrass, Italian 60 0 50 20 80 40 20 20 50 40 30 40   0 10 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 216 217 218 219 220 221 222 223 224 225 226 227 228 229 Barnyardgrass 60  90 90 60  80 0 90 90 90 30 90 50 80 90 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 50  90 90 90  90 80  90 90 90 90 90 90 90 90 Kochia 0 70 70 70  40 0 50 80 90 30 30 20 20 70 Morningglory — — — — — — — — — — — — — — Pigweed 0 40 70 0 20 0 30 50 80  0 30 20  0  0 Ragweed 0 50 50 0  0 0 20 50 90  0  0  0 20 — Ryegrass, Italian 0 60 60 0 30 0 50 60 70 40 20 30 40 20 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 230 231 232 233 234 235 236 239 240 241 242 244 245 246 Barnyardgrass 90 90 90 90 90 60  0 90 50  90 90 90 20 90  Corn — — — — — — — — — 50 20 0 0 0 Crabgrass, Large — — — — — — — — — 90 90 100 80 90  Foxtail, Giant 90 90 90 90 90 80  0 90 90  90 90 90 70 90  Kochia 30 90 80 80 50 0 0 70 0 — — — — — Morningglory — — — — — — — — —  0  0 0 0 0 Pigweed 20 70 60 30 20 0 0  0 0 30 20 50 30 0 Ragweed 20 90 90 50 20 0 30  90 0 — — — — — Ryegrass, Italian 30 60 80 60 30 0 50   0 0 — — — — — Velvetleaf — — — — — — — — —  0  0 0 0 0 Wheat — — — — — — — — — 30 30 0 0 — 500 g ai/ha Compounds Preemergence 247 248 249 250 251 256 257 258 259 260 261 262 263 264 Barnyardgrass 90  80  80  80  80 20  80  90  80  80 0 90 90 90 Corn 0 0 0 0 0 0 0 0 0 10 0 0 70 0 Crabgrass, Large 90  90  90  90  90 90  90  90  90  90 90  90 100 100 Foxtail, Giant 90  90  90  80  80 60  90  90  90  90 70  90 100 90 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 50 0 0 0 0 Pigweed 0 0 0 0 30 0 0 0 0 80 0 70 100 80 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 40 0 0 50 0 Wheat 0 0 0 0 0 0 0 0 0  0 0 0 60 0 500 g ai/ha Compounds Preemergence 267 268 269 270 271 272 273 275 276 277 278 279 280 281 Barnyardgrass 80 80 80 90 90 90 80  90 0 90 90  90 80  70  Corn 0 80 0 — — — — — — — — — — — Crabgrass, Large 90 90 90 — — — — — — — — — — — Foxtail, Giant 90 80 80 90 90 90 90  90 0 90 90  90 90  70  Kochia — — — 80 80 20 70  80 0 60 0 80 0 0 Morningglory 0 60 0 — — — — — — — — — — — Pigweed 50 60 70 20 80 30 0 30 0 30 0 40 0 0 Ragweed — — — 20 80  0 0 40 0 20 0  0 0 0 Ryegrass, Italian — — —  0 30  0 0 60 0 30 0 60 0 0 Velvetleaf 0  0 0 — — — — — — — — — — — Wheat 0  0 0 — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 282 283 284 285 286 287 288 289 290 291 292 293 294 295 Barnyardgrass 90  0 60 0 60 80  70 80  80  60 80  70  90 70  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 70  0 70 10  80 80  90 90  80  80 60  90  90 20  Kochia 50  0 30 0 40 0 50 0 0 20 80  0 90 0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 40 0 30 0  0 0 0  0 0 0 20 0 Ragweed 0 0  0 0  0 0  0 0 0  0 0 —  0 0 Ryegrass, Italian 0 0  0 0 20 0 20 0 0 30 0 0 30 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 296 297 298 299 300 301 302 303 304 305 306 307 308 309 Barnyardgrass 0 50  0 70  0 0 90 90 90 90 90 90  80  80 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 0 70  0 80  0 0 90 90 90 90 90 90  90  90 Kochia 0 0 0 0 0 0 70 80 70 70 80 0 0  0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 60 50 80 40 90 0 0  0 Ragweed 0 0 0 0 0 0 30 — — 50 80 0 0 — Ryegrass, Italian 0 0 0 0 0 0 60 40  0 90 80 0 0 20 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 310 311 312 313 314 315 316 317 318 319 320 321 322 323 Barnyardgrass 90 80  90 80  80  90 90 90  90 90 80 30  40  90 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90  90 80  90  90 90 90  90 90 90 50  70  90 Kochia 70 0 70 0 0 60 30 0 70 80 20 0 0 80 Morningglory — — — — — — — — — — — — — — Pigweed 40 0 20 0 0 30 20 0 20 20  0 0 0 30 Ragweed  0 0 30 0 0 30 30 0 40 40 30 0 0 80 Ryegrass, Italian 40 0 60 0 0 70 50 0 60 60 50 0 0 30 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 324 325 326 327 328 329 330 331 332 333 334 335 336 337 Barnyardgrass 90 90 30 80 80 0 70 80 80  90  0 50 60 20  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 60 90 90 60  80 90 90  90  50  90 90 30  Kochia 80 80 50 70 20 0 20  0 0 0 0 60 60 0 Morningglory — — — — — — — — — — — — — — Pigweed 60 60  0 20  0 0 20 20 0 0 0 30 20 0 Ragweed 60 50  0 30  0 0  0 20 0 0 0  0  0 0 Ryegrass, Italian 40 50 40 40 40 0 40 20 0 20  0  0 20 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 500 g ai/ha Compounds Preemergence 338 339 340 341 342 343 344 345 346 347 348 349 350 Barnyardgrass 20  80  80  80  80 80  90  90 90 90  60 90 90 Corn — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — Foxtail, Giant 80  80  90  90  90 80  90  90 90 40  90 90 90 Kochia 20  0 0 0  0 0 0 80 80 0 70 80 80 Morningglory — — — — — — — — — — — — — Pigweed 0 0 0 0 50 0 0 70 30 0 50 40 80 Ragweed 0 0 0 0  0 0 0  0  0 0 30 40 30 Ryegrass, Italian 0 20  20  0 20 0 30  40 30 0  0  0  0 Velvetleaf — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Barnyardgrass 30  30  60 60 70  50  20  20  20  0 0 60  0 80  Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90  90  90 90 80  80  80  80  80  90  70  90  50  90  Foxtail, Giant 70  90  90 80 90  90  70  60  70  60  20  70  0 80  Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 40 60 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Preemergence 15 16 28 29 32 36 37 38 41 42 45 46 47 48 Barnyardgrass 0 80  0 0 0 40  0 0 30  0 10  0 0 80  Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 60  90  30  30  80  20  0 70  60  80  80  70  10  90  Foxtail, Giant 20  90  0 0 70  20  0 0 10  20  50  40  0 80  Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 — — 0 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Preemergence 49 50 51 52 53 54 55 56 57 58 59 60 61 62 Barnyardgrass 0 30  0 80  80  0 20  0 40  0 80  80  0 80  Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 70  90  90  90  90  90  80  60  80  70  90  90  0 90  Foxtail, Giant 20  90  30  80  90  90  70  20  60  20  80  90  0 80  Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Preemergence 63 64 65 66 67 68 69 70 72 73 74 75 76 77 Barnyardgrass 50  80 40  80 30  80  80  20  0 50  60  50  80  80 Corn 0 20 0 20 0 0 0 0 0 0 0 0 0  0 Crabgrass, Large 90  80 90  80 90  90  90  80  80  80  90  90  90  90 Foxtail, Giant 70  80 80  80 80  90  90  70  60  80  90  80  90  90 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 0 0 0 0 20 Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 40 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0  0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0  0 125 g ai/ha Compounds Preemergence 78 79 80 81 82 83 84 85 86 87 88 89 90 91 Barnyardgrass 80 80 80 40  0 0 0 0 0 20  0 60  30  0 Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90 90 90 80  80  70  0 30  60  80  40  80  70  40  Foxtail, Giant 90 90 90 30  20  0 0 0 20  60  0 80  60  0 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 — 0 0 0 0 0 0 0 0 0 Pigweed 10 80 60 0 0 0 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Preemergence 92 93 94 95 97 101 102 103 107 109 110 111 112 113 Barnyardgrass 60  50  0 60  0 90 0 80  20  80  70  0 0 0 Corn 0 0 0 0 0  0 0 0 0 — — — — — Crabgrass, Large 80  90  0 90  0 90 0 90  80  — — — — — Foxtail, Giant 0 80  0 80  0 90 0 90  70  90  60  0 0 0 Kochia — — — — — — — — — 0 0 0 0 0 Morningglory 0 0 0 0 0  0 0 0 0 — — — — — Pigweed 0 0 0 0 0 10 0 0 0 0 0 0 0 0 Ragweed — — — — — — — — — 0 0 0 0 0 Ryegrass, Italian — — — — — — — — — 0 0 0 0 0 Velvetleaf 0 0 0 0 0 30 0 0 0 — — — — — Wheat 0 0 0 0 0 60 0 0 0 — — — — — 125 g ai/ha Compounds Preemergence 114 115 116 117 118 119 120 121 122 123 124 125 126 127 Barnyardgrass 20  0 0 0 50  90 90 80 80 80 70 80  70  70  Corn — 0 0 0 — — — — — — — — — — Crabgrass, Large — 70  70  60  — — — — — — — — — — Foxtail, Giant 20  20  0 20  90  90 90 90 90 90 80 80  90  90  Kochia 0 — — — 0 40 60 60 60 80 60 30  0 40  Morningglory — 0 0 0 — — — — — — — — — — Pigweed 0 0 0 0 0 30 30 50 50 70 70 0 0 0 Ragweed 0 — — — 0 70 60 70  0 70 40 0 0 0 Ryegrass, Italian 0 — — — 0 20 30  0  0 40  0 0 0 0 Velvetleaf — 0 0 0 — — — — — — — — — — Wheat — 0 0 0 — — — — — — — — — — 125 g ai/ha Compounds Preemergence 128 129 130 131 132 133 139 140 141 142 143 144 145 146 Barnyardgrass 60  80  60  50  70  20  70  80  90  90  60  90  80  90  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 80  80  80  50  70  30  50  50  50  70  30  60  70  80  Kochia 10  50  0 0 0 0 0 0 0 0 30  0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 147 148 149 150 151 152 153 154 156 157 160 161 162 163 Barnyardgrass 90  30  90 80  90 90 80  80 90  90 80 90 90 80  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 80  40  70 70  80 70 60  90 90  90 80 90 80 90  Kochia 30  30  10 60  90 30 60  40 20  50 80 20 50 0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0  0 0  0  0 0  0 0  0 70 20 60 40  Ragweed 0 0 60 0 90 50 0  0 0 30 70 20  0 0 Ryegrass, Italian 0 0 20 0 10  0 0 40 0 30 60  0  0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 164 165 166 167 168 169 170 171 172 174 175 181 182 183 Barnyardgrass 90 90 80 90 90 90  90 90 0 0 0 0 0 0 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 90 90 90 80  80 90 20  30  0 10  50  0 Kochia 60 70 30 20 40 40  50 60 30  0 0 50  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 50 50  0 50 40 0 50 20 0 0 0 0 0 0 Ragweed 20  0  0  0  0 0  0  0 0 0 0 0 0 0 Ryegrass, Italian 20  0 20 20  0 0  0  0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 184 185 186 188 189 190 194 195 196 197 198 199 200 201 Barnyardgrass 70  40  0 0 80  60  0 30  0 0 50  0 60  0 Corn — — — — 0 0 0 0 0 0 0 0 — — Crabgrass, Large — — — — 90  90  90  90  90  80  90  90  — — Foxtail, Giant 90  70  0 0 90  80  50  80  80  30  50  50  30  20  Kochia 0 0 0 0 — — — — — — — — 0 0 Morningglory — — — — 0 0 0 0 0 0 0 0 — — Pigweed 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 0 0 0 — — — — — — — — 0 0 Ryegrass, Italian 0 0 0 0 — — — — — — — — 0 0 Velvetleaf — — — — 0 0 0 0 0 0 0 0 — — Wheat — — — — 0 0 0 0 0 0 0 0 — — 125 g ai/ha Compounds Preemergence 202 203 204 205 206 207 208 209 210 211 212 213 214 215 Barnyardgrass 90 20  90  30  90 90 40  30  60  80 60  50  70  60  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 30  90  60  90 90 80  50  80  80 70  80  80  80  Kochia 70 0 0 20  70 20 0 0 0 40 0 0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 60 0 0 0 30  0 0 0 0 20 0 0 0 0 Ragweed 50 0 0 0 60  0 0 0 0 30 0 0 0 0 Ryegrass, Italian 60 0 20  0 40 20 0 0 0  0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 216 217 218 219 220 221 222 223 224 225 226 227 228 229 Barnyardgrass 20  70 80 30  30  0 70  90 90 20  50  20  50  70  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 40  90 90 90  80  60  90  90 90 80  70  80  80  90  Kochia 0 30 30 10  0 0 0 30 80 0 0 20  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 0 20 30 0 0 0 0 20 80 0 0 0 0 0 Ragweed 0  0  0 0 0 0 0 30 90 0 0 0 0 0 Ryegrass, Italian 0 40 40 0 0 0 20  30 60 0 0 0 30  10  Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 230 231 232 233 234 235 236 239 240 241 242 244 245 246 Barnyardgrass 30  90 90 80 60 0 0 50  20  80 60 40 20  80  Corn — — — — — — — — — 20 0 0 0 0 Crabgrass, Large — — — — — — — — — 90 90 90 60  90  Foxtail, Giant 90  90 90 90 70 40  0 80  70  90 90 90 60  80  Kochia 0 70 70 50 20 0 0 0 0 — — — — — Morningglory — — — — — — — — —  0 0 0 0 0 Pigweed 0 70 50 30  0 0 0 0 0  0 0 30 0 0 Ragweed 0 70 30 40  0 0 0 0 0 — — — — — Ryegrass, Italian 0 40 40 30 30 0 0 0 0 — — — — — Velvetleaf — — — — — — — — —  0 0 0 0 0 Wheat — — — — — — — — — 20 20 0 0 0 125 g ai/ha Compounds Preemergence 247 248 249 250 251 256 257 258 259 260 261 262 263 264 Barnyardgrass 90  30  50  20  20  0 40  20  10  70 0 80 80 50 Corn 0 0 0 0 0 0 0 0 0  0 0 0  0 0 Crabgrass, Large 90  90  80  80  80  80  90  90  — 90 80  90 90 100 Foxtail, Giant 80  80  50  50  40  20  80  50  60  80 10  80 90 80 Kochia — — — — — — — — — — — — — — Morningglory 0 0 0 0 0 0 0 0 0 20 0 0  0 0 Pigweed 0 0 0 0 0 0 0 0 0 60 0 50 60 50 Ragweed — — — — — — — — — — — — — — Ryegrass, Italian — — — — — — — — — — — — — — Velvetleaf 0 0 0 0 0 0 0 0 0 — 0 0 50 0 Wheat 0 0 0 0 0 0 0 0 0  0 0 0  0 0 125 g ai/ha Compounds Preemergence 267 268 269 270 271 272 273 275 276 277 278 279 280 281 Barnyardgrass 70  70 70 60  90 70  50  90 0 90 80  80  80  50  Corn 0 0 0 — — — — — — — — — — — Crabgrass, Large 90  80 80 — — — — — — — — — — — Foxtail, Giant 80  70 80 80  90 90  90  90 0 90 90  90  90  10  Kochia — — — 0 50 0 0 60 0 30 0 40  0 0 Morningglory 0 0 0 — — — — — — — — — — — Pigweed 0 30 50 0 40 0 0 20 0 20 0 0 0 0 Ragweed — — — 0 20 0 0 20 0 20 0 0 0 0 Ryegrass, Italian — — — 0  0 0 0 30 0 30 0 0 0 0 Velvetleaf 0 0 0 — — — — — — — — — — — Wheat 0 0 0 — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 282 283 284 285 286 287 288 289 290 291 292 293 294 295 Barnyardgrass 60  0 0 0 60 50  30  50  60  20  70  20  70  0 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 20  0 40  0 80 50  30  60  60  20  50  80  70  0 Kochia 0 0 0 0 30 0 30  0 0 20  30  0 40  0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 20 0 0 — 0 0 0 0 0 0 Ragweed 0 0 0 0  0 0 0 0 0 0 0 — 0 0 Ryegrass, Italian 0 0 0 0  0 0 0 0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 296 297 298 299 300 301 302 303 304 305 306 307 308 309 Barnyardgrass 0 0 0 10  0 0 90 90 90 80 90 80  70  80  Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 0 30  0 50  0 0 90 90 90 90 90 80  80  90  Kochia 0 0 0 0 0 0 50 70 — 70 70 0 0 0 Morningglory — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 10 20 70  0 80 0 0 0 Ragweed 0 0 0 0 0 0  0  0  0 30 — 0 0 0 Ryegrass, Italian 0 0 0 0 0 0  0 30  0 70 40 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 310 311 312 313 314 315 316 317 318 319 320 321 322 323 Barnyardgrass 90 70  80 50  20  90 80 90  90 90 20  0 0 90 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 80  90 30  30  90 90 90  90 90 30  0 0 90 Kochia 30 0 20 0 0 40  0 0 20 60 0 0 0 50 Morningglory — — — — — — — — — — — — — — Pigweed 40 0  0 0 0 30 20 0  0  0 0 0 0 20 Ragweed  0 0  0 0 0 20 20 0 20 30 0 0 0 20 Ryegrass, Italian 30 0 20 0 0 40 20 0 20 30 20  0 0 20 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 324 325 326 327 328 329 330 331 332 333 334 335 336 337 Barnyardgrass 90 90 0 70 40  0 60 20  70  50  0 0 50  0 Corn — — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — — Foxtail, Giant 90 90 50  80 80  0 50 50  80  80  0 70  80  0 Kochia 70 70 40  30 0 0 20 0 0 0 0 40  0 0 Morningglory — — — — — — — — — — — — — — Pigweed 30 30 0  0 0 0  0 0 0 0 0 0 0 0 Ragweed 30 30 0 20 0 0  0 0 0 0 0 0 0 0 Ryegrass, Italian 30 30 0 40 0 0 30 0 0 0 0 0 0 0 Velvetleaf — — — — — — — — — — — — — — Wheat — — — — — — — — — — — — — — 125 g ai/ha Compounds Preemergence 338 339 340 341 342 343 344 345 346 347 348 349 350 Barnyardgrass 0 60  60  50  50  20  50  80  80  50  30 70  90 Corn — — — — — — — — — — — — — Crabgrass, Large — — — — — — — — — — — — — Foxtail, Giant 30  70  80  80  70  60  80  90  90  20  90 80  90 Kochia 0 0 0 0 0 0 0 10  0 0  0 50  80 Morningglory — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 20  0 20 0 50 Ragweed 0 0 0 0 0 0 0 0 0 0 — 0 30 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0  0 0  0 Velvetleaf — — — — — — — — — — — — — Wheat — — — — — — — — — — — — —

Test B

Plant species in the flooded paddy test selected from rice (Oryza sativa), sedge, umbrella (small-flower umbrella sedge, Cyperus difformis), ducksalad (Heteranthera limosa), and barnyardgrass (Echinochloa crus-galli) were grown to the 2-leaf stage for testing. At time of treatment, test pots were flooded to 3 cm above the soil surface, treated by application of test compounds directly to the paddy water, and then maintained at that water depth for the duration of the test. Treated plants and controls were maintained in a greenhouse for 13 to 15 days, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table B, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

TABLE B 1000 g ai/ha Compounds Flood 98 99 100 104 105 106 108 109 110 115 116 117 193 194 Barnyardgrass 0 80 25 70 25 60 50 0 0 20 20 40 0 65 Ducksalad 90 95 75 95 90 90 95 95 95 90 80 90 60 80 Rice 0 10 0 0 10 15 0 0 0 0 15 0 20 20 Sedge, Umbrella 0 0 0 0 0 0 0 80 50 0 0 0 20 0 1000 g ai/ha Compounds Flood 195 196 197 198 199 200 201 209 213 214 215 234 235 236 Barnyardgrass 70 20 30 65 20 85 20 45 60 75 60 75 45 40 Ducksalad 100 90 75 95 80 95 70 95 85 90 80 85 50 70 Rice 15 0 10 15 0 15 0 0 0 20 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1000 g ai/ha Compounds Flood 240 241 242 244 245 246 247 248 249 250 251 259 260 261 Barnyardgrass 70 75 55 30 20 60 85 55 55 0 45 20 0 0 Ducksalad 85 100 100 100 90 95 95 95 85 80 90 90 95 90 Rice 0 10 0 0 0 20 0 0 15 0 0 10 0 0 Sedge, Umbrella 0 20 0 0 0 20 0 0 40 0 0 10 0 0 1000 g ai/ha Compounds Flood 262 263 264 267 268 269 344 345 346 Barnyardgrass 20 0 0 20 0 0 85 0 85 Ducksalad 100 90 100 100 100 100 90 30 100 Rice 0 0 0 15 20 0 10 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 103 118 119 120 121 122 123 124 125 126 127 128 129 130 Barnyardgrass 85 20 80 80 70 65 60 40 30 60 40 60 60 40 Ducksalad 100 100 100 100 100 100 100 100 85 80 40 95 100 40 Rice 0 0 10 20 35 15 0 0 0 0 20 20 15 20 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 30 0 0 0 500 g ai/ha Compounds Flood 131 132 133 139 140 141 142 143 144 146 147 148 149 150 Barnyardgrass 40 40 30 60 70 50 75 35 65 80 70 40 70 80 Ducksalad 70 85 60 100 100 100 100 100 100 100 100 100 100 100 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 30 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 151 152 153 154 160 161 162 163 164 165 166 167 168 169 Barnyardgrass 90 60 60 70 60 65 75 90 80 75 75 75 65 80 Ducksalad 100 100 100 90 100 100 100 100 100 100 100 100 100 100 Rice 0 15 10 0 10 10 0 15 20 10 0 10 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 170 171 175 181 182 202 216 217 218 219 220 221 222 223 Barnyardgrass 85 70 0 0 0 65 0 40 70 40 0 0 60 75 Ducksalad 100 100 30 0 30 100 0 100 100 100 100 0 100 100 Rice 15 0 0 0 0 15 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 224 225 226 227 228 229 230 231 232 233 239 272 273 274 Barnyardgrass 70 0 0 0 0 50 60 0 85 60 50 20 0 0 Ducksalad 100 90 100 90 90 100 75 0 100 100 100 100 70 35 Rice 0 0 0 0 0 0 0 0 20 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 275 276 277 278 279 280 281 282 283 284 285 286 287 288 Barnyardgrass 85 0 90 60 75 65 20 30 20 0 20 15 30 20 Ducksalad 100 30 100 100 100 100 75 95 85 80 100 75 75 65 Rice 0 0 0 0 10 0 0 0 0 10 0 10 0 0 Sedge, Umbrella 30 0 0 0 0 0 0 30 0 0 0 0 0 0 500 g ai/ha Compounds Flood 289 290 291 292 293 294 295 296 297 298 299 300 301 302 Barnyardgrass 30 40 0 50 35 20 30 30 0 0 30 0 0 80 Ducksalad 90 75 0 100 95 98 40 60 0 0 50 0 0 98 Rice 20 0 20 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 303 304 305 306 307 308 309 310 311 312 313 314 315 316 Barnyardgrass 80 80 75 75 65 70 65 60 50 75 60 25 70 60 Ducksalad 100 100 100 100 98 90 100 100 98 100 0 40 100 100 Rice 30 35 15 50 0 0 0 0 0 20 0 15 15 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 317 318 319 320 321 322 323 324 325 326 327 328 329 330 Barnyardgrass 75 75 70 45 20 0 80 80 70 0 0 0 0 0 Ducksalad 80 100 100 100 40 100 100 100 100 0 60 35 0 100 Rice 0 15 0 0 15 0 20 30 20 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 40 0 0 0 0 0 500 g ai/ha Compounds Flood 331 332 333 334 335 336 337 338 339 340 341 342 343 348 Barnyardgrass 40 40 0 30 0 50 0 0 40 0 0 0 0 40 Ducksalad 65 75 20 40 65 60 0 0 65 50 0 0 0 100 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Compounds 500 g ai/ha Flood 349 350 Barnyardgrass 40 60 Ducksalad 90 100 Rice 0 0 Sedge, Umbrella 0 0 250 g ai/ha Compounds Flood 30 31 32 33 34 35 36 37 38 39 40 41 42 43 Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ducksalad 0 0 50 100 95 80 60 0 0 0 0 70 60 0 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 40 20 0 0 0 20 0 0 250 g ai/ha Compounds Flood 45 46 47 48 49 50 51 52 53 54 55 56 57 58 Barnyardgrass 0 0 0 40 0 0 20 55 0 0 50 0 0 0 Ducksalad 80 0 0 100 70 90 80 90 100 70 75 0 0 0 Rice 20 0 0 20 0 0 15 25 0 20 50 0 0 0 Sedge, Umbrella 40 0 0 60 40 55 45 85 20 0 70 0 0 0 250 g ai/ha Compounds Flood 59 60 61 62 63 64 65 66 67 68 69 70 72 73 Barnyardgrass 40 30 0 20 20 0 0 0 0 40 40 40 0 0 Ducksalad 75 90 0 75 60 80 80 75 70 90 85 85 60 60 Rice 20 0 0 0 0 15 0 0 0 25 30 35 0 0 Sedge, Umbrella 60 60 30 80 0 40 40 50 50 70 65 70 0 0 250 g ai/ha Compounds Flood 74 75 76 77 78 79 80 81 82 83 84 87 89 95 Barnyardgrass 0 0 0 20 0 0 30 20  0 30 0 60 60 0 Ducksalad 90 0 90 100 85 90 75 70 70 50 0 80 70 90 Rice 0 0 0 10 0 0 0 — — 0 0 0 20 0 Sedge, Umbrella 0 0 0 0 0 0 0  0 80 0 0 0 0 0 250 g ai/ha Compounds Flood 97 194 195 196 197 198 199 235 241 242 243 256 257 258 Barnyardgrass 50 0 30 0 0 0 20 0 55 40 0 0 0 0 Ducksalad 70 45 35 0 0 70 90 0 100 90 0 60 70 60 Rice 50 0 0 0 0 0 0 0 0 20 0 0 15 0 Sedge, Umbrella 75 0 0 0 0 0 0 0 0 0 0 50 0 40

Test C

Seeds of plant species selected from blackgrass (Alopecurus myosuroides), ryegrass, Italian (Italian ryegrass, Lolium multiflorum), wheat (winter wheat, Triticum aestivum), galium (catchweed bedstraw, Galium aparine), corn (Zea mays), crabgrass, large (large crabgrass, Digitaria sanguinalis), foxtail, giant (giant foxtail, Setaria faberii), johnsongrass (Sorghum halepense), lambsquarters (Chenopodium album), morningglory (Ipomoea coccinea), nutsedge, yellow (yellow nutsedge, Cyperus esculentus), pigweed (Amaranthus retroflexus), ragweed (common ragweed, Ambrosia elation), soybean (Glycine max), barnyardgrass (Echinochloa crus-galli), oilseed rape (Brassica napus), waterhemp (common waterhemp, Amaranthus rudis), Kochia (Kochia scoparia), oat, wild (wild oat, Avena fatua), surinam grass (Brachiaria decumbens), foxtail, green (green foxtail, Setaria viridis), goosegrass (Eleusine indica), bromegrass, downy (downy bromegrass, Bromus tectorum), nightshade (eastern black nightshade, Solanum ptycanthum), cocklebur (common cocklebur, Xanthium strumarium), cupgrass, woolly (woolly cupgrass, Eriochloa villosa), bermudagrass (Cynodon dactylon), sunflower, (common oilseed sunflower, Helianthus annuus), Russian thistle (Salsola kali) and velvetleaf (Abutilon theophrasti) were planted into a blend of loam soil and sand and treated preemergence with test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant.

At the same time, plants selected from these crop and weed species and also barley (winter barley, Hordeum vulgare), windgrass (Apera spica-venti), chickweed (common chickweed, Stellaria media), deadnettle (henbit deadnettle, Lamium amplexicaule), and canarygrass (littleseed canarygrass, Phalaris minor) were planted in pots containing Redi-Earth® planting medium (Scotts Company, 14111 Scottslawn Road, Marysville, Ohio 43041) comprising spaghnum peat moss, vermiculite, wetting agent and starter nutrients and treated with postemergence applications of test chemicals formulated in the same manner. Plants ranged in height from 2 to 18 cm (1- to 4-leaf stage) for postemergence treatments. Treated plants and controls were maintained in a greenhouse for 13 to 15 days, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table C, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

Plant species in the flooded paddy test consisted of rice (Oryza sativa), sedge, umbrella (small-flower umbrella sedge, Cyperus difformis), ducksalad (Heteranthera limosa), and barnyardgrass (Echinochloa crus-galli) grown to the 2-leaf stage for testing. At time of treatment, test pots were flooded to 3 cm above the soil surface, treated by application of test compounds directly to the paddy water, and then maintained at that water depth for the duration of the test. Treated plants and controls were maintained in a greenhouse for 13 to 15 days, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table C, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

TABLE C 250 g ai/ha Compounds Postemergence 17 34 50 52 76 79 80 81 101 103 106 109 119 120 Barley 0 0 0 15 — — — 0 — — — — — — Barnyardgrass — — — — 90 60  70 — 90 65  30  45  80  65  Bermudagrass 0 0 0 10 — — — 0 — — — — — — Blackgrass 0 0 0  0 10 5  5 0  5 0 0 0 0 0 Bromegrass, Downy 0 0 0 10 — — — 7 — — — — — — Canarygrass 0 0 0  0 — — — 0 — — — — — — Chickweed 10  5 5 60 80 90  90 0 80 5 30  0 — — Cocklebur 0 25 5  5 — — — 0 — — — — — — Corn 0 0 5  5  0 0 10 0  0 0 0 5 5 0 Crabgrass, Large 70  60 75 75 75 75  75 7 85 85  60  70  90  75  Cupgrass, Woolly 0 30 10 10 — — — 0 — — — — — — Deadnettle 0 0 — — — — — — — — — — — — Foxtail, Giant 10  35 10 25 70 15  45 7 90 80  50  70  90  85  Foxtail, Green 0 60 30 80 — — — 48  — — — — — — Galium 0 10 — — 65 — 65 — 70 50  35  30  — — Goosegrass 0 25 25 20 — — — 0 — — — — — — Johnsongrass 0 0 10  0  0 5 10 0  0 0 0 0 5 0 Kochia 5 5 0 50 65 — 65 0 50 40  35  0 — — Lambsquarters 0 55 15 40 50 85  70 3 70 30  0 5 70  70  Morningglory 0 10 10 30 40 5  5 0 55 40  5 15  5 5 Nutsedge, Yellow 0 10 5 10  0 0  0 0  5 0 0 0 0 0 Oat, Wild 0 0 0  0  0 0  0 0  0 0 0 0 0 0 Oilseed Rape — — — — 10 0 60 — 35 5 0 5 5 0 Pigweed 0 10 20 60 30 35  75 0 45 10  30  10  25  60  Ragweed 0 5 10 55 55 45  30 0 45 10  5 5 25  45  Ryegrass, Italian 5 0 0  0  5 0  0 0  0 0 5 0 5 10  Soybean 0 10 20  5 10 10  25 8  5 0 5 5 5 0 Surinam Grass 60  60 15 30 — — — 0 — — — — — — Velvetleaf 0 5 45 35  0 0 25 0 30 0 5 5 20  25  Waterhemp — — — — 10 30  65 — 35 10  20  0 40  20  Wheat 0 0 0  0  5 0  0 0  0 0 0 0 0 0 Windgrass 0 5 0 20 — — — 20  — — — — — — 250 g ai/ha Compounds Postemergence 202 204 206 207 223 224 232 244 275 278 279 302 303 305 Barley — — — — — — — — — — — — — — Barnyardgrass 85 90 80 65 60 75 75 5 85 75  85 90 70 80 Bermudagrass — — — — — — — — — — — — — — Blackgrass 10 50 60  0  0  0  0 0 40 0  0  5  0 10 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed 85 65 85 90 80 85 85 65  85 0  5 70 — — Cocklebur — — — — — — — — — — — — — — Corn 35 40 50  5  5 10  0 0 55 0  0  0 15 45 Crabgrass, Large 75 80 80 65 80 75 75 40  85 75  80 85 90 80 Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 85 90 85 75 35 35 70 5 90 75  90 80 90 90 Foxtail, Green — — — — — — — — — — — — — — Galium 80 60 75 50 70 85 80 65  80 20  30 45 — — Goosegrass — — — — — — — — — — — — — — Johnsongrass 25  0 35  0  0 25 25 5 25 0  0 10  5 20 Kochia 80 40 70 30 60 70 75 50  85 5 35 60 — — Lambsquarters 85 30 20 15 60 60 85 35  75 20  45 70 80 65 Morningglory 10 35 45 20 35 35 60 5 20 0 25 25  0 20 Nutsedge, Yellow  0  0  0  0  0  0  5 5 20 15   0 20  0  0 Oat, Wild 10  5 50  0  0 15 30 0  5 0  0  0  0 30 Oilseed Rape 50 45 55 30 10  5 40 10  45 0  0  0 30  0 Pigweed 85 10 30 20 60 65 85 10  35 15  20 30 25 65 Ragweed 85  0  5 15 35 80 75 0 70 0 35 55 55 45 Ryegrass, Italian 35 15 35  0  0  5 40 0 25 0  0  0  5 45 Soybean 10  5  5  5 30  5 20 5 10 15  10 65  0  0 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 55 10 15  0 20 35 60 5 50 20  10 20 35 65 Waterhemp 85  5 30 10 10 30 80 5 20 5 15 25 25 40 Wheat  5  0 45  0  0  5  5 0  0 0  0  0  0  5 Windgrass — — — — — — — — — — — — — — 250 g ai/ha Compounds Postemergence 306 309 310 312 315 316 317 323 324 325 345 346 Barley — — — — — — — — — — — — Barnyardgrass 85 60 75 75 85 70 70  70 65 80 — 60 Bermudagrass — — — — — — — — — — — — Blackgrass  5  5  5  0 25  0 0 15  0 35 —  5 Bromegrass, Downy — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — Chickweed — 70 85 — — — — — — — 30 85 Cocklebur — — — — — — — — — — — — Corn 20 20 30 10 60  0 0 10  0 35 —  0 Crabgrass, Large 85 65 70 90 75 70 50  80 75 85 — 75 Cupgrass, Woolly — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — Foxtail, Giant 85 80 70 80 85 85 50  70 60 75 — 85 Foxtail, Green — — — — — — — — — — — — Galium — 60 65 — — — — — — — — 70 Goosegrass — — — — — — — — — — — — Johnsongrass  0 15  5  0 35  0 5 10 10  0 —  0 Kochia — 75 80 — — — — — — — — 40 Lambsquarters 75 70 70 55 80 65 25  65 65 65 — 65 Morningglory  5 10 70 20 10 10 10  25 15 50 —  5 Nutsedge, Yellow  0  0 25  0  0  0 0  0  0  0 —  5 Oat, Wild  5  0  0  0  0 30 0  0  5 15 —  0 Oilseed Rape 70  5 40  0 10  0 0  0  0 60 —  0 Pigweed 90 60 70 45 80 75 5 25 55 65 — 40 Ragweed 85 40 60 55 70 65 40  20 40 35 — 20 Ryegrass, Italian 20  5  5 10 45  5 0  5  0 30 —  0 Soybean  5  0  0  0 15  0 0  0  0  0 —  5 Surinam Grass — — — — — — — — — — — — Velvetleaf 65 15 40 35 55 35 0  0 55 40 — 20 Waterhemp 80 10 10 20 65 55 0 20 40 35 — 40 Wheat  0  0  0  0  5  0 0  0  0  5 —  0 Windgrass — — — — — — — — — — — — 125 g ai/ha Compounds Postemergence 17 34 48 50 52 60 76 79 80 81 101 103 106 109 Barley 0 0 0 0 0 20 — — — 0 — — — — Barnyardgrass — — — — — — 85  35 35 — 65 35  0 0 Bermudagrass 0 0 10 0 0 0 — — — 0 — — — — Blackgrass 0 0 0 0 0 0 0  0  0 0 10 0 0 0 Bromegrass, Downy 0 0 0 0 0 5 — — — 0 — — — — Canarygrass 0 0 0 0 0 0 — — — 0 — — — — Chickweed 0 5 30 0 45 30 65  90 90 0 70 5 5 0 Cocklebur 0 5 10 5 5 0 — — — 0 — — — — Corn 0 0 5 5 5 0 0  0  5 0  0 0 0 0 Crabgrass, Large 45  40 75 40  55 75 70  65 65 3 80 75  25  40  Cupgrass, Woolly 0 0 5 0 5 5 — — — 0 — — — — Deadnettle 0 0 — — — — — — — — — — — — Foxtail, Giant 0 5 40 5 0 30 20  15 45 0 75 45  45  50  Foxtail, Green 0 60 65 0 30 45 — — — 20  — — — — Galium 0 0 — — — — 50  60 65 — 30 40  50  30  Goosegrass 0 15 10 25  20 0 — — — 0 — — — — Johnsongrass 0 0 0 0 0 5 0  0  5 0  0 0 0 0 Kochia 0 5 20 0 40 45 50  55 65 0 50 35  30  0 Lambsquarters 0 10 10 10  40 20 40  85 60 0 35 40  0 0 Morningglory 0 5 10 10  10 10 40   5  5 0 25 10  10  5 Nutsedge, Yellow 0 10 0 0 10 5 0  0  0 0  0 0 0 0 Oat, Wild 0 0 0 0 0 0 0  0  0 0  0 0 0 0 Oilseed Rape — — — — — — 0  0 20 — 50 0 0 5 Pigweed 0 0 40 20  50 20 10  35 60 0 15 5 5 5 Ragweed 0 5 35 0 50 35 40  20 30 0  5 10  0 0 Ryegrass, Italian 0 0 0 0 0 0 0  0  0 0  0 0 0 0 Soybean 0 5 10 15  5 5 5 10  5 3  5 0 5 5 Surinam Grass 45  55 25 5 — 0 — — — 0 — — — — Velvetleaf 0 5 35 25  20 5 0  0 — 0 10 0 5 0 Waterhemp — — — — — — 5 10 45 — 20 5 10  0 Wheat 0 0 5 0 0 5 0  0  0 0  0 0 0 0 Windgrass 0 0 0 0 20 0 — — — 20  — — — — 125 g ai/ha Compounds Postemergence 119 120 202 204 206 207 223 224 232 244 275 277 278 279 Barley — — — — — — — — — — — — — — Barnyardgrass 65  40  65 80  80 35  45  50 70 5 75 80 55  85 Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0  5 0 40 0 0  0  0 0  5  0 0  0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed — — 85 55  85 60  50  70 85 20  85 40 0 30 Cocklebur — — — — — — — — — — — — — — Corn 0 0 10 0 30 0 0 10  0 0  0 10 0  0 Crabgrass, Large 80  70  60 70  70 40  55  55 60 5 65 70 65  70 Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 85  75  70 90  50 65  30  60 15 5 35 85 40  90 Foxtail, Green — — — — — — — — — — — — — — Galium — — 80 60  75 0 45  60 80 55  75 75 5 30 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0 25 0  0 0 0 15 20 0  0 10 0  0 Kochia — — 80 40  30 0 30  50 70 40  85 60 0 85 Lambsquarters 75  60  80 75  10 35  35  70 85 10  75 40 20  45 Morningglory 5 0 70 15  35 5 0 35 25 5 20 40 45  30 Nutsedge, Yellow 0 0  0 0  0 0 0  0  5 5  0  0 0  0 Oat, Wild 0 0 30 0 45 0 0  5  0 0  0  5 0  0 Oilseed Rape 0 0 50 0 50 10  0 20 65 5 35  0 5  0 Pigweed 15  40  85 10  50 10  10  60 85 5 30 30 15  30 Ragweed 45  40  80 0 25 0 35  45 85 0 70 40 10  35 Ryegrass, Italian 0 0  5 0 10 0 0  5  0 0  5 35 0  0 Soybean 0 0  5 0  5 5 0  5 10 5  0  0 40   0 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 15  5 30 0 15 0 0 25 30 5 10 15 10  10 Waterhemp 0 15  75 0 35 0 10  30 80 5  0  5 5 15 Wheat 0 0  0 0 30 0 0  5  5 0  0  0 0  0 Windgrass — — — — — — — — — — — — — — 125 g ai/ha Compounds Postemergence 302 303 304 305 306 309 310 312 315 316 317 323 324 325 Barley — — — — — — — — — — — — — — Barnyardgrass 40  70  40 70 85 55 50 70 70 60  25  35  55 70 Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0  0 30  5  5  5  0 30 0 0 0  0  0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed 5 — — — — 65 90 — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 0 0  5 40  0  0 60 10 10 0 0 5 55 10 Crabgrass, Large 70  65  80 75 75 60 70 80 70 60  45  70  70 65 Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 80  85  45 85 60 40 30 75 85 85  0 35  75 65 Foxtail, Green — — — — — — — — — — — — — — Galium 10  — — — — 55 50 — — — — — — — Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0  0 20  0  0  0 25  0 0 0 0  0  0 Kochia 0 — — — — 75 90 — — — — — — — Lambsquarters 60  65  70 50 90 65 65 95 65 40  25  65  70 70 Morningglory 50  0 45 75 65 25 10 10 35 10  0 5 10 35 Nutsedge, Yellow 0 0  0  0 — 30  0  0  0 0 0 0  0  0 Oat, Wild 0 0  0  0  0  0  0  0  0 5 0 0  0  5 Oilseed Rape 40  0  0  0 40 40  0  0  0 0 0 0  0 50 Pigweed 20  10  55 65 85 50 60 25 65 60  5 25  65 50 Ragweed 20  40  35 40 80 35 20 45 65 35  25  15  25 25 Ryegrass, Italian 0 0  0  0  5  0  0 35 15 0 0 0  0  0 Soybean 0 0 10  0  5 15  0  0  0 0 0 0  0  0 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 25  15 40 50  5  0  0 30 45  0 0 50 20 Waterhemp 20  0 80 35 80 10 10 20 60 10  20  0 20 25 Wheat 0 0  0  0  0  0  0  0  0 0 0 0  0  0 Windgrass — — — — — — — — — — — — — — Compound 125 g ai/ha Postemergence 346 Barley — Barnyardgrass 30  Bermudagras s — Blackgrass 0 Bromegrass, Downy — Canarygrass — Chickweed 40  Cocklebur — Corn 0 Crabgrass, Large 60  Cupgrass, Woolly — Deadnettle — Foxtail, Giant 40  Foxtail, Green — Galium 40  Goosegrass — Johnsongrass 0 Kochia 45  Lambsquarters 5 Morningglory 15  Nutsedge, Yellow 0 Oat, Wild 0 Oilseed Rape 0 Pigweed 20  Ragweed 0 Ryegrass, Italian 0 Soybean 0 Surinam Grass — Velvetleaf 5 Waterhemp 15  Wheat 0 Windgrass — 62 g ai/ha Compounds Postemergence 17 34 48 50 52 60 76 79 80 81 101 103 106 109 Barley 0 0 0 0 0 0 — — — 0 — — — — Barnyardgrass — — — — — — 35  0 20  — 35  10  0 0 Bermudagrass 0 0 0 0 0 0 — — — 0 — — — — Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 — — — 0 — — — — Canarygrass 0 0 0 0 0 0 — — — 0 — — — — Chickweed 0 0 30  0 25 10  40  80  85  0 60  5 0 0 Cocklebur 0 5 10  5 5 0 — — — 0 — — — — Corn 0 0 5 0 0 0 0 0 5 0 0 0 0 0 Crabgrass, Large 0 30  65  25  55 50  50  5 40  0 50  15  10  10  Cupgrass, Woolly 0 0 5 0 5 0 — — — 0 — — — — Deadnettle 0 0 — — — — — — — — — — — — Foxtail, Giant 0 5 20  5 0 15  5 15  0 0 20  0 35  15  Foxtail, Green 0 60  0 0 10 35  — — — 5 — — — — Galium 0 0 — — — — 50  60  55  — 50  0 0 0 Goosegrass 0 15  10  25  0 0 — — — 0 — — — — Johnsongrass 0 0 0 0 0 5 0 0 5 0 0 0 0 0 Kochia 0 5 10  0 35 10  50  55  55  0 30  30  40  0 Lambsquarters 0 0 — 10  10 20  40  50  55  0 25  0 25  0 Morningglory 0 5 10  0 10 10  10  0 5 0 15  0 5 0 Nutsedge, Yellow 0 5 0 0 10 0 0 0 0 0 0 0 0 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oilseed Rape — — — — — — 0 0 0 — 10  0 0 0 Pigweed 0 0 30  10  40 20  10  35  40  0 10  0 0 5 Ragweed 0 5 5 0 10 25  40  20  30  0 0 0 0 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 0 0 10  15  0 0 0 0 5 3 0 0 0 0 Surinam Grass 0 0 25  5 5 0 — — — 0 — — — — Velvetleaf 0 5 15  15  20 0 0 0 15  0 0 0 0 0 Waterhemp — — — — — — 5 10  45  — 5 5 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 — — — 0 — — — — 62 g ai/ha Compounds Postemergence 119 120 202 204 206 207 223 224 232 244 271 275 277 278 Barley — — — — — — — — — — — — — — Barnyardgrass 40  30  65 55  40 10  0 30 55 0 0 60  70  10  Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0  0 0  0 0 0  0  0 0 0 0 0 0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed — — 80 30  60 50  45  70 85 50  50  60  0 0 Cocklebur — — — — — — — — — — — — — — Corn 0 0  0 0  0 0 0  0  0 0 0 0 20  0 Crabgrass, Large 65  70  50 50  50 15  10  35 35 5 5 40  65  30  Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 25  65  25 10  50 0 35   0  5 0 0 75  85  10  Foxtail, Green — — — — — — — — — — — — — — Galium — — 80 45  75 0 5 45 80 30  30  55  60  0 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0 20 0  0 0 0  0 20 0 10  0 0 0 Kochia — — 75 30  70 0 5 40 70 10  10  85  5 0 Lambsquarters 50  55  80 65  75 10  5 50 85 20  55  60  40  0 Morningglory 0 5 10 5 20 5 0  5  0 0 45  10  30  0 Nutsedge, Yellow 0 0  0 0 20 0 0  0  0 10  0 0 0 0 Oat, Wild 0 0  0 0  5 0 0  0  0 0 0 0 0 0 Oilseed Rape 0 0  0 0 30 0 0 15 50 0 20  5 0 0 Pigweed 10  20  80 10  40 10  10  55 85 5 30  5 10  5 Ragweed 0 45  75 0  0 0 0 65 80 0 40  65  35  0 Ryegrass, Italian 0 0  0 0  0 0 0  0  0 0 0 0 5 0 Soybean 5 0  0 0  5 5 0 10 10 5 60  0 0 55  Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 0 20 0  0 0 0  0 15 5 5 10  0 0 Waterhemp 0 0 65 0  0 0 0 35 75 5 5 0 5 0 Wheat 0 0  0 0  0 0 0  0  0 0 0 0 0 0 Windgrass — — — — — — — — — — — — — — 62 g ai/ha Compounds Postemergence 279 302 303 304 305 306 309 310 312 315 316 317 323 324 Barley — — — — — — — — — — — — — — Barnyardgrass 55 20  60  0 55  45 15  25  70  65  35  0 10  35  Bermudagrass — — — — — — — — — — — — — — Blackgrass  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed 75 0 — — — — 50  45  — — — — — — Cocklebur — — — — — — — — — — — — — — Corn  0 0 0 0 5  0 0 0 15  0 0 0 0 0 Crabgrass, Large 65 50  40  60  55  45 30  10  50  65  50  25  40  60  Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 30 45  80  10  65  75 0 5 75  40  5 0 0 10  Foxtail, Green — — — — — — — — — — — — — — Galium 15 15  — — — — 40  50  — — — — — — Goosegrass — — — — — — — — — — — — — — Johnsongrass  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Kochia 30 0 — — — — 5 50  — — — — — — Lambsquarters  0 20  85  75  35  70 65  65  75  60  65  0 10  55  Morningglory 60 15  60  20  20  35 10  0 0 65  0 0 25  5 Nutsedge, Yellow  0 0 0 0 0  0 5 0 0 0 0 0 0 0 Oat, Wild  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Oilseed Rape 30 0 0 0 0 50 30  0 0 0 0 0 0 0 Pigweed 10 20  0 55  60  85 50  40  20  65  50  5 5 35  Ragweed 20 20  0 0 0 55 0 10  35  20  0 0 0 20  Ryegrass, Italian  0 0 0 5 0  0 0 0 0 5 0 0 0 0 Soybean 10 0 0 5 0  5 0 10  0 0 0 0 0 5 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 10 0 0 15  40  10 5 0 0 25  0 0 20  55  Waterhemp 20 20  35  65  10  65 5 10  45  60  10  0 0 10  Wheat  0 0 0 0 0  0 0 0 0 0 0 0 0 0 Windgrass — — — — — — — — — — — — — — Compounds 62 g ai/ha Postemergence 325 346 Barley — — Barnyardgrass 25  0 Bermudagrass — — Blackgrass 0 0 Bromegrass, Downy — — Canarygrass — — Chickweed — 65  Cocklebur — — Corn 0 0 Crabgrass, Large 65  25  Cupgrass, Woolly — — Deadnettle — — Foxtail, Giant 35  0 Foxtail, Green — — Galium — 25  Goosegrass — — Johnsongrass 0 0 Kochia — 50  Lambsquarters 45  5 Morningglory 5 5 Nutsedge, Yellow 0 0 Oat, Wild 0 0 Oilseed Rape 0 0 Pigweed 55  5 Ragweed 10  0 Ryegrass, Italian 0 0 Soybean 0 5 Surinam Grass — — Velvetleaf 15  0 Waterhemp 0 0 Wheat 0 0 Windgrass — — 31 g ai/ha Compounds Postemergence 17 34 48 50 52 60 76 79 80 81 101 103 106 109 Barley 0 0 0 0 0 0 — — — 0 — — — — Barnyardgrass — — — — — — 0 0 0 — 0 0 0 0 Bermudagrass 0 0 0 0 0 0 — — — 0 — — — — Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 — — — 0 — — — — Canarygrass 0 0 0 0 0 0 — — — 0 — — — — Chickweed 0 0 0 0 — 0 40  60  70  0 35  0 0 0 Cocklebur 0 0 5 5 5 0 — — — 0 — — — — Corn 0 0 5 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 0 0 40  10  50  20  0 5 5 0 25  0 10  10  Cupgrass, Woolly 0 0 0 0 0 0 — — — 0 — — — — Deadnettle 0 0 — — — — — — — — — — — — Foxtail, Giant 0 0 5 0 0 0 0 15  0 0 0 0 50  60  Foxtail, Green 0 0 0 0 0 20  — — — 5 — — — — Galium 0 0 — — — — 30  30  5 — 50  0 0 0 Goosegrass 0 10  10  25  0 0 — — — 0 — — — — Johnsongrass 0 0 0 0 0 5 0 0 5 0 0 0 0 0 Kochia 0 5 10  0 30  0 40  5 30  0 45  30  0 0 Lambsquarters 0 0 10  5 — 5 40  25  55  0 10  0 0 0 Morningglory 0 0 10  0 5 5 10  0 0 0 15  20  0 20  Nutsedge, Yellow 0 5 0 0 10  0 0 0 0 0 0 0 0 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oilseed Rape — — — — — — 0 0 0 — 5 0 0 0 Pigweed 0 0 25  10  25  — 5 35  40  0 0 0 0 5 Ragweed 0 5 5 0 10  10  25  20  30  0 0 0 25  0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 0 0 10  10  0 0 0 0 0 0 0 0 0 0 Surinam Grass 0 0 5 5 0 0 — — — 0 — — — — Velvetleaf 0 5 0 0 10  0 0 0 15  0 0 0 0 0 Waterhemp — — — — — — 0 10  30  — 0 0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 — — — 0 — — — — 31 g ai/ha Compounds Postemergence 119 120 202 204 206 207 223 224 232 244 271 275 277 278 Barley — — — — — — — — — — — — — — Barnyardgrass 25  0 25  5 25  0 0 0 5 0 0 30  15  0 Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed — — 80  0 85  30  40  70  70  45  5 50  40  0 Cocklebur — — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 55  55  30  0 45  10  0 0 25  5 5 15  15  0 Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 10  25  5 0 0 20  0 0 0 0 0 10  10  10  Foxtail, Green — — — — — — — — — — — — — — Galium — — 80  10  60  0 5 5 75  30  30  50  45  0 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0 0 0 0 0 0 0 0 0 10  0 0 0 Kochia — — 70  10  50  0 0 0 60  0 0 70  0 0 Lambsquarters 5 55  70  35  50  0 0 5 80  10  50  10  30  0 Morningglory 0 0 5 5 20  5 0 5 15  0 10  10  30  0 Nutsedge, Yellow 0 0 0 0 0 10  0 0 0 0 0 0 10  0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oilseed Rape 0 0 0 0 0 0 0 0 0 0 0 5 0 0 Pigweed 10  5 80  20  30  0 5 40  80  5 10  5 10  0 Ragweed 20  20  70  0 5 0 0 20  75  0 25  20  40  0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 5 0 0 0 5 0 10  0 0 5 15  0 0 50  Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 25  10  0 0 0 0 0 5 5 5 5 0 0 Waterhemp 0 0 60  0 0 0 0 25  75  5 0 0 5 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass — — — — — — — — — — — — — — 31 g ai/ha Compounds Postemergence 279 302 303 304 305 306 309 310 312 315 316 317 323 324 Barley — — — — — — — — — — —  — — — Barnyardgrass 15  0 10  0 20  0 0 5 40  25  10 0 0 0 Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy — — — — — — — — — — — — — — Canarygrass — — — — — — — — — — — — — — Chickweed 5 0 — — — — 30  20  — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 25  0 0 10  40  10  0 0 25  55  0 0 0 25  Cupgrass, Woolly — — — — — — — — — — — — — — Deadnettle — — — — — — — — — — — — — — Foxtail, Giant 0 0 — 0 0 5 10  0 55  0 5 0 0 0 Foxtail, Green — — — — — — — — — — — — — — Galium 0 10  — — — — 30  35  — — — — — — Gooesgrass — — — — — — — — — — — — — — Johnsongrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Kochia 0 0 — — — — 5 40  — — — — — — Lambsquarters 0 10  35  35  60  60  10  25  65  60  55  0 10  0 Morningglory 5 10  10  50  25  0 60  10  0 25  55  0 0 10  Nutsedge, Yellow 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Oilseed Rape 0 0 0 0 0 0 35  0 0 0 0 0 0 0 Pigweed 30  15  0 35  55  75  30  35  10  25  15  5 0 0 Ragweed 15  10  0 0 0 60  0 10  40  0 45  0 0 5 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 40  0 0 0 10  0 0 10  0 0 0 0 0 0 Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 0 35  5 10  0 5 35  30  10  0 0 0 0 Waterhemp 5 10  0 50  10  65  0 5 0 50  10  0 0 0 Wheat 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Windgrass — — — — — — — — — — — — — — Compounds 31 g ai/ha Postemergence 325 346 Barley — — Barnyardgrass 10  0 Bermudagrass — — Blackgrass 0 0 Bromegrass, Downy — — Canarygrass — — Chickweed — 40  Cocklebur — — Corn 0 0 Crabgrass, Large 55  0 Cupgrass, Woolly — — Deadnettle — — Foxtail, Giant 0 20  Foxtail, Green — — Galium — 30  Goosegrass — — Johnsongrass 0 100  Kochia — 45  Lambsquarters 20  45  Morningglory 5 0 Nutsedge, Yellow 0 0 Oat, Wild 0 0 Oilseed Rape 0 0 Pigweed 40  5 Ragweed 10  0 Ryegrass, Italian 0 0 Soybean 0 0 Surinam Grass — — Velvetleaf 0 0 Waterhemp 0 0 Wheat 0 0 Windgrass — — Compounds 16 g ai/ha Postemergence 48 271 277 304 Barley 0 — — — Barnyardgrass — 0 5 0 Bermudagrass 0 — — — Blackgrass 0 0 0 0 Bromegrass, Downy 0 — — — Canarygrass 0 — — — Chickweed 0 5 0 — Cocklebur 0 — — — Corn 0 0 0 0 Crabgrass, Large 20  0 5 10  Cupgrass, Woolly 0 — — — Foxtail, Giant 0 0 0 0 Foxtail, Green 0 — — — Galium — 5 40  — Goosegrass 10  — — — Johnsongrass 0 10  0 0 Kochia 0 0 0 — Lambsquarters — 45  25  65  Morningglory 10  0 15  20  Nutsedge, Yellow 0 0 0 0 Oat, Wild 0 0 0 0 Oilseed Rape — 0 0 0 Pigweed 10  5 5 25  Ragweed 0 15  10  0 Ryegrass, Italian 0 0 0 0 Soybean 5 45  0 0 Surinam Grass 0 — — — Velvetleaf 0 0 0 0 Waterhemp — 0 5 40  Wheat 0 0 0 0 Windgrass 0 — — — Compound 8 g ai/ha Postemergence 271 Barnyardgrass 0 Blackgrass 0 Chickweed 0 Corn 0 Crabgrass, Large 0 Foxtail, Giant 0 Galium 0 Johnsongrass 10 Kochia 0 Lambsquarters 10 Morningglory 0 Nutsedge, Yellow 0 Oat, Wild 0 Oilseed Rape 0 Pigweed 5 Ragweed 0 Ryegrass, Italian 0 Soybean 5 Velvetleaf 0 Waterhemp 0 Wheat 0 250 g ai/ha Compounds Preemergence 5 14 16 17 33 34 35 52 53 59 62 64 66 68 Barnyardgrass — — — — — — — — — — — — — — Bermudagrass 45 95 95 90 98 45 75 65 50 50 60 55 0 85 Blackgrass 30 0 — 95  5 45 50  0 0 60 80 30 20 80 Bromegrass, Downy 0 0 35 65 55 30 40  0 0 20  0 50 5  0 Cocklebur 0 0  0 5 10 0 0 — 5 —  5 — — — Corn 0 0 10 70 30 10 5 10 20 45 55 60 20 50 Crabgrass, Large 100 100 100  100 100  100 100 95 90 100  98 95 98 95 Cupgrass, Woolly 95 80 95 95 90 95 90 85 80 80 85 90 85 90 Foxtail, Giant 100 95 95 100 98 98 98 85 85 90 85 98 95 95 Foxtail, Green 95 95 90 98 100  100 98 90 90 98 90 98 98 95 Galium 40 85 — 90 90 60 30 90 70 85 90  0 0 90 Goosegrass 80 55 80 95 85 45 25 80 40 80 80 50 10 85 Johnsongrass 0 40 25 75 15 20 45 15 10  5 40 75 40 75 Kochia 0 0  0 80  0 0 10 20 20 40 25 35 10 35 Lambsquarters 95 — — 100 25 80 20 75 65 35 85 35 0 75 Morningglory 0 0  0 0  0 5 20  0 0 25 20 30 40 15 Nightshade 98 0  0 40 15 0 0 40 70 30 70  5 0 55 Nutsedge, Yellow 0 0 45 0 40 0 0 25 20 35 20 40 10 10 Oat, Wild 20 0 15 80 90 85 75 10 0 80 50 70 5 30 Oilseed Rape — — — — — — — — — — — — — — Pigweed 0 0  0 60 20 40 5 70 25 55 95 30 0 85 Ragweed 0 0  0 50 20 15 0 10 15 35 45 30 25  0 Russian Thistle — 0  0 — — 95 — — —  0 85  0 0 — Ryegrass, Italian 0 10 — 70 30 45 30  5 0  0 50  0 0  5 Soybean 0 0  0 0  5 5 0 15 20 20 35 40 20 15 Sunflower 0 0  0 50 10 0 10 20 20 40 60 25 5 15 Surinam Grass 95 95 100  95 95 100 100 80 75 80 85 80 75 85 Velvetleaf 0 0  0 10 10 0 20  5 10 25 30 25 25 25 Waterhemp — — — — — — — — — — — — — — Wheat 60 10 45 85 40 80 65 25 0  0 10 15 25 50 250 g ai/ha Compounds Preemergence 69 76 77 78 79 80 81 101 103 109 119 120 202 204 Barnyardgrass — 98 95 95 98 95 — 95 95  98 98 98 95 95 Bermudagrass 55 — — — — — 0 — — — — — — — Blackgrass 35 80 95 85 85 90 0 90 0 95 85 70 90 90 Bromegrass, Downy 0 — — — — — 0 — — — — — — — Cocklebur 0 — — — — — 0 — — — — — — — Corn 30 65 70 60 30 65 0 65 10  75 45 65 85 75 Crabgrass, Large 95 100  98 98 100  100  95  100  100  100  100  100  98 95 Cupgrass, Woolly 90 — — — — — 82  — — — — — — — Foxtail, Giant 90 98 100  98 98 98 73  98 98  100  98 98 98 95 Foxtail, Green 95 — — — — — 90  — — — — — — — Galium 75 85 90 85 90 90 0 85 80  100  90 90 90 90 Goosegrass 75 — — — — — 0 — — — — — — — Johnsongrass 0 80 90 60 10 55 0 75 40  70 70 65 85 85 Kochia 25 — — — — — — — — — — — — — Lambsquarters 85 35 98 85 90 90 27  90 65   0 85 90 100  100  Morningglory 25 40  0  0  0 20 0 25 0 30 35 40 40 40 Nightshade 0 — — — — — 0 — — — — — — — Nutsedge, Yellow 10 55  0  0  0 10 0  0 0  5  0  0  0  0 Oat, Wild 5 — — — — — 0 — — — — — — — Oilseed Rape — 75 85 75 80 90 — 80 5 40 80 90 90 60 Pigweed 25 40 85 40 65 90 0 85 5 20 85 80 100  75 Ragweed 20 — — — — — 0  5 0 10 80 80 100  65 Russian Thistle — — — — — — 0 — — — — — — — Ryegrass, Italian 10 40 45 45 30 45 0 50 0 70 40 30  5 30 Soybean 0  0  0  0  0  0 0 10 0  0  0  0 10 10 Sunflower 15 — — — — — 0 — — — — — — — Surinam Grass 85 — — — — — 90  — — — — — — — Velvetleaf 30 35 40 20 35 50 0 70 0 10 50 40 65 30 Waterhemp — 60 85 85 85 90 — 85 40  20 80 85 100  90 Wheat 5 80 90 90 75 80 0 55 10  85 90 85 60 90 250 g ai/ha Compounds Preemergence 206 207 211 218 223 224 231 232 233 241 246 247 262 263 Barnyardgrass 95 95 90 95 95 95 95 95 90 95 90 90 95  98 Bermudagrass — — — — — — — — — — — — — — Blackgrass 90 90 90 80 85 85 90 85 90 85 70 70 0 70 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 60 30 80  0 45 85 85 75 35 90  0 60 10  10 Crabgrass, Large 95 95 95 100  100  100  100  90 90 100  98 100  100  100  Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95 98 95 95 98 98 95 95 95 95 95 100  95  98 Foxtail, Green — — — — — — — — — — — — — — Galium 85 90 100  90 90 85 90 90 90 85 90 90 85  90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 85 60 65 40 55 85 60 70 45 90  5  5 0  0 Kochia — — — — — — — — — — — — — — Lambsquarters 100  70 100  85 90 95 100  90 90 100  90 80 100  80 Morningglory 10  0  0 20 20 30 20 20 20 30  5 20 10  10 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow  0  0 10  0  0  0  0 100   0  0  0  0 0  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 90 80 90 70  5 85 90 85 85 85 30 80 70  90 Pigweed 85  0 70 85 30 85 90 95 70 70 100  90 5 95 Ragweed 98  5 100  85 25 100  85 90 85 70 40 98 75  100  Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 20  0 50 50 15 15 15 40 40 55 10 50 0 35 Soybean  0  0  0 20 15  5  5  5  0  0 10  0 0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 60  0 35 40 35 40 60 75 45 40  0 25 0  5 Waterhemp 100  75 90 90 25 80 95 95 95 60 90 85 50  100  Wheat 70 45 45 10 35 45 80  5  0 80 30  0 0 50 250 g ai/ha Compounds Preemergence 274 275 278 279 280 302 303 305 306 307 309 310 312 315 Barnyardgrass 90 98 100  98 95 100  98 98 95 95 95 95 95 95 Bermudagrass — — — — — — — — — — — — — — Blackgrass 90 80 0 85  0 85 90 90 90  5 45 45 75 85 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 45 75 5 65  5 50 45 80 75 40 70 55 70 85 Crabgrass, Large 100  100  100  100  100  100  100  95 98 100  98 95 95 98 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95 100  100  98 95 100  100  95 100  95 95 90 95 98 Foxtail, Green — — — — — — — — — — — — — — Galium — 85 5 85 85 85 85 90 90 85 85 70 80 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 30 85 0 80 10 65 80 90 85 45 80 75 85 90 Kochia — — — — — — — — — — — — — — Lambsquarters  0 98 0 90 10 65 80 75 80 85 50 80 60 80 Morningglory  0 50 0 10 30  0 45 65 35  0 10  5 55 45 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow  0 100  5 55 100  10 25 100  10  0  0  0  0 20 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 30 90 5 60  0 10 85 90 75  5 70 85 30 80 Pigweed  0 40 0 75 20  0 80 85 90 35 40 20 55 85 Ragweed  0 85 0 65 60 10 80 75 80 35 65 35 10 80 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 30 60 0 60  5 40 75 80 70 10 10 25 30 50 Soybean  0 15 10  10  0  0 20  0  0  0  0  0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 20 30 0 30 10  0 55 55 65  0 15 35 40 50 Waterhemp  0 60 0 80 35 55 75 80 90  0 40 25 80 85 Wheat 40 90 0 30  0 30 90 90 85 15  0 10 65 90 250 g ai/ha Compounds Preemergence 316 317 318 319 323 324 325 345 346 350 Barnyardgrass 90 95 95 98 98 98 95 95 98 90 Bermudagrass — — — — — — — — — — Blackgrass 60 50 45 80 85 95 85 90 85 55 Bromegrass, Downy — — — — — — — — — — Cocklebur — — — — — — — — — — Corn 75 30 60 65 75 85 85 85  5 40 Crabgrass, Large 98 98 100  98 100  98 100  98 100  90 Cupgrass, Woolly — — — — — — — — — — Foxtail, Giant 95 95 90 95 98 95 95 98 98 90 Foxtail, Green — — — — — — — — — — Galium 90  0 100  85 85 85 80 85 90 90 Goosegrass — — — — — — — — — — Johnsongrass 85 30 60 75 60 85 75 90 60 30 Kochia — — — — — — — — — — Lambsquarters 65 10 60 75 95 85 80 85 100  90 Morningglory 35  0 40 40 30 55 40 35  0 100  Nightshade — — — — — — — — — — Nutsedge, Yellow 70 70  0 30 75 35  0  0  0  0 Oat, Wild — — — — — — — — — — Oilseed Rape 60  0  5 65 85 90 90 85 60 85 Pigweed 65  0 50 40 65 85 85 60 70 90 Ragweed 35  0 20 85 80 85 85 70 70 80 Russian Thistle — — — — — — — — — — Ryegrass, Italian  0 10 50 50 70 60 50 55 70 35 Soybean  0 10  0  0  0  0  0  0 10  0 Sunflower — — — — — — — — — — Surinam Grass — — — — — — — — — — Velvetleaf 30  5 35 65 45 50 65 40 25  5 Waterhemp 45 30 70 40 75 90 85 45 40 90 Wheat 45 35  5 35 80 85 70 80 40 15 125 g ai/ha Compounds Preemergence 5 14 16 17 33 34 35 48 52 53 59 60 62 64 Barnyardgrass — — — — — — — — — — — — — — Bermudagrass 20  95  90  85 70 0 0 0 40 50 40 0 50 25 Blackgrass 0 0 10  80 0 10 5 50 0 0 30 40 80 5 Bromegrass, Downy 0 0 30  45 0 10 5 0 0 0 0 0  0 0 Cocklebur 0 — 0  5 10 0 0 5 0 5 — 0  0 — Corn 0 0 5 30 20 0 5 20 10 20 10 20 30 55 Crabgrass, Large 100  98  100  100  100 100 100 95 90 90 90 95 95 95 Cupgrass, Woolly 90  0 95  90 90 95 85 85 75 80 80 75 80 85 Foxtail, Giant 100  90  90  100  98 98 98 95 80 65 85 90 85 90 Foxtail, Green 90  90  80  98 100 98 98 90 90 90 90 90 90 90 Galium — 70  — 70 60 5 5 60 90 0 30 5 85 0 Goosegrass 0 0 0 85 40 10 5 15 60 30 35 0 70 25 Johnsongrass 0 0 0 65 0 10 0 20 10 0 0 20 30 75 Kochia 0 0 0 60 0 0 5 10 15 0 10 0 15 20 Lambsquarters 95  — — 60 25 80 0 65 70 40 0 10 70 30 Morningglory 0 0 0 — 0 5 10 15 0 0 15 10 15 20 Nightshade 45  — 0 40 0 0 0 0 0 40 25 0 — 0 Nutsedge, Yellow 0 0 0  0 — 0 0 20 25 — 0 15 20 20 Oat, Wild 0 0 15   0 20 60 0 10 0 0 0 5 50 10 Oilseed Rape — — — — — — — — — — — — — — Pigweed 0 0 0 50 0 0 0 0 55 25 — 20 70 30 Ragweed 0 0 0 30 0 0 0 10 0 10 0 25 45 30 Russian Thistle — 0 0 — — 0 — — — — 0 60 85 0 Ryegrass, Italian 0 0 — 35 0 20 5 0 0 0 0 0 30 0 Soybean 0 0 0  0 0 5 0 15 15 15 20 25 35 40 Sunflower 0 0 0 20 — 0 10 0 0 20 15 0 25 0 Surinam Grass 95  95  98  90 95 100 100 85 45 75 60 70 80 65 Velvetleaf 0 0 0  0 10 0 20 0 5 0 0 0 25 10 Waterhemp — — — — — — — — — — — — — — Wheat 5 10  0  0 35 35 10 45 10 0 0 0  0 15 125 g ai/ha Compounds Preemergence 66 68 69 76 77 78 79 80 81 101 103 109 119 120 Barnyardgrass — — — 95 95 85 95 95 — 95 95 95 95 95 Bermudagrass 0 85 50 — — — — — 0 — — — — — Blackgrass 0 60 30 80 85 75 85 85 0 70 30 90 80 50 Bromegrass, Downy 0  0 0 — — — — — 0 — — — — — Cocklebur — — — — — — — — 0 — — — — — Corn 10 25 25 40 55 40 10  0 0  5  0 60 15 20 Crabgrass, Large 98 95 95 100  98 98 100  98 90  98 100  100  100  100  Cupgrass, Woolly 80 85 85 — — — — — 67  — — — — — Foxtail, Giant 85 90 85 95 95 95 95 98 37  98 95 98 98 98 Foxtail, Green 90 95 95 — — — — — 80  — — — — — Galium 0 90 5 — 80 60 85 90 0 90 40 50 85 50 Goosegrass 10 80 40 — — — — — 0 — — — — — Johnsongrass — 40 0 45 75 15 10 30 0 55 15 40 30 25 Kochia 10  0 0 — — — — — — — — — — — Lambsquarters 0 65 65  0 85 85 90 90 0 90 55  5 85 85 Morningglory 35 15 25 40  0  0  0 20 0 30  0  5 35 35 Nightshade 0 55 0 — — — — — 0 — — — — — Nutsedge, Yellow 0 10 0 20  0  0  0  0 0  0  0  0  0  0 Oat, Wild 0  0 5 — — — — — 0 — — — — — Oilseed Rape — — — 30 60 10 70 90 — 80  0  5 80 70 Pigweed 0 85 25  0 60 40 50 90 0 55  0  0 75 65 Ragweed 25  0 0 — — — — — 0  5 40  0 75 55 Russian Thistle 0 — — — — — — — 0 — — — — — Ryegrass, Italian 0  0 0 40 40 40 30 40 0 30  0 20 30 10 Soybean 20 10 0  0  0  0  0  0 0  0  0 55  0  0 Sunflower 0 10 10 — — — — — 0 — — — — — Surinam Grass 75 75 85 — — — — — 77  — — — — — Velvetleaf 25 10 30 25 30 20 20 35 0  5  0  0 40 35 Waterhemp — — — 50 70 85 80 90 — 50 65  0 70 75 Wheat 5 30 5 70 80 60 60 80 0 50  0 50 60 30 125 g ai/ha Compounds Preemergence 189 202 204 206 207 211 218 223 224 231 232 233 241 246 Barnyardgrass 90  95 95 95 85 85 95 90 90 95 95 85 95 75 Bermudagrass — — — — — — — — — — — — — — Blackgrass 55  90 90 90 85 85 50 85 70 85 70 60 80  5 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 40  75 55 65 55  0  0  0 85 70 70 10 80  5 Crabgrass, Large 98  98 100  95 95 95 100  95 90 100  90 90 98 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95  95 95 95 90 90 90 90 95 98 90 90 95 95 Foxtail, Green — — — — — — — — — — — — — — Galium 80  90 90 70 85 85 85 90 85 90 90 90 85 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 15  70 75 85 30 30 15 35 75 45 60 20 85  0 Kochia — — — — — — — — — — — — — — Lambsquarters 5 90 75 100  60 100  75 85 95 85 90 95 10 80 Morningglory 0 25 20  0  0  0 25 10  5  0 15 20 10 10 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0  0  0 0  0  0  0  0  0  0  0  0 100  Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 20  85  0 75  0 90 20  0 70 85 50 80 70  0 Pigweed 0 90  0 100   0  0 75 20 60 85 85 60 25 75 Ragweed 0 85 100  70  0 85 50 10 100  80 85 40 30  0 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 45 30 50 45  0 40  0 10  0 15 20 30 30 10 Soybean 0  0  5  0  0  5 40  5  0  0  0  5  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 50  0 40  0 30 15 25 45 35 65 45  5  0 Waterhemp 0 100  80 100  85 100  90  0 70 100  90 85 45 90 Wheat 0 55 80 70  5 30  0 10  0 20  0  0 90 10 125 g ai/ha Compounds Preemergence 247 262 263 274 275 277 278 279 280 302 303 304 305 306 Barnyardgrass 90 90 95 85  95 98 95  95 85  100  95 95 95 90 Bermudagrass — — — — — — — — — — — — — — Blackgrass 60  0 40 75  70 90 0 30 0 60  80 70 70 60 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 60 10  0 10  75 90 0  5 0 0 35 65 75 80 Crabgrass, Large 98 100  100  98  100  100  98  98 95  100  98 98 90 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 98 95 98 90  98 98 95  98 90  100  98 95 95 95 Foxtail, Green — — — — — — — — — — — — — — Galium 90 60 85 80  30 100  0 85 0 85  85 85 90 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 10  0  0 0 75 85 0 70 10  45  65 35 90 80 Kochia — — — — — — — — — — — — — — Lambsquarters 70 80 70 — 85 80 0 65 10  60  65 80 70 75 Morningglory  5 10 20 0  0 45 0 10 0 0 15 40 40 35 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 20  0 100  0 35 20 5  0 0 0  0  0  0  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 30 35 60 5 90 80 0 30 0 0 80 55 80 75 Pigweed 85  0 98 0 10 40 0  0 20  25  65 85 80 85 Ragweed 70 10 80 0 60 40 0 10 0 5 75 80 35 75 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 40  0  0 5 50 40 0 30 0 5 70 40 50 55 Soybean  0  0 100  5  0  5 10   0 0 0  0  0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 30  0 20 20  25 35 0  0 0 0 50 50 55 60 Waterhemp 100  60 90 — 15 55 0 55 75  65  65 85 80 85 Wheat  5  0 15 0 50 80 0 30 0 15  80 85 90 90 125 g ai/ha Compounds Preemergence 307 309 310 312 315 316 317 318 319 323 324 325 345 346 Barnyardgrass 85  90 90 90 90 90 95  95 95 98 95 95 95 95 Bermudagrass — — — — — — — — — — — — — — Blackgrass 10  50 50 70 65 30 50  30 30 45 70 70 90 75 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 40  65 55 55 80 65 25  10 60 10 75 70 65  0 Crabgrass, Large 95  95 95 95 95 95 95  98 95 98 98 95 95 98 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 85  90 90 90 95 90 90  75 95 95 95 98 95 98 Foxtail, Green — — — — — — — — — — — — — — Galium 100  75  0  5 80  0 0 40 80 85 85 50 90 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 60 45 80 85 75 0 45 65 45 80 75 85 20 Kochia — — — — — — — — — — — — — — Lambsquarters 10  30 55 50 70 65 0 50 65 75 80 80 85 100  Morningglory 0 10  5 40 35 25 0 30 45  0 35 30  0 30 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0  0  0 20  0 20   0  0 25  0  0  0  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 0 50 40 15 85 20 0  5 60 70 85 85 85 50 Pigweed 40   0 20 45 75 45 0 20 40 55 80 75 65 60 Ragweed 0 25  5 50 50 10 0  0 40 40 75 80 15 35 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 5  0 20 35 50 10 0  0 20  0 35 50 10  5 Soybean 0  0  0  0  0  0 0  0  0  0  0  0  5  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0  0  5 20 40 10 0 25 45 40 40 55 25 10 Waterhemp 0 30 25 65 85 35 10  10 35 60 80 80 40 10 Wheat 5  0  0 60 90 40 0  5 10 40 65 65 70  0 Compound 125 g ai/ha Preemergence 350 Barnyardgrass 90 Bermudagrass — Blackgrass 50 Bromegrass, Downy — Cocklebur — Corn  5 Crabgrass, Large 90 Cupgrass, Woolly — Foxtail, Giant 90 Foxtail, Green — Galium 90 Goosegrass — Johnsongrass  0 Kochia — Lambsquarters 90 Morningglory 100  Nightshade — Nutsedge, Yellow  0 Oat, Wild — Oilseed Rape 80 Pigweed 80 Ragweed  5 Russian Thistle — Ryegrass, Italian  5 Soybean  0 Sunflower — Surinam Grass — Velvetleaf  0 Waterhemp 90 Wheat  0 62 g ai/ha Compounds Preemergence 5 14 16 17 33 34 35 48 52 53 59 60 62 64 Barnyardgrass — — — — — — — — — — — — — — Bermudagrass 0 90  0 45 0 0 0 0 40 40 20 0 30 0 Blackgrass 0 0 5 50 0 0 0 20 0 0 0 10 45 5 Bromegrass, Downy 0 0 5 30 0 0 0 0 0 0 0 0  0 0 Cocklebur 0 0 0 5 — 0 0 0 0 — 0 0 — 0 Corn 0 0 0 0 10  0 0 20 10 20 10 10 20 0 Crabgrass, Large 100 98  95  98 98  98 98 90 90 85 85 95 90 90 Cupgrass, Woolly 85 0 95  85 85  85 80 70 70 65 70 75 75 70 Foxtail, Giant 100 85  70  95 95  95 90 85 80 65 85 85 80 80 Foxtail, Green 90 90  35  95 98  98 98 90 90 90 90 90 90 85 Galium 5 0 0 70 0 0 0 30 0 0 5 0  0 0 Goosegrass 0 0 0 50 5 5 0 10 20 10 25 0 25 20 Johnsongrass 0 0 0 5 0 10 0 10 0 0 0 20 10 40 Kochia 0 0 0 50 0 0 0 10 10 0 0 0  0 0 Lambsquarters 95 — — 60 0 40 0 65 40 0 0 — 65 10 Morningglory 0 0 0 0 0 0 10 0 0 0 0 10 10 20 Nightshade 45 0 0 20 0 0 0 0 0 0 — 0 15 0 Nutsedge, Yellow 0 0 0 0 10  0 0 0 25 20 0 0 10 20 Oat, Wild 0 0 5 0 0 0 0 0 0 0 0 0 40 10 Oilseed Rape — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 20 25 35 10 40 0 Ragweed 0 0 0 0 0 0 0 10 0 10 0 10 15 0 Russian Thistle 0 0 0 — — 0 0 — — — 0 50 30 0 Ryegrass, Italian 0 0 0 5 0 0 5 0 0 0 0 0  0 0 Soybean 0 0 0 0 — 0 0 10 10 15 15 25 30 35 Sunflower 0 0 0 10 10  0 0 0 0 15 5 0 20 0 Surinam Grass 85 80  95  90 80  95 90 75 35 25 35 70 60 50 Velvetleaf 0 0 0 0 10  0 20 0 5 0 0 0 20 10 Waterhemp — — — — — — — — — — — — — — Wheat 0 10  0 0 0 0 0 20 0 0 0 0  0 5 62 g ai/ha Compounds Preemergence 66 68 69 76 77 78 79 80 81 101 103 109 119 120 Barnyardgrass — — — 85 95 75 95  95 — 95 90  85  90 90 Bermudagrass 0 50 35 — — — — — 0 — — — — — Blackgrass 0 60  5 50 85 75 65  80 0 50 0 60  70 50 Bromegrass, Downy 0 0  0 — — — — — 0 — — — — — Cocklebur — — — — — — — — 0 — — — — — Corn 0 25 15 10 20  0 0  0 0  0 0 5  0  0 Crabgrass, Large 95  90 90 98 95 98 98  98 75  98 98  100  98 100  Cupgrass, Woolly 75  75 85 — — — — — 32  — — — — — Foxtail, Giant 75  90 85 95 90 95 90  95 17  95 95  95  90 95 Foxtail, Green 80  90 90 — — — — — 67  — — — — — Galium 0 5  0 —  5 50 5 90 0 40 80  100  80 95 Goosegrass 5 75 40 — — — — — 0 — — — — — Johnsongrass — 35  0 45 55  0 0  0 0 15 10  10   0  0 Kochia 0 0  0 — — — — — — — — — — — Lambsquarters 0 55 35  0 85 40 90  85 0 85 0 0 60 70 Morningglory 25  0 —  0  0  0 0  0 0  0 0 0  0  0 Nightshade 0 50  0 — — — — — 0 — — — — — Nutsedge, Yellow 0 10 —  0  0  0 0  0 0  0 0 5  0  0 Oat, Wild 0 —  0 — — — — — 0 — — — — — Oilseed Rape — — —  0 30 10 5 85 — 35 0 0  5  0 Pigweed 0 75 25  0 60 40 40  90 0  0 0 0 60 45 Ragweed 20  0  0 — — — — — 0  0 0 0 35 20 Russian Thistle 0 — — — — — — — 0 — — — — — Ryegrass, Italian 0 0  0 25 40 40 5 40 0 15 0 40  15  5 Soybean 20  0  0  0  0  0 0  0 0  0 10  0 20  0 Sunflower 0 0 10 — — — — — 0 — — — — — Surinam Grass 0 75 75 — — — — — 53  — — — — — Velvetleaf 20  10 30  0 25 15 0 30 0  0 0 0 15 20 Waterhemp — — — 50 40 75 40  80 — 70 0 50  65 60 Wheat 0 5  0 45 55 30 40   5 0 20 0 10   5 35 62 g ai/ha Compounds Preemergence 189 202 204 206 207 211 218 223 224 231 232 233 241 246 Barnyardgrass 90  90 90 90 85  65 90 85  85 90 85 75 95 75 Bermudagrass — — — — — — — — — — — — — — Blackgrass 50  80 90 90 80  20 10 35  65 85 70 45 70  0 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 0 85 25 60 0 25  0 0  0  5 35  0 65  0 Crabgrass, Large 95  95 90 90 90  95 90 90  90 95 90 90 95 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 90  90 90 90 90  70 90 85  90 90 90 90 95 90 Foxtail, Green — — — — — — — — — — — — — — Galium 0 90 90 70 0  5  0 0 40 85 85 80 80 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 60 40 65 0  0 10 0 35 10 20  0 80 20 Kochia — — — — — — — — — — — — — — Lambsquarters 0 90 100  100  0 85 40 70  65 85 85 85  0 65 Morningglory 0 25  0  0 0  0  0 0 25  0 15  0  0  5 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0  0  0 0  0  0 0 10  0  0  0  0 100  Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 0 80  0 70 0 35 60 0  5 55 30 40  0 30 Pigweed 0 85  0 100  0  0 50 5 25 70 85 50  0 75 Ragweed 0 85 30 10 0 10 35 0 40 100  85 40 25  0 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 30  30  0 40 0 35  0 0  0 10  0  0 20  0 Soybean 10  25 —  0 0  0  5 5 100   0  0  0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 30  0 50 0 10  0 0  5 25 40 25  0  0 Waterhemp 5 95 75 100  0 75 75 0  5 85 90 80 40 98 Wheat 0 30 70 40 0  0  0 5  0 15  0  0 45  0 62 g ai/ha Compounds Preemergence 247 262 263 271 274 275 277 278 279 280 302 303 304 305 Barnyardgrass 85 70  90  95 65  95 98 90  95  65  85  95 90 95 Bermudagrass — — — — — — — — — — — — — — Blackgrass 50 0 0 50 70  60 70 0 0 0 30  40 60 75 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 15 0 0  0 5 10 85 0 0 0 0 20 40 75 Crabgrass, Large 95 98  100  100  90  95 100  95  95  90  98  98 95 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95 70  95  98 85  95 98 90  95  80  95  95 95 95 Foxtail, Green — — — — — — — — — — — — — — Galium 90 40  85  — 0 90 90 0 0 0 5  0 95 80 Goosegrass — — — — — — — — — — — — — — Johnsongrass  0 0 0 10 0 50 65 0 25  0 15  55 35 85 Kochia — — — — — — — — — — — — — — Lambsquarters 90 70  100  20 0 75 75 0 0 0 0 60 70 70 Morningglory  0 0 0 10 0  0  0 0 0 25  0  0 50 30 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 20 0 0  0 0 25 20 0 0 0 0  0 25  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 30 35  60  20 0 50  0 0 0 30  0 35 55 60 Pigweed 55 0 70  25 0  0 35 0 5 0 20  55 75 70 Ragweed 85 20  90  10 0  5  0 0 0 0 5 70 60 15 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 35 0 0 10 0 40 35 0 10  0 0 35 75 50 Soybean  0 0 0  0 0  0  0 0 0 5 30   0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 20 0 5 10 20   0  0 0 0 0 0 25 35 30 Waterhemp 100  50  80  35 0  0 50 0 15  65  35  65 80 65 Wheat  0 0 10   0 0 45 70 0 15  0 5 75 50 90 62 g ai/ha Compounds Preemergence 306 307 309 310 312 315 316 317 318 319 323 324 325 345 Barnyardgrass 90 70  90  90  90 90 85  90  95  95 85 95 90 95 Bermudagrass — — — — — — — — — — — — — — Blackgrass 30 0 0 5 45 60 0 40  0  0  0 30 50 50 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 60 0 0 0 60 80 75  0 0 30  0 70 60 35 Crabgrass, Large 95 95  90  90  95 95 95  95  98  98 98 95 95 98 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95 85  90  85  90 90 90  90  70  85 95 90 95 90 Foxtail, Green — — — — — — — — — — — — — — Galium 60 0 0 0  0 80 0 0 0 70  0 60 20 90 Goosegrass — — — — — — — — — — — — — — Johnsongrass 55 0 10  0 50 85 75  0 0 55  0 65 35 75 Kochia — — — — — — — — — — — — — — Lambsquarters 65 0 0 5  0 40 20  0 55  65 50 70 70 75 Morningglory 35 0 0 0 35 25 0 0 40  40  0  0 30  0 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow  0 0 0 0 35  0 0 0 0  0 25  0  0  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 70 0 0 5  0 30 0 0 0  5 10 70 65 55 Pigweed 85 0 0 5 40 60 25  0 20  25 35 75 65 30 Ragweed 75 0 10  0  0 20 0 0 0 15 10 60 60 40 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 40 0 0 0 30 50 0 0 0 10 10 10 40 45 Soybean  0 0 0 0  0  0 0 0 0  0  0  0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 60 0 0 0 15 30 10  0 10  20 15 35 35  0 Waterhemp 85 0 0 0 45 75 35  0 30  35 50 70 75  5 Wheat 50 0 0 0 30 50 5 0 0  0 30 25 40 10 Compounds 62 g ai/ha Preemergence 346 350 Barnyardgrass 70 90  Bermudagrass — — Blackgrass 60 0 Bromegrass, Downy — — Cocklebur — — Corn  0 0 Crabgrass, Large 95 90  Cupgrass, Woolly — — Foxtail, Giant 90 90  Foxtail, Green — — Galium 20 85  Goosegrass — — Johnsongrass  0 0 Kochia — — Lambsquarters 35 90  Morningglory  0 100  Nightshade — — Nutsedge, Yellow  0 0 Oat, Wild — — Oilseed Rape  0 70  Pigweed 55 10  Ragweed 35 0 Russian Thistle — — Ryegrass, Italian 10 0 Soybean  0 0 Sunflower — — Surinam Grass — — Velvetleaf  0 0 Waterhemp 25 50  Wheat  0 0 31 g ai/ha Compounds Preemergence 5 14 16 17 33 34 35 48 52 53 59 60 62 64 Barnyardgrass — — — — — — — — — — — — — — Bermudagrass 0 75  0 0 0 0 0 0 0 40 20  0 0 0 Blackgrass 0 0 0 5 0 0 0 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Cocklebur 0 0 0 0 0 0 0 0 0 — — — 0 — Corn 0 0 0 0 0 0 0 0 10 10 0 0 20 0 Crabgrass, Large 100  90  95  95 95  95 95 85  80 80 85  85 85 85 Cupgrass, Woolly 80  0 55  80 60  50 55 70  40 35 40  55 65 30 Foxtail, Giant 95  85  0 90 75  90 80 80  55 40 50  70 65 50 Foxtail, Green 85  25  5 95 95  98 90 80  80 30 85  90 75 70 Galium 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Goosegrass 0 0 0 0 5 0 0 0 10 0 15  0 10 20 Johnsongrass 0 0 0 0 0 10 0 0 0 0 0 0 0 — Kochia 0 0 0 0 0 0 0 0 10 0 0 0 0 0 Lambsquarters 95  — 0 60 0 0 0 0 0 0 — 0 40 0 Morningglory 0 0 0 0 0 0 5 0 0 0 0 0 0 15 Nightshade 0 0 0 20 0 0 0 0 0 0 0 0 — 0 Nutsedge, Yellow 0 0 0 0 0 0 0 0 25 15 0 0 10 0 Oat, Wild 0 0 0 0 0 0 0 0 0 0 0 0 20 0 Oilseed Rape — — — — — — — — — — — — — — Pigweed 0 0 0 0 0 0 0 0 20 25 35  0 40 0 Ragweed 0 0 0 0 0 0 0 0 0 0 0 10 15 0 Russian Thistle — 0 0 — — 0 0 — — — 0 0 0 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Soybean 0 0 0 0 0 0 0 10  — 15 15  10 20 35 Sunflower 0 0 0 0 0 0 0 0 0 0 5 0 10 0 Surinam Grass 65  55  80  85 80  95 85 75  10 20 0 10 0 20 Velvetleaf 0 0 0 0 0 0 0 0 5 0 0 0 10 10 Waterhemp — — — — — — — — — — — — — — Wheat 0 5 0 0 0 0 0 0 0 0 0 0 0 0 31 g ai/ha Compounds Preemergence 66 68 69 76 77 78 79 80 81 101 103 109 119 120 Barnyardgrass — — — 80  90  60  40  85  — 90  50  70  80  85  Bermudagrass 0 30 35 — — — — — 0 — — — — — Blackgrass 0 0 0 50  85  30  0 30  0 0 0 0 0 35  Bromegrass, Downy 0 0 0 — — — — — 0 — — — — — Cocklebur 0 15 0 — — — — — 0 — — — — — Corn 0 15 15 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Large 90 90 90 98  95  95  95  95  50  95  95  98  98  98  Cupgrass, Woolly 10 75 75 — — — — — 0 — — — — — Foxtail, Giant 20 85 75 90  90  85  80  90  0 95  85  90  90  90  Foxtail, Green 50 90 90 — — — — — 20  — — — — — Galium 0 0 0 5 — 50  0 5 0 0 0 60  80  5 Goosegrass 5 55 20 — — — — — 0 — — — — — Johnsongrass 30 0 0 20  20  0 0 0 0 0 0 0 0 0 Kochia 0 0 0 — — — — — — — — — — — Lambsquarters 0 55 35 — 75  — 90  40  0 30  0 0 25  35  Morningglory 15 0 20 0 0 0 0 0 0 0 0 0 0 0 Nightshade 0 10 0 — — — — — 0 — — — — — Nutsedge, Yellow 0 10 0 0 0 0 0 0 0 0 0 0 0 0 Oat, Wild 0 — — — — — — — 0 — — — — — Oilseed Rape — — — 0 0 0 0 5 — 0 0 0 0 0 Pigweed 0 45 15 — 0 0 10  75  0 0 0 30  30  50  Ragweed 10 0 0 — — — — — 0 15  40  0 60  0 Russian Thistle 0 — — — — — — — 0 — — — — — Ryegrass, Italian 0 0 0 0 40  0 0 0 0 30  0 0 0 10  Soybean 15 0 0 0 0 0 0 0 0 0 10  100  0 0 Sunflower 0 0 10 — — — — — 0 — — — — — Surinam Grass 0 40 60 — — — — — 0 — — — — — Velvetleaf 10 10 30 0 0 15  0 0 0 15  0 0 0 0 Waterhemp — — — 50  40  50  25  15  — 50  0 0 20  0 Wheat 0 0 0 35  0 10  10  0 0 0 0 0 5 10  31 g ai/ha Compounds Preemergence 189 202 204 206 207 211 218 223 224 231 232 233 241 246 Barnyardgrass 85  90 80  90 75  30  80  65  75  85  85 80  90  20  Bermudagrass — — — — — — — — — — — — — — Blackgrass 10  70 90  85 0 0 0 35  0 50  60 30  50  0 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 0 20 45  30 0 0 0 0 10  0  0 0 85  0 Crabgrass, Large 95  90 90  90 90  100  90  85  90  90  85 90  95  95  Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 80  90 90  90 85  0 85  70  80  90  85 85  90  85  Foxtail, Green — — — — — — — — — — — — — — Galium 0 85 — 20 0 — 0 0 0 0 85 0 20  10  Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 10 10  25 0 0 0 0 0 0  0 0 85  0 Kochia — — — — — — — — — — — — — — Lambsquarters 0 80 100  75 0 100  10  70  55  40  75 85  0 65  Morningglory 0 15 0  0 0 0 0 0 5 0  0 0 0 5 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0  0 0  0 0 0 0 100  0 0  0 0 0 85  Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 0 25 0  5 0 0 0 0 0 0 30 0 0 0 Pigweed 0 85 0 70 0 — 5 20  0 35  85 50  0 30  Ragweed 0 65 30  80 0 0 40  0 10  80  65 10  0 0 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 0  0 0 30 0 0 0 0 0 0  0 0 20  0 Soybean 5  0 5  0 0 0 0 0 0 0  0 0 0 0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 10 0  0 0 0 0 0 0 10  25 15  0 0 Waterhemp 0 85 100  70 0 85  30  90  75  75  85 95  25  100  Wheat 0  0 0 35 0 0 0 0 0 0  0 0 0 0 31 g ai/ha Compounds Preemergence 247 262 263 271 274 275 277 278 279 280 302 303 304 305 Barnyardgrass 15  45  75  90 55  80  95 65  80  55  90  90 85 90 Bermudagrass — — — — — — — — — — — — — — Blackgrass 0 0 0 0 0 45  70 0 0 0 0  0 35 60 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 5 0 0 0 0 0 25 0 0 0 0 10  0 65 Crabgrass, Large 95  95  100  95 85  90  98 90  95  85  95  95 95 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 95  20  65  90 80  90  98 80  90  70  90  90 90 95 Foxtail, Green — — — — — — — — — — — — — — Galium 90  0 70  — 0 0 100  0 0 0 0 90 85 80 Goosegrass — — — — — — — — — — — — — — Johnsongrass 0 0 5 0 0 10  40 0 0 0 0  0  0 80 Kochia — — — — — — — — — — — — — — Lambsquarters 0 100  50  0 — 70  20 0 0 0 0 55 65 60 Morningglory 0 0 0 0 0 0  0 0 0 10  0  0  5  0 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow 0 75  0 0 0 45   0 0 0 0 0  0  0  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 5 0 40  0 0 0  0 0 0 0 0  0 50 20 Pigweed 0 0 70  0 0 0 10 5 0 10  0 35 55 10 Ragweed 100  0 0 0 — 5  0 0 0 0 35   5 60  0 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 0 0 0 0 0 15  40 0 0 0 0 30 30 15 Soybean 0 0 0 0 0 0  0 0 0 0 0  0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 0 0 5 0 0 0  0 0 0 0 0 10 20 25 Waterhemp 70  0 75  0 0 0 35 0 0 0 30  40 75 40 Wheat 0 0 0 0 0 5 60 0 0 0 0  0 40 45 31 g ai/ha Compounds Preemergence 306 307 309 310 312 315 316 317 318 319 323 324 325 345 Barnyardgrass 90 40  60  50  85 90 85  90  80  90 80  90 85 80 Bermudagrass — — — — — — — — — — — — — — Blackgrass  0 0 0 0 40 60 0 0 0 40 0 100   5 50 Bromegrass, Downy — — — — — — — — — — — — — — Cocklebur — — — — — — — — — — — — — — Corn 40 0 0 0 10 50 15  0 0  0 0 25 10 40 Crabgrass, Large 90 90  90  90  90 90 90  95  95  95 95  95 95 95 Cupgrass, Woolly — — — — — — — — — — — — — — Foxtail, Giant 90 65  90  80  90 90 85  80  10  70 90  90 90 85 Foxtail, Green — — — — — — — — — — — — — — Galium 90 0 0 0 90 90 0 0 0 95 0  0  0 20 Goosegrass — — — — — — — — — — — — — — Johnsongrass 35 0 10  0 30 75 50  0 0 40 0 40 20 35 Kochia — — — — — — — — — — — — — — Lambsquarters 55 0 0 0  0 40 0 0 10  60 40  50 45 100  Morningglory  0 0 0 0  0 20 0 25  30  55 0  0  0 25 Nightshade — — — — — — — — — — — — — — Nutsedge, Yellow  0 0 0 0  0  0 0 0 0  0 20   0  0  0 Oat, Wild — — — — — — — — — — — — — — Oilseed Rape 50 0 0 0  0  5 0 0 0  0 0  0  0 50 Pigweed 80 0 0 0 25 45 25  0 0 30 35  55 65 30 Ragweed 50 50  10  0  0  0 0 0 0  0 0 60  5 10 Russian Thistle — — — — — — — — — — — — — — Ryegrass, Italian 15 0 0 0 10 40 0 0 10   0 0  0 10  0 Soybean  0 0 0 0  0  0 0 0 0  0 0  0  0  0 Sunflower — — — — — — — — — — — — — — Surinam Grass — — — — — — — — — — — — — — Velvetleaf 25 0 0 5 10 30 0 0 0 30 15   0  0  0 Waterhemp 85 0 0 0 10 65 0 0 0 35 50  55 70  0 Wheat  5 0 0 0 30 50 0 0 0  0 5  0 10  0 Compounds 31 g ai/ha Preemergence 346 350 Barnyardgrass 50 75  Bermudagrass — — Blackgrass 20  0 Bromegrass, Downy — — Cocklebur — — Corn 0 0 Crabgrass, Large 95  90  Cupgrass, Woolly — — Foxtail, Giant 90  85  Foxtail, Green — — Galium 10  30  Goosegrass — — Johnsongrass 0 0 Kochia — — Lambsquarters 35  — Morningglory 0 100  Nightshade — — Nutsedge, Yellow 0 0 Oat, Wild — — Oilseed Rape 0 5 Pigweed 40  0 Ragweed 50  0 Russian Thistle — — Ryegrass, Italian 0 0 Soybean 0 0 Sunflower — — Surinam Grass — — Velvetleaf 0 0 Waterhemp 75  0 Wheat 0 0 16 g ai/ha Compounds Preemergence 48 189 271 277 304 Barnyardgrass — 45  75  95  85 Bermudagrass 0 — — — — Blackgrass 0 0 — 40  30 Bromegrass, Downy 0 — — — — Cocklebur 0 — — — — Corn 0 0 0 0  0 Crabgrass, Large 75 90  90  95  90 Cupgrass, Woolly 25 — — — — Foxtail, Giant 40 85  75  95  90 Foxtail, Green 70 — — — — Galium 0 0 — 0 100  Goosegrass 0 — — — — Johnsongrass 0 0 0 0  0 Kochia 0 — — — — Lambsquarters 0 0 0 0 30 Morningglory 0 0 0 0  0 Nightshade 0 — — — — Nutsedge, Yellow 0 0 0 0  0 Oat, Wild 0 — — — — Oilseed Rape — 0 0 0 30 Pigweed 0 0 0 0 40 Ragweed 0 0 0 0 25 Ryegrass, Italian 0 0 0 30  10 Soybean 10 0 0 0  0 Sunflower 0 — — — — Surinam Grass 10 — — — — Velvetleaf 0 0 0 0  0 Waterhemp — 0 0 0 70 Wheat 0 0 0 40   5 Compound 8 g ai/ha Preemergence 271 Barnyardgrass 0 Blackgrass 0 Corn 0 Crabgrass, Large 50 Foxtail, Giant 55 Johnsongrass 0 Lambsquarters 0 Morningglory 0 Nutsedge, Yellow 0 Oilseed Rape 0 Ragweed 0 Ryegrass, Italian 0 Soybean 0 Velvetleaf 0 Waterhemp 0 Wheat 0 Compounds 2000 g ai/ha Flood 77 247 Barnyardgrass 70 80 Ducksalad 100 100 Rice 60 15 Sedge, Umbrella 40 0 1000 g ai/ha Compounds Flood 77 87 89 101 102 103 107 111 112 113 114 189 190 200 Barnyardgrass 40 40 75 75 0 85 20 0 0 0 0 75 65 55 Ducksalad 100 100 100 100 0 100 70 40 0 70 80 100 100 100 Rice 20 30 0 10 0 10 0 0 0 0 0 0 15 0 Sedge, Umbrella 20 0 0 0 0 0 0 0 0 0 0 0 0 0 1000 g ai/ha Compounds Flood 203 204 205 206 207 208 210 211 212 247 270 271 344 346 Barnyardgrass 40 80 45 85 75 65 75 80 65 70 80 80 55 70 Ducksalad 50 100 65 100 80 100 100 100 100 100 100 100 85 100 Rice 0 10 0 15 15 15 0 15 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 30 0 0 0 0 0 0 500 g ai/ha Compounds Flood 77 87 89 101 102 103 107 111 112 113 114 120 189 190 Barnyardgrass 30 25 40 60 0 60 0 0 0 0 0 75 50 50 Ducksalad 100 100 100 100 0 95 60 30 0 50 70 100 95 85 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 g ai/ha Compounds Flood 200 203 204 205 206 207 208 210 211 212 247 270 271 275 Barnyardgrass 40 0 75 30 75 70 45 70 55 40 35 60 75 70 Ducksalad 100 20 100 50 100 100 45 100 75 75 85 100 100 100 Rice 0 0 0 0 15 15 0 0 15 0 0 0 0 10 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Compounds 500 g ai/ha Flood 277 344 346 Barnyardgrass 70 40 65 Ducksalad 95 65 100 Rice 0 0 0 Sedge, Umbrella 0 0 0 250 g ai/ha Compounds Flood 1 2 3 4 5 7 8 10 11 12 14 15 16 17 Barnyardgrass 0 0 55 40 55 0 0 0 0 65 0 0 15 25 Ducksalad 0 0 90 85 80 0 0 0 0 0 85 0 100 100 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 50 0 0 0 0 0 0 0 20 0 0 40 250 g ai/ha Compounds Flood 18 19 20 21 23 25 26 27 28 29 52 77 80 87 Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 20 20 0 Ducksalad 0 0 0 85 100 60 80 30 85 40 95 95 100 95 Rice 0 0 0 0 0 0 0 0 0 0 15 0 0 0 Sedge, Umbrella 0 0 0 0 30 0 0 0 0 0 75 0 65 0 250 g ai/ha Compounds Flood 89 92 93 101 102 103 107 111 112 113 114 119 120 189 Barnyardgrass 20 10 40 55 0 40 0 0 0 0 0 75 60 30 Ducksalad 85 70 85 95 0 90 30 0 0 30 30 100 100 80 Rice 0 20 30 0 0 0 0 0 0 0 0 20 0 0 Sedge, Umbrella 0 0 100 0 0 0 0 0 0 0 0 0 0 0 250 g ai/ha Compounds Flood 190 200 203 204 205 206 207 208 210 211 212 223 224 232 Barnyardgrass 25 25 0 70 20 60 60 20 45 50 15 0 60 60 Ducksalad 75 70 0 95 0 100 75 45 80 100 70 95 100 95 Rice 0 0 0 0 0 0 15 0 0 0 0 0 20 15 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 250 g ai/ha Compounds Flood 247 263 270 271 275 277 303 312 317 318 323 324 344 346 Barnyardgrass 25 80 30 45 60 70 70 60 30 70 65 70 35 45 Ducksalad 75 100 85 100 100 85 100 95 0 100 100 100 60 100 Rice 0 15 0 0 10 0 0 0 0 15 30 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Flood 1 2 3 4 5 7 8 10 11 12 16 17 18 19 Barnyardgrass 0 0 40 30 20 0 0 0 0 0 0 20 0 0 Ducksalad 0 0 85 80 70 0 0 0 0 0 85 100 0 0 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Flood 20 21 28 29 52 80 87 89 92 93 101 102 103 107 Barnyardgrass 0 0 0 0 0 0 0 20 10 0 20 0 10 0 Ducksalad 0 50 40 0 75 100 75 70 20 0 90 0 85 0 Rice 0 0 0 0 10 0 0 0 20 20 0 0 0 0 Sedge, Umbrella 0 0 0 0 50 55 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Flood 111 112 113 114 119 120 189 190 200 203 204 205 206 207 Barnyardgrass 0 0 0 0 60 50 10 10 15 0 50 0 35 40 Ducksalad 0 0 20 20 100 100 75 50 70 0 50 0 90 60 Rice 0 0 0 0 10 0 0 0 0 0 0 0 0 15 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Flood 208 210 211 212 223 224 232 263 270 271 275 277 303 312 Barnyardgrass 0 0 0 0 0 40 40 45 10 40 45 65 60 30 Ducksalad 0 0 60 0 65 80 75 100 75 70 100 80 70 65 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 125 g ai/ha Compounds Flood 317 318 323 324 344 346 Barnyardgrass 30 60 50 60 0 30 Ducksalad 0 100 90 95 50 95 Rice 0 10 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 62 g ai/ha Compounds Flood 1 2 3 4 5 7 8 10 11 12 14 15 16 17 Barnyardgrass 0 0 20 0 0 0 0 0 0 0 0 0 0 0 Ducksalad 0 0 60 30 30 0 0 0 0 0 40 0 40 80 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 62 g ai/ha Compounds Flood 18 19 20 21 23 25 26 27 28 29 52 80 92 93 Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 0 10 0 Ducksalad 0 0 0 0 30 0 0 0 30 0 40 70 20 0 Rice 0 0 0 0 0 0 0 0 0 0 10 0 10 20 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 40 35 0 0 62 g ai/ha Compounds Flood 119 120 223 224 232 263 275 277 303 312 317 318 323 324 Barnyardgrass 50 40 0 20 30 35 35 50 20 0 0 30 45 0 Ducksalad 100 100 50 40 75 90 85 65 60 60 0 60 75 70 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31 g ai/ha Compounds Flood 1 2 3 4 7 8 10 11 12 16 17 18 19 20 Barnyardgrass 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Ducksalad 0 0 40 20 0 0 0 0 0 0 40 0 0 0 Rice 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31 g ai/ha Compounds Flood 21 28 29 52 80 92 93 119 223 224 232 263 303 312 Barnyardgrass 0 0 0 0 0 10 0 30 0 0 0 20 0 0 Ducksalad 0 20 0 40 70 0 0 100 30 0 50 70 50 50 Rice 0 0 0 10 0 10 10 0 0 0 0 0 0 0 Sedge, Umbrella 0 0 0 0 35 0 0 0 0 0 0 0 0 0 Compounds 31 g ai/ha Flood 317 318 323 324 Barnyardgrass 0 20 25 0 Ducksalad 0 50 50 40 Rice 0 0 0 0 Sedge, Umbrella 0 0 0 0

Test D

Seeds of plant species selected from bluegrass (annual bluegrass, Poa annua), blackgrass (Alopecurus myosuroides), canarygrass (littleseed canarygrass, Phalaris minor), chickweed (common chickweed, Stellaria media), galium (catchweed bedstraw, Galium aparine), bromegrass, downy (downy bromegrass, Bromus tectorum), field poppy (Papaver rhoeas), field violet (Viola arvensis), foxtail, green (green foxtail, Setaria viridis), deadnettle (henbit deadnettle, Lamium amplexicaule), ryegrass, Italian (Italian ryegrass, Lolium multiflorum), Kochia (Kochia scoparia), lambsquarters (Chenopodium album), oilseed rape (Brassica napus), pigweed (Amaranthus retroflexus), chamomile (scentless chamomile, Matricaria inodora), Russian thistle (Salsola kali), speedwell (bird's-eye speedwell, Veronica persica), barley, spring (spring barley, Hordeum vulgare), wheat, spring (spring wheat, Triticum aestivum), buckwheat, wild (wild buckwheat, Polygonum convolvulus), mustard, wild (wild mustard, Sinapis arvensis), oat, wild (wild oat, Avena fatua), radish, wild (wild radish, Raphanus raphanistrum), windgrass (Apera spica-venti), barley, winter (winter barley, Hordeum vulgare), and wheat, winter (winter wheat, Triticum aestivum) were planted into a silt loam soil and treated preemergence with test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant.

At the same time, these species were planted in pots containing Redi-Earth® planting medium (Scotts Company, 14111 Scottslawn Road, Marysville, Ohio 43041) comprising spaghnum peat moss, vermiculite, wetting agent and starter nutrients and treated with postemergence applications of the test chemicals formulated in the same manner. Plants ranged in height from 2 to 18 cm (1- to 4-leaf stage). Treated plants and controls were maintained in a controlled growth environment for 7 to 21 days after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table D, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

TABLE D 250 g ai/ha Compounds Postemergence 6 12 17 33 34 52 80 202 231 Barley, Spring 0 5 0 0 0 0 0 5 0 Barley, Winter 0 0 0 0 0 0 0 0 0 Blackgrass 10 20 0 0 0 0 5 40 20 Bluegrass 0 10 0 0 0 0 10 15 10 Bromegrass, Downy 0 5 0 0 0 0 20 15 25 Buckwheat, Wild 10 10 20 10 0 0 0 10 0 Canarygrass 0 30 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 20 50 60 50 Chickweed 30 30 30 10 20 25 85 80 80 Deadnettle 10 20 10 10 0 25 40 70 70 Field Poppy 30 80 0 0 20 0 50 100 50 Field Violet 25 40 10 0 20 0 25 30 25 Foxtail, Green 20 25 0 0 0 0 65 70 70 Galium 0 25 30 0 0 35 60 70 55 Kochia 10 35 40 10 25 35 75 75 65 Lambsquarters 30 25 40 20 20 30 35 75 75 Mustard, Wild 0 — 30 0 20 25 85 85 75 Oat, Wild 5 20 0 0 0 0 10 15 10 Oilseed Rape 20 25 40 30 20 25 60 55 40 Pigweed 20 50 50 10 10 40 75 80 45 Radish, Wild 10 25 15 0 0 — 60 70 70 Russian Thistle 100 80 40 0 0 0 35 35 35 Ryegrass, Italian 0 15 0 0 0 0 0 15 0 Speedwell 15 25 0 10 30 70 65 90 75 Wheat, Spring 5 0 0 0 0 0 0 5 0 Wheat, Winter 0 0 0 0 0 0 5 0 0 Windgrass 0 5 0 0 0 0 25 45 15 Compounds Postemergence 6 12 17 33 34 50 52 80 202 231 125 g ai/ha Barley, Spring 0 5 0 0 0 0 0 0 0 0 Barley, Winter 0 0 0 0 0 0 0 0 0 0 Blackgrass 5 15 0 0 0 0 0 5 10 10 Bluegrass 0 10 0 0 0 0 0 15 10 10 Bromegrass, Downy 0 0 0 0 0 0 0 20 5 25 Buckwheat, Wild 0 10 10 0 0 10 0 0 0 0 Canarygrass 0 15 0 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 0 20 35 65 50 Chickweed 10 20 25 10 10 15 15 85 80 80 Deadnettle 10 15 10 0 0 0 20 70 60 35 Field Poppy 20 60 0 0 0 0 0 20 100 0 Field Violet 20 35 0 0 0 0 0 15 30 10 Foxtail, Green 0 20 0 0 0 0 0 65 70 70 Galium 0 20 10 0 0 0 25 55 70 55 Kochia 5 20 20 0 10 0 25 70 75 60 Lambsquarters 20 10 20 0 0 20 30 40 70 70 Mustard, Wild 0 100 30 0 10 40 20 85 80 65 Oat, Wild 0 15 0 0 0 0 0 5 10 10 Oilseed Rape 15 20 20 20 0 5 10 45 60 20 Pigweed 20 30 50 10 0 10 30 70 75 35 Radish, Wild 0 25 15 0 0 0 — 35 75 75 Russian Thistle 0 30 20 0 0 5 0 25 30 35 Ryegrass, Italian 0 10 0 0 0 0 0 0 10 0 Speedwell 0 10 0 0 0 — 40 70 85 75 Wheat, Spring 5 0 0 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 10 0 0 Windgrass 0 0 0 0 0 0 0 10 35 0 62 g ai/ha Barley, Spring 0 5 0 0 0 0 0 0 0 0 Barley, Winter 0 0 0 0 0 0 0 0 0 0 Blackgrass 5 10 0 0 0 0 0 5 5 10 Bluegrass 0 0 0 0 0 0 0 10 10 10 Bromegrass, Downy 0 0 0 0 0 0 0 15 0 20 Buckwheat, Wild 0 10 0 0 0 10 0 10 0 0 Canarygrass 0 15 0 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 0 0 30 60 25 Chickweed 0 0 0 0 0 20 10 45 75 80 Deadnettle 0 10 0 0 0 0 0 60 35 70 Field Poppy 20 50 0 0 0 0 0 55 75 20 Field Violet 20 30 0 0 0 0 0 20 30 20 Foxtail, Green 0 10 0 0 0 0 0 45 65 65 Galium 0 15 0 0 0 0 0 45 70 45 Kochia 5 20 20 0 0 15 20 75 70 60 Lambsquarters 20 10 0 0 0 5 0 45 60 50 Mustard, Wild — 40 10 0 0 — 20 80 80 65 Oat, Wild 0 10 0 0 0 0 0 10 10 10 Oilseed Rape 10 10 10 10 0 5 0 50 70 10 Pigweed 10 25 40 0 0 0 0 70 75 35 Radish, Wild 0 20 0 0 0 0 — 70 70 70 Russian Thistle 0 20 0 0 0 10 0 30 30 35 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 Speedwell 0 10 0 0 0 — 25 70 75 70 Wheat, Spring 5 0 0 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 0 10 10 5 31 g ai/ha Barley, Spring 0 0 0 0 0 0 0 0 0 0 Barley, Winter 0 0 0 0 0 0 0 0 0 0 Blackgrass 0 10 0 0 0 0 0 5 0 0 Bluegrass 0 0 0 0 0 0 0 5 0 5 Bromegrass, Downy 0 0 0 0 0 0 0 15 0 15 Buckwheat, Wild 0 0 0 0 0 10 0 0 0 0 Canarygrass 0 0 0 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 0 0 20 5 20 Chickweed 0 0 0 0 0 15 0 35 75 25 Deadnettle 0 0 0 0 0 0 0 70 5 35 Field Poppy 0 0 0 0 0 0 0 25 0 0 Field Violet 0 0 0 0 0 0 0 15 40 20 Foxtail, Green 0 0 0 0 0 0 0 45 60 10 Galium 0 0 0 0 0 0 0 20 60 40 Kochia 5 5 0 0 — 15 0 65 70 55 Lambsquarters 10 0 0 0 0 5 0 45 65 55 Mustard, Wild 0 10 0 0 0 60 10 70 85 35 Oat, Wild 0 0 0 0 0 0 0 10 5 5 Oilseed Rape 10 10 0 0 0 5 0 30 60 15 Pigweed 10 10 0 0 0 0 0 40 75 20 Radish, Wild 0 0 0 0 0 0 — 50 50 30 Russian Thistle 0 0 0 0 0 0 0 20 30 20 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 Speedwell 0 0 0 0 0 — 20 60 60 60 Wheat, Spring 0 0 0 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 0 0 0 0 16 g ai/ha Compounds Postemergence 6 12 17 33 34 50 52 Barley, Spring 0 0 0 0 0 0 0 Barley, Winter 0 0 0 0 0 0 0 Blackgrass 0 5 0 0 0 0 0 Bluegrass 0 0 0 0 0 0 0 Bromegrass, Downy 0 0 0 0 0 0 0 Buckwheat, Wild 0 0 0 0 0 10 0 Canarygrass 0 0 0 0 0 0 0 Chamomile 0 0 0 0 0 0 0 Chickweed 0 0 0 0 0 10 0 Deadnettle 0 0 0 0 0 0 0 Field Poppy 0 0 0 0 0 0 0 Field Violet 0 0 0 0 0 0 0 Foxtail, Green 0 0 0 0 0 0 0 Galium 0 0 0 0 0 0 0 Kochia 0 5 0 0 0 10 0 Lambsquarters 0 0 0 0 0 5 0 Mustard, Wild 0 0 0 0 0 40 0 Oat, Wild 0 0 0 0 0 0 0 Oilseed Rape 10 10 0 0 0 5 0 Pigweed 0 0 0 0 0 5 0 Radish, Wild 0 0 0 0 0 0 — Russian Thistle 0 0 0 0 0 5 0 Ryegrass, Italian 0 0 0 0 0 0 0 Speedwell 0 0 0 0 0 0 20 Wheat, Spring 0 0 0 0 0 0 0 Wheat, Winter 0 0 0 0 0 0 0 Windgrass 0 0 0 0 0 0 0 250 g ai/ha Compounds Preemergence 6 12 52 77 80 202 204 206 207 231 241 Barley, Spring 10 0 5 25 30 30 45 55 25 35 35 Barley, Winter 20 0 25 55 25 25 35 65 45 20 65 Blackgrass 0 0 0 65 25 75 65 90 75 55 75 Bluegrass 0 40 20 55 45 70 35 70 30 25 70 Bromegrass, Downy 10 10 0 25 10 20 45 70 15 15 60 Buckwheat, Wild 0 100 10 55 15 15 25 55 35 10 80 Canarygrass 20 40 0 85 20 75 75 85 75 35 75 Chamomile 90 20 80 — 85 100 — — 85 100 — Chickweed — 0 — 100 100 95 100 95 100 90 100 Deadnettle 40 50 30 75 70 85 35 75 20 85 45 Field Poppy 100 0 80 100 100 100 95 95 100 95 100 Field Violet 0 0 — 55 25 15 25 25 35 0 30 Foxtail, Green 10 0 60 85 80 95 100 98 90 98 90 Galium 100 10 20 85 75 85 25 80 20 40 80 Kochia 50 0 40 85 75 85 70 80 60 85 70 Lambsquarters 0 30 20 90 90 85 90 90 90 90 90 Mustard, Wild 20 70 10 45 70 75 20 75 30 15 25 Oat, Wild 0 0 0 45 20 40 40 55 20 30 55 Oilseed Rape 20 20 10 5 30 75 0 5 0 55 10 Pigweed 0 0 15 80 45 90 35 50 5 80 80 Radish, Wild — — — 30 70 80 0 30 15 0 0 Russian Thistle 30 0 30 — — 40 — — — 30 — Ryegrass, Italian 0 0 0 35 15 10 60 75 15 0 50 Speedwell 50 100 100 100 100 100 70 90 30 100 85 Wheat, Spring 0 0 0 25 20 35 30 65 10 20 40 Wheat, Winter 0 0 10 55 10 25 20 30 20 25 25 Windgrass 100 0 60 95 90 90 95 90 65 85 98 Compounds Preemergence 6 12 50 52 77 80 202 204 206 207 231 241 125 g ai/ha Barley, Spring 0 0 0 0 25 15 25 20 40 20 5 20 Barley, Winter 0 0 0 0 45 15 20 25 40 25 0 30 Blackgrass 0 0 0 0 40 20 65 40 85 20 15 50 Bluegrass 0 20 0 0 45 20 65 15 35 15 15 45 Bromegrass, Downy 0 0 0 0 10 5 0 35 55 15 0 15 Buckwheat, Wild 0 0 — 10 55 5 10 25 50 25 0 20 Canarygrass 20 20 0 0 65 10 60 10 85 0 20 65 Chamomile 70 0 5 75 — 80 75 — — 85 80 — Chickweed — 0 0 — 100 100 90 100 70 70 95 95 Deadnettle 40 0 100 0 60 65 80 25 40 20 60 35 Field Poppy 0 0 65 — 95 100 90 80 90 80 100 95 Field Violet 0 0 0 — 20 20 10 25 35 35 10 20 Foxtail, Green 0 0 40 0 70 75 98 98 98 75 95 90 Galium 100 0 0 0 85 65 80 10 50 45 35 35 Kochia 40 0 0 20 80 70 85 15 70 10 80 80 Lambsquarters 0 30 0 20 90 90 85 65 85 65 90 90 Mustard, Wild 10 20 80 0 25 65 20 20 0 25 0 15 Oat, Wild 0 0 0 0 20 10 35 60 40 5 25 20 Oilseed Rape 10 10 0 10 5 10 45 0 0 0 45 5 Pigweed 0 0 5 10 80 20 90 35 40 0 60 85 Radish, Wild — — — — 25 30 0 0 30 15 0 0 Russian Thistle 10 0 0 20 — — 35 — — — 15 — Ryegrass, Italian 0 0 0 0 25 5 5 45 55 5 0 20 Speedwell 30 0 0 100 35 85 90 10 65 25 100 70 Wheat, Spring 0 0 0 0 20 10 25 25 45 10 0 25 Wheat, Winter 0 0 0 0 25 10 25 15 25 10 15 10 Windgrass 100 0 0 40 90 75 90 85 90 20 75 95 62 g ai/ha Barley, Spring 0 0 0 0 5 10 25 15 35 5 5 10 Barley, Winter 0 0 0 0 0 5 20 20 30 10 0 10 Blackgrass 0 0 0 0 25 10 35 10 70 5 0 55 Bluegrass 0 0 0 0 5 10 25 0 30 15 0 15 Bromegrass, Downy 0 0 0 0 0 5 0 20 25 15 0 15 Buckwheat, Wild 0 0 0 0 75 0 10 25 65 15 0 15 Canarygrass 10 0 0 0 45 0 10 10 75 5 15 45 Chamomile 30 0 0 75 — 80 65 — — 80 75 — Chickweed — 0 0 — 90 100 80 100 100 60 85 80 Deadnettle 0 0 100 0 65 0 65 25 35 0 75 30 Field Poppy 0 0 0 50 90 100 85 85 90 75 80 95 Field Violet 0 0 0 — 20 20 0 15 35 15 0 15 Foxtail, Green 0 0 50 0 80 65 90 98 95 60 80 90 Galium 50 0 0 0 55 45 70 10 40 60 40 25 Kochia 30 0 10 20 75 35 85 45 60 10 20 30 Lambsquarters 0 0 0 0 85 80 85 30 80 30 80 90 Mustard, Wild 0 0 0 0 20 25 0 20 0 25 10 15 Oat, Wild 0 0 0 0 15 5 20 25 35 0 20 15 Oilseed Rape 0 10 0 0 5 10 35 0 0 0 0 0 Pigweed 0 0 25 10 70 10 80 5 20 0 50 15 Radish, Wild — — 0 — 10 30 0 0 25 10 0 0 Russian Thistle 0 0 0 0 — — 20 — — — 5 — Ryegrass, Italian 0 0 0 0 15 5 5 15 30 5 0 20 Speedwell 10 0 0 90 25 85 90 10 25 20 80 35 Wheat, Spring 0 0 0 0 10 10 5 0 25 10 5 0 Wheat, Winter 0 0 0 0 0 5 10 15 0 15 10 5 Windgrass 0 0 5 0 85 20 85 65 75 20 70 90 31 g ai/ha Barley, Spring 0 0 0 0 5 0 0 0 5 0 0 0 Barley, Winter 0 0 0 0 0 0 20 0 15 5 0 10 Blackgrass 0 0 0 0 10 5 30 5 30 0 0 20 Bluegrass 0 0 0 0 0 0 10 0 0 0 5 15 Bromegrass, Downy 0 0 0 0 0 0 0 0 10 0 0 0 Buckwheat, Wild 0 0 0 0 0 0 0 20 45 0 0 15 Canarygrass 0 0 0 0 25 0 5 0 55 0 0 20 Chamomile 0 0 0 20 — 80 60 — — 75 75 — Chickweed — — 0 — 75 85 45 100 30 60 75 90 Deadnettle 0 0 50 0 15 0 40 25 20 0 35 35 Field Poppy 0 0 50 50 75 90 85 75 80 55 80 90 Field Violet 0 0 0 — 15 0 0 10 15 10 0 15 Foxtail, Green 0 0 0 0 15 20 90 90 85 15 45 35 Galium 0 0 0 0 35 0 75 0 10 55 20 20 Kochia 0 0 10 20 35 15 85 20 45 10 0 20 Lambsquarters 0 0 0 0 85 85 80 35 50 0 45 85 Mustard, Wild 0 0 — 0 0 0 0 0 0 10 0 10 Oat, Wild 0 0 0 0 10 0 5 0 25 0 20 15 Oilseed Rape 0 0 0 0 5 0 0 0 0 0 0 0 Pigweed 0 0 10 10 25 5 75 0 5 0 50 15 Radish, Wild — — — — 0 15 0 0 25 15 0 0 Russian Thistle 0 0 0 0 — — 15 — — — 0 — Ryegrass, Italian 0 0 0 0 15 0 0 5 35 0 0 15 Speedwell 10 0 0 90 20 10 90 0 0 20 75 10 Wheat, Spring 0 0 0 0 10 0 0 0 10 5 0 0 Wheat, Winter 0 0 0 0 0 5 5 5 0 0 5 0 Windgrass 0 0 0 0 45 5 65 50 75 5 55 65 16 g ai/ha Compounds Preemergence 6 12 50 52 Barley, Spring 0 0 0 0 Barley, Winter 0 0 0 0 Blackgrass 0 0 0 0 Bluegrass 0 0 0 0 Bromegrass, Downy 0 0 0 0 Buckwheat, Wild 0 0 0 0 Canarygrass 0 0 0 0 Chamomile 0 0 0 20 Chickweed — — 0 — Deadnettle 0 0 50 0 Field Poppy — 0 0 30 Field Violet 0 0 0 — Foxtail, Green 0 0 0 0 Galium 0 0 0 0 Kochia 0 0 5 0 Lambsquarters 0 0 0 0 Mustard, Wild 0 0 50 0 Oat, Wild 0 0 0 0 Oilseed Rape 0 0 0 0 Pigweed 0 0 10 0 Russian Thistle 0 0 0 0 Ryegrass, Italian 0 0 0 0 Speedwell 0 0 0 40 Wheat, Spring 0 0 0 0 Wheat, Winter 0 0 0 0 Windgrass 0 0 0 0

Test E

Seeds of plant species selected from corn (Zea mays), soybean (Glycine max), velvetleaf (Abutilon theophrasti), lambsquarters (Chenopodium album), wild poinsettia (Euphorbia heterophylla), pigweed, palmer (palmer pigweed, Amaranthus palmeri), waterhemp (common waterhemp, Amaranthus rudis), surinam grass (Brachiaria decumbens), crabgrass, large (large crabgrass, Digitaria sanguinalis), crabgrass, Brazil (Brazilian crabgrass, Digitaria horizontalis), Panicum, fall (fall Panicum, Panicum dichotomiflorum), foxtail, giant (giant foxtail, Setaria faberii), foxtail, green (green foxtail, Setaria viridis), goosegrass (Eleusine indica), j ohnsongrass (Sorghum halepense), ragweed (common ragweed, Ambrosia elation), barnyardgrass (Echinochloa crus-galli), sandbur (southern sandbur, Cenchrus echinatus), arrowleaf sida (Sida rhombifolia), ryegrass, Italian (Italian ryegrass, Lolium multiflorum), dayflower, VA (Virginia dayflower, Commelina virginica), field bindweed (Convolvulus arvensis), morningglory (Ipomoea coccinea), nightshade (eastern black nightshade, Solanum ptycanthum), Kochia (Kochia scoparia), nutsedge, yellow (yellow nutsedge, Cyperus esculentus), cocklebur (common cocklebur, Xanthium strumarium), smartweed (ladysthumb smartweed, Polygonum persicaria) and beggarticks (hairy beggarticks, Bidens pilosa), were planted into a silt loam soil and treated preemergence with test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant. Treated plants and controls were maintained in a greenhouse for 21 days, after which time all species were compared to controls and visually evaluated. Plant response ratings, summarized in Table E, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

TABLE E Compounds Preemergence 14 16 17 66 80 103 202 204 206 232 350 250 g ai/ha Arrowleaf Sida 0 0 0 0 10 65 80 0 50 90 50 Barnyardgrass 75 70 98 50 80 90 98 98 98 95 98 Beggarticks 0 0 — 0 60 15 80 0 0 60 20 Cocklebur 0 0 — — 0 — — — 0 — — Corn 0 0 0 0 30 0 60 40 70 0 0 Crabgrass, Brazil 95 98 98 98 95 98 98 98 98 98 98 Crabgrass, Large 90 98 95 98 95 98 98 98 100 98 98 Dayflower, VA 0 — 0 0 0 0 40 30 20 10 40 Field Bindweed 0 0 0 0 0 35 70 30 50 40 60 Foxtail, Giant 90 95 98 — 90 98 98 98 98 98 80 Foxtail, Green 70 95 95 60 90 98 98 98 98 98 85 Goosegrass 0 0 35 0 80 0 98 0 90 95 25 Johnsongrass 0 0 0 0 30 20 25 40 90 25 0 Kochia 0 0 50 0 90 0 98 40 80 98 90 Lambsquarters 70 0 0 0 90 98 98 65 98 98 95 Morningglory 0 0 — 0 40 10 30 30 0 35 0 Nightshade 70 0 0 0 70 0 80 100 10 — 80 Nutsedge, Yellow 0 0 15 0 0 15 0 0 75 0 15 Panicum, Fall 40 — 0 0 0 0 85 75 98 60 0 Pigweed, Palmer 0 0 0 — 90 25 80 0 0 65 35 Poinsettia, Wild 25 0 20 20 0 0 65 20 25 40 30 Ragweed 0 0 0 20 20 0 90 0 75 95 65 Ryegrass, Italian 0 30 0 0 60 0 50 30 65 40 35 Sandbur 30 95 95 35 70 95 80 80 98 90 85 Smartweed — — — — 40 — — — — — — Soybean 0 0 0 0 40 0 0 — 0 0 0 Surinam Grass 60 60 75 35 70 95 95 95 98 98 65 Velvetleaf 0 0 0 0 0 0 40 0 50 80 0 Waterhemp 0 0 0 0 60 0 95 0 50 95 35 125 g ai/ha Arrowleaf Sida 0 0 0 0 0 0 70 0 10 65 20 Barnyardgrass 40 10 95 50 75 50 85 98 95 98 60 Beggarticks 0 0 — 0 20 0 35 0 0 20 20 Cocklebur 0 0 0 — 0 — — — 0 — — Corn 0 0 0 0 0 0 40 0 40 0 0 Crabgrass, Brazil 95 80 95 98 70 95 98 98 98 98 95 Crabgrass, Large 90 75 75 90 95 98 98 98 98 98 98 Dayflower, VA 0 0 0 0 0 0 0 20 0 0 0 Field Bindweed 0 0 0 0 0 40 50 0 30 40 65 Foxtail, Giant 10 25 95 98 80 95 95 95 98 95 50 Foxtail, Green 10 25 70 35 80 95 98 95 98 98 80 Goosegrass 0 0 0 0 70 0 90 0 70 85 0 Johnsongrass 0 0 0 0 10 0 20 35 75 0 0 Kochia 0 0 25 0 80 0 95 0 50 98 75 Lambsquarters 50 — 0 0 90 65 98 90 95 100 98 Morningglory 0 0 — 0 20 0 0 20 0 0 0 Nightshade 50 0 0 — 70 0 90 100 5 98 50 Nutsedge, Yellow 0 0 0 0 0 0 0 0 20 0 0 Panicum, Fall — 0 0 0 0 0 50 75 98 50 0 Pigweed, Palmer 0 0 0 — 65 0 85 0 0 80 35 Poinsettia, Wild 20 0 0 0 0 0 25 20 0 35 0 Ragweed 0 0 0 0 0 0 85 0 0 95 60 Ryegrass, Italian 0 0 0 0 45 0 25 25 80 20 20 Sandbur 0 70 65 0 65 75 85 75 95 90 65 Smartweed 0 Soybean 0 0 0 0 0 0 0 0 0 0 0 Surinam Grass 20 35 70 0 60 65 65 98 85 70 50 Velvetleaf 0 0 0 0 0 0 0 0 30 20 0 Waterhemp 0 0 0 0 50 0 95 0 50 85 0 62 g ai/ha Arrowleaf Sida 0 0 0 0 0 0 30 0 0 20 0 Barnyardgrass 0 0 80 20 50 30 80 75 75 70 40 Beggarticks 0 — — 0 0 0 0 0 0 0 0 Cocklebur 0 0 0 0 0 — — — 0 — — Corn 0 0 0 0 0 0 0 0 50 0 0 Crabgrass, Brazil 80 65 95 95 — 95 98 95 98 98 75 Crabgrass, Large 25 30 70 75 95 98 98 98 98 98 70 Dayflower, VA 0 0 0 0 0 0 0 0 0 0 0 Field Bindweed 0 0 0 0 0 0 40 0 20 0 60 Foxtail, Giant 0 15 35 0 75 90 50 95 98 90 20 Foxtail, Green 0 10 40 0 70 60 75 98 98 95 35 Goosegrass 0 0 0 0 60 0 70 0 0 80 0 Johnsongrass 0 0 0 0 0 0 0 0 50 0 0 Kochia 0 — 0 0 60 0 95 0 0 95 40 Lambsquarters 0 0 0 0 85 0 98 98 65 98 60 Morningglory — 0 — 0 0 0 0 0 0 0 0 Nightshade 30 0 0 0 60 0 50 20 0 75 0 Nutsedge, Yellow 0 0 0 0 0 0 0 0 15 0 0 Panicum, Fall 0 0 0 0 0 0 0 0 98 50 0 Pigweed, Palmer 0 0 0 — — 0 70 0 0 0 0 Poinsettia, Wild 15 0 0 0 0 0 0 0 10 0 0 Ragweed 0 0 0 0 0 0 80 0 0 75 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 35 10 25 Sandbur 0 35 50 0 50 35 70 50 80 65 35 Smartweed — — — — 20 — — — — — — Soybean 0 0 0 0 0 0 0 0 0 0 0 Surinam Grass 0 20 50 0 50 50 — 60 95 50 0 Velvetleaf 0 0 0 0 0 0 0 0 35 0 0 Waterhemp 0 0 0 0 30 0 60 0 — 80 0 31 g ai/ha Arrowleaf Sida 0 0 0 0 0 0 0 0 0 0 0 Barnyardgrass 0 0 0 0 20 0 40 20 70 60 15 Beggarticks 0 — — 0 0 0 0 0 0 0 0 Cocklebur — 0 0 0 — — — — 0 — — Corn 0 0 0 0 0 0 0 0 0 0 0 Crabgrass, Brazil 65 25 65 85 — 70 80 95 80 95 0 Crabgrass, Large — 20 20 10 90 65 98 95 98 95 50 Dayflower, VA 0 — 0 0 0 0 0 0 0 0 0 Field Bindweed 0 0 0 0 0 0 60 0 20 0 40 Foxtail, Giant 0 0 35 0 65 60 35 50 90 35 0 Foxtail, Green 0 0 25 0 60 20 10 40 80 80 20 Goosegrass 0 0 0 0 30 0 35 0 0 35 0 Johnsongrass 0 0 0 0 0 0 0 0 30 0 0 Kochia 0 0 0 0 60 0 95 0 0 90 0 Lambsquarters 0 0 0 0 80 0 0 98 35 95 80 Morningglory 0 0 — 0 0 0 0 0 0 0 0 Nightshade 0 0 — 0 — 0 0 0 0 25 0 Nutsedge, Yellow 0 0 0 0 0 0 0 0 15 0 0 Panicum, Fall 0 0 0 0 0 0 0 0 75 35 0 Pigweed, Palmer 0 0 0 — 0 0 0 0 0 0 0 Poinsettia, Wild 0 0 0 0 0 0 0 0 0 0 0 Ragweed 0 — 0 0 0 0 20 0 0 35 0 Ryegrass, Italian 0 0 0 0 0 0 0 0 0 0 0 Sandbur 0 0 0 0 30 10 35 20 65 35 15 Smartweed — — — — 0 — — — — — — Soybean 0 0 0 0 0 0 0 0 0 0 0 Surinam Grass 0 0 0 0 40 20 20 35 50 40 0 Velvetleaf 0 0 0 0 0 0 0 0 0 0 0 Waterhemp 0 0 0 0 20 0 50 0 50 35 0 16 g ai/ha Compounds Preemergence 14 16 17 66 80 Arrowleaf Sida 0 0 0 0 0 Barnyardgrass 0 0 0 0 0 Beggarticks 0 0 — 0 0 Cocklebur — 0 0 0 0 Corn 0 0 0 0 0 Crabgrass, Brazil 0 25 40 85 — Crabgrass, Large 0 10 15 0 50 Dayflower, VA 0 0 0 0 0 Field Bindweed 0 0 0 0 0 Foxtail, Giant 0 0 0 0 0 Foxtail, Green 0 0 0 0 50 Goosegrass 0 0 0 0 10 Johnsongrass 0 0 0 0 0 Kochia 0 — 0 0 — Lambsquarters 0 0 0 0 50 Morningglory 0 0 — 0 0 Nightshade 0 0 0 0 50 Nutsedge, Yellow 0 0 0 0 0 Panicum, Fall 0 0 0 0 0 Pigweed, Palmer 0 0 0 — 0 Poinsettia, Wild 0 0 0 0 0 Ragweed 0 — 0 0 0 Ryegrass, Italian 0 0 0 0 0 Sandbur 0 0 0 0 20 Smartweed — — — — 0 Soybean 0 0 0 0 0 Surinam Grass 0 0 0 0 30 Velvetleaf 0 0 0 0 0 Waterhemp 0 0 0 0 0

Test F

Three plastic pots (ca. 16-cm diameter) per rate were partially filled with sterilized Tama silt loam soil comprising a 35:50:15 ratio of sand, silt and clay and 2.6% organic matter. Separate plantings for each of the three pots were as follows. Seeds from the U.S. of Monochoria (Monochoria vaginalis), sedge, umbrella (small-flower umbrella sedge, Cyperus difformis), bulrush, hardstem (hardstem bulrush, Scirpus juncoides), and redstem (purple redstem, Ammannia coccinea), were planted into one 16-cm pot for each rate. Seeds from the U.S. of flatsedge, rice (rice flatsedge, Cyperus iria), sprangletop, Brdd. (bearded sprangletop, Leptochloa fascicularis), one stand of 9 or 10 water seeded rice seedlings (Rice, W.S. Jap, Oryza sativa cv. ‘Japonica—M202’ or Rice, W. S. Ind, ‘Indica’), and two stands of 3 or 4 seedlings of rice, transplanted (transplanted rice, Oryza sativa cv. ‘Japonica—M202’) were planted into one 16-cm pot for each rate. Seeds from the U.S. of barnyardgrass (Echinochloa crus-galli), waterplantain (common waterplantain, Alisma plantago-aquatica), and watergrass, late (late watergrass, Echinochloa oryzicola) were planted into one 16-cm pot for each rate. Plantings were sequential so that crop and weed species were at the 2.0 to 2.5-leaf stage at time of treatment.

Potted plants were grown in a greenhouse with day/night temperature settings of 30/27° C., and supplemental balanced lighting was provided to maintain a 16-h photoperiod. Test pots were maintained in the greenhouse until test completion.

At time of treatment, test pots were flooded to 3 cm above the soil surface, treated by application of test compounds directly to the paddy water, and then maintained at that water depth for the duration of the test. Effects of treatments on rice and weeds were visually evaluated by comparison to untreated controls after 21 d. Plant response ratings, summarized in Table F, are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

TABLE F 2000 g ai/ha Compounds Flood 5 17 247 Barnyardgrass 90 100 75 Bulrush, Hardstem — 40 — Flatsedge, Rice 0 40 35 Monochoria 75 95 75 Recistem 45 40 55 Rice, Transplanted 0 10 15 Rice, W.S. Jap — 85 — Sedge, Umbrella 0 20 0 Sprangletop, Brdd. 90 100 98 Watergrass, Late 100 95 90 Waterplantain 90 — 90 1000 g ai/ha Compounds Flood 5 17 103 247 Barnyardgrass 90 95 100 70 Bulrush, Hardstem — 0 — — Flatsedge, Rice 0 35 — 0 Monochoria 75 95 100 75 Redstern 45 35 — 50 Rice, Transplanted 0 10 0 10 Rice, W.S. Ind — — 15 — Rice, W.S. Jap — 60 — — Sedge, Umbrella 0 0 — 0 Sprangletop, Brdd. 85 85 100 98 Watergrass, Late 100 90 100 85 Waterplantain 85 — — 90 Compounds Flood 3 5 17 99 101 103 204 206 207 210 247 271 303 500 g ai/ha Barnyardgrass 90 75 90 80 90 100 100 100 100 100 70 100 100 Bulrush, Hardstem 30 — 0 — — — — — — — — — 80 Flatsedge, Rice 20 0 20 — — — — — — — 0 — 0 Monochoria 100 75 95 95 100 100 100 100 100 100 75 100 100 Redstem 20 40 0 — — — — — — — 0 — 30 Rice, Transplanted 0 0 10 0 0 0 0 40 0 0 0 15 30 Rice, W.S. Ind — — — 0 60 0 20 65 10 0 — 60 70 Rice, W.S. Jap 10 — 15 — — — — — — — — — — Sedge, Umbrella 0 0 0 — — — — — — — 0 — 0 Sprangletop, Brdd. 85 85 85 85 95 100 100 100 100 100 98 95 90 Watergrass, Late 85 75 90 50 85 98 98 100 90 90 70 100 100 Waterplantain — 80 — — — — — — — — 90 — — 250 g ai/ha Barnyardgrass 90 65 90 50 85 100 100 100 100 100 65 100 100 Bulrush, Hardstem 0 — 0 — — — — — — — — — 70 Flatsedge, Rice 0 0 20 — — — — — — — 0 — 0 Monochoria 90 75 90 85 100 100 100 100 100 85 70 100 100 Redstem 0 0 0 — — — — — — — 0 — 0 Rice, Transplanted 0 0 10 0 0 0 0 10 0 0 0 0 15 Rice, W.S. Ind — — — 0 35 0 10 45 0 0 — 30 40 Rice, W.S. Jap 0 — 15 — — — — — — — — — — Sedge, Umbrella 0 0 0 — — — — — — — 0 — 0 Sprangletop, Brdd. 80 85 85 75 95 100 100 100 100 100 95 80 85 Watergrass, Late 80 70 85 40 85 98 98 100 85 75 65 100 100 Waterplantain — 70 — — — — — — — — 85 — — 125 g ai/ha Barnyardgrass 55 90 25 85 60 100 100 60 75 60 75 100 — Bulrush, Hardstem — 0 — — — — — — — — — 0 — Flatsedge, Rice 0 20 — — — — — — — 0 — 0 — Monochoria 75 90 50 100 100 95 90 65 65 70 100 100 — Redstem 0 0 — — — — — — — 0 — 0 — Rice, Transplanted 0 10 0 0 0 0 0 0 0 0 0 0 — Rice, W.S. Ind — — 0 20 0 0 25 0 0 — 15 25 — Rice, W.S. Jap — 0 — — — — — — — — — — — Sedge, Umbrella 0 0 — — — — — — — 0 — 0 — Sprangletop, Brdd. 85 85 0 85 80 98 95 100 100 90 30 80 — Watergrass, Late 55 80 30 75 60 70 100 65 55 65 75 95 — Waterplantain 55 — — — — — — — — 80 — — — 64 g ai/ha Compounds Flood 101 103 206 271 Barnyardgrass 60 60 90 55 Monochoria 75 85 80 85 Rice, Transplanted 0 0 0 0 Rice, W.S. Ind 0 0 15 0 Sprangletop, Brdd. 75 80 90 20 Watergrass, Late 65 40 90 45 62 g ai/ha Compound Flood 303 Barnyardgrass 100 Bulrush, Hardstem 0 Flatsedge, Rice 0 Monochoria 100 Redstem 0 Rice, Transplanted 0 Rice, Water Seeded 0 Sedge, Umbrella 0 Sprangletop, Brdd. 70 Watergrass, Late 95

Test G

Seeds of small-flower umbrella sedge (CYPDI, Cyperus difformis) and ducksalad (HETLI, Heteranthera limosa) were sown on the soil surface in two separate quadrants of 11-cm (4-inch) tubs filled with steam pasteurized Tama soil. Simultaneously, plantings of barnyardgrass (ECHCG, Echinochloa crus-galli) and transplanted Japonica rice (ORYSA, Oryza sativa) were established in separate “plug” flats. Plants were grown in a greenhouse using supplemental lighting to maintain a photoperiod of approximately 16 h; daytime and nighttime temperatures were approximately 27-30° C. and 24-27° C., respectively. After 8 d, barnyardgrass plants were transplanted to one of the remaining quadrants of the tub, and the water level was adjusted to a final depth of 3-cm. Herbicide application timing was targeted at the 2.0 to 2.5 leaf stage and the plants were treated with test chemicals formulated in a non-phytotoxic solvent. Treated plants and controls were maintained in a greenhouse for 14 d, after which time all species were compared to controls and visually evaluated. Plant response ratings are summarized in Tables G1 through G12, and are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result.

Colby's Equation was used to determine the herbicidal effects expected from the mixtures. Colby's Equation (Colby, S. R. “Calculating Synergistic and Antagonistic Responses of Herbicide Combinations,” Weeds, 15(1), pp 20-22 (1967)) calculates the expected additive effect of herbicidal mixtures and for two active ingredients is of the form:

P_(a + b) = P_(a) + P_(b) − (P_(a)P_(b)/100)

where

-   -   P_(a+b) is the percentage effect of the mixture expected from         additive contribution of the individual components:     -   P_(a) is the observed percentage effect of the first active         ingredient at the same use rate as in the mixture, and     -   P_(b) is the observed percentage effect of the second active         ingredient at the same use rate as in the mixture.         In the following Tables, rates are shown in grams of active         ingredient per hectare (g a.i./ha); “Obsd.” is the observed         effect. “Exp.” is the expected effect calculated from Colby's         Equation.

TABLE G1 Observed and Expected Results from Compound 204 Alone and in Combination with Fentrazamide Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 204 Fentrazamide Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 100 90 — 85 — 50 — 0 — — 200 100 — 100 — 95 — 15 — 125 100 95 90 100 100 80 83 0 0 125 200 95 90 100 100 95 95 0 0 500 100 100 100 100 100 95 98 0 15 500 200 100 100 100 100 95 100 0 15

TABLE G2 Observed and Expected Results from Compound 103 Alone and in Combination with Fentrazamide Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 103 Fentrazamide Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 100 100 — 100 — 85 — 0 — — 200 100 — 100 — 85 — 0 — 125 100 70 100 100 100 50 94 0 0 125 200 100 100 100 100 75 97 0 15 500 100 100 100 100 100 80 94 10 0 500 200 100 100 100 100 80 97 10 15

TABLE G3 Observed and Expected Results from Compound 204 Alone and in Combination with Tefuryltrione Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 204 Tefuryltrione Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 100 100 — 100 — 40 — 0 — 125 100 100 100 100 100 95 79 0 0 500 100 100 100 100 100 95 94 0 0

TABLE G4 Observed and Expected Results from Compound 103 Alone and in Combination with Tefuryltrione Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 103 Tefuryltrione Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 100 90 — 90 — 0 — 0 — 125 100 98 90 100 100 55 60 0 0 500 100 98 90 100 100 90 80 0 15

TABLE G5 Observed and Expected Results from Compound 204 Alone and in Combination with Triafamone Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 204 Triafamone Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 20 0 — 0 — 90 — 0 — 125 20 0 0 98 100 85 97 0 0 500 20 45 0 100 100 90 99 0 0

TABLE G6 Observed and Expected Results from Compound 103 Alone and in Combination with Triafamone Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 103 Triafamone Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 20 0 — 0 — 85 — 0 — 125 20 0 0 100 100 85 94 0 0 500 20 0 0 100 100 90 97 0 15

TABLE G7 Observed and Expected Results from Compound 204 Alone and in Combination with Pyrimisulfan Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 204 Pyrimisulfan Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 20 98 — 100 — 75 — 25 — 125 20 100 98 100 100 85 91 25 25 500 20 100 98 100 100 95 98 25 25

TABLE G8 Observed and Expected Results from Compound 103 Alone and in Combination with Pyrimisulfan Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 103 Pyrimisulfan Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 20 100 — 100 — 80 — 20 — 125 20 100 100 100 100 85 92 20 20 500 20 100 100 100 100 85 96 0 32

TABLE G9 Observed and Expected Results from Compound 204 Alone and in Combination with Mefenecet Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 204 Mefenecet Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 300 100 — 100 — 30 — 0 — 125 300 100 98 100 100 60 76 0 0 500 300 100 98 100 100 90 93 0 0

TABLE G10 Observed and Expected Results from Compound 103 Alone and in Combination with Mefenecet Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 103 Mefenecet Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 300 100 — 100 — 65 — 10 — 125 300 100 98 100 100 70 86 10 10 500 300 100 98 100 100 80 93 20 24

TABLE G11 Observed and Expected Results from Compound 204 Alone and in Combination with Bensulfuron-methyl Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 204 Bensulfuron-methyl Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 65 — 0 — 500 — 0 — 100 — 90 — 0 — — 20 100 — 100 — 65 — 10 — 125 20 100 100 100 100 70 88 0 10 500 20 100 100 100 100 90 97 0 10

TABLE G12 Observed and Expected Results from Compound 103 Alone and in Combination with Bensulfuron-methyl Application Rate (g a.i./ha) CYPDI HETLI ECHCG ORYSA Cmpd. 103 Bensulfuron-methyl Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 125 — 0 — 100 — 60 — 0 — 500 — 0 — 100 — 80 — 15 — — 20 98 — 100 — 65 — 0 — 125 20 98 98 100 100 65 86 0 0 500 20 100 98 100 100 85 93 10 15

Test H

This test evaluated the effect of mixtures of compound 80 with several commercial herbicides on four plant species. Seeds of plant species selected from corn (ZEAMD, Zea mays), soybean (GLXMA, Glycine max), waterhemp (common waterhemp, AMATA, Amaranthus rudis), and giant foxtail (SETFA, Setaria faberii) were planted into a silt loam soil and treated preemergence with test chemicals formulated in a non-phytotoxic solvent mixture which included a surfactant and applied using a volume of 281 L/ha. Each treatment was replicated three times. Treated plants and controls were maintained in a greenhouse using supplemental lighting to maintain a photoperiod of about 16 h; daytime and nighttime temperatures were about 24-30° C. and 19-21° C., respectively. Nutrients were applied using a balanced fertilizer applied through the watering system. At 21 d after treatment, all species were compared to controls and visually evaluated. Plant response ratings were calculated as the means of the three replicates, are summarized in Tables H1 through H5 , and are based on a scale of 0 to 100 where 0 is no effect and 100 is complete control. A dash (−) response means no test result. The Expected (Exp.) results were calculated using Colby's Equation as described for Test G above.

TABLE H1 Observed and Expected Results from Compound 80 Alone and in Combination with Chlorimuron-ethyl Application Rate (g a.i./ha) ZEAMD GLXMA AMATA SETFA Cmpd 80 Chlorimuron-ethyl Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 1 22 — 0 — 47 — 0 — — 31 73 — 22 — 89 — 47 — 62 1 22 35 18 12 73 47 25 52 125 1 15 32 5 0 73 64 67 78 62 31 96 78 35 31 69 89 58 75 125 31 75 77 0 22 94 93 78 88

TABLE H2 Observed and Expected Results from Compound 80 Alone and in Combination with S-metolachlor Application Rate (g a.i./ha) ZEAMD GLXMA AMATA SETFA Cmpd 80 S-metolachlor Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 31 13 — 18 — 0 — 73 — — 125 20 — 15 — 85 — 99 — 62 31 10 28 8 28 33 0 93 87 125 31 30 24 25 18 75 33 96 94 62 125 25 34 28 25 85 85 98 100 125 125 37 30 12 15 98 90 93 100

TABLE H3 Observed and Expected Results from Compound 80 Alone and in Combination with Saflufenacil Application Rate (g a.i./ha) ZEAMD GLXMA AMATA SETFA Cmpd 80 Saflufenacil Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 1 20 — 0 — 0 — 0 — — 31 0 — 13 — 83 — 23 — 62 1 22 34 40 12 38 0 57 52 125 1 15 30 15 0 33 33 80 78 62 31 30 17 25 23 73 83 40 63 125 31 25 13 0 13 97 89 80 83

TABLE H4 Observed and Expected Results from Compound 80 Alone and in Combination with Atrazine Application Rate (g a.i./ha) ZEAMD GLXMA AMATA SETFA Cmpd 80 Atrazine Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 62 0 — 13 — 33 — 0 — — 125 0 — 48 — 90 — 8 — 62 62 18 17 20 23 83 33 63 52 125 62 10 13 0 13 87 55 78 78 62 125 20 17 5 54 100 90 58 56 125 125 23 13 30 48 98 93 70 80

TABLE H5 Observed and Expected Results from Compound 80 Alone and in Combination with Mesotrione Application Rate (g a.i./ha) ZEAMD GLXMA AMATA SETFA Cmpd 80 Mesotrione Obsd. Exp. Obsd. Exp. Obsd. Exp. Obsd. Exp. 62 — 17 — 12 — 0 — 52 — 125 — 13 — 0 — 33 — 78 — — 16 12 — 25 — 96 — 0 — 62 16 20 27 28 34 93 96 25 52 125 16 32 23 83 25 93 97 48 78 

1-13. (canceled)
 14. A compound of Formula 1:

or a salt thereof, wherein Q¹ is a 5- to 6-membered fully unsaturated heterocyclic ring, each ring containing ring members selected from carbon atoms and 1 to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, each ring optionally substituted with up to 5 substituents independently selected from R⁷ carbon atom ring members and selected from R⁹ on nitrogen atom ring members; Q²is a phenyl ring substituted with 1 to 2 substituents independently selected from R¹⁰; Y¹ is O; Y² is O; R¹ is H or CH₃; R² is H; R³ is H; R⁴ is H; R⁵ is H; R⁶ is H; each R⁷ is independently halogen or C₁-C₂ haloalkyl; each R⁹ is CH₃; each R¹⁰ is independently halogen or haloalkyl; provided that when Q¹ comprises a 3-furanyl or 3-pyridinyl ring directly bonded to the remainder of Formula 1, then said ring is substituted with at least one substituent selected from R⁷.
 15. A herbicidal composition comprising a compound of claim 14 and at least one component selected from the group consisting of surfactants, solid diluents, and liquid diluents.
 16. The herbicidal composition of claim 15 further comprising at least one additional active ingredient selected from the group consisting of other herbicides and herbicide safeners.
 17. A herbicidal mixture comprising (a) the compound of claim 14 and (b) at least one additional active ingredient selected from (b 1) photosystem II inhibitors, (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b3) acetyl-CoA carboxylase (ACCase) inhibitors, (b4) auxin mimics, (b5) 5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, (b6) photosystem I electron diverters, (b7) protoporphyrinogen oxidase (PPO) inhibitors, (b8) glutamine synthetase (GS) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors, (b10) auxin transport inhibitors, (b11) phytoene desaturase (PDS) inhibitors, (b12) 4-hydroxyphenyl-pyruvate dioxyenase (HPPD) inhibitors, (b13) homogentisate solenesyltransererase (HST) inhibitors, (b14) cellulose biosynthesis inhibitors, (b15) other herbicides selected from mitotic disruptors, organic arsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet, difenzoquat, dymron, etobenzanid, flurenol, fosamine, foamine-ammonium, metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid and pyributicarb, and (b16) herbicide safeners; and salts of compounds (b1) to (b16).
 18. A herbicidal mixture comprising (a) a compound of claim 14 and (b) at least one additional active ingredient selected from (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors, and (b12) 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors; and salts of compounds (b2), (b9), and (b12).
 19. A method for controlling the growth of undesired vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of claim
 14. 20. A mixture comprising a compound of claim 14 and a compound selected from benzobicyclon, bromobutide, fenquinotrione, metazosulfuron, pethoxamid, pretilachlor, pyrazolynate, pyrazolsulfuron-ethyl, pyrimisulfan, and triafamone.
 21. A compound of Formula 1:

or a salt thereof, wherein

R^(v) is R⁷ or R⁹; wherein substituent R⁷ is on the carbon atom ring members and substituent R⁹ is on the nitrogen atom ring members; r is 1 or 2; Q² is Ph(2,3-di-F) or Ph(2-F); Y¹ is O; Y² is O; R¹ is H or CH₃; R² is H; R³ is H; R⁴ is H; R⁵ is H; R⁶ is H; each R⁷ is independently halogen or C₁-C₂ haloalkyl; and each R⁹ is CH₃, provided when Q¹ comprises a 3-pyridinyl ring directly bonded to the remainder of Formula 1, then said ring is substituted with at least one substituent selected from R⁷.
 22. The compound of claim 21, or a salt thereof, wherein


23. The compound of claim 21, or a salt thereof, wherein Q¹ is


24. The compound of claim 21, or a salt thereof, wherein Q¹ is


25. The compound of claim 21, or a salt thereof, wherein Q² is Ph(2,3-di-F).
 26. The compound of claim 21, or a salt thereof, wherein Q² is Ph(2-F).
 27. The compound of claim 21, or a salt thereof, wherein R¹ is H.
 28. The compound of claim 21, or a salt thereof, wherein R¹ is CH₃.
 29. The compound of claim 21, or a salt thereof, wherein each R⁷ is independently halogen or Ci haloalkyl.
 30. The compound of claim 21, or a salt thereof, wherein each R⁷ is independently halogen or Ci fluoroalkyl.
 31. The compound of claim 21, or a salt thereof, wherein each R⁷ is independently halogen or CF₃.
 32. The compound of claim 21, or a salt thereof, wherein each R⁷ is independently F, Cl, Br or CF₃.
 33. The compound of claim or a salt thereof, wherein each R⁷ is independently F or CF₃.
 34. The compound of claim 21, or a salt thereof, wherein Q¹ is

Q² is (2,3-di-F), and R¹ is CH₃.
 35. A herbicidal composition comprising a compound of claim 21 and at least one component selected from the group consisting of surfactants, solid diluents, and liquid diluents.
 36. The herbicidal composition of claim 35 further comprising at least one additional active ingredient selected from the group consisting of other herbicides and herbicide safeners.
 37. A herbicidal mixture comprising (a) the compound of claim 21 and (b) at least one additional active ingredient selected from (1)1) photosystem II inhibitors, (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b3) acetyl-CoA carboxylase (ACCase) inhibitors, (b4) auxin mimics, (b5) 5-enol-pyruvylshikimate-3-phosphate (EPSP) synthase inhibitors, (b6) photosystem I electron diverters, (b7) protoporphyrinogen oxidase (PPO) inhibitors, (b8) glutamine synthetase (GS) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors, (b10) auxin transport inhibitors, (b11) phytoene desaturase (PDS) inhibitors, (b12) 4-hydroxyphenyl-pyruvate dioxyenase (HPPD) inhibitors, (b13) homogentisate solenesyltransererase (HST) inhibitors, (b14) cellulose biosynthesis inhibitors, (b15) other herbicides selected from mitotic disruptors, organic arsenicals, asulam, bromobutide, cinmethylin, cumyluron, dazomet, difenzoquat, dymron, etobenzanid, flurenol, fosamine, foamine-ammonium, metam, methyldymron, oleic acid, oxaziclomefone, pelargonic acid and pyributicarb, and (b16) herbicide safeners; and salts of compounds (b1) to (b16).
 38. A herbicidal mixture comprising (a) a compound of claim 21 and (b) at least one additional active ingredient selected from (b2) acetohydroxy acid synthase (AHAS) inhibitors, (b9) very long chain fatty acid (VLCFA) elongase inhibitors, and (b12) 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) inhibitors; and salts of compounds (b2), (b9), and (b12).
 39. A method for controlling the growth of undesired vegetation comprising contacting the vegetation or its environment with a herbicidally effective amount of a compound of claim
 21. 40. A mixture comprising a compound of claim 21 and a compound selected from benzobicyclon, bromobutide, fenquinotrione, metazosulfuron, pethoxamid, pretilachlor, pyrazolynate, pyrazolsulfuron-ethyl, pyrimisulfan, and triafamone. 